Predictive value of CA-153,CA-125 and Apo A for ocular metastasis in menopausal female patients with breast cancer

AIM:To establish a meaningful standard for diagnosing ocular metastasis(OM)in menopausal breast cancer(BC)women,and explore the relationship between CA-153,CA-125,apolipoprotein A,and OM.METHODS:A total of 1362 menopausal female BC patients with OM volunteered to take part in this study between July 2012 and July 2022.Women with BC who are menopausal were found to have an OM incidence of 1.6%.Furthermore,CA-153,CA-125,and apolipoprotein A(Apo A)all contributed to OM in women with BC who are postmenopausal according to binary logistic regression.Receiver operating curve(ROC)analysis was used to assess the diagnostic value of OM in patients with BC.RESULTS:Both CA-153 and CA-153+CA-125 showed a higher sensitivity of 95.45%,whereas CA-153+Apo A illustrated the highest specificity of 99.02%.Moreover,CA-153 and CA-153+CA-125 had higher areas under the curve(AUC)of 0.973.CONCLUSION:The data indicate that the serum concentrations of CA-153 exhibited the most significant predictors of the diagnosis of OM in menopausal women with BC.The current study researches the utility of risk factors in predicting of OM in menopausal BC women and put forward the latest suggestions on their clinical application.

Esophageal Cancer Metastasis to the Eye: A Case Report and Literature Review

Ocular metastasis is an uncommon occurrence that usually has a poor prognosis. The most frequent causes of intraocular metastases as reported in the literature are breast and lung cancers. Intraocular metastasis originating from esophageal cancer is very rare. We discuss a case of 58 years old man known case of adenocarcinoma of the esophagogastric junction presenting with ocular metastasis in King Abdulaziz Medical City, Jeddah, Saudi Arabia. Clinical symptoms led to the investigations and diagnosis of the ocular metastasis which without these symptoms it would have been missed. We concluded that a careful and good review of the whole body is essential in the optimal diagnosis of metastatic lesions especially when it comes to a rare metastasis like ocular metastasis from esophageal cancer.

Metastatic breast cancer:an unusual cause of diplopia

While secondary solid cancer into the eye orbit is rare,it is the most common site for primary metastasis in female breast cancer.We report a case of a sixty-six years old woman presenting to her optician with complaints of double vision.Magnetic resonance imaging revealed an invasive lesion in the superior and medial rectus muscles of the right orbit,biopsy of which confirmed this as an infiltrating breast carcinoma.Investigation of the primary lesion showed an advanced invasive ductal carcinoma of the right breast.She was then treated with radiotherapy to the orbit and a non steroidal aromatase inhibitor Anastrozol(Arimidex®).We herein review and discuss the literature,epidemiology,mechanism of tumor spread,the“seed and soil”theory,clinical presentation,pathology,and management of this uncommon presentation.