OPCAB (Off Pump Coronary Artery Bypass) for Kawasaki Disease

We hereby report a case of Kawasaki disease in a 32 year old male, with giant aneurysm of both coronary arteries and severe LV (left ventricular) dysfunction who underwent OPCAB (off pump coronary artery bypass grafting) two years ago. He presented with acute myocardial infarction of his anterior wall of left ventricle. He was stabilised with medical management and was taken up for surgery when his enzymes became normal. His LV function had improved over the time and now has a good ejection fraction.

Coronary artery bypass grafting with concomitant resection for carcinoma of lung

A 69-year-old woman with angina had a lesion in the left lower lobe on chest film. Angiography revealed coronary artery disease in three vessels. Combined off pump coronary artery bypass grafting （CABG） and left lower lobectomy were performed through median sternotomy. This approach avoids complications due to staged operations and cardiopulmonary bypass （CPB）. This report shows that simultaneous off pump CABG and pulmonary operations can be performed safely in patients with coronary artery disease （CAD） associated with lung cancer.

Peri-operative application of intra-aortic balloon pumping reduced in-hospital mortality of patients with coronary artery disease and left ventricular dysfunction

Background:There are few reports of peri-operative application of intra-aortic balloon pumping(IABP)in patients with coronary artery disease(CAD)and different grades of left ventricular dysfunction.This study aimed to analyze the early outcomes of perioperative application of IABP in coronary artery bypass grafting(CABG)among patients with CAD and left ventricular dysfunction,and to provide a clinical basis for the peri-operative use of IABP.Methods:A retrospective analysis of 612 patients who received CABG in the General Hospital of People's Liberation Army between May 1995 and June 2014.Patients were assigned to an IABP or non-IABP group according to their treatments.Logistic regression analysis was performed to investigate the influence of peri-operative IABP implantation on in-hospital mortality.Further subgroup analysis was performed on patients with severe(ejection fraction[EF]≤35%)and mild(EF=36%-50%)left ventricular dysfunction.Results:Out of 612 included subjects,78 belonged to the IABP group(12.7%)and 534 to the non-IABP group.Pre-operative left ventricular EF(LVEF)and EuroSCOREII·predicted mortality was higher in the IABP group compared with the non-IABP group(P<0.001 in both cases),yet the two did not differ significantly in terms of post-operative in-hospital mortality(P=0.833).Regression analysis showed that IABP implantation,recent myocardial infarction,critical status,non-elective operation,and postoperative ventricular fibrillation were risk factors affecting in-hospital mortality(P<0.01 in all cases).Peri-operative IABP implantation was a protective factor against in-hospital mortality(P=0.0010).In both the severe and mild left ventricular dysfunction subgroups,peri-operative IABP implantation also exerted a protective role against mortality(P=0.0303 and P=0.0101,respectively).Conclusions:Peri-operative IABP implantation could reduce the in-hospital mortality and improve the surgical outcomes of patients with CAD with both severe and mild left ventricular dysfunction.

Preliminary results of combined carotid endarterectomy and off-pump coronary artery bypass grafting in patients with coexistent carotid and coronary artery diseases

Background Coexistent carotid and coronary artery diseases are common and patients with them remain at a high risk for perioperative stroke or myocardial infarction after coronary bypass surgery. The aim of this study was to investigate the effect of combined carotid endarterectomy （CEA） and off-pump coronary artery bypass grafting （CABG） in patients with coexistent carotid and coronary artery diseases. Methods Between January 2002 and December 2007, consecutive patients with coexistent carotid and coronary artery diseases underwent one-stage unilateral CEA and off-pump CABG in Heart Institute of Nanjing First Hospital Affiliated to Nanjing Medical University. Perioperative complications were assessed and follow-up was carried out. Results A total of 51 cases of isolated off-pump CABG and unilateral CEA, including 34 right and 17 left, were performed. The mean blocked time of carotid artery in CEA was （25.5_±7.0） minutes. The mean number of distal grafts per patient was 3.30±0.45. The mean ventilation time, intensive care unit stay, and postoperative hospital stay was （11.3±5.4） hours, （2.1±0.9） days, and （12.5±6.1） days respectively. None of the patients had stroke or myocardial infarct. There was one perioperative death due to acute cardiac failure, resulting in an operative mortality of 1.96%. Follow-up was completed for 47 patients （92.16%） with a mean follow-up of （39.5±12.5） months. None of the patients manifested stroke, new angina or newly developed cardiac infarct. No late death occurred. Conclusion Combined CEA and off-pump CABG is a safe and effective procedure in selected patients with coexistent carotid and coronary artery diseases.

Off-pump surgery for coronary artery disease combined with mitral stenosis

Rheumatic heart disease is still highly prevalent in .developing countries where the incidence of coronaryartery disease （CAD） is also arising. Consequently the occurrence of coexistent CAD and mitral stenosis （MS） dominantly caused by rheumatic fever is more frequent in these countries. Comorbidities such as pulmonary and renal dysfunction occur frequently in these aging populations. Off-pump surgery is widely applied in patients with concomitant CAD and severe comorbidities due to lower incidence of postoperative morbidity. Closed mitral commissurotomy （CMC） is a well established treatment for patients with mitral stenosis. We report here a case of moderate stenosis combined with seriously diffuse 3-vessel CAD and severe chronic obstructive pulmonary disease （COPD） in an elder male treated with off-pump coronary artery bypass （OPCAB） plus CMC.

Sequential saphenous vein grafting combined with selective arterialization of middle cardiac vein during off-pump coronary artery bypass surgery

Currently coronary artery bypass grafting （CABG） is the most commonly used procedure for revascularization of coronary heart disease. However it may not be suitable for the patients with diffuse coronary artery diseases. Under this circumstance, retrograde perfusion via cardiac venous system, namely retrograde coronary venous bypass graft （CVBG）,

冠心病患者OPCABG术后新发心房颤动的危险因素分析及干预措施

目的探讨冠心病患者非体外循环冠状动脉旁路移植术(OPCABG)术后新发心房颤动的危险因素并建立logistic回归模型,分析该模型对术后新发心房颤动的预测价值,为临床制定干预措施提供参考。方法回顾性选取2021年10月至2023年8月河南省胸科医院收治的175例冠心病患者,依据OPCABG术后5 d是否新发心房颤动分为发生组49例、未发生组126例。比较两组临床资料,经多因素logistic回归分析术后新发心房颤动的影响因素,并建立logistic回归模型。采用受试者工作特征(ROC)曲线评价该模型对术后新发心房颤动的预测效能,Hosmer-Lemeshow法评价该模型的拟合度。结果左心房容积指数、术后主动脉内球囊反搏(IABP)辅助、右冠状动脉近段狭窄≥75%及术前中性粒细胞淋巴细胞比值(NLR)、血清生长分化因子15(GDF-15)为术后新发心房颤动的独立危险因素(P<0.05)。logistic回归模型预测术后新发心房颤动的曲线下面积(AUC)为0.928,敏感度、特异度分别为89.80%、85.71%,且具有良好校准能力。结论左心房容积指数、术后IABP辅助、右冠状动脉近段狭窄≥75%及术前NLR、血清GDF-15为冠心病患者OPCABG术后新发心房颤动的独立危险因素,基于上述影响因素建立logistic回归模型,该模型对术后新发心房颤动具有一定预测价值,临床可依据该模型筛选高危人群,采取积极干预措施,以降低术后新发心房颤动的发生风险。

红花黄色素注射液联合前列地尔治疗对冠状动脉旁路移植术后患者的影响

目的:探讨红花黄色素注射液联合前列地尔治疗对冠状动脉旁路移植术(CABG)后患者的影响。方法:选择2018年9月~2020年9月在邯郸市中心医院心血管外科行CABG的冠心病患者92例,按入院先后顺序,分为对照组(2018年9月~2019年9月,CABG后给予常规治疗+前列地尔)和研究组(2019年10月~2020年9月,在对照组基础上给予红花黄色素注射液),各46例,均治疗28d。停药3d后,比较两组疗效、心功能指标、心肌酶谱四项、围术期观察指标的变化。结果:停药3d后,与对照组比较,研究组临床总有效率(73.9%比91.3%)、左心室射血分数(LVEF)[(55.77±4.48)%比(62.18±4.21)%]均显著提高(P=0.028、<0.001);左心房内径(LAD)[(36.83±3.45)mm比(32.09±3.23)mm]、左心室舒张末期内径(LVEDd)[(49.04±4.65)mm比(43.83±5.24)mm]、肌酸激酶(CK)[(125.13±14.21)U/L比(62.56±8.42)U/L]、乳酸脱氢酶(LDH)[(203.58±31.63)U/L比(156.07±22.26)U/L]、天冬氨酸氨基转移酶(AST)[(44.25±12.98)U/L比(35.41±12.37)U/L]、肌酸激酶同工酶(CK-MB)[(28.11±9.84)U/L比(17.59±7.41)U/L]水平显著降低(P均<0.001)。结论:红花黄色素注射液联合前列地尔可提升CABG后疗效,改善患者心功能,减轻心肌损伤。

重度左心室功能低下患者心脏不停搏冠状动脉旁路移植术探讨

目的探讨重度左心室功能低下患者不停搏冠状动脉旁路移植术(off-pump coronary artery bypass grafting,Off-pump CABG)的可行性。方法筛选首都医科大学大兴教学医院2017年5月至2022年5月,无法介入干预或介入干预失败同时不伴有其他需外科干预的冠状动脉粥样硬化心脏病(冠心病)变患者32例,其中男28例、女4例,左心室射血分数(left ventricular ejection fraction,LVEF)<30%,年龄为(62.1±7.4)岁。术前均行心肌核素扫描,术前、术中同期预置主动脉球囊反搏。所有患者均采用体外循环湿备下非体外循环Off-pump CABG术。结果无患者死亡,32例患者心绞痛症状消失,生活质量明显改善。超声心动图3个不同时期(术前、术后10~14 d、术后1年)LVEF、左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)、左心室收缩末期内径(left ventricular end-systolic diameter,LVESD)比较,差异有统计学意义(P<0.05)。结论充分术前准备的重度左心室功能低下患者采用Off-pump CABG术安全、有效。

Contemporary coronary artery bypass grafting

Current evidence clearly demonstrates that coronary artery bypass grafting （CABG） remains the ＂gold standard＂ treatment for most patients with multivessel and left main stem disease. This article summarizes the relevant evidence basis demonstrating that CABG, in comparison to stenting, reduces mortality and subsequent myocardial infarction and the need for repeat revascularization. The article also describes the evidence basis to support the use of more arterial grafts during CABG and the current role of off-pump CABG.

非体外循环冠脉搭桥术中转体外循环冠脉搭桥患者的临床特征及危险因素

目的观察非体外循环冠脉搭桥术(off-pump coronary artery bypass grafting,OPCABG)中转体外循环冠脉搭桥术(on-pump coronary artery bypass grafting,ONCABG)患者的临床特征及危险因素。方法回顾性分析OPCABG并术中紧急中转为ONCABG的90例冠心病(coronary heart disease,CHD)患者的临床资料,将其归为中转组。另选取同期单纯行OPCABG的CHD患者300例设为非体外循环组。观察中转组和非体外循环组患者术前和术中的临床特征,采用多因素logistic回归分析影响OPCABG患者发生紧急中转体外循环的危险因素。结果2组性别、年龄、体质量指数(body mass index,BMI)、糖尿病史、高血压史、高血脂史、慢性阻塞性肺疾病、脑卒中史、外周血管疾病史、左主干病变、前降支病变、回旋支病变、房颤、左乳内动脉使用率、桡动脉使用率比较,差异无统计学意义(P>0.05);中转组心力衰竭史患者、经皮冠状动脉介入术(percutaneous coronary intervention,PCI)史患者、右冠病变患者、3周内心肌梗死史患者占比及桥血管数量高于非体外循环组,且左心室射血分数(left ventricular ejection fraction,LVEF)数据低于非体外循环组,差异有统计学意义(P<0.05)。经多因素logistic回归分析证实,术前心力衰竭史、术前PCI史、术前右冠病变、术前3周内心肌梗死史均是影响OPCABG患者发生紧急中转体外循环的危险因素,均有P<0.05。结论术前心力衰竭史、术前PCI史、术前右冠病变、术前3周内心肌梗死史均是影响OPCABG患者发生紧急中转体外循环的危险因素,临床可通过控制以上危险因素来减少患者中转发生风险。

预防性置入主动脉内球囊反搏应用于高危冠心病行冠状动脉旁路移植术患者的临床疗效分析

目的分析高危冠心病行冠状动脉旁路移植术术前预防性置入主动脉内球囊反搏(IABP)的临床疗效。方法围绕南阳医学高等专科学校第一附属医院2020年12月至2022年12月期间收治62例高危冠心病患者展开研究;依据患者手术情况进行分组(对照组、实验组各31例),两组患者治疗术式均为冠状动脉旁路移植术。对照组置入IABP的时机为术中或术后,实验组置入IABP时机则为术前。比较两组治疗有效率、治疗前后心功能指标变化情况、术后恢复指标及术后并发症发生情况。结果实验组治疗有效率(96.77%)高于对照组(80.65%),差异有统计学意义(P<0.05)。治疗前,两组心功能指标对比,差异无统计学意义(P>0.05);治疗后,两组心输出量(CO)、每搏输出量(SV)、左室射血分数(LVEF)均高于治疗前,左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)均低于治疗前,实验组CO、SV、LVEF高于对照组,LVESD、LVEDD低于对照组,差异有统计学意义(P<0.05)。实验组IPBP支持时间、机械通气维持时间、ICU监护时间、住院总时长均短于对照组,差异有统计学意义(P<0.05);实验组术后并发症发生率(6.45%)低于对照组(29.03%),差异有统计学意义(P<0.05)。结论预防性置IABP应用于高危冠心病行冠状动脉旁路移植术患者的临床疗效,有利于改善预后,在术后康复、减少术后并发症等方面均有突出体现,值得应用。

Hybrid minimally invasive coronary artery revascularization

Background Hybrid coronary revascularization （HCR） is an altemative coronary revascularization strategy that combines a minimally invasive, survival advantage of the left internal mammary artery （LIMA） -left anterior descending （LAD） coronary artery bypass with less-invasive percutaneous coronary intervention （PCI） to non-LAD coronary lesions by using drug-eluting stents. We report our experience of hybrid minimally invasive approach in 15 patients. Methods From December 2012 to October 2013, 15 patients underwent revascularization of the left anterior descending artery through minimally invasive coronary artery bypass grafting （MIDCAB）. All patients by endoscopic assist beating heart coronary artery bypass grafting. Seven patients were scheduled for a hybrid procedure. Percutaneous coronary intervention of non- LAD was performed 3 to 5 days preoperatively. Demographic data, perioperative outcome, and annual follow-up were obtained from all the patients. Results In-hospital mortality was 6.67%. The rate of conversion to full median sternotomy was 13.3%. Ventilation time was 6.9 ± 5.1 h. Blood loss volume was 241 ± 67.8 mL. ICU stay was 21.3 ± 10.8 h. Hospital postoperative stay lasted for 7.5 ± 1.3 days. Prior to PCI patients showed 100% patent LIMA （Tables 3 and 4）. A mean follow-up was 8.5 months. One year graft patency rate was 100% （8/8 patients for 254-slice tomography）. Two patients required reintervention. Conclusions Minimally invasive hybrid coronary revascularization is a safe, feasible and efficacious approach with good results and should be performed in selected patients by surgeons with experience in minimally invasive bypass surgery plus collaboration with cardiologists, eluting stents.

70岁及以上老年患者体外循环与非体外循环冠状动脉旁路移植术的对比研究

目的比较70岁及以上老年患者体外循环和非体外循环冠状动脉旁路移植术的疗效。方法回顾性分析2006年1月—2013年6月首都医科大学附属北京世纪坛医院心脏外科收治的单纯接受冠状动脉旁路移植术的70岁及以上老年冠心病患者106例,并按是否行体外循环冠状动脉旁路移植术分为体外循环组(45例)和非体外循环组(61例)。体外循环组麻醉成功后全身肝素化,经升主动脉和右心房插管建立体外循环;非体外循环组麻醉成功后全身半量肝素化,应用Medtronic心脏固定器。观察患者术中的静脉桥血管远端吻合口数、手术操作时间(从切皮到缝皮完毕)、术后重症监护病房(ICU)治疗时间、术后机械通气时间、术后住院时间、术后心房纤颤持续时间、住院费用;术后3个月复查超声心动图测定左心室射血分数(LVEF)和左心室舒张末期内径(LVEDD)。结果两组患者术中的静脉桥血管远端吻合口数、手术操作时间及术后住院时间比较,差异均无统计学意义(P>0.05)。非体外循环组患者术后ICU治疗时间、术后机械通气时间均短于体外循环组(P<0.05);非体外循环组患者术后心房纤颤持续时间>10min的发生率低于体外循环组(P<0.05);体外循环组患者的住院费用低于非体外循环组(P<0.05)。术后3个月两组患者的LVEF、LVEDD比较,差异无统计学意义(P>0.05);且两组患者的LVEF、LVEDD分布情况比较,差异无统计学意义(P>0.05)。结论非体外循环冠状动脉旁路移植术相比于体外循环冠状动脉旁路移植术对70岁及以上老年患者的疗效可能较好,为临床治疗提供了有益的参考依据。

体外与非体外循环冠状动脉旁路移植术698例

目的总结体外与非体外循环冠状动脉旁路移植术治疗冠心病患者的临床经验,以提高相关手术技术水平及治疗效果。方法2000年1月至2009年3月我科对698例冠心病患者行冠状动脉旁路移植术,其中男551例,女147例;年龄28.0～79.0岁,平均年龄67.2岁。典型心绞痛552例,陈旧性心肌梗死131例。心功能分级(NYHA)Ⅱ级301例,Ⅲ级339例,Ⅳ级58例。选择性冠状动脉造影显示:单支血管病变21例,2支病变87例,3支病变590例,合并左主干病变201例。行非体外循环下冠状动脉旁路移植术346例,体外循环下冠状动脉旁路移植术352例。择期手术687例,急诊手术11例。结果全组共移植血管2025支,每例移植血管1～6支,平均2.9支。术中取左乳内动脉693支,游离右乳内动脉115支,左桡动脉229支,右桡动脉81支;全动脉化126例。呼吸机辅助呼吸时间0～127h,平均11.5h。应用"快通道"技术在手术室清醒并拔除气管内插管后回ICU38例。应用主动脉内球囊反搏28例(术前置入1例,术中、术后置入27例)。择期手术死亡25例(3.64%),死于急性心肌梗死5例,低心排血量综合征3例,鱼精蛋白过敏2例,呼吸衰竭3例,肾功能衰竭2例,多器官功能衰竭10例;急诊手术死亡4例(36.36%),死于低心排血量综合征3例,急性心肌梗死1例。术后新发心房颤动151例(21.63%),其中147例(97.35%)给予补充电解质、应用抗心律失常(盐酸胺碘酮)等治疗后转为窦性心律;二次开胸止血术12例;出院时心绞痛消失511例,缓解20例。随访415例(62.03%),随访时间1个月～8.2年,随访期间死亡3例,死于肺癌1例,交通伤1例,原因不明1例。心绞痛消失317例,复发21例。心功能分级(NYHA)Ⅱ级269例(65.29%),Ⅲ级142例(34.46%),Ⅳ级1例(0.24%)。结论结合中国人的病情特点,制定相应的手术方案,合理选择旁路移植血管,可保证和优化外科手术效果;主动脉内球囊反搏可有效地改善重症患者的预后,对其使用应积极果断,以免失去最佳的支持时机。

主动脉内球囊反搏置入时机对高危冠心病患者行冠状动脉旁路移植术的短期效果评价和危险因素分析

目的:探讨主动脉内球囊反搏(IABP)置入时机对高危冠心病患者行冠状动脉(冠脉)旁路移植术(CABG)的短期效果评价和危险因素分析。方法:回顾性分析我院2010-01至2015-12收治并应用IABP辅助CABG的197例高危冠心病患者,男性91例(46.2%),平均动脉压为(70.3±8.2)mm Hg(1 mm Hg=0.133 k Pa)。根据IABP置入时间分为术前置入组(n=89)和术中、术后置入组(n=108)。比较两组围手术期情况,以及机械通气率、重症监护室停留时间,Kaplan-Meier生存分析评价两组的生存情况,并应用Logistic回归分析术后30天死亡的危险因素,应用受试者工作特征性(ROC)曲线和约登指数评估危险因素对病死率的最佳预测阈值和相应的敏感性和特异性。结果:197例患者的主动脉阻断时间为(86.7±37.3)min,体外循环平均时间为(147.3±18.4)min。两组间年龄、性别比例、肌酸激酶同功酶、肌钙蛋白I、肌酐、平均动脉压、欧洲心脏手术风险评估系统评分等均无显著差异(P>0.05)。术前置入组与术中、术后置入组比较,术后48 h心肌酶峰值明显降低(mmol/L,130.6±25.4 vs149.7±18.2),机械通气时间(h,81.5±10.3 vs 107.9±11.5)、总住院时间(d,21.3±4.1 vs 27.7±9.4)显著减少,急性肾损伤(3.4%vs23.1%)、脑并发症(5.6%vs 19.4%)和术后30天死亡率(4.5%vs 36.1%)的发生率降低,差异均有统计学意义(P<0.05)。Kaplan-Meier生存分析显示术前置入组患者的中位生存时间较术中、术后置入组显著延长(d,27.9±1.2 vs 16.5±2.2,P<0.05),Logistic回归分析发现再置入IABP(比值比=2.37,95%可信区间:1.42~5.72,P=0.01)为预测术后30天病死率的重要因素。ROC曲线显示再次置入IABP预测患者术后30天病死率的敏感性为75.3%,特异性为67.4%。结论:对于高危CABG的患者,术前置入IABP辅助治疗有助于降低术后心肌酶峰值,缩短呼吸机支持时间和总住院时间,降低短期病死率。再次置入IABP是短期死亡的危险因素。

非体外循环下冠状动脉旁路移植围术期血浆脑钠肽释放及其相关性研究

背景:B型脑钠肽已成为心血管疾病诊断重要的血清标志物,作为心血管疾病危险因素分层的重要因子。目的:分析冠状动脉旁路移植前后B型脑钠肽与各项血流动力学参数的关系。方法:选择30例冠心病行冠脉旁路移植患者,分为左室射血分数≥50%心功能正常患者13例;左室射血分数<50%心功能不全患者17例。观察患者移植前1 d、移植后7 h、移植后1,3,5,7 d血浆B型脑钠肽水平变化趋势,分析移植前后B型脑钠肽与心功能各项指标的相关关系。结果与结论:左室射血分数≥50%组患者冠脉旁路移植前后血浆B型脑钠肽水平显著低于左室射血分数<50%组;组内比较移植后血浆B型脑钠肽水平均显著高于移植前(P<0.05或P<0.001)。患者冠脉旁路移植前B型脑钠肽水平与纽约心脏病协会心功能分级、左房内径、左室内径呈正相关(r=0.61;r=0.34;r=0.67);与左室射血分数、心排血量呈负相关(r=-0.75;r=-0.70)。患者移植后B型脑钠肽峰值浓度与出院前纽约心脏病协会心功能分级、超声心动图左室舒张末期内径、肺动脉压力呈正相关(r=0.72;r=0.70;r=0.45)。结果说明冠心病患者冠脉旁路移植前血浆B型脑钠肽质量浓度与左心室射血分数及左心室舒张末期内径有很好的相关性,能准确反映冠脉旁路移植前后的心功能状态。

肿瘤合并冠心病患者的同期外科治疗

目的：探讨肿瘤合并冠心病患者同期冠状动脉旁路移植术和肿瘤切除术的可能性和可行性。方法：自2000年8月至2006年7月,10例怀疑肿瘤（泌尿系肿瘤4例、消化系肿瘤2例、肺部肿瘤4例）合并冠心病的患者接受同期冠状动脉旁路移植术和肿瘤切除术。根据肿瘤的不同部位选用不同的手术切口。除1例外均先行冠状动脉旁路移植术,后行肿瘤切除术。2例采用体外循环下冠状动脉旁路移植术,其余8例采用非体外循环冠状动脉旁路移植术。术后随诊。结果：同期手术效果好,无住院死亡,未出现术后外科性出血,无心肌缺血梗死,并发症少。术后住院时间10～34d（平均22.4d）,均病愈出院。1例失去随访,9例患者随诊6个月至7年3个月,其中2例死于肿瘤转移,其余随诊满意,均未出现心血管事件。结论：对于合并冠心病的良、恶性肿瘤患者实施同期冠状动脉旁路移植术和肿瘤切除术可行,而且效果满意。

非体外循环心脏跳动下冠状动脉旁路移植术582例

目的总结582例非体外循环辅助下冠状动脉旁路移植术(OPCAB)的手术技巧及术后处理的临床经验,并对其疗效及治疗经验进行初步探讨.方法回顾1998年10月～2005年4月共完成OPCAB 582例,男506例,女76例,年龄35～86岁,其中不稳定型心绞痛558例,术前合并其他疾病480例.结果搭桥为2.6±1.3支/例,搭桥术后辅助呼吸时间为3.2±1.2h,术后住院为7±1.6天,心绞痛症状均消失.死亡2例,再次开胸止血1例,其余患者术后无纵隔感染和出血等并发症,均痊愈出院.近、中期随访临床效果满意.结论 OPCAB由于避免了体外循环,减少了手术创伤和全身炎症反应,缩短了术后恢复时间,术后早期并发症发生率和死亡率低,对高危患者具明显优势.

非体外循环冠状动脉旁路移植280例分析

目的 :探讨微创非体外循环冠状动脉旁路移植 (OPCAB)手术方法及评价其初步临床结果。方法 :2 80例冠状动脉粥样硬化性心脏病病人中左主干病变 3 8例 ( 13 6% ) ,单支、双支和三支系统病变为 12、2 9和2 3 9例。均经正中切口行OPCAB ,人均旁路移植 3 3 8支 ( 1～ 5支 )。应用左乳内动脉 2 61例 ,桡动脉 2例 ,17例为大隐静脉。结果 :2 73例病人顺利完成手术 ,3例转成体外循环冠状动脉旁路移植。 2 2 4例病人均在手术后 0～ 12 (平均 5 9±4 6)小时顺利拔除气管插管 ,其中 5例手术终在手术室拔除气管插管后回重症监护病房。胸腔引流量 ( 2 5 0± 98)ml,10 3例病人未输血。2例手术后 5天和 9天大面积脑梗塞分别于手术后 18天和 2 9天死亡 ,其余均康复出院。结论 :对于单纯冠状动脉旁路移植病人 ,OPCAB是一项安全、可行和有效的术式。