Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma(DBA/2J)mice

Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.

Cu^(2+)-Catalyzed Oscillatory Oxidation of Ascorbic Acid by O_2 Flow

A novel heterogeneous oscillator, the Cu2+-catalyzed oscillatory oxidation of ascorbic acid (Vitamin C) in aqueous solution by O-2 flow was reported. Both the potential oscillations on Pt-electrode corresponding to [Cu2+] and the absorbance oscillations at lambda =260 nm corresponding to [ascorbic acid] were observed. Oscillations in the completely homogeneous system were also observed. Effects of several factors on the oscillations were investigated.

Limit cycle oscillation suppression of 2-DOF airfoil using nonlinear energy sink

This paper presents a novel mechanical attachment, i.e., nonlinear energy sink （NES）, for suppressing the limit cycle oscillation （LCO） of an airfoil. The dynamic responses of a two-degree-of-freedom （2-DOF） airfoil coupled with an NES are studied with the harmonic balance method. Different structure parameters of the NES, i.e., mass ratio between the NES and airfoil, NES offset, NES damping, and nonlinear stiffness in the NES, are chosen for studying the effect of the LCO suppression on an aeroelastic system with a supercritical Hopf bifurcation or subcritical Hopf bifurcation, respectively. The results show that the structural parameters of the NES have different influence on the supercritical Hopf bifurcation system and the subcritical Hopf bifurcation system.

Oscillations during partial oxidation of methane to synthesis gas over Ru/Al_2O_3 catalyst

Oscillations in temperatures of catalyst bed as well as concentrations of gas phase species at the exit of reactor were observed during the partial oxidation of methane to synthesis gas over Ru/Al2O3 in the temperature range of 600 to 850℃. XRD, H2-TPR and in situ Raman techniques was used to characterize the catalyst. Two types of ruthenium species, i.e. the ruthenium species weakly interacted with Al2O3 and that strongly interacted with the support, were identified by H2-TPR experiment. These species are responsible for two types of oscillation profiles observed during the reaction. The oscillations were the result of these ruthenium species switching cyclically between the oxidized state and the reduced state under the reaction condition. These cyclic transformations, in turn, were the result of temperature variations caused by the varying levels of the strongly exothermic CH4 combustion and the highly endothermic CH4 reforming （with H2O and CO2） reactions （or the less exothermic direct partial oxidation of methane to CO and H2）, which were favored by the oxidized and the metallic sites, respectively. The major pathway of synthesis gas formation over the catalyst was via the combustion-reforming mechanism.

Effects of Aconitine on [Ca^(2+)] Oscillation in Cultured Myocytes of Neonatal Rats

In order to investigate the effects of aconitine on [Ca2＋] oscillation patterns in cultured myocytes of neonatal rats, fluorescent Ca2＋ indicator Fluo-4 NW and laser scanning confocal micro- scope （LSCM） were used to detect the real-time changes of [Ca2＋] oscillation patterns in the cultured myocytes before and after aconitine （1.0 μmol/L） incubation or antiarrhythmic peptide （AAP） and aconitine co-incubation. The results showed under control conditions, [Ca2＋] oscillations were irregu- lar but relatively stable, occasionally accompanied by small calcium sparks. After incubation of the cultures with aconitine, high frequency [Ca2＋] oscillations emerged in both nuclear and cytoplasmic regions, whereas typical calcium sparks disappeared and the average [Ca2＋] in the cytoplasm of the cardiomyocyte did not change significantly. In AAP-treated cultures, intracellular [Ca2＋] oscillation also changed, with periodic frequency, increased amplitudes and prolonged duration of calcium sparks. These patterns were not altered significantly by subsequent aconitine incubation. The basal value of [Ca2＋] in nuclear region was higher than that in the cytoplasmic region. In the presence or absence of drugs, the [Ca2＋] oscillated synchronously in both the nuclear and cytoplasmic regions of the same cardiomyocyte. It was concluded that although oscillating strenuously at high frequency, the average [Ca2＋] in the cytoplasm of cardiomyocyte did not change significantly after aconitine incuba- tion, compared to the controls. The observations indicate that aconitine induces the changes in [Ca2＋] oscillation frequency other than the Ca2＋ overload.

Oscillating Solitons for （2＋1）-Dimensional Nonlinear Models

用扩大同类的天平法和可变分离假设，我们与三个任意的函数发现了新可变分离解决方案(2+1 )-dimensionaldispersive 长波浪的方程。基于导出的答案，我们揭示了象 dromion 那样的丰富的 oscillatingsolitons， multi-dromion， solitoff，独居等等，由选择适当功能飘动。

The fertilization-induced Ca^(2+) oscillation in mouse oocytes is cytoplasmic maturation dependent

Mature eggs (at metaphase Ⅱ stage) produce a series of Ca2+ oscillation at fertilization. To define whether the fertilization-induced Ca2+ oscillation is restrict to the metaphase Ⅱ eggs and cell cycle dependent, mouse oocytes at prophase Ⅰ (arrested at germinal vesicle stage),metaphase Ⅰ, metaphase Ⅱ, as well as the pronuclear embryos at interphase of the first mitotic division derived from fertilization or parthenogenetic activation were inseminated after removal of zona pellucida. The results show that the fertilization-induced Ca2+ oscillation is not specific to metaphase Ⅱ eggs. This is supported by the fact that immature oocytes generated the Ca2+ oscillations at fertilization regardless of their nuclear progression from prophase Ⅰ to metaphase Ⅰ (in vitro matured) stage. More interestingly, it was first found that pronuclear embryos at interphase derived from parthenogenetic activation showed Ca2+ oscillations in response to fertilization while the zygotes at interphase did not after reinsemination or intracytoplasmic injection of sperm extracts which induce Ca2+ oscillations in MII eggs. This suggests that the ability of oocytes to generate Ca2+ oscillation in response to sperm penetration is not regulated in a cell cycle dependent manner but dependent on the cytoplasmic maturation.

Negative differential resistance and quantum oscillations in FeSb_2 with embedded antimony

We present a systematical study on single crystalline FeSb2 using electrical transport and magnetic torque measurements at low temperatures. Nonlinear magnetic field dependence of Hall resistivity demonstrates a multi-carrier transport instinct of the electronic transport. Current-controlled negative differential resistance(CC-NDR) observed in currentvoltage characteristics below ～ 7 K is closely associated with the intrinsic transition ～ 5 K of FeSb2, which is, however,mediated by extrinsic current-induced Joule heating effect. The antimony crystallized in a preferred orientation within the FeSb2 lattice in the high-temperature synthesis process leaves its fingerprint in the de Haas-Van Alphen(dHvA) oscillations, and results in the regular angular dependence of the oscillating frequencies. Nevertheless, possible existence of intrinsic non-trivial states cannot be completely ruled out. Our findings call for further theoretical and experimental studies to explore novel physics on flux-free grown FeSb_2 crystals.

Oscillation in Response and Recovery Properties of SnO_2 Gas Sensor

Six kinds of Sn(OH)_4 precipitates were prepared by the chemical precipitation method (liquid-phase),of which the pH values are 3.0 (sample 1),4.5 (sample 2),6.0 (sample 3),7.5 (sample 4),9.0 (sample 5) and 10.5 (sample 6),respectively. After washed and dried,the Sn(OH)_4 precipitates were first calcined into tin oxide powder.Six kinds of gas sensors were made from the obtained SnO_2 powders.The XRD patterns of all the samples were recorded.The sensing properties of all samples to C_2H_5OH and H_2 gases were measured in different gas concentrations and temperatures,including the sensitivities of all samples,their response and recovery properties.The recovery properties of all samples to C_2H_5OH exhibit the sinusoidal oscillation character.

Bioscillation and Birhythmicity in the H_2O_2-KSCN-CuSO_4-NaOH System

Two kinds of different mechanistic oscillations can be displayed in the H_2O_2-KSCN-CuSO_4-NaOH system. One discovered by this study is the pH oscillation in a continuous flow stirred tank reactor(CSTR) resulting from the oxidation of KSCN. The other is the oscillation of H_2O_2 decomposition in both CSTR and batch reactors(reported by Orbáin in 1986). Under appropriate experimental conditions, the system exhibits a birhythmicity in a CSTR. Two different pH oscillations are reported here. The pH oscillations which accompany the decomposition of H_2O_2 exist in the batch reactor and the CSTR at a high flowrate, but the pH oscillations in a CSTR at a low flowrate originates from proton positive and negative feedback in the oxidation of KSCN. The oscillation of non-catalyzed oxidation of KSCN by hydrogen peroxide in a CSTR can be found. Also we have observed whether Cu^(2+) exists or not in the batch system, the pH increases to near neutral ultimately after pH drops twice.

Current Controlled Relaxation Oscillations in Ge_2Sb_2Te_5-Based Phase Change Memory Devices

The relaxation oscillation of the phase change memory （PCM） devices based on the Ge2Sb2Te5 material is investigated by applying square current pulses. The current pulses with different amplitudes could be accurately given by the independently designed current testing system. The relaxation oscillation across the PCM device could be measured using an oscilloscope. The oscillation duration decreases with time, showing an inner link with the shrinking threshold voltage Vth. However, the relaxation oscillation would not terminate until the remaining voltage Von reaches the holding voltage Vh. This demonstrates that the relaxation oscillation might be controlled by Von. The increasing current amplitudes could only quicken the oscillation velocity but not be able to eliminate it, which indicates that the relaxation oscillation might be an inherent behavior for the PCM cell.

Oscillation in the KMnO4-NH2CH2COOH CSTR System

The chemical oscillating reactions in KMnO4-NH2CH2COOH-H3PO CSTR system in the presence and absence of Ag+ have been studied.The reaction conditions and phase diagrams have been determined. Some effects on the oscillation have then studied. The stabilization of colloidal particles of MnO2 by PO43-has been investigated. The roles of Ag+ in the above reactions have also been studied.

Kinematics of a 2D Asymmetric Nonlinear Oscillator

Motion of a point-like massive particle under the influence of two nonidentical linear springs conducive to an irregular planar oscillation is analyzed. For a two dimensional oscillations the equation of motion is a coupled highly nonlinear differential equation. The set of equations cannot be solved analytically. Utilizing a Computer Algebra System (CAS) such as Mathematica [1] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300390031003500360035003100380030000000 we solve the equations numerically. Kinematics of the particle is presented. For a comprehensive visual understanding the oscillations are simulated. We also include an extended atlas of useful two-dimensional time-folded diagrams.

CO_(2)气泡群上升过程的CFD-PBM模拟

为揭示CO_(2)气泡群在方形鼓泡塔中上升过程的气液两相流行为,采用双流体模型耦合PBM(种群平衡方法)进行数值模拟,考虑气泡间的聚并和破碎现象,与部分实验结果相互对比,验证数值模型具有一定的可靠性,并分析入口气速、塔高宽比和入口分布器结构对气液流动情况、相含率和液相速度的影响,模拟结果表明:气泡群的上升过程出现了周期性的羽流震荡现象,改变气速会影响塔内气泡羽流的震荡程度;流动过程液相发生湍动,随着塔高宽比增大,液相循环模式实现了从“冷却塔”形式到“交错涡旋”的转变;不同入口结构下相含率分布有差异,大入口的震荡更早到来,但震荡持续时间较小入口结构短。研究CO_(2)气泡群的多相流动规律为鼓泡塔的设计和优化提供了理论参考。

Observation of oscillations in the transport for atomic layer MoS_2

In our experiment, an atomic layer MoS2structure grown on SiO2/Si substrates is used in transport test. The voltage U14,23 oscillates and the corresponding period varies with applied current. The largest period appears at 45 μA. The oscillation periods are different when samples are under laser radiation or in darkness. We discover that under the laser irradiation, the oscillation period occurs at lower current than in the darkness case. Meanwhile, the drift velocity is estimated at ~10~7 cm/s. Besides, by studying the envelope of U14,23 versus applied current, we see a beating phenomenon at a certain current value. The beating period in darkness is larger than under laser irradiation. The difference between beating periods reveals the energy difference of electrons. Similar results are obtained by using different laser power densities and different light sources. The possible mechanism behind the oscillation period is discussed.

Impact frequency variation of self-excited oscillation pulsed supercritical carbon dioxide jets

In order to obtain the impact frequency of resonant coal breaking by self-excited oscillation pulsed supercritical carbon dioxide(SC-CO_(2))jet,large eddy simulation was used to analyze the formation and development process of self-excited oscillation pulsed SC-CO_(2)jet,the variation of jet impact frequency in the nozzle and the free flow field,and the variation of jet impact frequency at different positions in the jet axis and under different cavity lengths.The test device of jet impact frequency was developed,and experiments were performed to verify the conclusions of the numerical simulations.The results show that the frequency of the self-excited oscillation pulsed SC-CO_(2)jet is different in the nozzle and the free flow field.In the nozzle,the frequency generated by the fluid disturbance is the same,and the jet frequency at the exit of the nozzle is consistent with that inside the nozzle.In the free flow field,due to the compressibility of CO_(2),the pressure,velocity and other parameters of SC-CO_(2)jets have obvious fluctuation patterns.This feature causes the impact frequency of the self-excited oscillation pulsed SC-CO_(2)jet to decrease gradually in the axis.Changing the cavity length allows the adjustment of the jet impact frequency in the free flow field by affecting the disturbance frequency of the self-excited oscillation pulsed SC-CO_(2)jet inside the nozzle.

温度调谐ZnGeP_(2)长波红外光参量振荡器

为了获得可调谐长波红外激光输出,本文设计了一种基于ZnGeP_(2)(ZGP)温度调谐的长波红外光参量振荡器。采用中心波长为2097 nm的Ho:YAG激光器泵浦不同相位匹配角的ZGP晶体,通过改变晶体工作温度来研究ZnGeP_(2)光参量振荡器(ZGP-OPO)的温度调谐特性。在15~30℃温度范围内,实现了7.53~8.77μm分段可调谐长波激光输出,总调谐宽度为1.24μm。整个调谐范围内,输出功率大于1.503 W,当闲频光波长为8.77μm时,输出功率为1.503 W,斜率效率和光光转换效率分别为12.19%和6.53%。实验结果表明,ZGP温度调谐是实现连续可调谐长波红外激光输出的有效技术途径。本实验研究在可调谐长波固体激光器工程化领域具有潜在的应用价值。

Proposed Wave Momentum Source for Generating the 22-Year Solar Cycle

For the 22-year solar cycle oscillation there is no external time dependent source. A nonlinear oscillation, the solar cycle must be generated internally, and Babcock-Leighton models apply an artificial nonlinear source term that can simulate the observations—which leaves open the question of the actual source mechanism for the solar cycle. Addressing this question, we propose to take guidance from the wave mechanism that generates the 2-year Quasi-biennial Oscillation (QBO) in the Earth atmosphere. Upward propagating gravity waves, eastward and westward, deposit momentum to generate the observed zonal wind oscillation. On the Sun, helioseismology has provided a thorough understanding of the acoustic p-waves, which propagate down into the convective envelope guided by the increasing temperature and related propagation velocity. Near the tachocline with low turbulent viscosity, the waves propagating eastward and westward can produce an axisymmetric 22-year oscillation of the zonal flow velocities that can generate the magnetic solar dynamo. Following the Earth model, waves in opposite directions can generate in the Sun wind and magnetic field oscillations in opposite directions, the proposition of a potential solar cycle mechanism.

氨基酸-BrO_3^--Mn^(2+)-H_2SO_4-丙酮体系的振荡反应

本文首次报导L-蛋氨酸（以Met表示）、L-胱氨酸（以Cys表示）、L-色氨酸（以Trp表示）、L-丝氨酸（以Ser表示）、L-酪氨酸（以Tyr表示）等五种氨基酸分别作底物在BrO3--Mn2+-H2SO4-丙酮（以Act表示）体系的振荡行为。 1 实验部分 1.1 试剂及药品实验中各种氨基酸均为生化试剂,其余物质均为分析纯,溶液用去离子水配制。 1.2 实验仪器及方法实验在恒温30±0.2℃下进行,以217型双液接甘汞电极为参比,采用213型光亮铂电极和PXS-215型离子活度计测量电势（E）随时间的变化来反映ln（[Ox]/[Red]）,振荡现象可通过XWC自动平衡记录仪记录的E～t曲线观察。

Ca^(2+)、pH在花粉及萌发花粉管生长中的作用研究进展

花粉正常萌发并生长是精细胞顺利到达胚囊并实现受精作用的前提,因而是高等植物有性生殖的一个关键环节.花粉管生长涉及一系列过程,而花粉 或花粉管 内外的Ca2+和pH的变化与花粉萌发、花粉管生长有着密切的关系.比较详细地论述了Ca2+和pH在花粉萌发、花粉管生长过程中的分布特点、生理功能及分子机制.