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Dear Editor,Protein-protein interactions(PPIs)often play important roles in biological processes(Zhang et al.,2016).The split Renilla luciferase complementation assay(SRLCA)is one of the methods in studying PPIs.SRLCA is based on the complementation of the N-terminal domains of Renilla luciferase(LN)and C-terminal domains

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晚霉素对革兰阳性菌具有很好的抗菌活性,尤其对抗甲氧西林金黄色葡萄球菌和抗万古霉素肠球菌具有广谱的抗菌功效。本文介绍其关键的生物合成机制和关键酶,并结合组合生物技术,提出其生物合成的发展方向。