Objective: To determine the incidence of autism among children in Olmsted Coun ty, Minnesota. Design: Through the Rochester Epidemiology Project, all inpatient and outpatient diagnoses are indexed for computerized ret...Objective: To determine the incidence of autism among children in Olmsted Coun ty, Minnesota. Design: Through the Rochester Epidemiology Project, all inpatient and outpatient diagnoses are indexed for computerized retrieval. This computeri zed diagnostic index was used to identify children with any developmental disord er. A glossary of symptoms of autism was used to review medical and school recor ds of these children for symptoms consistent with Diagnostic and Statistical Man ual of Mental Disorders, Fourth Edition (DSM-IV) criteria for autistic disorder . Setting: Olmsted County, Minnesota. Subjects: All residents of Olmsted County 21 years or younger between 1976 and 1997.Main Outcome Measure: The incidence o f research-identified autism based on DSM-IV criteria for autistic Results: Th e age-adjusted incidence of researchidentified autism was 5.5 (95%confidence interval, 1.4-9.5) per 100000 chidren from 1980 to 1983 and 44.9 (95%confid ence interval, 32.9-56.9) from 1995 to 1997 (8.2-fold increase). This incre ase was confined to children younger than 10 years who were born after 1987.Con clusions: The incidence of researchidentified autism increased in Olmsted County from 1976 to 1997, with the increase occurring among young children after the i ntroduction of broader, more precise diagnostic criteria, increased availability of services, and increased awareness of autism. Although it is possible that un identified environmental factors have contributed to an increase in autism, the timing of the increase suggests that it may be due to improved awareness, change s in diagnostic criteria, and availability of services, leading to identificatio n of previously unrecognized young children with autism.展开更多
来自北京大学第一医院皮肤性病科等处的研究人员发表了题为＂Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome＂的文章,首次确定了一种重症角化性皮肤病——Olmsted综合征的致病基因为TRPV3,并通过电生理...来自北京大学第一医院皮肤性病科等处的研究人员发表了题为＂Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome＂的文章,首次确定了一种重症角化性皮肤病——Olmsted综合征的致病基因为TRPV3,并通过电生理学等方法阐明其发病机制,为皮肤角化及瘙痒机制的研究提供了全新的思路。展开更多
Olmsted syndrome is a rare disorder characterized by the combination of periorificial keratotic plaques and bilateral palmoplantar keratoderma. New associated features continue to be reported. Olmsted syndrome in a fe...Olmsted syndrome is a rare disorder characterized by the combination of periorificial keratotic plaques and bilateral palmoplantar keratoderma. New associated features continue to be reported. Olmsted syndrome in a female patient is particularly rare, and we report such a case having a haemangioma in addition to other features of the syndrome.展开更多
The incidence of medically recognized cluster headache within Olmsted County, Minnesota, from 1989 through 1990, was determined by using modified Internationa l Headache Society criteria. The results were compared wit...The incidence of medically recognized cluster headache within Olmsted County, Minnesota, from 1989 through 1990, was determined by using modified Internationa l Headache Society criteria. The results were compared with previously published incidence data from 1979 through 1981. The overall age-and sex-adjusted incid ence decreased from 9.8/100,000 person-years in 1979-1981 to 2.07/100,000 pers on-years in 1989-1990.展开更多
文摘Objective: To determine the incidence of autism among children in Olmsted Coun ty, Minnesota. Design: Through the Rochester Epidemiology Project, all inpatient and outpatient diagnoses are indexed for computerized retrieval. This computeri zed diagnostic index was used to identify children with any developmental disord er. A glossary of symptoms of autism was used to review medical and school recor ds of these children for symptoms consistent with Diagnostic and Statistical Man ual of Mental Disorders, Fourth Edition (DSM-IV) criteria for autistic disorder . Setting: Olmsted County, Minnesota. Subjects: All residents of Olmsted County 21 years or younger between 1976 and 1997.Main Outcome Measure: The incidence o f research-identified autism based on DSM-IV criteria for autistic Results: Th e age-adjusted incidence of researchidentified autism was 5.5 (95%confidence interval, 1.4-9.5) per 100000 chidren from 1980 to 1983 and 44.9 (95%confid ence interval, 32.9-56.9) from 1995 to 1997 (8.2-fold increase). This incre ase was confined to children younger than 10 years who were born after 1987.Con clusions: The incidence of researchidentified autism increased in Olmsted County from 1976 to 1997, with the increase occurring among young children after the i ntroduction of broader, more precise diagnostic criteria, increased availability of services, and increased awareness of autism. Although it is possible that un identified environmental factors have contributed to an increase in autism, the timing of the increase suggests that it may be due to improved awareness, change s in diagnostic criteria, and availability of services, leading to identificatio n of previously unrecognized young children with autism.
文摘来自北京大学第一医院皮肤性病科等处的研究人员发表了题为＂Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome＂的文章,首次确定了一种重症角化性皮肤病——Olmsted综合征的致病基因为TRPV3,并通过电生理学等方法阐明其发病机制,为皮肤角化及瘙痒机制的研究提供了全新的思路。
文摘Olmsted syndrome is a rare disorder characterized by the combination of periorificial keratotic plaques and bilateral palmoplantar keratoderma. New associated features continue to be reported. Olmsted syndrome in a female patient is particularly rare, and we report such a case having a haemangioma in addition to other features of the syndrome.
文摘The incidence of medically recognized cluster headache within Olmsted County, Minnesota, from 1989 through 1990, was determined by using modified Internationa l Headache Society criteria. The results were compared with previously published incidence data from 1979 through 1981. The overall age-and sex-adjusted incid ence decreased from 9.8/100,000 person-years in 1979-1981 to 2.07/100,000 pers on-years in 1989-1990.
