A novel one-time-programmable memory unit based on Schottky-type p-GaN diode

In this work,a novel one-time-programmable memory unit based on a Schottky-type p-GaN diode is proposed.During the programming process,the junction switches from a high-resistance state to a low-resistance state through Schottky junction breakdown,and the state is permanently preserved.The memory unit features a current ratio of more than 10^(3),a read voltage window of 6 V,a programming time of less than 10^(−4)s,a stability of more than 108 read cycles,and a lifetime of far more than 10 years.Besides,the fabrication of the device is fully compatible with commercial Si-based GaN process platforms,which is of great significance for the realization of low-cost read-only memory in all-GaN integration.

Evaluation of the Effectiveness and Safety of One-Time Endodontics in the Treatment of Chronic Apical Periodontitis with Sinus Tract in Pediatric Deciduous Teeth

Objective:To observe the effectiveness and safety of one-time endodontics in the treatment of chronic apical periodontitis with sinus tract in pediatric deciduous teeth.Methods:109 cases of children with chronic apical periodontitis with sinus tract in the deciduous teeth treated in our hospital from January 2022 to December 2023 were selected and grouped by the randomized numerical table method,with 54 cases in the experimental group and 55 cases in the control group.The experimental group was treated with one-time endodontics and the control group was treated with conventional endodontics.Results:After the treatment,the total effective rate of treatment was higher in the experimental group than in the control group(P<0.05);the incidence of adverse events was lower in the experimental group than in the control group(P<0.05);the satisfaction of the children's family members was higher in the experimental group than in the control group(P<0.05);the pain duration was lower in the experimental group than in the control group(P<0.05).Conclusion:In the experimental group,children with chronic apical periodontitis with sinus tract of the deciduous teeth were given one-time endodontic treatment,and the results of its implementation were relatively good.

One-time fertilization at first flowering improves lint yield and dry matter partitioning in late planted short-season cotton

Cotton producers have substantially reduced their inputs(labor,nutrients,and management)mainly by adopting a shortseason cropping management that is characterized by late sowing,high density,and reduced fertilization with one-time application at the first bloom stage without lint yield reduction.However,it has been hypothesized that one-time fertilization at an earlier growth stage could be a more effective and economic management practice.A two-year field experiment was conducted by applying five fertilizer one-time fertilization at 0(FT1),5(FT2),10(FT3),15(FT4),and 20(FT5)days after the first flower appeared in the field and one three-split fertilizer application taken as the conventional control(FT6),making six treatments altogether.Cotton growth period,biomass accumulation,yield,and its formation were quantified.The results showed that the one-time fertilization did not affect the cotton growth progress as compared to FT6,however,the total crop cycles for FT3–FT5 were 3 days shorter.FT1 produced the highest cotton lint yield(1396 kg ha–1),which was similar to the FT6 but higher than the other treatments,and could be attributed to more bolls per unit area and higher lint percentage.Cotton yield was positively correlated with cotton plant biomass accumulated.FT1 had both the highest average(VT)(193.7 kg ha–1 d–1)and the highest maximum(VM)(220.9 kg ha–1 d–1)rates during the fast biomass accumulation period.These results suggest that one-time fertilizer application at the first flower stage might be an adjustment that is more effective than at first bloom,and allowed for easier decision making for application date due to non counting of plants with flowers is needed.

One-time sintering process to modify xLi2MnO3(1-x)LiMO2 hollow architecture and studying their enhanced electrochemical performances

To solve the critical problems of lithium rich cathode materials, e.g., structure instability and short cycle life, we have successfully prepared a ZrO2-coated and Zr-doping xLi2MnO3·(1–x)LiMO2 hollow architecture via one-time sintering process. The modified structural materials as lithium-ion cathodes present good structural stability and superior cycle performance in LIBs. The discharge capacity of the ZrO2-coated and Zr-doped hollow pristine is 220 mAh g-1 at the 20th cycle at 0.2 C(discharge capacity loss, 2.7%)and 150 m Ah g-1 at the 100 th cycle at 1 C(discharge capacity loss, 17.7%), respectively. However, hollow pristine electrode only delivers 203 m Ah g-1 at the 20 th cycle at 0.2 C and 124 mAh g-1 at the 100 th cycle at 1 C, respectively, and the corresponding to capacity retention is 92.2% and 72.8%, respectively.Diffusion coefficients of modified hollow pristine electrode are much higher than that of hollow pristine electrode after 100 cycles(approach to 1.4 times). In addition, we simulate the adsorption reaction of HF on the surface of ZrO2-coated layer by the first-principles theory. The calculations prove that the adsorption energy of HF on the surface of ZrO2-coated layer is about-1.699 e V, and the ZrO2-coated layer could protect the hollow spherical xLi2MnO3·(1–x)LiMO2 from erosion by HF. Our results would be applicable for systematic amelioration of high-performance lithium rich material for anode with the respect of practical application.

Cryptanalysis of the One-Time Proxy Signature Scheme Used in Mobile Agents

We ayptanalyze Kim et. al's one-time proxy signature scheme used in mobileagents, and then a successful forgery is introduced It is showed that a dishonest customer cansuccessfully forge a valid one-time proxy signature by impersonating the stiver Furthermore, he canrequest the server with responsibility for the forged bidding information.

The Mechanisms of CD8+ T Cells Exhaustion in the Tumor Microenvironment and Immune Therapy

In the tumor immune microenvironment, CD8+ T cells differentiate towards functional failure. The exhaustion of CD8+ T cells (Tex) showed varying degrees of effect dysfunction, loss of proliferation ability, and sustained high expression of a variety of inhibitory receptors, with metabolic and epigenetic changes. Tex cells are heterogeneous, including several subsets with different characteristics at different stages of differentiation. Immune checkpoint inhibitors (ICIs) can restore the effect or function of Tex cells, indicating that this T cell subset plays a key role in tumor immunotherapy. The understanding of the mechanism of CD8+ T cell exhaustion will be helpful to the implementation of tumor immunotherapy. This article reviews the production, differentiation and functional characteristics of Tex cells and their relationship with tumor immunotherapy.

Design of 32 kbit one-time programmable memory for microcontroller units

A 32 kbit OTP(one-time programmable)memory for MCUs(micro-controller units)used in remote controllers was designed.This OTP memory is used for program and data storage.It is required to apply 5.5V to BL(bit-line)and 11V to WL(word-line)for a OTP cell of 0.35μm ETOX(EEPROM tunnel oxide)type by MagnaChip.We use 5V transistors on column data paths to reduce the area of column data paths since they require small areas.In addition,we secure device reliability by using HV(high-voltage)transistors in the WL driver.Furthermore,we change from a static logic to a dynamic logic used for the WL driver in the core circuit.Also,we optimize the WD(write data)switch circuit.Thus,we can implement them with a small-area design.In addition,we implement the address predecoder with a small-area logic circuit.The area of the designed 32 kbit OTP with 5V and HV devices is 674.725μm×258.75μm(=0.1745mm2)and is 56.3% smaller than that using 3.3V devices.

Progressive exhaustion:A qualitative study on the experiences of Iranian family caregivers regarding patients undergoing hemodialysis

Objective:The aim of this study was to explore the burden of care for patients undergoing hemodialysis from the experiences of family caregivers.Methods:In this qualitative study,a content analysis approach was used for data collection and analysis.Participants were 16 family caregivers selected through purposive sampling from four medical education centers affiliated with Ahvaz Jundishapur University of Medical Sciences,Iran.Semi-structured interviews were held to collect data.Results:Four categories were developed as follows:‘care challenges’,‘psychological vulnerabilities’,‘the chronic nature of care’and“care in the shade”.The categories led to the development of the main theme of‘progressive exhaustion’experienced by the family caregivers during the provision of care to patients undergoing hemodialysis.Conclusion:Family caregivers have a significant role in the process of patient care,and this role leads them to progressive exhaustion;therefore,the overall health of the caregivers should be taken into account and more attention should be paid to their quality of life,social welfare,and satisfaction level.

One-time Shaping Technological System of Lightweight Roof Greening

Lightweight roof greening is an important way for improving urban ecological environment and has good ecological and social benefits, but the investment is- too-high for the investors. Therefore, it is necessary to improve the system of lightweight roof greening. This study introduced a lightweight roof greening mode with low cost, simple construction, rapid formation, good economic benefit and convenient curing.

The Effects of Job Insecurity, Emotional Exhaustion, and Met Expectations on Hotel Employees’ Pro-Environmental Behaviors: Test of a Serial Mediation Model

There are a plethora of empirical pieces about employees’pro-environmental behaviors.However,the extant literature has either ignored or not fully examined various factors(e.g.,negative or positive non-green workplace factors)that might affect employees’pro-environmental behaviors.Realizing these voids,the present paper proposes and tests a serial mediation model that examines the interrelationships of job insecurity,emotional exhaustion,met expectations,and proactive pro-environmental behavior.We used data gathered from hotel customer-contact employees with a time lag of one week and their direct supervisors in China.After presenting support for the psychometric properties of the measures via confirmatory analysis in LISREL 8.30,the abovementioned linkages were gauged using the PROCESS plug-in for statistical package for social sciences.The findings delineated support for the hypothesized associations.Specifically,emotional exhaustion and met expectations partly mediated the effect of job insecurity on proactive pro-environmental behavior.More importantly,emotional exhaustion and met expectations serially mediated the influence of job insecurity on proactive pro-environmental behavior.These findings have important theoretical implications as well as significant implications for diminishing job insecurity,managing emotional exhaustion,increasing met expectations,and enhancing ecofriendly behaviors.

OBSERVATION ON THERAPEUTIC EFFECTS OF FENGJIU THERAPY IN 300 CASES OF EXHAUSTION SYNDROME

Fengjiu Yi(Model FJY - 1) is a patent medical and health instrument newly developed by the authors. It incorporates the drug action and physiotherapy into an integral whole, exerting comprehensive regulation and it is an effective therapeutic method. In the present paper, 300 cases of exhaustion syndrome were all cured by the instrument after 7 - 17 sessions of treatment.

Effect of Nucleating Agent on the Crystallization of Tailings Glass Ceramics Prepared by One-time Sintering

Glass ceramics was made by the one-time sintering method using the main raw material of iron tailings. On the basis of quaternary system of CaO-MgO-Al2O3-SiO2, using DTA, XRD and SEM, the effects of different nucleating agents and mixing amounts as well as heat treatment on the crystallization of railings glass ceramics were studied. The experimental results show that, nucleating agent and heat treatment are two necessary conditions for one-time sintering preparation of tailings glass ceramics namely, only adding nucleating agent or experiencing heat treatment, the quaternary system can not crystallize. The composite nucleating agent consisting of Cr2O3 and TiO2 can further lead to the crystallization of the CaO-MgO-A1203-SiO2 quaternary system at the lower temperature, with the major phase of diopside. In the range of mass content, 0%-4%, crystal intensity and crystal content grow. But when mass content is more than 4%, the crystal size will become coarser and the crystal distribution will be less regular. Different heat treatment regimes do not change the composition of the crystalline major phase in the glass ceramics crystallization of CaO-MgO-Al2O3-SiO2 system. In the range of 30-60 minutes, with the extension of nucleation and crystallization, crystallization degree enhanced, but if the holding time surpasses 60 minutes, the crystallization is worse.

A Health Impairment Process of Sickness Presenteeism in Norwegian Physicians: The Mediating Role of Exhaustion

Although work factors have been associated with both presenteeism and exhaustion among hospital physicians, we lack knowledge on the dynamic relationship between demands in the work context and presenteeism and how this can be mediated by symptoms of exhaustion when controlling for job resources. The objective of this study is to examine a health impairment process of presenteeism among university hospital physicians. A cross-sectional survey of 545 university hospital physicians in Norway was conducted. Variables included in the model were presenteeism, exhaustion, work-family conflict, role conflict, social support and control over work pace. Findings from structural equation modeling indicated that exhaustion mediates the relationship between job demands and presenteeism. Job resources had no direct effect on presenteeism in the hypothesized model. The variables in the study explained 17% of the variance in presenteeism. The study is one of the first to demonstrate that the relationship between job demands and presenteeism is mediated by exhaustion when controlling for job resources. The results highlight the importance of considering the link between health symptoms and job demands to reduce the negative effects of presenteeism.

Transgene IL-21-Engineered T Cell-Based Vaccine Potently Converts CTL Exhaustion via the Activation of the mTORC1 Pathway in Chronic Infection

CD8+ cytotoxic T lymphocyte (CTL) exhaustion is one of the major obstacles for the effectiveness of virus control in chronic infectious diseases. We previously generated novel ovalbumin (OVA)-specific 41BBL-expressing OVA-TEXO and human immunodeficiency virus (HIV-1) Gag-specific Gag-TEXO vaccines, inducing therapeutic immunity in wild-type C57BL/6 (B6) mice, and converting CTL exhaustion in recombinant OVA-specific adenovirus AdVOVA-infected B6 (AdVOVA-B6) mice with chronic infection. IL-21 cytokine plays an important role in controlling chronic infections. Therefore, in this study, we constructed recombinant transgene IL-21-expressing AdVIL-21, and generated IL-21-expressing OVA-TEXO/IL-21 and Gag-TEXO/IL21 vaccines, or control vaccines (OVA-TEXO/Null and Gag-TEXO/Null) by infecting OVA-TEXO and Gag-TEXO cells with AdVIL-21 or the control AdVNull, lacking transgene, and assessed their effects in B6 or AdVOVA-B6 mice. We demonstrate that both OVA-TEXO/IL-21 and control OVA-TEXO/Null vaccines are capable of converting CTL exhaustion in chronic infection. However, the OVA-TEXO/IL-21 vaccine more efficiently rescues exhausted CTLs by increasing stronger CTL proliferation and effector cytokine IFN-γ expression than the control OVA-TEXO/Null vaccine in AdVOVA-B6 mice with chronic infection, though both vaccines stimulated comparable OVA-specific CTL responses and protective immunity against OVA-expressing BL6-10OVA melanoma lung metastasis in wild-type B6 mice. In vivo, the OVA-TEXO/IL-21-stimulated CTLs more efficiently up-regulate phosphorylation of mTORC1-controlled EIF4E and expression of mTORC1- regulated T-bet molecule than the control OVA-TEXO/Null-stimulated ones. Importantly, the Gag-TEXO/IL21 vaccine induces stronger Gag-specific therapeutic immunity against established Gag-expressing BL6-10Gag melanoma lung metastases than the control Gag-TEXO/Null vaccine in chronic infection. Therefore, this study should have a strong impact on developing new therapeutic vaccines for patients with chronic infections.

A One-Time Pad Encryption Scheme Based on Efficient Physical-Layer Secret Key Generation for Intelligent IoT System

The one-time pad(OTP)is an applicationlayer encryption technique to achieve the informationtheoretic security,and the physical-layer secret key generation(SKG)technique is a promising candidate to provide the random keys for OTP.In this paper,we propose a joint SKG and OTP encryption scheme with the aid of a reconfigurable intelligent surface(RIS)to boost secret key rate.To maximize the efficiency of secure communication,we divide the process of secure transmission into two stages:SKG and then encrypted packet transmission.Meanwhile,we design an optimal algorithm for allocating time slots for SKG to maximize SKG efficiency without security risk.Furthermore,we design a key updating protocol based on our SKG scheme for OTP encryption.Simulation results verify that our scheme can generate keys securely and efficiently,and significantly improve the secure communication performance in an intelligent IoT system.

An Evaluation Study of a Nature Based Rehabilitation in Sweden for Patients with Exhaustion Disorder

The aim of this study was to evaluate a Nature Based Rehabilitation (NBR) for a group of patients with Exhaustion Disorder (ED) in the southwest Sweden. A multidisciplinary team consisting of an occupational therapist, a physiotherapist, a medical doctor practising symbolic drama and a nurse with gardening experience provided NBR in an agricultural environment. Patients were offered 14 weeks of rehabilitation in a group of eight persons, three mornings per week. Seventeen patients participated in the study and 15 completed the study. A semi-structured interview was conducted at the beginning of the rehabilitation and at the end and a follow-up interview by telephone was done one year after completion of the rehabilitation. The interviews were recorded and transcribed. Assessment scales used included: Stress and Crisis Inventory (SCI-93), Coping Resources Inventory (CRI) and Visual Analogue Scale (VAS). Weekly notes from the staff members were reviewed and compared with the patient’s own experience. The interviews and the staff notes were analysed with semantic thematic analysis. Result showed that this kind of NBR with a multidisciplinary team promotes improved health and improved quality of life for patients with ED and may thus constitute a good alternative to treatment, provided the ED has not become chronic.

Design of Manure Gas Exhaustion to Reduce Ammonia Concentrations in Loose-Housing Systems for Laying Hens

Uniformity of air flow in extraction openings in exhaust air channels for manure gas exhaustion is determined by the distribution of pressure. The areas required in extraction vents and in extraction ducts are determined by the uniformity of air flow desired along the duct and by the loss of pressure that can be accepted. The area ratio between the vents and the cross section of the exhaust air duct will have a strong influence on both uniformity of flow and loss of pressure. The following ventilation properties were studied： Uniformity of air flow; Variations in static pressure along a duct; Air velocity at different distances from the vents. The area ratio should be about 1 for uniform exhaustion. The studies showed that the relative variation in air velocity is independent of the level of the ventilation rate. The uniformity of the exhaust distance is influenced in about the same way by the area ratio as the air velocity in the exhaust vents. Thus, it is important that the area ratio is not too high if a good exhaust function should be guaranteed. The studies also demonstrated that the uniformity of the exhaust distance is independent of the ventilation flow rate. The exhaust ventilation range is, maximally 0.3 m from the vents. The static friction coefficient was on average 0.80.

System analysis based on the T cell exhaustion‑related genes identifies CD38 as a novel therapy target for ovarian cancer

Ovarian cancer(OV)is highly heterogeneous tumor with a very poor prognosis.Studies increasingly show that T cell exhaustion is prognostically relevant in OV.The aim of this study was to dissect the heterogeneity of T cell subclusters in OV through single cell transcriptomic analysis.The single RNA-sequencing(scRNA-seq)data of five OV patients were analyzed,and six major cell clusters were identified after threshold screening.Further clustering of T cell-associated clusters revealed four subtypes.Pathways related to oxidative phosphorylation,G2M checkpoint,JAK-STAT and MAPK signaling were significantly activated,while the p53 pathway was inhibited in the CD8+exhausted T cells.The standard marker genes of CD8+T cell exhaustion were screened to develop a T-cell related gene score(TRS)based on random forest plots in TCGA cohort.The patients with low TRS have better prognosis compared to the patients with high TRS in both TCGA and GEO.In addition,most genes included in the TRS showed significant differences in expression levels between the high-and low-risk groups.Immune cell infiltration was analyzed using the MCPcounter and xCell algorithms,which revealed significant differences between the two risk groups,indicating that the different prognoses may stem from the respective immune landscapes.In addition,CD38 knockdown in OV cell lines increased apoptosis and inhibited invasion in vitro.Finally,we performed a drug sensitivity analysis and identified six potential drug candidates for OV.To summarize,we identified the heterogeneity and clinical significance of T cell exhaustion in OV and built a superior prognostic model based on T cell exhaustion genes,which can contribute to the development of more precise and effective therapies.

C12-3.43/0.981 Type 12MW Exhaustion and Condensing Stean Turbine

TheQingdaoJienengPowerGroupCompanyinShandongmanufactUreseightseriesofsteamtIJrbinesin140varieties,witheachturbinebelow25MaTheC12-3.43/0.98type12MWexhaustionandcondensingsteamturbinehasthefollowingfeatures:12mW:ipa,435C,0.981Mpa,andh/h,whichcanbeusedi...

Revolutionizing tumor immunotherapy:unleashing the power of progenitor exhausted T cells

In exploring persistent infections and malignancies, a distinctive subgroup of CD8^(+) T cells, progenitor exhausted CD8^(+) T(Tpex) cells, has been identified. These Tpex cells are notable for their remarkable self-renewal and rapid proliferation abilities. Recent strides in immunotherapy have demonstrated that Tpex cells expand and differentiate into responsive exhausted CD8^(+) T cells, thus underscoring their critical role in the immunotherapeutic retort. Clinical examinations have further clarified a robust positive correlation between the proportional abundance of Tpex cells and enhanced clinical prognosis. Tpex cells have found noteworthy applications in the formulation of inventive immunotherapeutic approaches against tumors. This review describes the functions of Tpex cells in the tumor milieu, particularly their potential utility in tumor immunotherapy. Precisely directing Tpex cells may be essential to achieving successful outcomes in immunotherapy against tumors.