Signal transducer and activator of transcription 3（STAT3） is a dual functional transcription factor with the functions of signal transduction and transcription regulation. It is reported that the expression of STAT3...Signal transducer and activator of transcription 3（STAT3） is a dual functional transcription factor with the functions of signal transduction and transcription regulation. It is reported that the expression of STAT3 in ovarian cancer is significantly higher and STAT3 can facilitate ovarian cancer growth and metastasis. To clarify the definite effect and molecular mechanism of STAT3 involved in ovarian cancer growth and metastasis, STAT3 expression was significantly downregulated by transfecting ovarian cancer model SK-OV-3 cells with the plasmid vector which express specific RNAi that targets human STAT3. The downregulated STAT3 not only decreased the invasion and migration but also inhibited the proliferation of SK-OV-3 cells. Western blot assay shows that the expression of vascular endothelial growth factor（VEGF） and that of Survivin were reduced in the cells with the plasma vector expressing specific RNAi that targets human STAT3. These results demonstrate that STAT3 involved in the invasion and migration of SK-OV-3 regulates the expression of VEGF and Survivin. In addition, VEGF and Survivin could play an important role in ovarian cancer growth and metastasis.展开更多
This paper focuses mainly on the stability analysis of two-lane traffic flow with lateral friction,which may be caused by irregular driving behavior or poorly visible road markings,and also attempts to reveal the form...This paper focuses mainly on the stability analysis of two-lane traffic flow with lateral friction,which may be caused by irregular driving behavior or poorly visible road markings,and also attempts to reveal the formation mechanism of traffic jams.Firstly,a two-lane optimal velocity(OV) model without control signals is proposed and its stability condition is obtained from the viewpoint of control theory.Then delayed-feedback control signals composed of distance headway information from both lanes are added to each vehicle and a vehicular control system is designed to suppress the traffic jams.Lane change behaviors are also incorporated into the two-lane OV model and the corresponding information about distance headway and feedback signals is revised.Finally,the results of numerical experiments are shown to verify that when the stability condition is not met,the position disturbances and resulting lane change behaviors do indeed deteriorate traffic performance and cause serious traffic jams.However,once the proper delayed-feedback control signals are implemented,the traffic jams can be suppressed efficiently.展开更多
基金Supported by the Basis of Bethune Medical Research Fund of Jilin Province of China(No.200705114)
文摘Signal transducer and activator of transcription 3（STAT3） is a dual functional transcription factor with the functions of signal transduction and transcription regulation. It is reported that the expression of STAT3 in ovarian cancer is significantly higher and STAT3 can facilitate ovarian cancer growth and metastasis. To clarify the definite effect and molecular mechanism of STAT3 involved in ovarian cancer growth and metastasis, STAT3 expression was significantly downregulated by transfecting ovarian cancer model SK-OV-3 cells with the plasmid vector which express specific RNAi that targets human STAT3. The downregulated STAT3 not only decreased the invasion and migration but also inhibited the proliferation of SK-OV-3 cells. Western blot assay shows that the expression of vascular endothelial growth factor（VEGF） and that of Survivin were reduced in the cells with the plasma vector expressing specific RNAi that targets human STAT3. These results demonstrate that STAT3 involved in the invasion and migration of SK-OV-3 regulates the expression of VEGF and Survivin. In addition, VEGF and Survivin could play an important role in ovarian cancer growth and metastasis.
基金Project supported by the National Natural Science Foundation of China(No. 70971094)the National Natural Science Youth Foundation of China (No. 50908155)the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT),China
文摘This paper focuses mainly on the stability analysis of two-lane traffic flow with lateral friction,which may be caused by irregular driving behavior or poorly visible road markings,and also attempts to reveal the formation mechanism of traffic jams.Firstly,a two-lane optimal velocity(OV) model without control signals is proposed and its stability condition is obtained from the viewpoint of control theory.Then delayed-feedback control signals composed of distance headway information from both lanes are added to each vehicle and a vehicular control system is designed to suppress the traffic jams.Lane change behaviors are also incorporated into the two-lane OV model and the corresponding information about distance headway and feedback signals is revised.Finally,the results of numerical experiments are shown to verify that when the stability condition is not met,the position disturbances and resulting lane change behaviors do indeed deteriorate traffic performance and cause serious traffic jams.However,once the proper delayed-feedback control signals are implemented,the traffic jams can be suppressed efficiently.
