The purpose of this research was to elucidate the relationship between tonsillar hypertrophy and Obstructive Sleep Apnea Syndrome (OSAS) in terms of cephalometric analysis, as well as to determine factors that affect ...The purpose of this research was to elucidate the relationship between tonsillar hypertrophy and Obstructive Sleep Apnea Syndrome (OSAS) in terms of cephalometric analysis, as well as to determine factors that affect OSAS severity. 25 patients were enrolled in this study. Lateral cephalograms of the subjects were taken. Disease severity was evaluated by the Apnea Hypopnea Index (AHI). Cephalometric measurements (angle between line S-N and line N-A (SNA), angle between line S-N and line N-B (SNB), distance between the Mandibular Plane and the Hyoid (MPH), posterior airway space, the width of the airway behind the base of tongue along the B-Go line (PAS), upper airway space, the distance parallel to long axis of the airway, between a horizontal plane tangent to the superior aspect of the hyoid and a horizontal plane tangent to the posterior palate (UAL), multiplication of PAS and UAL (PAS × UAL)) were analyzed and compared between the groups with and without tonsillar hypertrophy. PAS and PAS × UAL were lower in the no hypertrophy group. SNB was significantly lower in the severe apnea group than mild to moderate group in no hypertrophy group (p = 0.035). In conclusion, patients with tonsillar hypertrophy had severe obstruction, but they had a relatively larger pharyngeal space on cephalometric analysis. After exclusion of the tonsillar hypertrophy group, cephalometric analysis could be more effective for analyzing OSAS severity.展开更多
Background Previous studies have suggested an association between obstructive sleep apnea(OSA) and left ventricular(LV) remodeling, but it remains unclear whether there's a specific remodeling pattern related to t...Background Previous studies have suggested an association between obstructive sleep apnea(OSA) and left ventricular(LV) remodeling, but it remains unclear whether there's a specific remodeling pattern related to the OSA. Methods This study was a cross-sectional study of 1377 cardiovascular disease(CVD) patients. Respiratory events during sleep were recorded by portable monitors and apnea hypopnea index(AHI) was used to quantify OSA severity. Echocardiography was used to assess left ventricular structure. The left ventricular geometry was divided into four groups according to left ventricular mass index(LVMI) and relative wall thickness(RWT):normal geometry, concentric remodeling, concentric hypertrophy and eccentric hypertrophy. Results The prevalence of OSA was significantly higher in patients with abnormal left ventricular geometry(75.2% vs. 68.9%, P=0.012). Compared to patients with AHI < 5, those with AHI ≥ 30 had an odds ratio of 1.53(95%CI: 1.03-2.28)for LV hypertrophy in male patients, after adjustment for age, body mass index, hypertension, diabetes, coronary artery disease and metabolism syndrome. Furthermore, after adjustment for confounding factor, severe OSA(compared with non-OSA) was significantly associated with the increased risk of eccentric hypertrophy in men(OR: 2.34, 95%CI: 1.23-4.44). No association was observed between OSA and other types of LV remodeling in neither men or women. Conclusions OSA is implicated in LV remodeling and severe OSA is independently associated with a higher risk of eccentric LV hypertrophy in male patients[.S Chin J Cardiol 2019;20(1):1-9]展开更多
目的观察儿童轻中度阻塞性睡眠呼吸暂停低通气综合征(OS A H S)抗炎治疗的临床疗效,分析儿童OSAHS与炎症的关系。方法选取2016年1-11月经多导睡眠监测(PSG)确诊的轻中度OSAHS患儿50例,记录病史、腺样体大小、扁桃体大小、OSA-18问卷评分...目的观察儿童轻中度阻塞性睡眠呼吸暂停低通气综合征(OS A H S)抗炎治疗的临床疗效,分析儿童OSAHS与炎症的关系。方法选取2016年1-11月经多导睡眠监测(PSG)确诊的轻中度OSAHS患儿50例,记录病史、腺样体大小、扁桃体大小、OSA-18问卷评分,给予糠酸莫米松鼻喷剂联合口服孟鲁司特治疗12周,治疗结束后复查PSG、腺样体大小、扁桃体大小及OSA-18问卷,并对治疗前后的数据进行比较。结果在50例患儿中,轻度OSAHS37例,中度OSAHS 13例;共治愈19例(38%),其中轻度OSAHS 17例,中度OSAHS 2例;显效14例(28%);有效5例(10%);总体有效率为76%(38/50)。与治疗前比较,轻度OSAHS患儿治疗后阻塞性呼吸暂停指数(OAI)、混合性呼吸暂停指数(MAI)降低,腺样体、扁桃体体积缩小,OSA-18评分降低,差异均有统计学意义(P<0.05)。中度OSAHS患儿治疗后OAI较治疗前明显降低(P<0.05),而腺样体、扁桃体体积及OSA-18评分、MAI与治疗前比较差异无统计学意义(P>0.05)。扁桃体体积变化与PSG参数变化无明显相关性。结论抗炎治疗可明显改善OSAHS患儿的PSG指数、腺样体和扁桃体体积及生活质量,对轻度OSAHS患儿疗效更为显著。展开更多
目的探讨低温等离子扁桃体部分消融术在治疗儿童阻塞性睡眠呼吸暂停综合征(OSAHS)中的治疗效果及应用前景。方法回顾性分析78例OSAHS患儿的临床资料,所有患儿主要阻塞病变为扁桃体及腺样体肥大,扁桃体无慢性炎症表现,应用低温等离子行...目的探讨低温等离子扁桃体部分消融术在治疗儿童阻塞性睡眠呼吸暂停综合征(OSAHS)中的治疗效果及应用前景。方法回顾性分析78例OSAHS患儿的临床资料,所有患儿主要阻塞病变为扁桃体及腺样体肥大,扁桃体无慢性炎症表现,应用低温等离子行扁桃体部分消融术及鼻内镜腺样体消融术。结果术中出血1~5 m L,无术中及术后并发症。随访6~12个月,所有患儿睡眠打鼾及张口呼吸均消失,扁桃体无再生及反复炎症发作。结论行低温等离子扁桃体部分消融术治疗儿童OSAHS微创、安全、有效,更个体化、人性化,是一种较好的治疗儿童OSAHS的手术方法,适合在临床广泛开展。展开更多
文摘The purpose of this research was to elucidate the relationship between tonsillar hypertrophy and Obstructive Sleep Apnea Syndrome (OSAS) in terms of cephalometric analysis, as well as to determine factors that affect OSAS severity. 25 patients were enrolled in this study. Lateral cephalograms of the subjects were taken. Disease severity was evaluated by the Apnea Hypopnea Index (AHI). Cephalometric measurements (angle between line S-N and line N-A (SNA), angle between line S-N and line N-B (SNB), distance between the Mandibular Plane and the Hyoid (MPH), posterior airway space, the width of the airway behind the base of tongue along the B-Go line (PAS), upper airway space, the distance parallel to long axis of the airway, between a horizontal plane tangent to the superior aspect of the hyoid and a horizontal plane tangent to the posterior palate (UAL), multiplication of PAS and UAL (PAS × UAL)) were analyzed and compared between the groups with and without tonsillar hypertrophy. PAS and PAS × UAL were lower in the no hypertrophy group. SNB was significantly lower in the severe apnea group than mild to moderate group in no hypertrophy group (p = 0.035). In conclusion, patients with tonsillar hypertrophy had severe obstruction, but they had a relatively larger pharyngeal space on cephalometric analysis. After exclusion of the tonsillar hypertrophy group, cephalometric analysis could be more effective for analyzing OSAS severity.
文摘Background Previous studies have suggested an association between obstructive sleep apnea(OSA) and left ventricular(LV) remodeling, but it remains unclear whether there's a specific remodeling pattern related to the OSA. Methods This study was a cross-sectional study of 1377 cardiovascular disease(CVD) patients. Respiratory events during sleep were recorded by portable monitors and apnea hypopnea index(AHI) was used to quantify OSA severity. Echocardiography was used to assess left ventricular structure. The left ventricular geometry was divided into four groups according to left ventricular mass index(LVMI) and relative wall thickness(RWT):normal geometry, concentric remodeling, concentric hypertrophy and eccentric hypertrophy. Results The prevalence of OSA was significantly higher in patients with abnormal left ventricular geometry(75.2% vs. 68.9%, P=0.012). Compared to patients with AHI < 5, those with AHI ≥ 30 had an odds ratio of 1.53(95%CI: 1.03-2.28)for LV hypertrophy in male patients, after adjustment for age, body mass index, hypertension, diabetes, coronary artery disease and metabolism syndrome. Furthermore, after adjustment for confounding factor, severe OSA(compared with non-OSA) was significantly associated with the increased risk of eccentric hypertrophy in men(OR: 2.34, 95%CI: 1.23-4.44). No association was observed between OSA and other types of LV remodeling in neither men or women. Conclusions OSA is implicated in LV remodeling and severe OSA is independently associated with a higher risk of eccentric LV hypertrophy in male patients[.S Chin J Cardiol 2019;20(1):1-9]
文摘目的观察儿童轻中度阻塞性睡眠呼吸暂停低通气综合征(OS A H S)抗炎治疗的临床疗效,分析儿童OSAHS与炎症的关系。方法选取2016年1-11月经多导睡眠监测(PSG)确诊的轻中度OSAHS患儿50例,记录病史、腺样体大小、扁桃体大小、OSA-18问卷评分,给予糠酸莫米松鼻喷剂联合口服孟鲁司特治疗12周,治疗结束后复查PSG、腺样体大小、扁桃体大小及OSA-18问卷,并对治疗前后的数据进行比较。结果在50例患儿中,轻度OSAHS37例,中度OSAHS 13例;共治愈19例(38%),其中轻度OSAHS 17例,中度OSAHS 2例;显效14例(28%);有效5例(10%);总体有效率为76%(38/50)。与治疗前比较,轻度OSAHS患儿治疗后阻塞性呼吸暂停指数(OAI)、混合性呼吸暂停指数(MAI)降低,腺样体、扁桃体体积缩小,OSA-18评分降低,差异均有统计学意义(P<0.05)。中度OSAHS患儿治疗后OAI较治疗前明显降低(P<0.05),而腺样体、扁桃体体积及OSA-18评分、MAI与治疗前比较差异无统计学意义(P>0.05)。扁桃体体积变化与PSG参数变化无明显相关性。结论抗炎治疗可明显改善OSAHS患儿的PSG指数、腺样体和扁桃体体积及生活质量,对轻度OSAHS患儿疗效更为显著。
文摘目的探讨低温等离子扁桃体部分消融术在治疗儿童阻塞性睡眠呼吸暂停综合征(OSAHS)中的治疗效果及应用前景。方法回顾性分析78例OSAHS患儿的临床资料,所有患儿主要阻塞病变为扁桃体及腺样体肥大,扁桃体无慢性炎症表现,应用低温等离子行扁桃体部分消融术及鼻内镜腺样体消融术。结果术中出血1~5 m L,无术中及术后并发症。随访6~12个月,所有患儿睡眠打鼾及张口呼吸均消失,扁桃体无再生及反复炎症发作。结论行低温等离子扁桃体部分消融术治疗儿童OSAHS微创、安全、有效,更个体化、人性化,是一种较好的治疗儿童OSAHS的手术方法,适合在临床广泛开展。
