This study tested a novel method designed to provide useful information for medical diagnosis and treatment. We measured electroencephalography (EEG) during a test of eye opening and closing, a common test in routine ...This study tested a novel method designed to provide useful information for medical diagnosis and treatment. We measured electroencephalography (EEG) during a test of eye opening and closing, a common test in routine EEG examination. This test is mainly used for measuring the degree of alpha blocking and sensitivity during eyes opening and closing. However, because these factors depend on the subject’s awareness, drowsiness can interfere with accurate diagnosis. We sought to determine the optimal EEG frequency band and optimal brain region for distinguishing healthy individuals from patients suffering from several neurophysiological diseases (including dementia, cerebrovascular disorder, schizophrenia, alcoholism, and epilepsy) while fully awake, and while in an early drowsy state. We tested four groups of subjects (awake healthy subjects, drowsy healthy subjects, awake patients and drowsy patients). The complexity of EEG band frequencies over five lobes in the human brain was analyzed using wavelet-based approximate entropy (ApEn). Two-way analysis of variance tested the effects of the two factors of interest (subjects’ health state, and subjects’ wakefulness state) on five different lobes of the brain during eyes opening and closing. The complexity of the theta and delta bands over frontal and central regions, respectively, was significantly greater in the healthy state during eyes opening. In contrast, patients exhibited increased complexity of gamma band activity over the temporal region only, during eyes-close. The early drowsy state and wakefulness state increased the complexity of theta band activity over the temporal region only during eyes-close and eyes-open states respectively, and this change was significantly greater in control subjects compared with patients. We propose that this method may be useful in routine EEG examination, to aid medical doctors and clinicians in distinguishing healthy individuals from patients, regardless of whether the subject is fully awake or in the early stages of drowsiness.展开更多
In 1979, the Changchun Jingyuetan Remote Sensing Study and Test Site (RSSTS)began its work, and it was formally established in 1985. The RSSTS is subordinated the Changchun Branch of Chinese Academy of Sciences and is...In 1979, the Changchun Jingyuetan Remote Sensing Study and Test Site (RSSTS)began its work, and it was formally established in 1985. The RSSTS is subordinated the Changchun Branch of Chinese Academy of Sciences and is supported by the Changchun Institute of Geography and Changchun Institute of Optics and Fine Machnics, Chinese Academy of Sciences. It is under the management of the Resource & Environment Bureau of Chinese Academy of Sciences and it is the study base of remote sensing basis and application tests in China. The RSSTS is situated in the Jingyuetan scenic spot of the suburbs of Changchun City, Jilin Province. It is located at 43°40′—43°50′N and 125°18′-125°18′E.展开更多
On 14 September, China released a cosmetic testing method standardizing new requirements to test for anti -infective agents in cosmetic products. The draft is for public consultation until 28 Sep, 2018.“Testing Metho...On 14 September, China released a cosmetic testing method standardizing new requirements to test for anti -infective agents in cosmetic products. The draft is for public consultation until 28 Sep, 2018.“Testing Method of Anti-infective Agents in Cosmetics” is used to screen for the presence of 36 kinds of antiinfective agents in cosmetic product types such as liquid water-based, cream, lotion, etc. and determine the quality and quantity by High Performance Liquid Chromatography- Tandem Mass Spectrometry (HPLC-MS/MS).展开更多
Open Meta-Analysis软件是用于二分类数据、连续型数据以及诊断数据Meta分析的开放软件,该软件提供了四种模型来执行诊断准确性试验的Meta分析,即诊断随机效应模型、倒方差混合效应模型、双变量模型和分层综合受试者工作特征曲线法,其...Open Meta-Analysis软件是用于二分类数据、连续型数据以及诊断数据Meta分析的开放软件,该软件提供了四种模型来执行诊断准确性试验的Meta分析,即诊断随机效应模型、倒方差混合效应模型、双变量模型和分层综合受试者工作特征曲线法,其中前两者为单变量模型,只能执行单个指标合并,而后两者为双变量模型,能够对灵敏度和特异度之间的负相关性进行综合分析。本文以实例就Open Meta-Analysis软件实现诊断准确性试验Meta分析做相关简述。展开更多
The management of overburden is an important task in open pit exploitations. Site topography and morphology as well as geological and geotechnical properties of natural and remoulded materials are the most important f...The management of overburden is an important task in open pit exploitations. Site topography and morphology as well as geological and geotechnical properties of natural and remoulded materials are the most important factors affecting the disposal phase. Economic and environmental requirements must be followed in order to achieve the best reclamation results, keeping into account site constraints such as slope stability, hauling and dumping issues, and interactions with groundwater. This paper deals with the above mentioned issues, illustrating a rational approach applied on the case of a large limestone quarry where the thickness of the overburden is relevant and the spoil material has to be dumped in a flooded pit. The proposed multidisciplinary approach led to the selection of most suitable methods for excavation, transportation and disposal. The selection was based on a detailed laboratory and site characterisation that defined favorable and adverse factors to be considered during the preliminary study of a large quarrying project.展开更多
Fine and coarse aggregates play an important role in the fracture of concrete. However, quantitative information available on the effect of the coarse aggregate size on the fracture properties of concrete is still lim...Fine and coarse aggregates play an important role in the fracture of concrete. However, quantitative information available on the effect of the coarse aggregate size on the fracture properties of concrete is still limited. In the present paper, the effect of coarse aggregate size （single grade of 5～10, 10～16, 16～20 and 20～25 mm） on stress-crack opening （σ-w） relation in normal and high strength concretes （compressive strength of 40 and 80 MPa, respectively） was studied. The investigation was based on three-point bending tests implemented by fictitious crack analysis. The result shows that coarse aggregate size and cement matrix strength significantly influence the shape of σ-w curve. For a given total aggregate content, in normal strength concrete, smaller size of aggregate leads to a high tensile strength and a sharp stress drop after the peak stress. The smaller the coarse aggregate, the steeper the σ-w curve. By contrast, in high strength concrete, the effect of aggregate size on σ-w relation almost vanishes. A similar σ-w relation is obtained for the concrete except for the case of 20～25 mm coarse aggregate size. The stress drop after the peak stress is more significant for high strength concrete than that for normal strength concrete. Meanwhile, the smaller the coarse aggregate size, the higher the flexural strength. Fracture energy and characteristic length increase with increasing coarse aggregate size in both normal and high strength concretes.展开更多
The equations governing wind-induced internal pressure responses for a two-compartment building with a dominant opening and background porosity were derived.The unsteady form of the Bernoulli equation,the law of mass ...The equations governing wind-induced internal pressure responses for a two-compartment building with a dominant opening and background porosity were derived.The unsteady form of the Bernoulli equation,the law of mass conservation,and adiabatic equation were used for the derivation.The precision of the governing equations was verified by a wind tunnel test on a rigid model of a low-rise building.The results show that the governing equations can effectively analyze the wind-induced internal pressure responses.The internal pressure responses in both compartments are suppressed due to the additional damping provided by background porosity.The responses of internal pressure in both compartments,especially in the compartment without an external opening,decrease with increased lumped leakage area.展开更多
Background:The chronic unpredictable mild stress(CUMS)model has long been considered the best model for exploring the pathophysiological mechanisms underlying depression.However,there are no widely recognised standard...Background:The chronic unpredictable mild stress(CUMS)model has long been considered the best model for exploring the pathophysiological mechanisms underlying depression.However,there are no widely recognised standards for strategies for modeling and for behavioral testing.The present study aimed to optimize the protocols for food deprivation and the sucrose preference test(SPT)for the CUMS model.Methods:We first evaluated the effects of different long periods of food deprivation on the body weight of Sprague Dawley(SD)rats by testing food deprivation for 24 hours(8:00-8:00^+),food deprivation for 12 hours during the daytime(8:00-20:00)and food deprivation for 12 hours at night(20:00-8:00^+).Next,we established a SD rat CUMS model with 15 different stimulations,and used body weight measurement,SPT,forced swim test(FST),open field test(OFT)and Morris water maze(MWM)test to verify the success of the modeling.In the SPT,consumption of sucrose and pure water within 1 and 12 hours was measured.Results:Twelve hours of food deprivation during the daytime(8:00-20:00)had no effect on body weight,while 12 hours of food deprivation at night(20:00-8:00^+)and 24 hours of food deprivation(8:00-8:00^+)significantly reduced the mean body weight of the SD rats.When SPT was used to verify the successful establishment of the CUMS rat model,sucrose consumption measured within 12 hours was less variable than that measured within 1 hour.Conclusions:Twelve hours of food deprivation in the daytime(8:00-20:00)may be considered a mild stimulus for the establishment of a CUMS rat model.Measuring sucrose consumption over 12 hours is recommended for SPT.展开更多
A frequency domain method for estimating wind-induced fluctuating internal pressure of structure with single windward opening is presented in this paper and wind tunnel tests were carried out to verify the theory. The...A frequency domain method for estimating wind-induced fluctuating internal pressure of structure with single windward opening is presented in this paper and wind tunnel tests were carried out to verify the theory. The nonlinear differential equation of internal pressure dynamics and iteration algorithm were applied to calculate fluctuating internal pressure and time domain analysis was used to verify the accuracy of the proposed method. A simplified estimation method is also provided and its scope of application is clarified. The mechanism of internal pressure fluctuation is obtained by using the proposed method in the frequency domain and a new equivalent opening ratio is defined to evaluate internal pressure fluctuation. A series of low-rise building models with various openings and internal volumes were designed for wind tunnel tests with results agreeing well with analytical results. It is shown that the proposed frequency domain method based on Gaussian distribution of internal pressure fluctuations can be applied to predict the RMS internal pressure coefficient with adequate accuracy for any opening dimensions, while the simplified method can only be used for structure with single dominant opening. Helmholtz resonance is likely to occur when the equivalent opening ratio is adequately high, and controlling individual opening dimension is an effective strategy for avoiding Helmholtz resonance in engineering.展开更多
Rockburst,earthquake and blasting cause some dynamic loads on rock support and rock reinforcement system.Elements of rock support and rock reinforcement are generally made of steel bar or cables,which are resistant ag...Rockburst,earthquake and blasting cause some dynamic loads on rock support and rock reinforcement system.Elements of rock support and rock reinforcement are generally made of steel bar or cables,which are resistant against corrosion.These support elements may be subjected to vibrations induced by turbines,vehicle traffic and long-term corrosion in addition to dynamic loading caused by earthquake,rockburst and blasting.In this study,some theoretical,numerical and experimental studies are conducted on rockbolts and rock anchors under shaking and impulsive loading.Then the outcomes of these studies are presented and their practical implications are discussed accordingly.展开更多
文摘This study tested a novel method designed to provide useful information for medical diagnosis and treatment. We measured electroencephalography (EEG) during a test of eye opening and closing, a common test in routine EEG examination. This test is mainly used for measuring the degree of alpha blocking and sensitivity during eyes opening and closing. However, because these factors depend on the subject’s awareness, drowsiness can interfere with accurate diagnosis. We sought to determine the optimal EEG frequency band and optimal brain region for distinguishing healthy individuals from patients suffering from several neurophysiological diseases (including dementia, cerebrovascular disorder, schizophrenia, alcoholism, and epilepsy) while fully awake, and while in an early drowsy state. We tested four groups of subjects (awake healthy subjects, drowsy healthy subjects, awake patients and drowsy patients). The complexity of EEG band frequencies over five lobes in the human brain was analyzed using wavelet-based approximate entropy (ApEn). Two-way analysis of variance tested the effects of the two factors of interest (subjects’ health state, and subjects’ wakefulness state) on five different lobes of the brain during eyes opening and closing. The complexity of the theta and delta bands over frontal and central regions, respectively, was significantly greater in the healthy state during eyes opening. In contrast, patients exhibited increased complexity of gamma band activity over the temporal region only, during eyes-close. The early drowsy state and wakefulness state increased the complexity of theta band activity over the temporal region only during eyes-close and eyes-open states respectively, and this change was significantly greater in control subjects compared with patients. We propose that this method may be useful in routine EEG examination, to aid medical doctors and clinicians in distinguishing healthy individuals from patients, regardless of whether the subject is fully awake or in the early stages of drowsiness.
文摘In 1979, the Changchun Jingyuetan Remote Sensing Study and Test Site (RSSTS)began its work, and it was formally established in 1985. The RSSTS is subordinated the Changchun Branch of Chinese Academy of Sciences and is supported by the Changchun Institute of Geography and Changchun Institute of Optics and Fine Machnics, Chinese Academy of Sciences. It is under the management of the Resource & Environment Bureau of Chinese Academy of Sciences and it is the study base of remote sensing basis and application tests in China. The RSSTS is situated in the Jingyuetan scenic spot of the suburbs of Changchun City, Jilin Province. It is located at 43°40′—43°50′N and 125°18′-125°18′E.
文摘On 14 September, China released a cosmetic testing method standardizing new requirements to test for anti -infective agents in cosmetic products. The draft is for public consultation until 28 Sep, 2018.“Testing Method of Anti-infective Agents in Cosmetics” is used to screen for the presence of 36 kinds of antiinfective agents in cosmetic product types such as liquid water-based, cream, lotion, etc. and determine the quality and quantity by High Performance Liquid Chromatography- Tandem Mass Spectrometry (HPLC-MS/MS).
文摘The management of overburden is an important task in open pit exploitations. Site topography and morphology as well as geological and geotechnical properties of natural and remoulded materials are the most important factors affecting the disposal phase. Economic and environmental requirements must be followed in order to achieve the best reclamation results, keeping into account site constraints such as slope stability, hauling and dumping issues, and interactions with groundwater. This paper deals with the above mentioned issues, illustrating a rational approach applied on the case of a large limestone quarry where the thickness of the overburden is relevant and the spoil material has to be dumped in a flooded pit. The proposed multidisciplinary approach led to the selection of most suitable methods for excavation, transportation and disposal. The selection was based on a detailed laboratory and site characterisation that defined favorable and adverse factors to be considered during the preliminary study of a large quarrying project.
文摘Fine and coarse aggregates play an important role in the fracture of concrete. However, quantitative information available on the effect of the coarse aggregate size on the fracture properties of concrete is still limited. In the present paper, the effect of coarse aggregate size （single grade of 5～10, 10～16, 16～20 and 20～25 mm） on stress-crack opening （σ-w） relation in normal and high strength concretes （compressive strength of 40 and 80 MPa, respectively） was studied. The investigation was based on three-point bending tests implemented by fictitious crack analysis. The result shows that coarse aggregate size and cement matrix strength significantly influence the shape of σ-w curve. For a given total aggregate content, in normal strength concrete, smaller size of aggregate leads to a high tensile strength and a sharp stress drop after the peak stress. The smaller the coarse aggregate, the steeper the σ-w curve. By contrast, in high strength concrete, the effect of aggregate size on σ-w relation almost vanishes. A similar σ-w relation is obtained for the concrete except for the case of 20～25 mm coarse aggregate size. The stress drop after the peak stress is more significant for high strength concrete than that for normal strength concrete. Meanwhile, the smaller the coarse aggregate size, the higher the flexural strength. Fracture energy and characteristic length increase with increasing coarse aggregate size in both normal and high strength concretes.
基金Project(90715040) supported by the Major Research Program of the National Natural Science Foundation of ChinaProject(50878159) supported by the General Program of the National Natural Science Foundation of China
文摘The equations governing wind-induced internal pressure responses for a two-compartment building with a dominant opening and background porosity were derived.The unsteady form of the Bernoulli equation,the law of mass conservation,and adiabatic equation were used for the derivation.The precision of the governing equations was verified by a wind tunnel test on a rigid model of a low-rise building.The results show that the governing equations can effectively analyze the wind-induced internal pressure responses.The internal pressure responses in both compartments are suppressed due to the additional damping provided by background porosity.The responses of internal pressure in both compartments,especially in the compartment without an external opening,decrease with increased lumped leakage area.
基金This work was supported by Social livelihood projects of Chongqing Science and Technology Bureau(cstc2017shms-zdyfX0048,csts2017shmsA00007).
文摘Background:The chronic unpredictable mild stress(CUMS)model has long been considered the best model for exploring the pathophysiological mechanisms underlying depression.However,there are no widely recognised standards for strategies for modeling and for behavioral testing.The present study aimed to optimize the protocols for food deprivation and the sucrose preference test(SPT)for the CUMS model.Methods:We first evaluated the effects of different long periods of food deprivation on the body weight of Sprague Dawley(SD)rats by testing food deprivation for 24 hours(8:00-8:00^+),food deprivation for 12 hours during the daytime(8:00-20:00)and food deprivation for 12 hours at night(20:00-8:00^+).Next,we established a SD rat CUMS model with 15 different stimulations,and used body weight measurement,SPT,forced swim test(FST),open field test(OFT)and Morris water maze(MWM)test to verify the success of the modeling.In the SPT,consumption of sucrose and pure water within 1 and 12 hours was measured.Results:Twelve hours of food deprivation during the daytime(8:00-20:00)had no effect on body weight,while 12 hours of food deprivation at night(20:00-8:00^+)and 24 hours of food deprivation(8:00-8:00^+)significantly reduced the mean body weight of the SD rats.When SPT was used to verify the successful establishment of the CUMS rat model,sucrose consumption measured within 12 hours was less variable than that measured within 1 hour.Conclusions:Twelve hours of food deprivation in the daytime(8:00-20:00)may be considered a mild stimulus for the establishment of a CUMS rat model.Measuring sucrose consumption over 12 hours is recommended for SPT.
基金Project (No. 50378085) supported by the National Natural ScienceFoundation of China
文摘A frequency domain method for estimating wind-induced fluctuating internal pressure of structure with single windward opening is presented in this paper and wind tunnel tests were carried out to verify the theory. The nonlinear differential equation of internal pressure dynamics and iteration algorithm were applied to calculate fluctuating internal pressure and time domain analysis was used to verify the accuracy of the proposed method. A simplified estimation method is also provided and its scope of application is clarified. The mechanism of internal pressure fluctuation is obtained by using the proposed method in the frequency domain and a new equivalent opening ratio is defined to evaluate internal pressure fluctuation. A series of low-rise building models with various openings and internal volumes were designed for wind tunnel tests with results agreeing well with analytical results. It is shown that the proposed frequency domain method based on Gaussian distribution of internal pressure fluctuations can be applied to predict the RMS internal pressure coefficient with adequate accuracy for any opening dimensions, while the simplified method can only be used for structure with single dominant opening. Helmholtz resonance is likely to occur when the equivalent opening ratio is adequately high, and controlling individual opening dimension is an effective strategy for avoiding Helmholtz resonance in engineering.
文摘Rockburst,earthquake and blasting cause some dynamic loads on rock support and rock reinforcement system.Elements of rock support and rock reinforcement are generally made of steel bar or cables,which are resistant against corrosion.These support elements may be subjected to vibrations induced by turbines,vehicle traffic and long-term corrosion in addition to dynamic loading caused by earthquake,rockburst and blasting.In this study,some theoretical,numerical and experimental studies are conducted on rockbolts and rock anchors under shaking and impulsive loading.Then the outcomes of these studies are presented and their practical implications are discussed accordingly.
