Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular matrix is excessively deposited.Fibrosis can lead to vital organ failure and there are no effective treatments yet.Although epit...Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular matrix is excessively deposited.Fibrosis can lead to vital organ failure and there are no effective treatments yet.Although epithelial-mesenchymal transition(EMT)may be one of the key cellular mechanisms,the underlying mechanisms of fibrosis remain largely unknown.EMT is a cell phenotypic process in which epithelial cells lose their cell-to-cell adhesion and polarization,after which they acquire mesenchymal features such as infiltration and migration ability.Upon injurious stimulation in different organs,EMT can be triggered by multiple signaling pathways and is also regulated by epigenetic mechanisms.This narrative review summarizes the current understanding of the underlying mechanisms of EMT in fibrogenesis and discusses potential strategies for attenuating EMT to prevent and/or inhibit fibrosis.Despite better understanding the role of EMT in fibrosis development,targeting EMT and beyond in developing therapeutics to tackle fibrosis is challenging but likely feasible.展开更多
Fibrosis is the remodeling and repair processes of chronic injuries. There are few effective therapies. Chinese medicine formula, the main pattern of traditional Chinese medicine(TCM) in clinic, applies a multi-compon...Fibrosis is the remodeling and repair processes of chronic injuries. There are few effective therapies. Chinese medicine formula, the main pattern of traditional Chinese medicine(TCM) in clinic, applies a multi-component, multi-target and complicated approach in the treatment of diseases, and certainly shows good comprehensive therapeutic effects on fibrosis. In this review, the clinical study, effects and mechanism of action of Fuzheng Huayu recipe in the treatment of liver, pulmonary, and renal fibrosis was analyzed and evaluated. Meanwhile, based on the understanding of TCM pathogenesis for liver cirrhosis, this review will also briefly introduce the research of different classical Chinese medicine formulae with various functions in the treatment of experimental liver fibrosis induced by different methods, including comparing the efficacy, analyzing the action characteristics and mechanism of effective formulae, exploring pathological and biological basis of TCM diagnostic and therapeutic pattern, which will contribute to the research of TCM in the treatment of organ fibrosis.展开更多
基金supported by the BOC chair grant,the Westminster Medical School Research Trust and BJA/RCoA project grant.
文摘Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular matrix is excessively deposited.Fibrosis can lead to vital organ failure and there are no effective treatments yet.Although epithelial-mesenchymal transition(EMT)may be one of the key cellular mechanisms,the underlying mechanisms of fibrosis remain largely unknown.EMT is a cell phenotypic process in which epithelial cells lose their cell-to-cell adhesion and polarization,after which they acquire mesenchymal features such as infiltration and migration ability.Upon injurious stimulation in different organs,EMT can be triggered by multiple signaling pathways and is also regulated by epigenetic mechanisms.This narrative review summarizes the current understanding of the underlying mechanisms of EMT in fibrogenesis and discusses potential strategies for attenuating EMT to prevent and/or inhibit fibrosis.Despite better understanding the role of EMT in fibrosis development,targeting EMT and beyond in developing therapeutics to tackle fibrosis is challenging but likely feasible.
基金supported by National Natural Science Foundation of China (81573873, 81273728, 8153000502, 81270053, 81573810)China Postdoctoral Science Foundation (2015T80445)+1 种基金Natural Science Foundation of Shanghai, China (14ZR1441400)E-institutes of Shanghai Municipal Education Commission, China (E03008)
文摘Fibrosis is the remodeling and repair processes of chronic injuries. There are few effective therapies. Chinese medicine formula, the main pattern of traditional Chinese medicine(TCM) in clinic, applies a multi-component, multi-target and complicated approach in the treatment of diseases, and certainly shows good comprehensive therapeutic effects on fibrosis. In this review, the clinical study, effects and mechanism of action of Fuzheng Huayu recipe in the treatment of liver, pulmonary, and renal fibrosis was analyzed and evaluated. Meanwhile, based on the understanding of TCM pathogenesis for liver cirrhosis, this review will also briefly introduce the research of different classical Chinese medicine formulae with various functions in the treatment of experimental liver fibrosis induced by different methods, including comparing the efficacy, analyzing the action characteristics and mechanism of effective formulae, exploring pathological and biological basis of TCM diagnostic and therapeutic pattern, which will contribute to the research of TCM in the treatment of organ fibrosis.
