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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?
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作者 Giovanni Ribaudo Matteo Giannangeli +1 位作者 Margrate Anyanwu Alessandra Gianoncelli 《Neural Regeneration Research》 SCIE CAS 2025年第6期1701-1702,共2页
The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect... The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them. 展开更多
关键词 gateway HomEoSTASIS preserve
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The Design of Multi-Connector IoT Central Gateway Based on Raspberry Pi and Docker
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作者 Jie Wang 《Journal of Electronic Research and Application》 2024年第5期66-71,共6页
With the vigorous development of Internet of Things(IoT)technology,the demand for communication and data exchange between different types of IoT devices is increasing day by day.To solve the problems of diversity and ... With the vigorous development of Internet of Things(IoT)technology,the demand for communication and data exchange between different types of IoT devices is increasing day by day.To solve the problems of diversity and complexity of communication protocols between devices,this paper proposes a design scheme of a multi-connector IoT central gateway based on Raspberry Pi and Docker.Through the research and application of related technologies,by integrating multiple communication interfaces and utilizing containerization technology,an efficient,flexible,and scalable IoT central gateway has been realized,which can support the connection and data interaction of multiple communication protocols and provide strong support for the stable operation and development of the IoT system. 展开更多
关键词 Internet of Things Raspberry Pi DoCKER CoNNECToR Central gateway
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Optimal gateway deployment under different queuing mechanisms in smart grid 被引量:1
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作者 赵军辉 姜婷婷 王海明 《Journal of Southeast University(English Edition)》 EI CAS 2016年第1期16-20,共5页
By optimizing the network topology, this paper proposes a newmethod of queuing theory clustering algorithm based on dynamic programming in a home energy management system( HEMS). First, the total cost of the HEMS sy... By optimizing the network topology, this paper proposes a newmethod of queuing theory clustering algorithm based on dynamic programming in a home energy management system( HEMS). First, the total cost of the HEMS system is divided into two parts, the gateway installation cost and the data transmission cost. Secondly, through comparing two kinds of different queuing theories, the cost problem of the HEMS is converted into the problem of gateway deployment. Finally, a machine-to-machine( M2M) gateway configuration scheme is designed to minimize the cost of the system. Simulation results showthat the cost of the HEMS system mainly comes from the installation cost of the gateways when the gateway buffer space is large enough. If the gateway buffer space is limited, the proposed queue algorithm can effectively achieve optimal gateway setting while maintaining the minimal cost of the HEMS at desired levels through marginal analyses and the properties of cost minimization. 展开更多
关键词 smart grid home energy management system(HEmS) queuing theory gateway deployment
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采用Automation GATEWAY实现蜗杆的参数化建模 被引量:2
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作者 崔彦彬 姚志岗 《仪器仪表与分析监测》 2008年第4期21-23,共3页
文章首先在Pro/E中创建了蜗杆的参数化实体模型,其次利用Automation GATEWAY控件作接口,实现VB和Pro/E连接,开发了用户参数输入界面。最终程序控制Pro/E参数表,根据界面输入参数自动进行模型再生,从而提高蜗杆的设计效率。
关键词 蜗杆 VB 参数化建模 AUTomATIoN gateway
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使用DICOM Gateway实现非标准Modality的集成 被引量:4
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作者 傅建兵 吴春旭 钟金鑫 《计算机系统应用》 2006年第3期70-72,共3页
DICOM标准在医疗影像系统中被广泛采用,但目前许多医疗影像设备(Modality)还不支持DICOM标准。我们结合Kodak公司的实践经验,开发了Kodak DV Gateway,实现了将非标准Modality集成到PACS系统中,对于医院的“无胶片化”和“数字化”具有... DICOM标准在医疗影像系统中被广泛采用,但目前许多医疗影像设备(Modality)还不支持DICOM标准。我们结合Kodak公司的实践经验,开发了Kodak DV Gateway,实现了将非标准Modality集成到PACS系统中,对于医院的“无胶片化”和“数字化”具有重要的意义。 展开更多
关键词 DICom gateway modalily集成
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DSP Gateway在OMAP平台的实现 被引量:3
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作者 李生笔 张雪英 《电脑开发与应用》 2008年第4期22-25,共4页
OMAP与其他平台最大的不同之处在于其非对称双核处理器结构,OMAP上GPP与DSP之间的通信成为关系系统整体表现的一个关键性问题。诺基亚日本研究中心的科学家开发得DSP Gateway正是为了解决这一难题。主要介绍了DSP Gateway的基本原理与实... OMAP与其他平台最大的不同之处在于其非对称双核处理器结构,OMAP上GPP与DSP之间的通信成为关系系统整体表现的一个关键性问题。诺基亚日本研究中心的科学家开发得DSP Gateway正是为了解决这一难题。主要介绍了DSP Gateway的基本原理与实现,对示例程序进行了验证,证明DSP运行正常,GPP可以通过DSP Gateway对DSP进行控制。 展开更多
关键词 DSP gateway omAP LINUX
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SecIngress:An API Gateway Framework to Secure Cloud Applications Based on N-Variant System 被引量:6
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作者 Dacheng Zhou Hongchang Chen +2 位作者 Guozhen Cheng Weizhen He Lingshu Li 《China Communications》 SCIE CSCD 2021年第8期17-34,共18页
Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multip... Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multiple variants of a single software in parallel and then checking their behaviors’consistency.However,it is complex to upgrade current Software as a Service(SaaS)applications to adapt N-variant system architecture.Challenges arise from the inability of tenants to adjust the application architecture in the cloud environment,and the difficulty for cloud service providers to implement N-variant systems using existing API gateways.This paper proposes SecIngress,an API gateway framework,to overcome the challenge that it is hard in the cloud environment to upgrade the applications based on N-variants system.We design a two-stage timeout processing method to lessen the service latency and an Analytic Hierarchy Process Voting under the Metadata mechanism(AHPVM)to enhance voting accuracy.We implement a prototype in a testbed environment and analyze the security and performance metrics before and after deploying the prototype to show the effectiveness of SecIngress.The results reveal that SecIngress enhances the reliability of cloud applications with acceptable performance degradation. 展开更多
关键词 N-variant system API gateway cloud security analytic hierarchy process
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Control over Surrounding Rocks Deformation of Soft Floor and Whole-Coal Gateways with Trapezoidal Supports 被引量:5
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作者 ZHAIXin-xian LIDe-Quan +1 位作者 SHAOQiang SUNYu-feng 《Journal of China University of Mining and Technology》 EI 2005年第2期118-123,共6页
In Gengcun Colliery, Yima Coal Group Co. Ltd.the characteristics of the gateways of thick coal seam and the coal seam is with fully mechanized sublevel caving mining are that the thickness of roof coal seam of gateway... In Gengcun Colliery, Yima Coal Group Co. Ltd.the characteristics of the gateways of thick coal seam and the coal seam is with fully mechanized sublevel caving mining are that the thickness of roof coal seam of gateways is larger, their surrounding rocks are the whole-coal mass and the coal seam is prone to Spontaneous Combustion. With the natural equilibrium arch theory, the reasonable adjacent distance of No.11 mine-type metal supports was calculated in trapezoidal gateways based on these characteristics. Then, in-situ supporting experiments were carried out. The results indicate that under the action of virgin rock stress, the width of broken rocks zone of surrounding rocks is 1.7–2.0 m in return heading and 1.1–1.3 m in going headway. And their surrounding rocks belong to the Ⅳ-type soften rock and the Ⅲ-type common surrounding rock respectively. Therefore, under the movable abutment pressure, the gateways deformation is serious. It is suggested that the designed gateways have to use pre-broadened cross section to suit their deformation. At the same time, the accumulated water on gateway floor must be drained in time. These measures were taken in the 1302 and 1304 coal faces in Gengcun Colliery, and the satisfactory results have been obtained. 展开更多
关键词 whole-coal gateway gateway the natural equilibrium arch theory trapezoidal support
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An Approach for Enabling Intelligent Edge Gateway Based on Microservice Architecture in Cloud Manufacturing 被引量:5
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作者 WANG Liping TANG Dunbing +2 位作者 NIE Qingwei SONG Jiaye LIU Changchun 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2022年第3期338-348,共11页
Cloud manufacturing has become a reality. It requires sensing and capturing heterogeneous manufacturing resources and extensive data analysis through the industrial internet. However,the cloud computing and serviceori... Cloud manufacturing has become a reality. It requires sensing and capturing heterogeneous manufacturing resources and extensive data analysis through the industrial internet. However,the cloud computing and serviceoriented architecture are slightly inadequate in dynamic manufacturing resource management. This paper integrates the technology of edge computing and microservice and develops an intelligent edge gateway for internet of thing(IoT)-based manufacturing. Distributed manufacturing resources can be accessed through the edge gateway,and cloud-edge collaboration can be realized. The intelligent edge gateway provides a solution for complex resource ubiquitous perception in current manufacturing scenarios. Finally,a prototype system is developed to verify the effectiveness of the intelligent edge gateway. 展开更多
关键词 edge computing intelligent gateway microservice architecture cloud manufacturing
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Asymmetrical multi-gateways based internet connectivity for MANET6 被引量:3
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作者 赵蕴龙 门朝光 杨孝宗 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2005年第2期173-178,共6页
Mobile ad hoc networks (MANETs) are autonomous and infrastructureless networks that support multi-hop wireless communications among mobile hosts. Providing global internet connectivity to MANETs is a strong trend nowa... Mobile ad hoc networks (MANETs) are autonomous and infrastructureless networks that support multi-hop wireless communications among mobile hosts. Providing global internet connectivity to MANETs is a strong trend nowadays, so the mobile hosts can enjoy the tremendous services of the Internet. In this paper, we present an asymmetrical approach that uses multiple Internet Gateways to provide MANETs nodes with Internet connectivity and access to the Internet’s resources. The rational utilization of all available Internet Gateways can meet the load of MANETs balance and reduce the latency of packets communication between MANETs and the Internet; this can be concluded from the results of the simulation experiments. 展开更多
关键词 mANET6 mobile IPv6 AoDV internet gateways internet connectivity
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The Key Technologies in Multi-Call Processing of the VoIP Gateway 被引量:1
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作者 HUANGYong-feng ZHUMing-fang BAIYi-zhi 《Wuhan University Journal of Natural Sciences》 CAS 2005年第3期511-514,共4页
Because Gateway serves many users, there are some related problems to besolved, such as the allocation and management of multiple calls, the synchronization of multiplethreads, the state transference and time-out proc... Because Gateway serves many users, there are some related problems to besolved, such as the allocation and management of multiple calls, the synchronization of multiplethreads, the state transference and time-out processing. To solve these problems,key technologies inour implementation will be proposed, which are important to the stability and efficiency of theGateway. At last, the test of our Gateway is shown and analyzed. 展开更多
关键词 VoIP gateway multi-call
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A Novel Onboard-gateway-based Mechanism to Improve TCP Performance in Aeronautical Satellite Networks 被引量:1
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作者 GU Ming ZHANG Jun 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2007年第3期260-265,共6页
The IP-based networks on aircraft serve to support Intemet services via satellites. However, in aeronautical satellite hybrid networks, the TCP protocol performance often deteriorates due to improper decreases and slo... The IP-based networks on aircraft serve to support Intemet services via satellites. However, in aeronautical satellite hybrid networks, the TCP protocol performance often deteriorates due to improper decreases and slow recovery of the congestion window. This paper proposes a window size determination and notification mechanism, onboard-gateway-based mechanism (OGBM), which is based on the onboard gateway in the networks on aircraft. A cross-layer approach is adopted by the onboard gateway to obtain the satellite link bandwidth information. And then, by the gateway, through changing the receiver's advertised window field in ACK packets, TCP sources are notified of the window size of each TCP source calculated on the ground of bandwidth delay product and flow numbers. The mechanism is able to avoid improper changes of TCP window and serve multiple users. Simulation results show that the mechanism with the fairness index close to l improves TCP performance in aeronautical satellite networks. 展开更多
关键词 congestion control TCP gateway aeronautical satellite network
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Gateways Placement in Backbone Wireless Mesh Networks 被引量:2
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作者 Maolin TANG 《International Journal of Communications, Network and System Sciences》 2009年第1期44-50,共7页
This paper presents a novel algorithm for the gateway placement problem in Backbone Wireless Mesh Networks (BWMNs). Different from existing algorithms, the new algorithm incrementally identifies gateways and assigns m... This paper presents a novel algorithm for the gateway placement problem in Backbone Wireless Mesh Networks (BWMNs). Different from existing algorithms, the new algorithm incrementally identifies gateways and assigns mesh routers to identified gateways. The new algorithm can guarantee to find a feasible gateway placement satisfying Quality-of-Service (QoS) constraints, including delay constraint, relay load constraint and gateway capacity constraint. Experimental results show that its performance is as good as that of the best of existing algorithms for the gateway placement problem. But, the new algorithm can be used for BWMNs that do not form one connected component, and it is easy to implement and use. 展开更多
关键词 gateway PLACEmENT BACKBoNE WIRELESS mESH Networks
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Development of Guangxi' s Tourism Economy During Chinese New Year
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作者 Liu Xiongsheng Xu Xiaoming 《China & The World Cultural Exchange》 2024年第4期30-33,共4页
Through a variety of folk customs and festivals,Guangxi makes full use of the national Intangible Cultural Heritage(ICH)to develop local folk tourism.Bordered by the Beibu Gulf in the south and the Southwest in the we... Through a variety of folk customs and festivals,Guangxi makes full use of the national Intangible Cultural Heritage(ICH)to develop local folk tourism.Bordered by the Beibu Gulf in the south and the Southwest in the west,Guangxi is an important gateway for China's opening up to the outside world.As the only ethnic minority autonomous region with advantages along the coast,along the river and along the border. 展开更多
关键词 oUTSIDE AUToNomoUS gateway
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Construction of adenovirus vectors encoding the lumican gene by gateway recombinant cloning technology 被引量:1
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作者 Gui-Fang Wang Bing Qi +3 位作者 Lei-Lei Tu Lian Liu Guo-Cheng Yu Jing-Xiang Zhong 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第9期1271-1275,共5页
AIM: To construct adenovirus vectors of lumican gene by gateway recombinant cloning technology to further understand the role of lumican gene in myopia. METHODS: Gateway recombinant cloning technology was used to co... AIM: To construct adenovirus vectors of lumican gene by gateway recombinant cloning technology to further understand the role of lumican gene in myopia. METHODS: Gateway recombinant cloning technology was used to construct adenovirus vectors. The wild-type (wt) and mutant (mut) forms of the lumican gene were synthesized and amplified by polymerase chain reaction (PCR). The lumican cDNA fragments were purified and ligated into the adenovirus shuttle vector pDown- multiple cloning site (MCS)-/internal ribozyme entry site (IRES)/enhanced green fluorescent protein (EGFP). Then the desired DNA fragments were integrated into the destination vector pAV.Desld yielding the final expression constructs pAV.Exld-CMV〉wt-lumican/IRES/ EGFP and pAV.Exld-cytomegalovirus (CMV) 〉mutlumican/IRES/EGFP, respectively.RESULTS: The adenovirus plasmids pAV.Exld-CMV〉 wt-lumican/IRES/EGFP and pAV.Exld-CMV 〉mutlumican/IRESlEGFP were successfully constructed by gateway recombinant cloning technology. Positive clones identified by PCR and sequencing were selected and packaged into recombinant adenovirus in HEK293 cells. CONCLUSION: We construct adenovirus vectors containing the lumican gene by gateway recombinant cloning technology, which provides a basis for investigating the role of lumicangene in the pathogenesis of high myopia. 展开更多
关键词 mYoPIA LUmICAN adenovirus vector gateway recombinant cloning technology
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Influence of mining thickness to the mechanical characteristics of gateways at FMTC faces 被引量:1
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作者 谢广祥 王磊 《Journal of Coal Science & Engineering(China)》 2008年第1期1-5,共5页
To make a better understanding of the mechanical characteristics of the surrounding rocks in the tailentry and headentry with different coal seam thickness at fully mechanized top-coal caving face (FMTC face), the s... To make a better understanding of the mechanical characteristics of the surrounding rocks in the tailentry and headentry with different coal seam thickness at fully mechanized top-coal caving face (FMTC face), the stress transition and displacement around the periphery of the gateways with different coal thicknesses were investigated in details by means of in situ measurement and 3-D numerical simulation. The research shows that the stresses decrease in the two spallings of the headentry and floor at goal with the increase in mining thickness. The roof pressure in the gates does not change obviously with the coal thickness, but the thicker the coal seam is, the farther the maximum stress will apply to the coal rib at the working face. The vertical stress is higher than the horizontal stress at two spallings of the gate, while its horizontal stress is higher than the vertical stress at the roof. The relative displacement between the roof and floor and the two spallings in the gateways increases gradually with the increase in coal seam thickness in a definite range in front of the face. Near the mining face, the stress decreases in the surrounding rock of the gates, while the deformation appears the most intensive. It is proposed that the support concept to the tailentry and headentry should be changed from loading control to deformation control. 展开更多
关键词 FmTC face coal seam thickness gatewayS STRESS DISPLACEmENT
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Ancient Zhenyuan, Gateway to East Guizhou
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作者 MENG JIAXIN 《China Today》 2024年第1期76-80,共5页
This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyua... This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyuan is located in Zhenyuan County,Qiandongnan Miao and Dong Autonomous Prefecture in southwest China’s Guizhou Province.Covering an area of just around three square kilometers,it sits on the banks of the Wuyang River and is surrounded by mountains.Zhenyuan has been a county for more than 2,281 years and was the prefectural capital during the Yuan(1271-1368)and Qing(1644-1911)dynasties.It is a multicultural region,with Miao,Dong,and other ethnic minorities making up nearly half of the population. 展开更多
关键词 GUIZHoU gateway SoUTHWEST
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Parameters determination and bolting control of gateway floor 被引量:1
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作者 GOU Pan-feng XIN Ya-jun 《Journal of Coal Science & Engineering(China)》 2011年第4期388-392,共5页
Gateway floor heave control is the key to guarantee mine safe and efficient production. Through analysis of floor instability characteristics and bolting control, gateway floor strata show second level stress under ab... Gateway floor heave control is the key to guarantee mine safe and efficient production. Through analysis of floor instability characteristics and bolting control, gateway floor strata show second level stress under abutment pressure, which causes plastic flow failure in floor strata; gateway floor instability shows mainly shear-break slippage of "triangle sliding body". Mechanics of floor bolting is mainly a function of connection and combination. Main area of bolting control lies in two gateway floor angles. The paper analyzes mechanics principle of gateway floor instability, constructs stability mechanics model of gateway floor bolting, obtains gateway floor stability criterion of different bolting angles and optimum formula of bolting parameters, carries out the engineering example, and guides better field application. It provides theoretical base for bolting gateway floor instability control. 展开更多
关键词 parameter determination BoLTING gateway floor heave mechanical model judge criterion
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Optimization of an Underwater Wireless Sensor Network Architecture with Wave Glider as a Mobile Gateway 被引量:1
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作者 Tatiana A.Fedorova Vladimir A.Ryzhov +1 位作者 Nikolay N.Semenov Shaharin A.Sulaiman 《Journal of Marine Science and Application》 CSCD 2022年第2期179-196,共18页
This paper presents an original probabilistic model of a hybrid underwater wireless sensor network(UWSN),which includes a network of stationary sensors placed on the seabed and a mobile gateway.The mobile gateway is a... This paper presents an original probabilistic model of a hybrid underwater wireless sensor network(UWSN),which includes a network of stationary sensors placed on the seabed and a mobile gateway.The mobile gateway is a wave glider that collects data from the underwater network segment and retransmits it to the processing center.The authors consider the joint problem of optimal localization of stationary network nodes and the corresponding model for bypassing reference nodes by a wave glider.The optimality of the network is evaluated according to the criteria of energy efficiency and reliability.The influence of various physical and technical parameters of the network on its energy efficiency and on the lifespan of sensor nodes is analyzed.The analysis is carried out for networks of various scales,depending on the localization of stationary nodes and the model of bypassing the network with a wave glider.As a model example,the simulation of the functional characteristics of the network for a given size of the water area is carried out.It is shown that in the case of a medium-sized water area,the model of“bypassing the perimeter”by a wave glider is practically feasible,energy efficient and reliable for hourly data measurements.In the case of a large water area,the cluster bypass model becomes more efficient. 展开更多
关键词 Underwater wireless sensor network(UWSN) Wave glider(WG) Sensor network architecture mobile gateway Hydroacoustic communication
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Proposal for Energy Consumption Reduction between Connected Objects in a Network Running on MQTT Protocol
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作者 Saidou Haman Djorwe Temoa +1 位作者 Eric Michel Deussom Djomadji Kolyang   《Journal of Computer and Communications》 2024年第10期177-188,共12页
The “Internet of Things” (IoT) refers to a set of intelligent “objects” that can communicate with each other directly or through a network. The IoT is the embodiment of the idea that everything can be connected an... The “Internet of Things” (IoT) refers to a set of intelligent “objects” that can communicate with each other directly or through a network. The IoT is the embodiment of the idea that everything can be connected anywhere and at any time. The concept can be applied to sectors such as e-health, e-government, automotive, geographic information systems, remote sensing, home networking, e-commerce and climate change mitigation. Unlike the Internet, the IoT has its own constraints, notably those linked to heterogeneity. This divergence is linked to different protocols, technologies and algorithms implemented in these connected objects for their interconnection. It should be noted that IoT devices can communicate with each other using different protocols and dedicated M2M (Machine to Machine) communication technologies. The aim of this work is to find solutions for optimising energy consumption during data exchanges between connected objects, with respect to certain constraints by using firstly this exchange for only Message Queuing Telemetry Transport (MQTT) and secondly the combination of the MQTT protocol and the Constrained Application Protocol (CoAP) protocol to check the quantity of the energy optimized. The MQTT protocol, for example, is one of the most widely used protocols for connected objects. Admittedly, this protocol consumes less energy, but in the situation of a very large number of users, the problem of saturation inevitably arises. In this article, we propose a solution of optimising energy consumption by combining the MQTT protocol with the CoAP protocol which can allow to use the standby mode contrary to the use of MQTT where the broker is always being turning. This solution has not yet been implemented but is being discussed. In this article, we’re going to use the joulemeter which is an application developed by Microsoft to measure and estimate the energy consumption of computers and applications. In our case, we take the example of the “Service Broker for network connections” of the Windows’s 10 Operating System, in my own computer to show the difference between the consumption of energy without the standby mode and with standby mode, because with the MQTT, the Broker’s MQTT is always on. Now, with the combination MQTT and CoAP, it is possible that we have standby mode and to compare these two cases in term of consumption of an energy. And to do it, we must use the joulemeter that we installed in our computer to simulate it. This is achieved by using the CoAP protocol combined with the MQTT protocol. The aim of our work is to reduce energy consumption in order to solve the problem of saturation of the MQTT by linking it to CoAP protocol by using Joulemeter mentioned above. 展开更多
关键词 Internet of Things HETERoGENEITY message Queuing Telemetry Transport Constrained Application Protocol Application-Layer Semantic gateway gateway
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