Objective: To evaluate salivary and serum levels of Immunoglobulin A (IgA) in patients with oro-facial squamous cell carcinoma. Methods: This is a cross sectional study. Patients with oro-facial squamous cell carcinom...Objective: To evaluate salivary and serum levels of Immunoglobulin A (IgA) in patients with oro-facial squamous cell carcinoma. Methods: This is a cross sectional study. Patients with oro-facial squamous cell carcinoma attending the Oral Pathology and Radiotherapy clinics of the University College Hospital, Ibadan, Nigeria were included. Seventy subjects comprising 22 patients with untreated OSCC, 18 patients with OSCC receiving treatment and 30 healthy, age and gender matched individuals were included. Serum and salivary samples from the participants were analysed for IgA levels using ELISA technique. Results: The mean value of serum IgA in OSCC patients receiving treatment was significantly lower compared with healthy controls (p = 0.03), while no significant difference was observed comparing untreated OSCC patients with treated and healthy controls. The salivary IgA levels did not show any significant difference between the three groups (p = 0.73). Also, there was no correlation between serum and salivary levels of IgA among the subjects. Conclusions: Serum IgA appeared to be better index than salivary IgA levels in monitoring response to treatment in patients with oro-facial carcinoma.展开更多
Objectire To evaluate the radiation tolerance of the reconstructive flaPs used following radicalexcision of oro - maxillofacial tumors. methods The survival and radiation response of 88 flaps (preoperative 14and posto...Objectire To evaluate the radiation tolerance of the reconstructive flaPs used following radicalexcision of oro - maxillofacial tumors. methods The survival and radiation response of 88 flaps (preoperative 14and postoperative 74) in 82 patients were reviewed. Results The survival rate of 14 flaps done on preradiatedareas was 85.7% (12/14), markedly inferior to that of the flaps receiving postoperative radiation (98.6%, 73/74). Therate of radiation response of the flaps (35.1%) was signofcantly lower than that of the normal oral mucosasurrounding the flap (83.8%, P<0.01). Conclusion The good radiation tolerability of the transplants followingtumors excision pointed to the salety of its postoperative radiotherapy.展开更多
Open oro-nasal defects resulting after oral tumor resection need structural and functional rehabilitation using dental prostheses. Conventional removable prostheses have usually been indicated and performed for prosth...Open oro-nasal defects resulting after oral tumor resection need structural and functional rehabilitation using dental prostheses. Conventional removable prostheses have usually been indicated and performed for prosthodontics. When the patient has an edentulous maxilla, the unfavorable stability of the prosthesis will cause dysfunction of mastication and pronunciation. To achieve improvement of the impaired functional situation, implant-supported full fixed prostheses (IPSPs) for the edentulous maxilla with a removable obturator offer a reasonable solution. We present herein the case of a 70-year-old Japanese man who has presented with oro-nasal defect due to surgical procedures for oral cancer. He was treated with implant-supported full fixed prostheses in a conventional two-step procedure. After prosthesis treatment, a palatal obturator was set. The patient has shown no clinical or radiological evidence of failure as of 24 months after the end of treatment. Functional evaluation of mastication and pronunciation showed dramatic improvements. For a patient with an edentulous maxilla and palatal fistula, full-arch fixed prostheses supported by a combination of axially and non-axially positioned implants and a removable oro-nasal obturator, using the anterior alveolar bone, without bone transplantation or maxillary sinus elevation, could offer an effective, minimally invasive treatment alternative.展开更多
What is"2moro"?"2moro"=Tomorrow=阳光+希望=如朝阳般的两个阳光大男孩。这对滚石最新压轴超级新人在台湾、香港与及大陆持续飙升的人气表明,崇尚自然环保,坚持简单与高品质的乐活风潮,在造星运动上也有了成功案...What is"2moro"?"2moro"=Tomorrow=阳光+希望=如朝阳般的两个阳光大男孩。这对滚石最新压轴超级新人在台湾、香港与及大陆持续飙升的人气表明,崇尚自然环保,坚持简单与高品质的乐活风潮,在造星运动上也有了成功案例。号称"天然系帅哥"的台湾双生兄弟:哥哥彦均和弟弟彦甫,给人的第一眼印象便是未受大气污染,无公害有机培养的纯净生物:牙齿洁白,头发乌黑,体魄健壮,皮肤泛着健康的光泽,笑容很阳光,声音很亲切,性格很爽朗。没有明星的排场也没有小男生的扭捏作态,见到粉丝"左拥右抱",冷笑话让人抓不住头脑。体院毕业的两兄弟走在街上试过最高记录一天收到18张经纪公司的名片!所以也不奇怪3年来接了六七十个广告,知名度爆增。之后由广告模特儿跨足偶像剧,各自担任男主角挑大梁,现在两兄弟转战歌坛,超高的人气让两兄弟有点始料不及。展开更多
文摘Objective: To evaluate salivary and serum levels of Immunoglobulin A (IgA) in patients with oro-facial squamous cell carcinoma. Methods: This is a cross sectional study. Patients with oro-facial squamous cell carcinoma attending the Oral Pathology and Radiotherapy clinics of the University College Hospital, Ibadan, Nigeria were included. Seventy subjects comprising 22 patients with untreated OSCC, 18 patients with OSCC receiving treatment and 30 healthy, age and gender matched individuals were included. Serum and salivary samples from the participants were analysed for IgA levels using ELISA technique. Results: The mean value of serum IgA in OSCC patients receiving treatment was significantly lower compared with healthy controls (p = 0.03), while no significant difference was observed comparing untreated OSCC patients with treated and healthy controls. The salivary IgA levels did not show any significant difference between the three groups (p = 0.73). Also, there was no correlation between serum and salivary levels of IgA among the subjects. Conclusions: Serum IgA appeared to be better index than salivary IgA levels in monitoring response to treatment in patients with oro-facial carcinoma.
文摘Objectire To evaluate the radiation tolerance of the reconstructive flaPs used following radicalexcision of oro - maxillofacial tumors. methods The survival and radiation response of 88 flaps (preoperative 14and postoperative 74) in 82 patients were reviewed. Results The survival rate of 14 flaps done on preradiatedareas was 85.7% (12/14), markedly inferior to that of the flaps receiving postoperative radiation (98.6%, 73/74). Therate of radiation response of the flaps (35.1%) was signofcantly lower than that of the normal oral mucosasurrounding the flap (83.8%, P<0.01). Conclusion The good radiation tolerability of the transplants followingtumors excision pointed to the salety of its postoperative radiotherapy.
文摘Open oro-nasal defects resulting after oral tumor resection need structural and functional rehabilitation using dental prostheses. Conventional removable prostheses have usually been indicated and performed for prosthodontics. When the patient has an edentulous maxilla, the unfavorable stability of the prosthesis will cause dysfunction of mastication and pronunciation. To achieve improvement of the impaired functional situation, implant-supported full fixed prostheses (IPSPs) for the edentulous maxilla with a removable obturator offer a reasonable solution. We present herein the case of a 70-year-old Japanese man who has presented with oro-nasal defect due to surgical procedures for oral cancer. He was treated with implant-supported full fixed prostheses in a conventional two-step procedure. After prosthesis treatment, a palatal obturator was set. The patient has shown no clinical or radiological evidence of failure as of 24 months after the end of treatment. Functional evaluation of mastication and pronunciation showed dramatic improvements. For a patient with an edentulous maxilla and palatal fistula, full-arch fixed prostheses supported by a combination of axially and non-axially positioned implants and a removable oro-nasal obturator, using the anterior alveolar bone, without bone transplantation or maxillary sinus elevation, could offer an effective, minimally invasive treatment alternative.
文摘目的探讨脑卒中吞咽障碍行间歇经口至食管管饲法(intermittent oro-esophageal tube feeding,IOE)发生误吸的风险评估及模型构建。方法选取2020年1月至2022年12月温州医科大学附属第二医院就诊的脑卒中吞咽障碍行IOE的146例患者为研究对象,根据IOE后是否误吸将其分为未误吸组(117例)和误吸组(29例),收集患者的临床资料,采用多因素Logistic回归分析患者发生误吸的危险因素,并建立列线图预测模型,利用C指数进行区分度评价,校准曲线进行列线图拟合度检测。结果两组患者的脑卒中病史、误吸史、脑卒中部位、自主咳嗽、洼田饮水试验、美国国立卫生研究院卒中量表(National Institutes of Health stroke scale,NIHSS)评分、置管体位、置管深度比较差异均有统计学意义(P<0.05);多因素Logistic回归分析结果显示,有脑卒中病史、有误吸史、脑卒中部位为脑干、洼田饮水试验4~5级、NIHSS评分高、侧卧位置管、置管深度低均是脑卒中吞咽障碍行IOE患者误吸的危险因素(P<0.05),自主咳嗽是脑卒中吞咽障碍行IOE患者误吸的保护因素(P<0.05);列线图预测模型判断误吸风险的C指数为0.705(95%CI:0.591~0.857),Hosmer-Lemeshow检验模型的拟合度良好;受试者操作特征曲线结果显示列线图预测模型的曲线下面积为0.756,敏感度为75.42%,特异性为77.09%。结论脑卒中病史、误吸史、脑卒中部位、自主咳嗽、洼田饮水试验、NIHSS评分、置管体位、置管深度均是脑卒中吞咽障碍行IOE患者误吸的影响因素,模型构建成功,构建的模型有良好的区分度和拟合度。
