It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment.Herein,the free radical genera-tor MNPs-mCPBA was ...It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment.Herein,the free radical genera-tor MNPs-mCPBA was constructed with Zn_(0.4)Co_(0.6)F_(e2)O_(4)@Zn_(0.4)Mn_(0.6)Fe_(2)O_(4)nanoparticles(MNPs)and 3-chloroperbenzoic acid(mCPBA).We believe that the iron(Ⅱ)on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals(C_(6)H_(4)ClCOOO)in an acidic tumor microenvironment,which realizes the acid-dependent tumor treat-ment strategy independent on the H_(2)O_(2)level in tumors.In addition,the generated organic free radicals(C_(6)H_(4)ClCOOO)effectively induced immunogenic cell death(ICD)and increased T cell infiltration.Un-der the synergetic treatment with an anti-PD-L1 antibody(α-PD-L1),a favorable anti-tumor effect was achieved.展开更多
Geothermometer is one of the most useful methods to reconstruct the thermal history of sedimentary basins. This paper introduces the application of free radicals concentration of organic matter as a thermal indicator ...Geothermometer is one of the most useful methods to reconstruct the thermal history of sedimentary basins. This paper introduces the application of free radicals concentration of organic matter as a thermal indicator in the thermal history reconstruction of carbonate succession, based on anhydrous thermal simulation results of type I and H1 kerogen. A series of free radicals data are obtained under thermal simulation of different heating temperatures and times, and quantitative modds between free radical concentration （Ng） of organic matter and time-temperature index （TTI） for types I and type H1 kerogen are also obtained. This Ng.TTI relation was used to model the Ordovician thermal gradients of Well TZ12 in the Tarim Basin. The modeling result is corresponding to the results obtained by apatite fission track data and published data. This new method of thermal history reconstruction will be benefit to the hydrocarbon generation and accumulation study and resource assessment of carbonate succession.展开更多
基金supported by the National Natural Sci-ence Foundation of China(No.21877080)the Shanghai En-gineering Research Center of Green Energy Chemical Engineering(No.18DZ2254200).
文摘It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment.Herein,the free radical genera-tor MNPs-mCPBA was constructed with Zn_(0.4)Co_(0.6)F_(e2)O_(4)@Zn_(0.4)Mn_(0.6)Fe_(2)O_(4)nanoparticles(MNPs)and 3-chloroperbenzoic acid(mCPBA).We believe that the iron(Ⅱ)on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals(C_(6)H_(4)ClCOOO)in an acidic tumor microenvironment,which realizes the acid-dependent tumor treat-ment strategy independent on the H_(2)O_(2)level in tumors.In addition,the generated organic free radicals(C_(6)H_(4)ClCOOO)effectively induced immunogenic cell death(ICD)and increased T cell infiltration.Un-der the synergetic treatment with an anti-PD-L1 antibody(α-PD-L1),a favorable anti-tumor effect was achieved.
基金This work is funded by the National Natural Science Foundation of China （Grant 40472066）the National Major Fundamental Research and Development Project （Nos. 2005CB422102 and 1999043302）.
文摘Geothermometer is one of the most useful methods to reconstruct the thermal history of sedimentary basins. This paper introduces the application of free radicals concentration of organic matter as a thermal indicator in the thermal history reconstruction of carbonate succession, based on anhydrous thermal simulation results of type I and H1 kerogen. A series of free radicals data are obtained under thermal simulation of different heating temperatures and times, and quantitative modds between free radical concentration （Ng） of organic matter and time-temperature index （TTI） for types I and type H1 kerogen are also obtained. This Ng.TTI relation was used to model the Ordovician thermal gradients of Well TZ12 in the Tarim Basin. The modeling result is corresponding to the results obtained by apatite fission track data and published data. This new method of thermal history reconstruction will be benefit to the hydrocarbon generation and accumulation study and resource assessment of carbonate succession.
