Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

Development of Guangxi' s Tourism Economy During Chinese New Year

Through a variety of folk customs and festivals,Guangxi makes full use of the national Intangible Cultural Heritage(ICH)to develop local folk tourism.Bordered by the Beibu Gulf in the south and the Southwest in the west,Guangxi is an important gateway for China's opening up to the outside world.As the only ethnic minority autonomous region with advantages along the coast,along the river and along the border.

Ancient Zhenyuan, Gateway to East Guizhou

This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyuan is located in Zhenyuan County,Qiandongnan Miao and Dong Autonomous Prefecture in southwest China’s Guizhou Province.Covering an area of just around three square kilometers,it sits on the banks of the Wuyang River and is surrounded by mountains.Zhenyuan has been a county for more than 2,281 years and was the prefectural capital during the Yuan(1271-1368)and Qing(1644-1911)dynasties.It is a multicultural region,with Miao,Dong,and other ethnic minorities making up nearly half of the population.

A Duty Cycle-Based Gateway Selection Algorithm for LoRaWAN Downlink Communication

Long Range Wide Area Network(LoRaWAN)has been developed to meet the requirements for the enormous device-to-device communication of Inter-net of Things(IoT)networks,which consist of a large number of participating devices spread over large coverage areas with low data rates and low power con-sumption.It supports communications in both directions,uplink,and downlink directions.However,the downlink communication in the current LoRaWAN raises the bottleneck issue at gateways due to the used gateway selection algo-rithm.This paper proposes a novel gateway selection algorithm based on the duty cycle time-off values for the existing gateways,Duty Cycle Gateway Selection(DCGS),to direct acknowledgment packets as downlink traffic towards the most suitable gateway.Thus,the proposed system avoids subsequent retransmission of previously sent traffic that leads to excessive traffic overloading the network.The proposed system avoids exhausting a gateway duty cycle with downlink traffic by distributing the downlink traffic among available gateways based on the duty cycle time off.DCGS is evaluated using FloRa and INET frameworks in the well-known network simulator OMNeT++.The result shows the superior perfor-mance of the proposed approach over the existing Signal-to-Noise ratio(SNR)based selection mechanism.It clearly indicates that the DCGS maintains a better confirmed packet delivery rate while reducing number of retransmissions,colli-sions,and power consumption.

An Optimal Cluster Head and Gateway Node Selection with Fault Tolerance

In Mobile Ad Hoc Networks(MANET),Quality of Service(QoS)is an important factor that must be analysed for the showing the better performance.The Node Quality-based Clustering Algorithm using Fuzzy-Fruit Fly Optimiza-tion for Cluster Head and Gateway Selection(NQCAFFFOCHGS)has the best network performance because it uses the Improved Weighted Clustering Algo-rithm(IWCA)to cluster the network and the FFO algorithm,which uses fuzzy-based network metrics to select the best CH and entryway.However,the major drawback of the fuzzy system was to appropriately select the membership func-tions.Also,the network metrics related to the path or link connectivity were not considered to effectively choose the CH and gateway.When learning fuzzy sets,this algorithm employs a new Continuous Action-set Learning Automata(CALA)approach that correctly modifies and chooses the fuzzy membership functions.Despite the fact that it extends the network’s lifespan,it does not assist in the detection of defective nodes in the routing route.Because of this,a new Fault Tolerance(NQCAEFFFOCHGS-FT)mechanism based on the Distributed Connectivity Restoration(DCR)mechanism is proposed,which allows the net-work to self-heal as a consequence of the algorithm’s self-healing capacity.Because of the way this method is designed,node failures may be utilised to rebuild the network topology via the use of cascaded node moves.Founded on the fractional network information and topologic overhead related with each node,the DCR is suggested as an alternative to the DCR.When compared to the NQCAFFFOCHGS algorithm,the recreation results display that the proposed NQCAEFFFOCHGS-FT algorithm improves network performance in terms of end-to-end delay,energy consumption,Packet Loss Ratio(PLR),Normalized Routing Overhead(NRO),and Balanced Load Index(BLI).

Widening the Gateway--China aims to foster internationally competitive manufacturing within an open environment

A mong the eight major steps China announced at the Third Belt and Road Forum for International Cooperation to support high-quality Belt and Road cooperation,the cancelation of all restrictions on foreign investment access in the manufacturing sector is the most striking measure,or at least one of the most eye-catching.

采用Automation GATEWAY实现蜗杆的参数化建模

文章首先在Pro/E中创建了蜗杆的参数化实体模型,其次利用Automation GATEWAY控件作接口,实现VB和Pro/E连接,开发了用户参数输入界面。最终程序控制Pro/E参数表,根据界面输入参数自动进行模型再生,从而提高蜗杆的设计效率。

使用DICOM Gateway实现非标准Modality的集成

DICOM标准在医疗影像系统中被广泛采用,但目前许多医疗影像设备(Modality)还不支持DICOM标准。我们结合Kodak公司的实践经验,开发了Kodak DV Gateway,实现了将非标准Modality集成到PACS系统中,对于医院的“无胶片化”和“数字化”具有重要的意义。

DSP Gateway在OMAP平台的实现

OMAP与其他平台最大的不同之处在于其非对称双核处理器结构,OMAP上GPP与DSP之间的通信成为关系系统整体表现的一个关键性问题。诺基亚日本研究中心的科学家开发得DSP Gateway正是为了解决这一难题。主要介绍了DSP Gateway的基本原理与实现,对示例程序进行了验证,证明DSP运行正常,GPP可以通过DSP Gateway对DSP进行控制。

SecIngress:An API Gateway Framework to Secure Cloud Applications Based on N-Variant System

Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multiple variants of a single software in parallel and then checking their behaviors’consistency.However,it is complex to upgrade current Software as a Service(SaaS)applications to adapt N-variant system architecture.Challenges arise from the inability of tenants to adjust the application architecture in the cloud environment,and the difficulty for cloud service providers to implement N-variant systems using existing API gateways.This paper proposes SecIngress,an API gateway framework,to overcome the challenge that it is hard in the cloud environment to upgrade the applications based on N-variants system.We design a two-stage timeout processing method to lessen the service latency and an Analytic Hierarchy Process Voting under the Metadata mechanism(AHPVM)to enhance voting accuracy.We implement a prototype in a testbed environment and analyze the security and performance metrics before and after deploying the prototype to show the effectiveness of SecIngress.The results reveal that SecIngress enhances the reliability of cloud applications with acceptable performance degradation.

Improved-Equalized Cluster Head Election Routing Protocol for Wireless Sensor Networks

Throughout the use of the small battery-operated sensor nodes encou-rage us to develop an energy-efficient routing protocol for wireless sensor networks(WSNs).The development of an energy-efficient routing protocol is a mainly adopted technique to enhance the lifetime of WSN.Many routing protocols are available,but the issue is still alive.Clustering is one of the most important techniques in the existing routing protocols.In the clustering-based model,the important thing is the selection of the cluster heads.In this paper,we have proposed a scheme that uses the bubble sort algorithm for cluster head selection by considering the remaining energy and the distance of the nodes in each cluster.Initially,the bubble sort algorithm chose the two nodes with the maximum remaining energy in the cluster and chose a cluster head with a small distance.The proposed scheme performs hierarchal routing and direct routing with some energy thresholds.The simulation will be performed in MATLAB to justify its performance and results and compared with the ECHERP model to justify its performance.Moreover,the simulations will be performed in two scenarios,gate-way-based and without gateway to achieve more energy-efficient results.

The Key Technologies in Multi-Call Processing of the VoIP Gateway

Because Gateway serves many users, there are some related problems to besolved, such as the allocation and management of multiple calls, the synchronization of multiplethreads, the state transference and time-out processing. To solve these problems,key technologies inour implementation will be proposed, which are important to the stability and efficiency of theGateway. At last, the test of our Gateway is shown and analyzed.

A Novel Onboard-gateway-based Mechanism to Improve TCP Performance in Aeronautical Satellite Networks

The IP-based networks on aircraft serve to support Intemet services via satellites. However, in aeronautical satellite hybrid networks, the TCP protocol performance often deteriorates due to improper decreases and slow recovery of the congestion window. This paper proposes a window size determination and notification mechanism, onboard-gateway-based mechanism （OGBM）, which is based on the onboard gateway in the networks on aircraft. A cross-layer approach is adopted by the onboard gateway to obtain the satellite link bandwidth information. And then, by the gateway, through changing the receiver＇s advertised window field in ACK packets, TCP sources are notified of the window size of each TCP source calculated on the ground of bandwidth delay product and flow numbers. The mechanism is able to avoid improper changes of TCP window and serve multiple users. Simulation results show that the mechanism with the fairness index close to l improves TCP performance in aeronautical satellite networks.

AEECA for Reliable Communication to Enhance the Network Life Time for WSN

Nowadays,wireless sensor networks play a vital role in our day to day life.Wireless communication is preferred for many sensing applications due its convenience,flexibility and effectiveness.The sensors to sense the environmental factor are versatile and send sensed data to central station wirelessly.The cluster based protocols are provided an optimal solution for enhancing the lifetime of the sensor networks.In this paper,modified K-means++algorithm is used to form the cluster and cluster head in an efficient way and the Advanced Energy-Efficient Cluster head selection Algorithm(AEECA)is used to calculate the weighted fac-tor of the transmission path and effective data collection using gateway node.The experimental results show the proposed algorithm outperforms the existing routing algorithms.

Data-Driven Model for Risk Assessment of Cable Fire in Utility Tunnels Using Evidential Reasoning Approach

Cable fire is one of the most important events for operation and maintenance(O&M)safety in underground utility tunnels(UUTs).Since there are limited studies about cable fire risk assessment,a comprehensive assessment model is proposed to evaluate the cable fire risk in different UUT sections and improve O&M efficiency.Considering the uncertainties in the risk assessment,an evidential reasoning(ER)approach is used to combine quantitative sensor data and qualitative expert judgments.Meanwhile,a data transformation technique is contributed to transform continuous data into a five-grade distributed assessment.Then,a case study demonstrates how the model and the ER approach are established.The results show that in Shenzhen,China,the cable fire risk in District 8,B Road is the lowest,while more resources should be paid in District 3,C Road and District 25,C Road,which are selected as comparative roads.Based on the model,a data-driven O&M process is proposed to improve the O&M effectiveness,compared with traditional methods.This study contributes an effective ER-based cable fire evaluation model to improve the O&M efficiency of cable fire in UUTs.

Gateways Placement in Backbone Wireless Mesh Networks

This paper presents a novel algorithm for the gateway placement problem in Backbone Wireless Mesh Networks (BWMNs). Different from existing algorithms, the new algorithm incrementally identifies gateways and assigns mesh routers to identified gateways. The new algorithm can guarantee to find a feasible gateway placement satisfying Quality-of-Service (QoS) constraints, including delay constraint, relay load constraint and gateway capacity constraint. Experimental results show that its performance is as good as that of the best of existing algorithms for the gateway placement problem. But, the new algorithm can be used for BWMNs that do not form one connected component, and it is easy to implement and use.

Construction of adenovirus vectors encoding the lumican gene by gateway recombinant cloning technology

AIM： To construct adenovirus vectors of lumican gene by gateway recombinant cloning technology to further understand the role of lumican gene in myopia. METHODS： Gateway recombinant cloning technology was used to construct adenovirus vectors. The wild-type （wt） and mutant （mut） forms of the lumican gene were synthesized and amplified by polymerase chain reaction （PCR）. The lumican cDNA fragments were purified and ligated into the adenovirus shuttle vector pDown- multiple cloning site （MCS）-/internal ribozyme entry site （IRES）/enhanced green fluorescent protein （EGFP）. Then the desired DNA fragments were integrated into the destination vector pAV.Desld yielding the final expression constructs pAV.Exld-CMV〉wt-lumican/IRES/ EGFP and pAV.Exld-cytomegalovirus （CMV） 〉mutlumican/IRES/EGFP, respectively.RESULTS： The adenovirus plasmids pAV.Exld-CMV〉 wt-lumican/IRES/EGFP and pAV.Exld-CMV 〉mutlumican/IRESlEGFP were successfully constructed by gateway recombinant cloning technology. Positive clones identified by PCR and sequencing were selected and packaged into recombinant adenovirus in HEK293 cells. CONCLUSION： We construct adenovirus vectors containing the lumican gene by gateway recombinant cloning technology, which provides a basis for investigating the role of lumicangene in the pathogenesis of high myopia.

A New Multiple Gateway Transmit Diversity Technique for Future Satellite Networks

The next generation of High Throughput Satellite(HTS)will exploit Q/V band for the feeder link and Ka band for the user link.The exploitation of multiple gateways(GWs)is a transmit diversity measure to compensate severe rain attenuation of Q/V band feeder links.This paper introduces a new smart gateway diversity combination scheme that combinates N-active(K=2)and N+1 diversity method in detail from the working principle,gateway switching strategy,evaluation of system availability and implementation complexity.In addition,a feeder link outage event prediction algorithm featuring combination scheme is given detailly based on modified time-adaptive linear regression.Compared with the existing N+P scheme,the proposed scheme can provide higher system availability and more stable user’s experience under the condition of properly increasing the complexity of payload design.Compared with Nactive scheme that has been reported,it is much easier to implement in engineering and more cost-effective.As a result,the combination scheme is a realistic solution based on a trade-off between performance improvement and implementation complexity.

Nicotine-induced dopamine plasticity: a gateway to neurotransmitter replacement?

Nicotine,the principal neuroactive component of tobacco,acts on the reward systems of smokers,inducing addiction.Experimental evidence indicates that nicotine-induced addiction alters the activity of dopaminergic neurons within reward-processing brain centers.The effect of developmental nicotine exposure on neuroplasticity of identified reward neurocircuitry in the adult is finally emerging and begins to be understood at the molecular,cellular,and behavioral level(Romoli et al.,2019).

Analysis on Construction Requirements for Integrated Gateway Offices

This article describes the significance of constructing integrated gateway office offices by telecom operators in the new era,as well as the change and improvement of the function requirements of in- tegrated gateway office offices with the continuous development of cross-network services.It puts forward ZTE's overall solution for the inter-network interworking with regard to the construction of in- tegrated gateway office offices.