Objective To evaluate the clinical effect of acupoint injection therapy for paralysis of oculomotor nerve with Chinese herbal medicines. Methods A total number of 456 patients from 3 centers with paralysis of oculomot...Objective To evaluate the clinical effect of acupoint injection therapy for paralysis of oculomotor nerve with Chinese herbal medicines. Methods A total number of 456 patients from 3 centers with paralysis of oculomotor nerve were randomly divided into an acupoint injection group and a control group with 228 cases each. Patients in the acupoint injection group were treated with injection of Chinese herbal medicines to Jingming （晴明 BL 1）, Yangbai （阳白GB 14}, Sibai （四白 ST 24 Tongziliao （瞳子髎 GB I） on the affected side, and Ganshu （肝俞 BL 18） on both sides, Compound Angelica Injection was the main drug, and the corresponding acupoints and other injection drugs were also used according to differentiation of syndrome. Patients in the control group were treated with common western medicine. The treatment was given once a day, 10 times constituted one course with 3 days of interval. After 3 courses, the effect was assessed. TCM syndrome score, eyeball movement degree, the sizes of oculi rimae and pupil of the two groups were recorded before and after treatment. Results The effective rate of acupoint injection group was 91.7% （209/228）, and that of the control group was 73.6% （168/228）. There was statistical significance in comparing the difference between the two groups （P〈0.05）. TCM syndrome scores of the two groups after the treatment became less obviously than those before the treatment （P〈0.01, P〈0.05）, the score of acupoint injection group was more reduced than that of the control group （P〈0.05）. Eyeball movement degree and oculi rimae were enlarged and the pupil reduced in the affected eye in both groups after the treatment Call P〈0.05）. The musculus rectus medialis for the eyeball movement in the acupoint injection group was more improved than that of the control group, and the oculi rimae was bigger in the acupoint injection group than that in the control group （both P〈0.05）. Conclusion Acupoint injection therapy with Chinese herbal medicines has assured effect on the treatment of oculomotor paralysis.展开更多
Objective To assess the efficacy of acupuncture therapy on oculomotor paralysis. Methods Acupuncture was applied to 30 subjects with definite diagnosis of oculomotor paralysis in China and Uganda. Each treatment laste...Objective To assess the efficacy of acupuncture therapy on oculomotor paralysis. Methods Acupuncture was applied to 30 subjects with definite diagnosis of oculomotor paralysis in China and Uganda. Each treatment lasted 1 hour per day, and 10 days was taken as one course. Main acupoints： ①Sīzhúkōng （丝竹空 TE 23）, Tāiyáng （太阳 EX-HN 5）, Hégǔ（合谷LI 4）, Yìmíng （翳明 EXTRA）; ②Cuánzhú （攒竹BL 2）, Tóuwéi （头维 ST 8）, Wàiguān （外关 TE 5）, Yìmíng （翳明 EXTRA）. These two groups of acupoints were alternatively used everyday. Subsidiary acupoints： the medial rectus muscle paresis：Jīngmíng （睛明BL 1）, the superior rectus muscle paresis： Yángbái （阴白GB 14）, the inferior rectus muscle paresis： Sìbái （ 四白 ST 2）, the inferior oblique muscle paresis： Tóngzǐliao（瞳子髎 GB 1 ）. The size of the palpebral fissure, the size of the pupil and the position distance of the muscles were measured before and after the treatment. Results Thirty eyes of 30 subjects were treated, 10 cases were cured （33.33%）, 12 cases effective （40.00%） and 8 cases failed （26.67%）. The total effective rate was 73.33%. Of 10 cases with curative effect, 7 cases were traumatic palsy. It was shown that acupuncture was more effective on traumatic palsy. There were significant differences in the size of the palpebral fissure, the size of the pupil and the position distance of the muscles before and after treatment （P〈0.05,P〈0.01）. Conclusion Acupuncture benefits recovering the function of paralytic nerve and muscle, which is probably due to that acupuncture stimulates oculomotor nerve or nerve endings as well as muscle spindles and muscle tendons; and it activates neuromuscular connection. Additionally, acupuncture may help the regeneration of oculomotor nerve so that the function of paralytic nerve and muscle can be repaired.展开更多
Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehen...Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehensive measure of its severity. In this study, we designed the Ocular Motor Nerve Palsy Scale and investigated its validity and reliability. Six experts were invited to grade and evaluate the scale. The study recruited 106 patients with a definite diagnosis of unilateral isolated ocular motor nerve palsy. Three physicians evaluated the patients using the scale. One of the three physicians evaluated the patients again after 24 hours. The content validity index（CVI） and factor analysis were used to analyze the scale＇s construct validity. The intraclass correlation coefficient and Cronbach＇s alpha were used to evaluate the inter-rater and test-retest reliability and the internal consistency. The CVI results（I-CVI = 1.0, S-CVI = 0.9, Pc = 0.016, K＊ = 1） indicated good content validity. Factor analysis extracted two common factors that accounted for 85.2% of the variance. Furthermore, the load value of each component was above 0.8, indicating good construct validity. The Ocular Motor Nerve Palsy Scale was found to be highly reliable, with an inter-rater reliability intraclass correlation coefficient of 0.965（P 0.01）, a test-retest reliability intraclass correlation coefficient of 0.976（P 0.01）, and Cronbach＇s alpha values of 0.63–0.70. In conclusion, the Ocular Motor Nerve Palsy Scale with good validity and reliability can be used to quantify the severity of ocular motor nerve palsy. This study was registered at Chinese Clinical Trial Registry（registration number： Chi CTR-OOC-17010702）.展开更多
基金Supported by designated project of 2008 Scientific Plan of TCM and Integrative Medicine of Hebei Administration of TCM:2008080
文摘Objective To evaluate the clinical effect of acupoint injection therapy for paralysis of oculomotor nerve with Chinese herbal medicines. Methods A total number of 456 patients from 3 centers with paralysis of oculomotor nerve were randomly divided into an acupoint injection group and a control group with 228 cases each. Patients in the acupoint injection group were treated with injection of Chinese herbal medicines to Jingming （晴明 BL 1）, Yangbai （阳白GB 14}, Sibai （四白 ST 24 Tongziliao （瞳子髎 GB I） on the affected side, and Ganshu （肝俞 BL 18） on both sides, Compound Angelica Injection was the main drug, and the corresponding acupoints and other injection drugs were also used according to differentiation of syndrome. Patients in the control group were treated with common western medicine. The treatment was given once a day, 10 times constituted one course with 3 days of interval. After 3 courses, the effect was assessed. TCM syndrome score, eyeball movement degree, the sizes of oculi rimae and pupil of the two groups were recorded before and after treatment. Results The effective rate of acupoint injection group was 91.7% （209/228）, and that of the control group was 73.6% （168/228）. There was statistical significance in comparing the difference between the two groups （P〈0.05）. TCM syndrome scores of the two groups after the treatment became less obviously than those before the treatment （P〈0.01, P〈0.05）, the score of acupoint injection group was more reduced than that of the control group （P〈0.05）. Eyeball movement degree and oculi rimae were enlarged and the pupil reduced in the affected eye in both groups after the treatment Call P〈0.05）. The musculus rectus medialis for the eyeball movement in the acupoint injection group was more improved than that of the control group, and the oculi rimae was bigger in the acupoint injection group than that in the control group （both P〈0.05）. Conclusion Acupoint injection therapy with Chinese herbal medicines has assured effect on the treatment of oculomotor paralysis.
文摘Objective To assess the efficacy of acupuncture therapy on oculomotor paralysis. Methods Acupuncture was applied to 30 subjects with definite diagnosis of oculomotor paralysis in China and Uganda. Each treatment lasted 1 hour per day, and 10 days was taken as one course. Main acupoints： ①Sīzhúkōng （丝竹空 TE 23）, Tāiyáng （太阳 EX-HN 5）, Hégǔ（合谷LI 4）, Yìmíng （翳明 EXTRA）; ②Cuánzhú （攒竹BL 2）, Tóuwéi （头维 ST 8）, Wàiguān （外关 TE 5）, Yìmíng （翳明 EXTRA）. These two groups of acupoints were alternatively used everyday. Subsidiary acupoints： the medial rectus muscle paresis：Jīngmíng （睛明BL 1）, the superior rectus muscle paresis： Yángbái （阴白GB 14）, the inferior rectus muscle paresis： Sìbái （ 四白 ST 2）, the inferior oblique muscle paresis： Tóngzǐliao（瞳子髎 GB 1 ）. The size of the palpebral fissure, the size of the pupil and the position distance of the muscles were measured before and after the treatment. Results Thirty eyes of 30 subjects were treated, 10 cases were cured （33.33%）, 12 cases effective （40.00%） and 8 cases failed （26.67%）. The total effective rate was 73.33%. Of 10 cases with curative effect, 7 cases were traumatic palsy. It was shown that acupuncture was more effective on traumatic palsy. There were significant differences in the size of the palpebral fissure, the size of the pupil and the position distance of the muscles before and after treatment （P〈0.05,P〈0.01）. Conclusion Acupuncture benefits recovering the function of paralytic nerve and muscle, which is probably due to that acupuncture stimulates oculomotor nerve or nerve endings as well as muscle spindles and muscle tendons; and it activates neuromuscular connection. Additionally, acupuncture may help the regeneration of oculomotor nerve so that the function of paralytic nerve and muscle can be repaired.
基金supported by the National Natural Science Foundation of China,No.81674052
文摘Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehensive measure of its severity. In this study, we designed the Ocular Motor Nerve Palsy Scale and investigated its validity and reliability. Six experts were invited to grade and evaluate the scale. The study recruited 106 patients with a definite diagnosis of unilateral isolated ocular motor nerve palsy. Three physicians evaluated the patients using the scale. One of the three physicians evaluated the patients again after 24 hours. The content validity index（CVI） and factor analysis were used to analyze the scale＇s construct validity. The intraclass correlation coefficient and Cronbach＇s alpha were used to evaluate the inter-rater and test-retest reliability and the internal consistency. The CVI results（I-CVI = 1.0, S-CVI = 0.9, Pc = 0.016, K＊ = 1） indicated good content validity. Factor analysis extracted two common factors that accounted for 85.2% of the variance. Furthermore, the load value of each component was above 0.8, indicating good construct validity. The Ocular Motor Nerve Palsy Scale was found to be highly reliable, with an inter-rater reliability intraclass correlation coefficient of 0.965（P 0.01）, a test-retest reliability intraclass correlation coefficient of 0.976（P 0.01）, and Cronbach＇s alpha values of 0.63–0.70. In conclusion, the Ocular Motor Nerve Palsy Scale with good validity and reliability can be used to quantify the severity of ocular motor nerve palsy. This study was registered at Chinese Clinical Trial Registry（registration number： Chi CTR-OOC-17010702）.
