High-entropy oxides(HEOs)have gained great attention as an emerging kind of highperformance anode materials for lithium-ion batteries(LIBs)due to the entropy stabilization and multi-principal synergistic effect.Herein...High-entropy oxides(HEOs)have gained great attention as an emerging kind of highperformance anode materials for lithium-ion batteries(LIBs)due to the entropy stabilization and multi-principal synergistic effect.Herein,the porous perovskite-type RE(Co_(0.2)Cr_(0.2)Fe_(0.2)Mn_(0.2)Ni_(0.2))O_(3)(RE(=La,Sm,and Gd)is the abbreviation of rare earth)HEOs were successfully synthesized by a solution combustion synthesis(SCS)method.Owing to the synergistic effect of lattice distortion and oxygen vacancies(Ov),the Gd(Co_(0.2)Cr_(0.2)Fe_(0.2)Mn_(0.2)Ni_(0.2))O_(3) electrode exhibits superior high-rate lithium-ion storage performance and excellent cycling stability.A reversible capacity of 403 mAh·g^(-1) at a current rate of 0.2 A·g^(-1) after 500 cycles and a superior high-rate capacity of 394 mAh·g^(-1)even at 1.0 A·g^(-1)after 500 cycles are achieved.Meanwhile,the Gd(Co_(0.2)Cr_(0.2)Fe_(0.2)Mn_(0.2)Ni_(0.2))O_(3) electrode also exhibits a pronounced pseudo-capacitive behavior,contributing to an additional capacity.By adjusting and balancing the lattice distortion and oxygen vacancies of the electrode materials,the lithium-ion storage performance can be further regulated.展开更多
Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life expectancy.The clinical need for more efficient and safe therapies has contr...Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life expectancy.The clinical need for more efficient and safe therapies has contributed to the exploration of emerging strategies.Recently,there has been increased interest in oncolytic viruses(OVs)as a therapeutic modality for HCC.OVs undergo selective replication in cancerous tissues and kill tumor cells.Strikingly,pexastimogene devacirepvec(Pexa-Vec)was granted an orphan drug status in HCC by the U.S.Food and Drug Administration(FDA)in 2013.Meanwhile,dozens of OVs are being tested in HCC-directed clinical and preclinical trials.In this review,the pathogenesis and current therapies of HCC are outlined.Next,we summarize multiple OVs as single therapeutic agents for the treatment of HCC,which have demonstrated certain efficacy and lowtoxicity.Emerging carrier cell-,bioengineered cell mimetic-or nonbiological vehicle-mediated OV intravenous delivery systems in HCC therapy are described.In addition,we highlight the combination treatments between oncolytic virotherapy and other modalities.Finally,the clinical challenges and prospects of OV-based biotherapy are discussed,with the aim of continuing to develop a fascinating approach in HCC patients.展开更多
基金supported by the Natural Science Foundation of Anhui Province(Grant No.2008085ME125)University Natural Science Research Project of Anhui Province(Grant Nos.KJ2020A0268 and KJ2020A0270).
文摘High-entropy oxides(HEOs)have gained great attention as an emerging kind of highperformance anode materials for lithium-ion batteries(LIBs)due to the entropy stabilization and multi-principal synergistic effect.Herein,the porous perovskite-type RE(Co_(0.2)Cr_(0.2)Fe_(0.2)Mn_(0.2)Ni_(0.2))O_(3)(RE(=La,Sm,and Gd)is the abbreviation of rare earth)HEOs were successfully synthesized by a solution combustion synthesis(SCS)method.Owing to the synergistic effect of lattice distortion and oxygen vacancies(Ov),the Gd(Co_(0.2)Cr_(0.2)Fe_(0.2)Mn_(0.2)Ni_(0.2))O_(3) electrode exhibits superior high-rate lithium-ion storage performance and excellent cycling stability.A reversible capacity of 403 mAh·g^(-1) at a current rate of 0.2 A·g^(-1) after 500 cycles and a superior high-rate capacity of 394 mAh·g^(-1)even at 1.0 A·g^(-1)after 500 cycles are achieved.Meanwhile,the Gd(Co_(0.2)Cr_(0.2)Fe_(0.2)Mn_(0.2)Ni_(0.2))O_(3) electrode also exhibits a pronounced pseudo-capacitive behavior,contributing to an additional capacity.By adjusting and balancing the lattice distortion and oxygen vacancies of the electrode materials,the lithium-ion storage performance can be further regulated.
基金by the National Natural Science Foundation of China(No.81700453).
文摘Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life expectancy.The clinical need for more efficient and safe therapies has contributed to the exploration of emerging strategies.Recently,there has been increased interest in oncolytic viruses(OVs)as a therapeutic modality for HCC.OVs undergo selective replication in cancerous tissues and kill tumor cells.Strikingly,pexastimogene devacirepvec(Pexa-Vec)was granted an orphan drug status in HCC by the U.S.Food and Drug Administration(FDA)in 2013.Meanwhile,dozens of OVs are being tested in HCC-directed clinical and preclinical trials.In this review,the pathogenesis and current therapies of HCC are outlined.Next,we summarize multiple OVs as single therapeutic agents for the treatment of HCC,which have demonstrated certain efficacy and lowtoxicity.Emerging carrier cell-,bioengineered cell mimetic-or nonbiological vehicle-mediated OV intravenous delivery systems in HCC therapy are described.In addition,we highlight the combination treatments between oncolytic virotherapy and other modalities.Finally,the clinical challenges and prospects of OV-based biotherapy are discussed,with the aim of continuing to develop a fascinating approach in HCC patients.
