BACKGROUND Colon cancer(CC)is one of the most common cancers of the digestive tract,the third most common cancer worldwide,and the second most common cause of cancer-related deaths.Previous studies have demonstrated a...BACKGROUND Colon cancer(CC)is one of the most common cancers of the digestive tract,the third most common cancer worldwide,and the second most common cause of cancer-related deaths.Previous studies have demonstrated a higher risk of lymph node metastasis(LNM)in young patients with CC.It might be reasonable to treat patients with early-onset locally advanced CC with extended lymph node dissection.However,few studies have focused on early-onset CC(ECC)patients with LNM.At present,the methods of predicting and evaluating the prognosis of ECC patients with LNM are controversial.From the data of patients with CC obtained from the Surveillance,Epidemiology,and End Results(SEER)database,data of young patients with ECC(≤50 years old)was screened.Patients with unknown data were excluded from the study,while the remaining patients were included.The patients were randomly divided into a training group(train)and a testing group(test)in the ratio of 7:3,while building the model.The model was constructed by the training group and verified by the testing group.Using multiple Cox regression models to compare the prediction efficiency of LNM indicators,nomograms were built based on the best model selected for overall survival(OS)and cause-specific survival(CSS).In the two groups,the performance of the nomogram was evaluated by constructing a calibration plot,time-dependent area under the curve(AUC),and decision curve analysis.Finally,the patients were grouped based on the risk score predicted by the prognosis model,and the survival curve was constructed after comparing the survival status of the high and low-risk groups.RESULTS Records of 26922 ECC patients were screened from the SEER database.N classification,positive lymph nodes(PLN),lymph node ratio(LNR)and log odds of PLN(LODDS)were considered to be independent predictors of OS and CSS.In addition,independent risk factors for OS included gender,race,marital status,primary site,histology,grade,T,and M classification,while the independent prognostic factors for CSS included race,marital status,primary site,grade,T,and M classification.The prediction model including LODDS is composed of minimal Akaike information criterion,maximal concordance indexes,and AUCs.Factors including gender,race,marital status,primary site,histology,grade,T,M classification,and LODDS were integrated into the OS nomogram,while race,marital status,primary site,grade,T,M classification,and LODDS were included into the CSS nomogram.The nomogram representing both cohorts had been successfully verified in terms of prediction accuracy and clinical practicability.CONCLUSION LODDS is superior to N-stage,PLN,and LNR of ECC.The nomogram containing LODDS might be helpful in tumor evaluation and clinical decision-making,since it provides an appropriate prediction of ECC.展开更多
Fermat’s last theorem, had the statement that there are no natural numbers A, B, and C such that A<sup>n</sup> + B<sup>n</sup> = C<sup>n</sup>, in which n is a natural number great...Fermat’s last theorem, had the statement that there are no natural numbers A, B, and C such that A<sup>n</sup> + B<sup>n</sup> = C<sup>n</sup>, in which n is a natural number greater than 2. We have shown that any product of two odd numbers can generate Fermat or Pythagoras triple (A, B, C) following n = 2 and also it is applicable A<sup>2</sup> + B<sup>2</sup> + C<sup>2</sup> + D<sup>2</sup> + so on =A<sub>n</sub><sup>2 </sup>where all are natural numbers.展开更多
Oppositional Defiant Disorder(ODD)and Attention Deficit/Hyperactivity Disorder(ADHD)are mental health conditions that have traditionally been managed through behavioral therapies and medication.However,the integration...Oppositional Defiant Disorder(ODD)and Attention Deficit/Hyperactivity Disorder(ADHD)are mental health conditions that have traditionally been managed through behavioral therapies and medication.However,the integration of Artificial Intelligence(AI)has brought about a revolutionary shift in treatment approaches.This article explores the role of AI-driven noninvasive treatments for ODD and ADHD.AI offers personalized treatment plans,predictive analytics,virtual therapeutic platforms,and continuous monitoring,enhancing the effectiveness and accessibility of interventions.Ethical considerations and the need for a balanced approach are discussed.As technology evolves,collaborative efforts between mental health professionals and technologists will shape the future of mental health care for individuals with ODD and ADHD.展开更多
We propose a new generator of continuous distributions with at least four positive parameters called the Kumaraswamy-Odd Rayleigh-G family. Some special cases were presented. The plots of the Kumaraswamy Odd Rayleigh ...We propose a new generator of continuous distributions with at least four positive parameters called the Kumaraswamy-Odd Rayleigh-G family. Some special cases were presented. The plots of the Kumaraswamy Odd Rayleigh Log-Logistic (</span><i><span style="font-family:Verdana;">KORLL</span></i><span style="font-family:Verdana;">) distribution indicate that the distribution can take many shapes depending on the parameter values. The negative skewness and kurtosis indicates that the distribution has li</span><span style="font-family:Verdana;">ghter tails than the normal distribution. The Monte Carlo simulation results indicate that the estimated biases decrease when the sample size increases. Furthermore, </span></span><span style="font-family:Verdana;">the root mean squared error estimates decay</span><span style="font-family:""><span style="font-family:Verdana;"> towards zero as the sample size increases. This part shows the consistency of the maximum likelihood estimators. From the considered analytical measures, the new </span><i><span style="font-family:Verdana;">KORLL</span></i><span style="font-family:Verdana;"> provides </span></span><span style="font-family:Verdana;">the best fit to the analysed five real data sets indicating that this new model outclasses its competitors.展开更多
The filtration structure of finite-dimensional special odd Hamilton superalgebras over a field of prime characteristic was studied. By determining ad-nilpotent dements in the even part, the natural filtration of speci...The filtration structure of finite-dimensional special odd Hamilton superalgebras over a field of prime characteristic was studied. By determining ad-nilpotent dements in the even part, the natural filtration of special odd Hamiltonian superalgebras is proved to be invariant. Using this result, the special odd Hamilton superalgebras is classified. Finally, the automorphism group of the restricted special odd Hamilton superalgebras is determined.展开更多
The optimum design of equivalent accelerated life testing plan based on proportional hazards-proportional odds model using D-optimality is presented. The defined equivalent test plan is the test plan that has the same...The optimum design of equivalent accelerated life testing plan based on proportional hazards-proportional odds model using D-optimality is presented. The defined equivalent test plan is the test plan that has the same value of the determinant of Fisher information matrix. The equivalent test plan of step stress accelerated life testing (SSALT) to a baseline optimum constant stress accelerated life testing (CSALT) plan is obtained by adjusting the censoring time of SSALT and solving the optimization problem for each case to achieve the same value of the determinant of Fisher information matrix as in the baseline optimum CSALT plan. Numer- ical examples are given finally which demonstrate the equivalent SSALT plan to the baseline optimum CSALT plan reduces almost half of the test time while achieving approximately the same estimation errors of model parameters.展开更多
In this paper, the forced odd order neutral differential equations of the form are considered d n d t n[x(t)-R(t)x(t-τ)]+P(t)x(t-σ)=f(t),t≥t 0.A sufficient condition for the oscillation of all solutions is...In this paper, the forced odd order neutral differential equations of the form are considered d n d t n[x(t)-R(t)x(t-τ)]+P(t)x(t-σ)=f(t),t≥t 0.A sufficient condition for the oscillation of all solutions is obtained.展开更多
Objective: Our aims were to establish novel nomogram models, which directly targeted patients with signet ring cell carcinoma(SRC), for individualized prediction of overall survival(OS) rate and cancer-specific surviv...Objective: Our aims were to establish novel nomogram models, which directly targeted patients with signet ring cell carcinoma(SRC), for individualized prediction of overall survival(OS) rate and cancer-specific survival(CSS).Methods: We selected 1,365 SRC patients diagnosed from 2010 to 2015 from Surveillance, Epidemiology and End Results(SEER) database, and then randomly partitioned them into a training cohort and a validation cohort.Independent predicted indicators, which were identified by using univariate testing and multivariate analyses, were used to construct our prognostic nomogram models. Three methods, Harrell concordance index(C-index), receiver operating characteristics(ROC) curve and calibration curve, were used to assess the ability of discrimination and predictive accuracy. Integrated discrimination improvement(IDI), net reclassification improvement(NRI) and decision curve analysis(DCA) were used to assess clinical utility of our nomogram models.Results: Six independent predicted indicators, age, race, log odds of positive lymph nodes(LODDS), T stage, M stage and tumor size, were associated with OS rate. Nevertheless, only five independent predicted indicators were associated with CSS except race. The developed nomograms based on those independent predicted factors showed reliable discrimination. C-index of our nomogram for OS and CSS was 0.760 and 0.763, which were higher than American Joint Committee on Cancer(AJCC) 8 th edition tumor-node-metastasis(TNM) staging system(0.734 and 0.741, respectively). C-index of validation cohort for OS was 0.757 and for CSS was 0.773. The calibration curves also performed good consistency. IDI, NRI and DCA showed the nomograms for both OS and CSS had a comparable clinical utility than the TNM staging system.Conclusions: The novel nomogram models based on LODDS provided satisfying predictive ability of SRC both in OS and CSS than AJCC 8 th edition TNM staging system alone.展开更多
Using the coherent state representation of Wigner operator and the technique of integration within an ordered product (IWOP) of operators, this paper derives the Wigner functions for the photon-depleted even and odd...Using the coherent state representation of Wigner operator and the technique of integration within an ordered product (IWOP) of operators, this paper derives the Wigner functions for the photon-depleted even and odd coherent states (PDEOCSs). Moreover, in terms of the Wigner functions with respect to the complex parameter a the nonclassical properties of the PDEOCSs are discussed. The results show that the nonclassicality for the state |β, m〉o (or |β,m〉e) is more pronounced when m is even (or odd). According to the marginal distributions of the Wigner functions, the physical meaning of the Wigner functions is given. Further, the tomograms of the PDEOCSs are calculated with the aid of newly introduced intermediate coordinate-momentum representation in quantum optics.展开更多
As Lewis proposed his octet rule, itself inspired by Abegg’s rule, that a molecule is stable when all its composing atoms have eight electrons in their valence shell, it perfectly applied to the vast majority of know...As Lewis proposed his octet rule, itself inspired by Abegg’s rule, that a molecule is stable when all its composing atoms have eight electrons in their valence shell, it perfectly applied to the vast majority of known stable molecules. Only a few stable molecules were known that didn’t fall under this rule, such as PCl5 and SF6, and Lewis chose to leave them aside at the time of his research. With further advances in chemistry, more exceptions to this rule of eight have been found, usually with the central atom of the structure having more or less than eight electrons in its valence shell. Theories have been developed in order to modify the octet rule to suit these molecules, defining these as hyper- or hypo-valent molecules and using other configurations for the electrons. The present paper aims to propose a representation rule for gaseous single-bonded molecules that makes it possible to reconcile both;molecules following the octet theory and those which do not. In this representation rule, each element of the molecule is subscripted with two numbers that follow a set of simple criteria. The first represents the number of valence electrons of the element;while the second is calculated by adding the first number to the number of the element’s covalent bonds within the molecule. The latter is equal to eight for organic molecules following the octet rule. Molecules being exceptions to the octet rule are now encompassed by this new even-odd rule: they have a valid chemical structural formula in which the second number is even but not always equal to eight. Both rules—octet and even-odd—are discussed and compared, using several well-known gaseous molecules having one or several single-bonded elements. A future paper will discuss the application of the even-odd rule to charged molecules.展开更多
文摘BACKGROUND Colon cancer(CC)is one of the most common cancers of the digestive tract,the third most common cancer worldwide,and the second most common cause of cancer-related deaths.Previous studies have demonstrated a higher risk of lymph node metastasis(LNM)in young patients with CC.It might be reasonable to treat patients with early-onset locally advanced CC with extended lymph node dissection.However,few studies have focused on early-onset CC(ECC)patients with LNM.At present,the methods of predicting and evaluating the prognosis of ECC patients with LNM are controversial.From the data of patients with CC obtained from the Surveillance,Epidemiology,and End Results(SEER)database,data of young patients with ECC(≤50 years old)was screened.Patients with unknown data were excluded from the study,while the remaining patients were included.The patients were randomly divided into a training group(train)and a testing group(test)in the ratio of 7:3,while building the model.The model was constructed by the training group and verified by the testing group.Using multiple Cox regression models to compare the prediction efficiency of LNM indicators,nomograms were built based on the best model selected for overall survival(OS)and cause-specific survival(CSS).In the two groups,the performance of the nomogram was evaluated by constructing a calibration plot,time-dependent area under the curve(AUC),and decision curve analysis.Finally,the patients were grouped based on the risk score predicted by the prognosis model,and the survival curve was constructed after comparing the survival status of the high and low-risk groups.RESULTS Records of 26922 ECC patients were screened from the SEER database.N classification,positive lymph nodes(PLN),lymph node ratio(LNR)and log odds of PLN(LODDS)were considered to be independent predictors of OS and CSS.In addition,independent risk factors for OS included gender,race,marital status,primary site,histology,grade,T,and M classification,while the independent prognostic factors for CSS included race,marital status,primary site,grade,T,and M classification.The prediction model including LODDS is composed of minimal Akaike information criterion,maximal concordance indexes,and AUCs.Factors including gender,race,marital status,primary site,histology,grade,T,M classification,and LODDS were integrated into the OS nomogram,while race,marital status,primary site,grade,T,M classification,and LODDS were included into the CSS nomogram.The nomogram representing both cohorts had been successfully verified in terms of prediction accuracy and clinical practicability.CONCLUSION LODDS is superior to N-stage,PLN,and LNR of ECC.The nomogram containing LODDS might be helpful in tumor evaluation and clinical decision-making,since it provides an appropriate prediction of ECC.
文摘Fermat’s last theorem, had the statement that there are no natural numbers A, B, and C such that A<sup>n</sup> + B<sup>n</sup> = C<sup>n</sup>, in which n is a natural number greater than 2. We have shown that any product of two odd numbers can generate Fermat or Pythagoras triple (A, B, C) following n = 2 and also it is applicable A<sup>2</sup> + B<sup>2</sup> + C<sup>2</sup> + D<sup>2</sup> + so on =A<sub>n</sub><sup>2 </sup>where all are natural numbers.
文摘Oppositional Defiant Disorder(ODD)and Attention Deficit/Hyperactivity Disorder(ADHD)are mental health conditions that have traditionally been managed through behavioral therapies and medication.However,the integration of Artificial Intelligence(AI)has brought about a revolutionary shift in treatment approaches.This article explores the role of AI-driven noninvasive treatments for ODD and ADHD.AI offers personalized treatment plans,predictive analytics,virtual therapeutic platforms,and continuous monitoring,enhancing the effectiveness and accessibility of interventions.Ethical considerations and the need for a balanced approach are discussed.As technology evolves,collaborative efforts between mental health professionals and technologists will shape the future of mental health care for individuals with ODD and ADHD.
文摘We propose a new generator of continuous distributions with at least four positive parameters called the Kumaraswamy-Odd Rayleigh-G family. Some special cases were presented. The plots of the Kumaraswamy Odd Rayleigh Log-Logistic (</span><i><span style="font-family:Verdana;">KORLL</span></i><span style="font-family:Verdana;">) distribution indicate that the distribution can take many shapes depending on the parameter values. The negative skewness and kurtosis indicates that the distribution has li</span><span style="font-family:Verdana;">ghter tails than the normal distribution. The Monte Carlo simulation results indicate that the estimated biases decrease when the sample size increases. Furthermore, </span></span><span style="font-family:Verdana;">the root mean squared error estimates decay</span><span style="font-family:""><span style="font-family:Verdana;"> towards zero as the sample size increases. This part shows the consistency of the maximum likelihood estimators. From the considered analytical measures, the new </span><i><span style="font-family:Verdana;">KORLL</span></i><span style="font-family:Verdana;"> provides </span></span><span style="font-family:Verdana;">the best fit to the analysed five real data sets indicating that this new model outclasses its competitors.
基金Sponsored by the Scientific Research Fund of Heilongjiang Provincial Education Department (11541109)the Science Foundation of Harbin Normal University (KM2007-11)
文摘The filtration structure of finite-dimensional special odd Hamilton superalgebras over a field of prime characteristic was studied. By determining ad-nilpotent dements in the even part, the natural filtration of special odd Hamiltonian superalgebras is proved to be invariant. Using this result, the special odd Hamilton superalgebras is classified. Finally, the automorphism group of the restricted special odd Hamilton superalgebras is determined.
文摘The optimum design of equivalent accelerated life testing plan based on proportional hazards-proportional odds model using D-optimality is presented. The defined equivalent test plan is the test plan that has the same value of the determinant of Fisher information matrix. The equivalent test plan of step stress accelerated life testing (SSALT) to a baseline optimum constant stress accelerated life testing (CSALT) plan is obtained by adjusting the censoring time of SSALT and solving the optimization problem for each case to achieve the same value of the determinant of Fisher information matrix as in the baseline optimum CSALT plan. Numer- ical examples are given finally which demonstrate the equivalent SSALT plan to the baseline optimum CSALT plan reduces almost half of the test time while achieving approximately the same estimation errors of model parameters.
文摘In this paper, the forced odd order neutral differential equations of the form are considered d n d t n[x(t)-R(t)x(t-τ)]+P(t)x(t-σ)=f(t),t≥t 0.A sufficient condition for the oscillation of all solutions is obtained.
文摘Objective: Our aims were to establish novel nomogram models, which directly targeted patients with signet ring cell carcinoma(SRC), for individualized prediction of overall survival(OS) rate and cancer-specific survival(CSS).Methods: We selected 1,365 SRC patients diagnosed from 2010 to 2015 from Surveillance, Epidemiology and End Results(SEER) database, and then randomly partitioned them into a training cohort and a validation cohort.Independent predicted indicators, which were identified by using univariate testing and multivariate analyses, were used to construct our prognostic nomogram models. Three methods, Harrell concordance index(C-index), receiver operating characteristics(ROC) curve and calibration curve, were used to assess the ability of discrimination and predictive accuracy. Integrated discrimination improvement(IDI), net reclassification improvement(NRI) and decision curve analysis(DCA) were used to assess clinical utility of our nomogram models.Results: Six independent predicted indicators, age, race, log odds of positive lymph nodes(LODDS), T stage, M stage and tumor size, were associated with OS rate. Nevertheless, only five independent predicted indicators were associated with CSS except race. The developed nomograms based on those independent predicted factors showed reliable discrimination. C-index of our nomogram for OS and CSS was 0.760 and 0.763, which were higher than American Joint Committee on Cancer(AJCC) 8 th edition tumor-node-metastasis(TNM) staging system(0.734 and 0.741, respectively). C-index of validation cohort for OS was 0.757 and for CSS was 0.773. The calibration curves also performed good consistency. IDI, NRI and DCA showed the nomograms for both OS and CSS had a comparable clinical utility than the TNM staging system.Conclusions: The novel nomogram models based on LODDS provided satisfying predictive ability of SRC both in OS and CSS than AJCC 8 th edition TNM staging system alone.
基金Project supported by the National Natural Science Foundation of China (Grant No 10574060)the Natural Science Foundation of Shandong Province of China (Grant No Y2004A09)
文摘Using the coherent state representation of Wigner operator and the technique of integration within an ordered product (IWOP) of operators, this paper derives the Wigner functions for the photon-depleted even and odd coherent states (PDEOCSs). Moreover, in terms of the Wigner functions with respect to the complex parameter a the nonclassical properties of the PDEOCSs are discussed. The results show that the nonclassicality for the state |β, m〉o (or |β,m〉e) is more pronounced when m is even (or odd). According to the marginal distributions of the Wigner functions, the physical meaning of the Wigner functions is given. Further, the tomograms of the PDEOCSs are calculated with the aid of newly introduced intermediate coordinate-momentum representation in quantum optics.
文摘As Lewis proposed his octet rule, itself inspired by Abegg’s rule, that a molecule is stable when all its composing atoms have eight electrons in their valence shell, it perfectly applied to the vast majority of known stable molecules. Only a few stable molecules were known that didn’t fall under this rule, such as PCl5 and SF6, and Lewis chose to leave them aside at the time of his research. With further advances in chemistry, more exceptions to this rule of eight have been found, usually with the central atom of the structure having more or less than eight electrons in its valence shell. Theories have been developed in order to modify the octet rule to suit these molecules, defining these as hyper- or hypo-valent molecules and using other configurations for the electrons. The present paper aims to propose a representation rule for gaseous single-bonded molecules that makes it possible to reconcile both;molecules following the octet theory and those which do not. In this representation rule, each element of the molecule is subscripted with two numbers that follow a set of simple criteria. The first represents the number of valence electrons of the element;while the second is calculated by adding the first number to the number of the element’s covalent bonds within the molecule. The latter is equal to eight for organic molecules following the octet rule. Molecules being exceptions to the octet rule are now encompassed by this new even-odd rule: they have a valid chemical structural formula in which the second number is even but not always equal to eight. Both rules—octet and even-odd—are discussed and compared, using several well-known gaseous molecules having one or several single-bonded elements. A future paper will discuss the application of the even-odd rule to charged molecules.