Changes in ocular surface status and dry eye symptoms following femtosecond laser-assisted cataract surgery

AIM: To observe the changes in ocular surface and the dry eye symptoms following femtosecond laser-assisted cataract surgery(FLACS). METHODS: Patients with no eye signs or symptoms in Guangzhou Aier Eye Hospital between October 2017 and September 2018, who underwent FLACS and intraocular lens(IOL) implantation for age-related cataract were enrolled. Tear film stability assessed with OCULUS Keratograph 5 M, Schirmer’s I test(SIT), and corneal fluorescein staining(CFS) were evaluated before and after surgery at 1 d, 1 wk, 1, and 3 mo in order. Ocular Surface Disease Index scores(OSDI) and Subjective Symptom Questionnaires(SSQs) were recorded at the same time point.RESULTS: Thirty-eight eyes of 38 patients were enrolled. The noninvasive tear film break-up time(first break-up time and average break-up time) decreased in a peak at the 1 wk visit, and then increased to basic levels at 1 mo. The tear meniscus height(TMH) increased transiently at 1 d, and declined in the following 3 mo visits. The SIT had a transient increase at 1 d(P=0.357) and a decrease at 1 wk and 1 mo(both P<0.05) but returned to the preoperative levels at 3 mo after surgery(P=0.062). CFS scores were significantly improved compared with those before surgery, and had a statistical difference(P<0.05). OSDI scores and SSQs after surgery were obviously higher, and had a statistical difference(P<0.001) but didn’t return to the basic level by 3 mo. CONCLUSION: Dry eye signs and symptoms can occur immediately following FLACS and have a peak severity on day 7 postoperatively. Most signs of dry eye can return to preoperative basic levels within 3 mo postoperatively. However, all cases can not recover from CFS and dry eye symptoms at 3 mo postoperatively.

Influence of Psychological Intervention before Emergent Ocular Trauma Surgery on Patients' Negative Emotions

Purpose:.To investigate the effect of preoperative psychological intervention on alleviating negative emotions in patients undergoing emergent ocular trauma surgery.Methods:..A total of 100 patients undergoing emergent ocular trauma surgery were selected using convenience sampling and randomly divided into control(n=49) and experimental(n =51) groups. Patients in the control group received conventional nursing and their counterparts in the observation group were treated with individualized psychological interventions including psychological support, relaxation training, and humanistic care based on conventional nursing care..Self-rating anxiety scale(SAS), self-rating depression scale(SDS), and fear visual analog scale(FVAS) scores were statistically compared between the two groups.Results:.The scores of SAS, SDS, and FAVS were significantly lower in the experimental group than in the control group(all P<0.001).Conclusion:.Comprehensive psychological intervention effectively eliminates negative emotions in patients undergoing emergent ocular trauma surgery and accelerates their physical and mental recovery.

Cysticercosis of the eye

Cysticercosis is a preventable and eradicable cause of blindness endemic in the Indian subcontinent, South- East Asia and other developing countries. Ocular and orbital cysticercosis has varied presentations depending upon the site of involvement, number of lesion and the host immune response. In this article we present a review of the various clinical manifestations, diagnosis and management protocol for orbital and ocular cysticercosis. Owing to its varied presentation, cysticercosis may pose a diagnostic challenge to the health professionals. Early diagnosis and management can prevent the vision loss and optimize visual outcomes.

Ocular surface and tear film changes after eyelid surgery

Eyelid surgery is widely and extensively used in facial plastic and reconstructive surgeries.There are many categories of eyelid surgeries,the most common of which include blepharoplasty,ptosis surgery,and eyelid reconstruction.In many cases,these procedures are combined,and there are many different techniques for each type of operation.Upper eyelid blepharoplasty usually includes the excision of skin,preseptal orbicularis oculi muscle,and orbital fat.Common methods of lower eyelid blepharoplasty are the skin-muscle flap,the skin flap,and the transconjunctival.Ptosis surgery is mainly divided into three types:transcutaneous,transconjunctival,and sling surgery.Surgeons often used the Hughes or Cutler-Beard Bridge Flaps in eyelid reconstruction.Different types and methods of surgery have their own advantages and disadvantages,and postoperative complications may occur.Therefore,postoperative complications of eyelid surgeries,such as dry eye symptoms,should be taken into serious consideration.Relevant literature involving these complaints can be found in PubMed by searching the terms“dry eye”,“eyelid”,“surgery”,and other related keywords.Moreover,various ocular surface and tear film alterations may be detected using the Ocular Surface Disease Index(OSDI),tear film breakup time,Schirmer test,fluorescein staining,and lissamine green staining after various eyelid surgeries.As dry eye disease is prevalent in the general population,it is more urgent to figure out what we can learn from these complaints.Further exploration in this field may help surgeons to choose a better surgical method and give an accurate evaluation of the postoperative effect.

Pain perception enhancement in consecutive secondeye phacoemulsification cataract surgeries under topical anesthesia

Cataract is the main cause of visual impairment and blindness worldwide while the only effective cure for cataract is still surgery.Consecutive phacoemulsification under topical anesthesia has been the routine procedure for cataract surgery.However,patients often grumbled that they felt more painful during the second-eye surgery compared to the first-eye surgery.The intraoperative pain experience has negative influence on satisfaction and willingness for second-eye cataract surgery of patients with bilateral cataracts.Intraoperative ocular pain is a complicated process induced by the nociceptors activation in the peripheral nervous system.Immunological,neuropsychological,and pharmacological factors work together in the enhancement of intraoperative pain.Accumulating published literatures have focused on the pain enhancement during the secondeye phacoemulsification surgeries.In this review,we searched PubMed database for articles associated with pain perception differences between consecutive cataract surgeries published up to Feb.1,2024.We summarized the recent research progress in mechanisms and interventions for pain perception enhancement in consecutive secondeye phacoemulsification cataract surgeries.This review aimed to provide novel insights into strategies for improving patients’intraoperative experience in second-eye cataract surgeries.

Reliability of the ocular trauma score for the predictability of traumatic and post-traumatic retinal detachment after open globe injury

AIM: To elucidate the question of whether the ocular trauma score(OTS) and the zones of injury could be used as a predictive model of traumatic and post traumatic retinal detachment(RD) in patients with open globe injury(OGI).METHODS: A retrospective observational chart analysis of OGI patients was performed. The collected variables consisted of age, date, gender, time of injury, time until repair, mechanism of injury, zone of injury, injury associated vitreous hemorrhage, trauma associated RD, post traumatic RD, aphakia at injury, periocular trauma and OTS in cases of OGI. RESULTS: Totally 102 patients with traumatic OGI with a minimum of 12 mo follow-up and a median age at of 48.6 y(range: 3-104 y) were identified. Final best corrected visual acuity(BCVA) was independent from the time of repair, yet a statistically significant difference was present between the final BCVA and the zone of injury. Severe trauma presenting with an OTS score Ⅰ(P<0.0001) or Ⅱ(P<0.0001) revealed a significantly worse BCVA at last follow up when compared to the cohort with an OTS score >Ⅲ. OGI associated RD was observed in 36/102 patients(35.3%), whereas post traumatic RD(defined as RD following 14 d after OGI) occurred in 37 patients(36.3%). OGI associated RD did not correlate with the OTS and the zone of injury(P=0.193), yet post traumatic RD correlated significantly with zone Ⅲ injuries(P=0.013). CONCLUSION: The study shows a significant association between lower OTS score and zone Ⅲ injury with lower final BCVA and a higher number of surgeries, but only zone Ⅲ could be significantly associated with a higher rate of RD.

Aggressive surgical management after transarterial chemoembolization(TACE)for liver metastases from ocular melanoma

Metastatic melanoma is also a challenge for surgeons. Recently, it has been reported that aggressive surgery combined with supportive therapy may be potential benefit for the condition. Therefore, we report a case of ocular melanoma metastatic to multiple visceral sites treated by cytoreductive surgery after initial intra-,arterial hepatic chemoembolization

The Anatomical Dry Eye <br/>—A Different Form of Ocular Surface Disease Deserves Focus

Introduction: Dry eye disease is currently considered mainly tear film related ocular surface condition. This concept does, however, not respect ocular surface topography. The micro-anatomy of the corneal changes may lead to enhanced demands on the tear film and lead to significant complaints. However, they often remain undetected and hence untreated. It is suggested that the pathophysiology for an entire subgroup of dry eye disease patients is primarily of surface morphological nature. Methods: The tear film break up was observed and used to identify anatomical alterations in eyes of patients with dry eye complaints. The localization and pattern of TFBUT using fluorescein was compared between eye with normal surfaces and surface alterations. Results: Premature tear film rupture was localized at constantly same areas and did match changes on the ocular epitheliopathy in patients with diseases such as microcystic epithliopathy, MFD, and after excimer laser treatment. Disusssion: Whereas in normal surfaces TFBUT does occur within the floating tear film, the anatomical dry eye identifies itself with constant location of tear film break up and a constant spreading pattern. In contrast to the classic, tear film caused dry eye, the anatomical dry eye is accessible to treatment. This should catch our attention and intent to identify it. It is the ease of possible treatment that should make these ocular surface alterations prime target of dry eye disease diagnostic. It is hence suggested to introduce the anatomical dry eye as a subgroup in the large group of dry eye and ocular surface disease.

A narrative review of ocular surface disease considerations in the management of glaucoma

s from those searches were screened for relevance to our review topics.Publications were included if the subjects included glaucoma patients,and if ocular surface outcomes were described.Non-English papers were excluded.Key Content and Findings:Topical glaucoma medications frequently cause adverse effects on the ocular surface,both through direct action of the medications themselves as well as through toxicity from their associated preservatives.Optimization of the ocular surface may improve medication compliance rates.Traditional surgical treatments for glaucoma,such as trabeculectomy,can exacerbate OSD by disrupting the ocular surface but can also reduce the need for chronic medications.Optimization of ocular surface health is imperative in reducing trabeculectomy complication rates,while also potentially reducing the need for trabeculectomy in patients that are able to achieve intraocular pressure control through improved drop tolerability.The introduction of MIGS represents a promising alternative to existing therapies and has been shown to alleviate the overall medication burden.It would be reasonable to assume that decreasing the medication burden could reduce OSD prevalence and severity.However,more research is needed to directly assess the extent of improvement seen after MIGS.Conclusions:A comprehensive understanding of the importance of OSD in medical and surgical management of glaucoma is essential in optimizing patient care and improving outcomes.

Patch graft for pterygium surgery:stitch it or stick it?

Pterygia are an extremely common ocular condition believed to be occurring due to proliferation and overgrowth of abnormal epithelial and fibrovascular tissue onto the cornea.They are characterized by cellular proliferation,neovascularization and inflammation.Indications for treatment vary from minor cosmetic concerns to significant visual loss.Management options include an array of surgical techniques including simple resection(leaving the sclera bare),or resection followed by covering the sclera with primary conjunctival closure,a conjunctival or conjunctivolimbal autograft(CAG and CLAG respectively)from another site on the bulbar conjunctiva of the same eye,or with human amniotic membrane(HAM).

Efficacy of Combined Vitreous Surgery and Choroidal Suture Fixation on Choroidal Avulsion

Purpose:To evaluate the feasibility and efficacy of combined vitreous surgery and choroidal suture fixation on choroidal avulsion.Methods:A total of 21 patients.(21 eyes).with choroidal avulsion,secondary to open eye trauma and a history of one-stage eyeball wall closure were retrospectively evaluated in the present study.Preoperative findings included 3 to 7.5 mmHg(averagely 5.1±1.1mmHg) of intraocular pressure and presence/suspicion of visual light perception.Vitreo-retinal surgery in combination with choroidal suture fixation was conducted for these patients at 4 to 21 days(averagely 9.41±2.7 days) after the trauma.The postoperative follow-up lasted for 3 to 9 months(averagely 5.5±1.5 months).Results:The intraoperative findings indicated several choroid residuals with different densities attached on the sclera at the choroidal detachment area.Retinal proliferation/detachment,incarceration and/or partial retinal loss were also observed.Intraoperatively,the retina was separated and released,and the suture fixation outside the sclera in combination with intraocular photocoagulation and silicone oil filling were performed at the avulsed choroidal area.The suture fixation on the ciliary body was also introduced in some of the patients.At one month posteoperatively,a complete choroidal reattachment was achieved in 16 eyes(16/21,76.19%) and partial reattachment in the remaining 5 eyes.At the end of follow-up,partial choroidal redetachment was observed in 4 of 16 eyes(25%),resulting in complete reattachment in 12 eyes(12/21,57.1%) and partial reattachment in 9 eyes(9/21,33.34%).The complete choroidal reattachment rate at the end of follow-up was not significantly different from that observed at one month after the surgery.(Chi-square test,P<0.05),while the complete retinal reattachment rate at this time point was significantly lower than that at one month postoperatively(Chi-square test,P>0.05).Conclusion:Transscleral suture fixation serves as a reliable technique,particularly improving the choroidal reattachment rate in the choroidal avulsion.

经鼻内镜手术治疗以眼部症状为首发的真菌性蝶窦炎

目的探讨以眼部症状为首发的真菌性蝶窦炎的早期诊断及导航辅助下真菌病变清除术。方法对2007年1月-2022年12月广州市中山大学附属第一医院耳鼻咽喉科收治的17例以眼部症状为首发的真菌性蝶窦炎患者的临床表现、影像学检查、手术方法及术后转归等方面进行回顾性分析,总结临床经验。结果17例患者影像学均符合真菌性鼻窦炎,且术后病理确诊为真菌感染。11例患者术后眼部症状得到不同程度改善,包括视力下降、眼球运动障碍、眼睑下垂等,6例患者术后症状无明显改善。结论临床上病因不明的渐进性视力下降及迁延不愈的头痛,应考虑真菌性蝶窦炎可能,及时完善头颅CT、MRI等检查,一经确诊首选鼻内镜下手术治疗。术中导航技术可辅助准确定位病变并判断病变范围,保障手术安全并提高手术效率。侵袭性真菌性鼻窦炎需要联合系统性抗真菌治疗。

基于横向沟通的减压小组法改善眼部整形手术患者心理压力的效果观察

目的:观察基于横向沟通的减压小组法改善眼部整形手术患者心理压力效果。方法:选取笔者医院2021年1月-2022年12月收治的82例改善眼部整形手术患者为研究对象,遵随机数字表法分为41例常规组(常规护理)和41例减压组(常规组基础上+基于横向沟通的减压小组法),比较干预前后两组间患者心理压力、自尊水平、体像障碍、人格障碍、治疗依从性及护理满意度。结果:干预后,两组心理压力评分(紧张、抑郁、精力、慌张、疲劳、自尊感和愤怒)均降低,且减压组显著低于常规组(P<0.05);干预后,两组自尊水平评分(外表、行为及社会)均升高,且减压组显著高于常规组(P<0.05);干预后,两组MBSRQ及PDQ-4+评分均降低,且减压组显著低于常规组(P<0.05);减压组治疗依从率显著高于常规组(P<0.05);减压组护理满意度评分(护理技术、病房环境、护患沟通和健康教育)均显著高于常规组(P<0.05)。结论:基于横向沟通的减压小组法能有效改善眼部整形手术患者心理压力,增强患者自尊水平,减轻患者体像障碍及人体障碍,提高患者治疗依从性和护理满意度。

斜视术后眼表及睑板腺功能变化的危险因素分析

目的探讨斜视患者术后眼表及睑板腺功能变化及其危险因素分析。方法回顾性病例对照研究。选取2019年1月至2021年6月我院收治的126例(188只眼)斜视患者为研究对象,根据手术切口将患者分为角膜缘切口组(A组)、跨肌止端切口组(B组)、近穹隆切口组(C组)三个组别,分别于术后1周、术后1个月、术后6个月观察患者的眼表与睑板腺功能变化,并分析眼表与睑板腺功能变化的单因素,采用Logistic回归分析进一步明确影响斜视患者术后眼表与睑板腺功能变化的因素。结果眼表疾病评分指数(OSDI)、角膜上皮荧光染色评分(CFSS)、泪膜脂质层厚度(LLT)、SchirmerⅠ试验(SⅠt)、泪膜破裂时间(TBUT)、睑板腺开口评分的组间比较有统计学意义(F_(组间)=35.912、28.093、32.115、35.021、32.984、35.765,P<0.05),不同时间点比较差异有统计学意义(F_(时点)=67.982、69.038、62.091、59.181、64.282、61.224,P<0.05),同时各指标的组间与时点之间存在交互效应(F_(交互)=52.126、56.098、55.223、59.719、54.033、49.914,P<0.05)。其中C组OSDI、CFSS、LLT、SⅠt、TBUT、睑板腺开口评分改善优于B组、A组(P<0.05)。性别、家族病史、术前立体视觉异常、合并弱视与斜视患者术后眼表与睑板腺功能恢复无关(P>0.05)。发病年龄、病程、无控制正位、术后无立体视觉训练、手术切口、手术累及肌肉数目是影响斜视患者眼表与睑板腺功能恢复的影响因素(P<0.05)。进一步使用Logistic回归分析结果显示,发病年龄>9岁、病程>1年、手术行角膜缘切口或跨肌止端切口、手术累及肌肉数目≥2条、术后无立体视觉训练是影响斜视患者术后眼表与睑板腺功能恢复的独立危险因素(P<0.05)。结论斜视患者手术时行近穹隆切口对其术后眼表与睑板腺功能恢复最佳。发病年龄>9岁、病程>1年、手术行角膜缘切口或跨肌止端切口、手术累及肌肉数目≥2条、术后无立体视觉训练均是影响斜视患者术后眼表与睑板腺功能恢复的危险因素。

一例全身麻醉非眼科手术患者角膜擦伤的根本原因分析与改进

对1例全身麻醉非眼科手术患者角膜擦伤事件进行根本原因分析。按照问题定义与事件描述,识别可能原因,剖析根本原因,制定并执行改进措施的步骤,完整呈现“全身麻醉非眼科手术患者角膜擦伤”事件根本原因分析的全过程。从针对心电监护操作建立督导及考核机制,加强麻醉护理人员面罩通气手法的培训,科室规范中增加面罩通气期间的眼睛保护措施,并针对特殊手术体位的眼睛保护措施等方面加以改进,取得了较好效果。为临床管理者提供质量管理的思路与方法,以便更好地识别系统中的问题,制定针对性的改善计划与预防措施。

角膜屈光手术对角膜生物力学影响的研究进展

角膜屈光手术是目前屈光手术的主流术式,随着全飞秒、全激光手术方式的发展,手术变得更加安全精准,不仅角膜创伤小,术后恢复时间也进一步缩短。角膜具有屈光特性和典型的生物软组织力学特性,角膜力学特性不仅参与维持角膜形态,影响角膜手术尤其屈光手术的效果及预后,而且还与部分角膜疾病的发生和发展密切相关。近年来生物力学研究发展迅速,其在眼部疾病的诊疗中发挥着越来越重要的作用。角膜生物力学的变化与术前角膜的形态、不同手术方式的选择、术后角膜厚度的改变等多种因素相关,但手术导致的角膜自身形态改变是不可逆的,若术后角膜生物力学的变化较大,可能会引起医源性角膜扩张、继发性圆锥角膜等并发症的发生。为了规避术后角膜扩张风险和指导个性化的术式选择,了解角膜生物力学特性的影响至关重要。文章对角膜的基础结构、角膜生物力学特性、生物力学测量方法和不同术式及不同角膜瓣厚度术后生物力学变化的研究进展进行综述,为近视患者的个性化精准治疗提供理论指导。

程序化综合护理干预结合视觉适应训练对眼部手术患儿恐惧状态及配合度的影响

目的 分析程序化综合护理干预结合视觉适应训练对眼部手术患儿恐惧状态及配合度的影响。方法选取2019年6月至2022年6月我院收治的82例眼部手术患儿为研究对象,以随机数字表法将其分为对照组和观察组,各41例。对照组采用常规护理,观察组在对照组基础上采用程序化综合护理干预结合视觉适应训练。比较两组的干预效果。结果 干预后,观察组的医疗恐惧调查量表(CMFS)各维度评分均低于对照组(P<0.05)。观察组的配合优良率高于对照组(P<0.05)。观察组的苏醒躁动率低于对照组(P<0.05)。观察组家属的临床护理满意度调查表各维度评分及总分均高于对照组(P<0.05)。结论 程序化综合护理干预结合视觉适应训练不仅能减轻眼部手术患儿恐惧情绪,提高其配合度,也能减少术后苏醒躁动情况,提高家属对护理的满意度,值得推广。

妥布霉素地塞米松滴眼液对白内障术后干眼症患者眼部症状改善情况和泪膜稳定性的影响

目的探究妥布霉素地塞米松滴眼液对白内障术后干眼症患者眼部症状改善情况和泪膜稳定性的影响。方法选取2022年7月—2023年6月南京市六合区中医院收治的98例白内障手术后发生干眼症的患者为研究对象,经电脑随机分为两组,对照组(49例)行重组牛碱性成纤维细胞生长因子眼用凝胶治疗,观察组(49例)配合运用妥布霉素地塞米松滴眼液治疗。经过30 d的持续治疗,对比两组眼部症状、泪膜稳定性、不良反应发生情况。结果观察组眼表疾病指数量表(Ocular Surface Disease Index,OSFI)评分和角膜荧光染色(Corneal Fiuoresence Staining Score,CFS)评分低于对照组,差异有统计学意义(P均<0.05);治疗后,观察组泪膜破裂时间、泪液分泌试验、泪膜厚度指标均优于对照组,差异有统计学意义(P均<0.05);观察组不良反应发生率为8.16%,低于对照组的12.24%,差异无统计学意义(χ^(2)=0.446,P=0.505)。结论妥布霉素地塞米松滴眼液能够良好治疗白内障术后干眼症患者,改善眼部症状,保持泪膜稳定。

复杂眼外伤处理中Ⅰ期玻璃体手术联合睫状体离断复位观察

目的:评价Ⅰ期玻璃体手术联合睫状体缝合治疗合并睫状体离断的复杂眼外伤的临床治疗效果。方法:观察2011-01-01/2014-10-31期间连续收治严重眼外伤合并睫状体离断患者13例13眼。其中2眼钝挫伤,7眼穿通伤和4眼破裂伤,伴随症状有角膜裂伤、角巩膜缘裂伤、巩膜裂伤、前房积血、虹膜根部离断、瞳孔括约肌撕裂、晶状体破裂或脱位、玻璃体积血、视网膜挫伤、视网膜脱离、脉络膜挫伤、脉络膜上腔出血、球内异物等。术前检查视力无光感~手动/眼前。术前UBM或三面镜检查或术中发现睫状体离断,脱离范围2∶00~6∶00。钝挫伤患者眼压分别5.4mmHg和10.2mmHg。手术时间为伤后6h^3d,主要操作包括关闭角膜巩膜伤口、切除玻璃体、切除晶状体、清除积血、视网膜复位、缝合方法复位脱离睫状体。脉络膜出血采用巩膜外穿刺切开放液处理。眼内采用惰性气体或硅油填充。结果:术后检查13例脱离睫状体均复位。术后1mo,患眼视力有不同程度提高,检查最佳矫正视力手动/眼前~4.7,眼压9.8~24.5mmH g(除外严重角膜裂伤缝合术后角膜水肿1眼),术后三面镜或UBM检查睫状体复位,B超或眼底镜检查视网膜复位。结论:对于合并睫状体离断复杂眼外伤眼,采用Ⅰ期玻璃体手术联合睫状体缝合治疗可有效恢复眼球解剖结构,并有效保存视功能。

内眼手术患者术前结膜囊细菌分布及药物敏感性分析

目的探讨内眼手术患者术前结膜囊细菌分布情况以及药物敏感性,为临床预防性用药和术后眼内炎的治疗提供依据。方法采用前瞻性病例对照研究设计,连续收集2015年2—8月于沈阳市第四人民眼科住院拟行内眼手术的非感染性眼病患者,在术前预防性使用抗生素等处理前进行结膜囊标本采集并进行需氧菌和厌氧菌培养,观察结膜囊细菌培养阳性率和菌种分布情况。采用全自动微生物药物敏感试验分析系统对培养阳性的需氧菌进行眼科常用抗菌药物的敏感性试验。结果本研究共纳入患者192例192眼,其中男88例,占45.83%;平均年龄(58±15)岁。结膜囊标本需氧菌培养阳性81例,阳性率为42.19%。共分离需氧菌91株,主要为革兰阳性菌占91.21%;其中表皮葡萄球菌,占64.84%,其次为缓慢葡萄球菌和金黄色葡萄球菌,分别占7.69%和3.30%。革兰阴性菌包括克氏枸橼酸杆菌、摩根菌、变形杆菌和阴沟肠杆菌。凝固酶阴性的葡萄球菌(CNS)占所有阳性需氧菌的80.22%。厌氧菌培养阳性标本28例,占14.58%,主要为疮疱丙酸杆菌和大芬戈尔德菌,分别占71.43%和10.71%。药物敏感性试验结果显示,大多数CNS对庆大霉素和万古霉素敏感,耐药率小于10%,而普遍对红霉素和头孢他啶耐药,耐药率分别占69.86%和63.01%。对于眼科常用的左氧氟沙星、环丙沙星和莫西沙星,细菌耐药性分别是42.47%、39.73%和17.81%。对3种及以上抗生素同时耐药的CNS占38.36%。结论内眼手术患者结膜囊存在较高比例的需氧菌及厌氧菌生长。CNS是常见的分离菌种,且相当一部分对眼科常用的抗生素耐药。根据地区常见菌种和药物敏感试验结果调整预防性措施或治疗性用药对于提高手术安全性和治疗有效性具有重要意义。