The purpose of this study was to investigate the effects of yogurt containing Lactobacillus gasseri OLL2716 (LG21) on autonomic nerve activities, peripheral blood flow, skin condition (skin pig-mentations and moisture...The purpose of this study was to investigate the effects of yogurt containing Lactobacillus gasseri OLL2716 (LG21) on autonomic nerve activities, peripheral blood flow, skin condition (skin pig-mentations and moisture), saliva s-IgA and examination of quality of life (QOL). 20 healthy female volunteers (yogurt containing LG21 group: 10 people, yogurt containing Bifidobacterium (Bif) group: 10 people) were examined. The subjects ingested 100 g of yogurt twice daily for 4 weeks. Analysis was before and after 4 weeks dosage. By the effects for the autonomic nervous activity, parasympathetic increase was observed in the LG21 yogurt group, but was not significant increase. The LG21 yogurt was significantly increased on the peripheral blood flow. The LG21 yogurt was significantly increased on saliva s-IgA. The LG21 yogurt and Bif yogurt were significantly decrease on skin pigmentation. Also, LG21 yogurt was significantly increased on skin moisture. As a result of QOL questionnaire, incomplete evacuation, lower abdominal fullness, cold extremities and pimply or rough skin improved in LG21 yogurt and Bif yogurt after the administration period. These results suggest that the improvement effects of LG21 yogurt may be related to the activity of the parasympathetic nervous system.展开更多
During initial studies of ECRH in the HL-1M tokamak, non-standard central MHD activities,such as saturated sawtooth, partially saturated sawtooth, double sawtooth, and the strong m = 1 bursts have been observed while ...During initial studies of ECRH in the HL-1M tokamak, non-standard central MHD activities,such as saturated sawtooth, partially saturated sawtooth, double sawtooth, and the strong m = 1 bursts have been observed while changing the heating location, the ECRH power, the plasma density. Complete suppression of sawtooth is achieved for the duration of the ECRH, when the heating power is applied on the high-field side of low-density plasma, and exceeds a threshold value of power. The m = 1 bursts riding on the ramp phase of sawtooth can only be excited when the ECRH location is near the q = 1 surface on the high field side. The conditions under which the various relaxation activities are produced or suppressed are described. Experimental results imply that the energetic electrons generated during ECRH are responsible for the modification/or stabilization/or excitation of the instability. Near the q = 1 surface, the passing electrons play the role of reducing the shear and tending to stabilize the sawtooth activity, while the barely-trapped electrons play the role of enhancing or driving an internal kink instability.展开更多
Sensory modalities are important for survival but the molecular mechanisms remain challenging due to the polymodal functionality of sensory neurons. Here, we report the C. elegans outer labial lateral(OLL) sensilla se...Sensory modalities are important for survival but the molecular mechanisms remain challenging due to the polymodal functionality of sensory neurons. Here, we report the C. elegans outer labial lateral(OLL) sensilla sensory neurons respond to touch and cold. Mechanosensation of OLL neurons resulted in cell-autonomous mechanically-evoked Ca~(2+) transients and rapidly-adapting mechanoreceptor currents with a very short latency.Mechanotransduction of OLL neurons might be carried by a novel Na~+ conductance channel, which is insensitive to amiloride. The bona fide mechano-gated Na~+ -selective degenerin/epithelial Na~+ channels, TRP-4, TMC, and Piezo proteins are not involved in this mechanosensation.Interestingly, OLL neurons also mediated cold but not warm responses in a cell-autonomous manner. We further showed that the cold response of OLL neurons is not mediated by the cold receptor TRPA-1 or the temperaturesensitive glutamate receptor GLR-3. Thus, we propose the polymodal functionality of OLL neurons in mechanosensation and cold sensation.展开更多
文摘The purpose of this study was to investigate the effects of yogurt containing Lactobacillus gasseri OLL2716 (LG21) on autonomic nerve activities, peripheral blood flow, skin condition (skin pig-mentations and moisture), saliva s-IgA and examination of quality of life (QOL). 20 healthy female volunteers (yogurt containing LG21 group: 10 people, yogurt containing Bifidobacterium (Bif) group: 10 people) were examined. The subjects ingested 100 g of yogurt twice daily for 4 weeks. Analysis was before and after 4 weeks dosage. By the effects for the autonomic nervous activity, parasympathetic increase was observed in the LG21 yogurt group, but was not significant increase. The LG21 yogurt was significantly increased on the peripheral blood flow. The LG21 yogurt was significantly increased on saliva s-IgA. The LG21 yogurt and Bif yogurt were significantly decrease on skin pigmentation. Also, LG21 yogurt was significantly increased on skin moisture. As a result of QOL questionnaire, incomplete evacuation, lower abdominal fullness, cold extremities and pimply or rough skin improved in LG21 yogurt and Bif yogurt after the administration period. These results suggest that the improvement effects of LG21 yogurt may be related to the activity of the parasympathetic nervous system.
文摘During initial studies of ECRH in the HL-1M tokamak, non-standard central MHD activities,such as saturated sawtooth, partially saturated sawtooth, double sawtooth, and the strong m = 1 bursts have been observed while changing the heating location, the ECRH power, the plasma density. Complete suppression of sawtooth is achieved for the duration of the ECRH, when the heating power is applied on the high-field side of low-density plasma, and exceeds a threshold value of power. The m = 1 bursts riding on the ramp phase of sawtooth can only be excited when the ECRH location is near the q = 1 surface on the high field side. The conditions under which the various relaxation activities are produced or suppressed are described. Experimental results imply that the energetic electrons generated during ECRH are responsible for the modification/or stabilization/or excitation of the instability. Near the q = 1 surface, the passing electrons play the role of reducing the shear and tending to stabilize the sawtooth activity, while the barely-trapped electrons play the role of enhancing or driving an internal kink instability.
基金supported by the National Natural Science Foundation of China (31471023, 31771113, and 31800878)the China Postdoctoral Science Foundation (2020M671695, 2020T130592, 2019T120505, and 2018M640551)。
文摘Sensory modalities are important for survival but the molecular mechanisms remain challenging due to the polymodal functionality of sensory neurons. Here, we report the C. elegans outer labial lateral(OLL) sensilla sensory neurons respond to touch and cold. Mechanosensation of OLL neurons resulted in cell-autonomous mechanically-evoked Ca~(2+) transients and rapidly-adapting mechanoreceptor currents with a very short latency.Mechanotransduction of OLL neurons might be carried by a novel Na~+ conductance channel, which is insensitive to amiloride. The bona fide mechano-gated Na~+ -selective degenerin/epithelial Na~+ channels, TRP-4, TMC, and Piezo proteins are not involved in this mechanosensation.Interestingly, OLL neurons also mediated cold but not warm responses in a cell-autonomous manner. We further showed that the cold response of OLL neurons is not mediated by the cold receptor TRPA-1 or the temperaturesensitive glutamate receptor GLR-3. Thus, we propose the polymodal functionality of OLL neurons in mechanosensation and cold sensation.
