Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud....Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud. Using modern NMR techniques including NOESY and 1H_NMR line broadening effect experiments, CD spectra and MS analysis as well as chemical methods, their structures were identified as (13aR)_6_hydroxy_3,7_dimethoxy_phenanthroindolizidine (1), (13aS,14R)_14_hydroxy_3,6,7_trimethoxy_phenanthro_indolizidine (2), (13aS,14S)_14_hydroxy_3,6,7_trimethoxy_phenanthroindolizidine (3), and (13aS,14S)_6,14_dihydroxy_3,7_dimethoxy_phenanthroindolizidine (4) respectively. Compound 1 is a new compound, compounds 2-4 are obtained from this plant for the first time. Compounds 1, 3 and 4 showed strong antitumor activities.展开更多
文摘Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud. Using modern NMR techniques including NOESY and 1H_NMR line broadening effect experiments, CD spectra and MS analysis as well as chemical methods, their structures were identified as (13aR)_6_hydroxy_3,7_dimethoxy_phenanthroindolizidine (1), (13aS,14R)_14_hydroxy_3,6,7_trimethoxy_phenanthro_indolizidine (2), (13aS,14S)_14_hydroxy_3,6,7_trimethoxy_phenanthroindolizidine (3), and (13aS,14S)_6,14_dihydroxy_3,7_dimethoxy_phenanthroindolizidine (4) respectively. Compound 1 is a new compound, compounds 2-4 are obtained from this plant for the first time. Compounds 1, 3 and 4 showed strong antitumor activities.
