Oral submucosal fibrosis(OSF)is a chronic,progressive and insidious oral mucosal disease.Its development is highly associated with areca chewing and eventually evolves into oral squamous cell carcinoma(OSCC),which is ...Oral submucosal fibrosis(OSF)is a chronic,progressive and insidious oral mucosal disease.Its development is highly associated with areca chewing and eventually evolves into oral squamous cell carcinoma(OSCC),which is currently recognized as a precancerous state by the International Center for Research on Cancer(IARC).Due to the extremely complex carcinogenesis process of OSF,the carcinogenesis mechanism is not clear,and most scholars believe that the disease is the result of multiple factors.Therefore,this paper mainly summarized the latest research on the molecular mechanism of OSF canceration,aiming at understanding the law of OSF canceration and providing theoretical reference for early detection,diagnosis and treatment of OSF canceration.展开更多
口腔黏膜下纤维性变(oral submucous fibrosis,OSF)是世界卫生组织(World Health Organization,WHO)国际癌症研究中心(International Agency for Research on Cancer,IARC)认定的口腔黏膜潜在的恶性病变。咀嚼槟榔可引起口腔黏膜下纤维...口腔黏膜下纤维性变(oral submucous fibrosis,OSF)是世界卫生组织(World Health Organization,WHO)国际癌症研究中心(International Agency for Research on Cancer,IARC)认定的口腔黏膜潜在的恶性病变。咀嚼槟榔可引起口腔黏膜下纤维性变,其发病与咀嚼槟榔的频率及时间有着密切的量效依赖关系。本文就口腔黏膜下纤维性变是否是一种口腔癌前病变,咀嚼槟榔导致口腔黏膜潜在的恶性病变,以及国外、中国大陆与台湾地区有关该病的研究作一概述,供口腔科医师参考。展开更多
基金National Natural Science Foundation of China(No.81960199)Major Science and Technology Plan and Key R&D Plan Project of Hainan Province(No.ZDYF2021SHFZ114)Hainan Provincial Department of Health Project(No.22A200001)。
文摘Oral submucosal fibrosis(OSF)is a chronic,progressive and insidious oral mucosal disease.Its development is highly associated with areca chewing and eventually evolves into oral squamous cell carcinoma(OSCC),which is currently recognized as a precancerous state by the International Center for Research on Cancer(IARC).Due to the extremely complex carcinogenesis process of OSF,the carcinogenesis mechanism is not clear,and most scholars believe that the disease is the result of multiple factors.Therefore,this paper mainly summarized the latest research on the molecular mechanism of OSF canceration,aiming at understanding the law of OSF canceration and providing theoretical reference for early detection,diagnosis and treatment of OSF canceration.
文摘口腔黏膜下纤维性变(oral submucous fibrosis,OSF)是世界卫生组织(World Health Organization,WHO)国际癌症研究中心(International Agency for Research on Cancer,IARC)认定的口腔黏膜潜在的恶性病变。咀嚼槟榔可引起口腔黏膜下纤维性变,其发病与咀嚼槟榔的频率及时间有着密切的量效依赖关系。本文就口腔黏膜下纤维性变是否是一种口腔癌前病变,咀嚼槟榔导致口腔黏膜潜在的恶性病变,以及国外、中国大陆与台湾地区有关该病的研究作一概述,供口腔科医师参考。
