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Effect of different interventions on orthodontic tooth movement acceleration:A network meta-analysis
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作者 CHEN Hui-ying ZHANG Li +2 位作者 ZHAN Le WAN Ni MO Li-wen 《Journal of Hainan Medical University》 CAS 2024年第2期41-50,共10页
Objective: To explore the effectiveness of various interventions in accelerating tooth movement, a systematic review and net-work meta analysis were used to draw a conclusion. Methods: MEDLINE, EMBASE, Willey Library,... Objective: To explore the effectiveness of various interventions in accelerating tooth movement, a systematic review and net-work meta analysis were used to draw a conclusion. Methods: MEDLINE, EMBASE, Willey Library, EBSCO, Web of Science Databases, and Cochrane Central Register of Controlled Trials databases to identify relevant studies. ADDIS 1.16.6 and Stata 16.0 software were used for NMA. Results: Five thousand five hundred and forty-two articles were searched out. After screening by two independent investigators, forty-seven randomized controlled trials, 1 390 participants, were included in this network meta-analysis. A total of 11 interventions involving Piezocision (Piezo), Photobiomodulation therapy (PBMT), Plate- let-rich plasma(PRP), Electromagnetic field(EF), Low intensity laser therapy(LLLT), Low intensity pulsed ultrasound(LI-PUS), Low-frequency vibrations(LFV), Distraction osteogenesis(DAD), Corticotomy(Corti), Microosteoperforations (MOPS), Traditional orthodontic(OT)were identified and classified into 3 classes including surgical treatment, non-surgical treatment and traditional orthodontic treatment. According to SUCRA probability ranking of the best intervention effect, when orthodontic treatment lasted for 1 month, PBMT (90.6%), Piezo(87.4%) and MOPs(73.6%)were the top three interventions to improve the efficiency of canine tooth movement. When orthodontic treatment lasted for 2 months, Corti (75.7%), Piezo (69.6%) and LFV(58.9%)were the top three interventions for improving the mobility efficiency of canine tooth movement. When orthodontic treatment lasted for 3 months, Cort (73.3%), LLLT(68.4%)and LFV(60.8%)were the top three interventions for improving the mobility efficiency of canine tooth movement. Conclusion: PBMT and Piezo can improve the efficiency of canine tooth movement significantly after 1 month, while Corti and LFV can improve the efficiency of canine tooth movement better after 2 and 3 months. 展开更多
关键词 orthodontic tooth movement ACCELERATION Network Meta-analysis Randomized controlled trials
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Regular nicotine intake increased tooth movement velocity,osteoclastogenesis and orthodontically induced dental root resorptions in a rat model 被引量:4
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作者 christian kirschneck michael maurer +2 位作者 michael wolf claudia reicheneder peter proff 《International Journal of Oral Science》 SCIE CAS CSCD 2017年第3期174-184,共11页
Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further (side) effects can be expected during orthodontic treatment a... Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further (side) effects can be expected during orthodontic treatment at a nicotine exposure corresponding to that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments of 21 animals each (A/B/C) to 3 experimental groups (7 rats, 112/3). (A) cone-beam-computed tomography (CBCT); (B) histology/serology; (C) reverse- transcription quantitative real-time polymerase chain reaction (RT-qPCR)/cotinine serology--(1) control; (2) orthodontic tooth movement (OTM) of the first and second upper left molar (NiTi closed coil spring, 0.25 N); (3) OTM with 1.89 mg-kg- 1 per day s.c. of L(- )-nicotine. After 14 days of OTM, serum cotinine and IL-6 concentration as well as orthodontically induced inflammatory root resorption (OIIRR), osteoclast activity (histology), orthodontic tooth movement velocity (CBCT, within 14 and 28 days of OTM) and relative gene expression of known inflammatory and osteoclast markers were quantified in the dental-periodontal tissue (RT-qPCR). Animals exposed to nicotine showed significantly heightened serum cotinine and IL-6 levels corresponding to those of regular European smokers. Both the extent of root resorption, osteoclast activity, orthodontic tooth movement and gene expression of inflammatory and osteoclast markers were significantly increased compared to controls with and without OTM under the influence of nicotine. We conclude that apart from increased periodontal bone loss, a progression of dental root resorption and accelerated orthodontic tooth movement are to be anticipated during orthodontic therapy, if nicotine consumption is present. Thus patients should be informed about these risks and the necessity of nicotine abstinence during treatment. 展开更多
关键词 dental research inbred Fischer344 NICOTINE orthodonticS rats root resorption tooth movement
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Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response 被引量:2
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作者 Yu Wang Qian Li +5 位作者 Fuliang Liu Shanshan Jin Yimei Zhang Ting Zhang Yunyan Zhu Yanheng Zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2018年第4期244-252,共9页
The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression,growth and differentiation, has been extensively investigated. However, metabolic regulation... The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression,growth and differentiation, has been extensively investigated. However, metabolic regulation in mechanobiology remains largely unexplored. Here, we identified glucose transporter 1(GLUT1)—the primary glucose transporter in various cells—as a novel mechanosensitive gene in orthodontic tooth movement(OTM). Using an in vivo rat OTM model, we demonstrated the specific induction of Glut1 proteins on the compressive side of a physically strained periodontal ligament. This transcriptional activation could be recapitulated in in vitro cultured human periodontal ligament cells(PDLCs), showing a time-and dose-dependent mechanoresponse. Importantly, application of GLUT1 specific inhibitor WZB117 greatly suppressed the efficiency of orthodontic tooth movement in a mouse OTM model, and this reduction was associated with a decline in osteoclastic activities. A mechanistic study suggested that GLUT1 inhibition affected the receptor activator for nuclear factor-κ B Ligand(RANKL)/osteoprotegerin(OPG)system by impairing compressive force-mediated RANKL upregulation. Consistently, pretreatment of PDLCs with WZB117 severely impeded the osteoclastic differentiation of co-cultured RAW264.7 cells. Further biochemical analysis indicated mutual regulation between GLUT1 and the MEK/ERK cascade to relay potential communication between glucose uptake and mechanical stress response. Together, these cross-species experiments revealed the transcriptional activation of GLUT1 as a novel and conserved linkage between metabolism and bone remodelling. 展开更多
关键词 Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response otm RANKL
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External Root Resorption During Standardised Orthodontic Tooth Movement In Young And Adult Rats 被引量:2
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作者 RENYi-jin JC.Maltha AMKuijpers-Jagtman 《口腔医学研究》 CAS CSCD 2004年第3期282-285,共4页
目的 :比较研究幼鼠和成年鼠正畸牙齿移动过程中的牙根吸收。方法 :本研究包括两组大鼠 ,其中幼鼠 30只 (年龄约 6周 ) ,成年鼠 30只 (年龄约 912个月 )。大鼠上颌牙一侧用于实验侧 ,另一侧用于对照。实验侧的三颗磨牙用结扎丝颌粘接剂... 目的 :比较研究幼鼠和成年鼠正畸牙齿移动过程中的牙根吸收。方法 :本研究包括两组大鼠 ,其中幼鼠 30只 (年龄约 6周 ) ,成年鼠 30只 (年龄约 912个月 )。大鼠上颌牙一侧用于实验侧 ,另一侧用于对照。实验侧的三颗磨牙用结扎丝颌粘接剂固为一个整体 ,在超弹性拉簧作用下 (力值为 0 .1牛顿 )向切牙侧移动。 1,2 ,4 ,8和 12周时给予大鼠过量麻醉剂 ,材料用于组织学研究。上颌第一磨牙的近中颊侧根为根吸收研究对象。压力侧和张力侧的牙根吸收程度在显微镜下进行长度测量。实验侧与对照侧 ,压力侧与张力侧 ,幼鼠与成年鼠之间的牙根吸收程度分别以实验时间为参照 ,在统计学手段下进行了组间和组内分析和比较 ,以探讨牙齿移动时间和年龄因素对于牙根吸收的影响。结果 :实验侧的牙根吸收在幼鼠与成年鼠之间在 1,2 ,4 ,8周时均没有统计学差异。而在第 12周时 ,成年鼠实验侧牙根吸收大于幼鼠 (P <0 .0 5 )。成年鼠实验组压力侧的牙根吸收明显大于对照组压力侧 ,而在幼鼠组没有发现这一差异。两组年龄幼鼠的实验组其压力侧和张力侧的牙根吸收均高度相关。结论 :相对于对照侧 ,正畸牙齿移动并没有在幼鼠的实验侧诱发更多的牙根吸收。在成年鼠 ,长期的正畸作用力倾向于诱发更多的牙根吸收。这些研究结果表明对于正? 展开更多
关键词 年龄 牙齿移动 牙根吸收 正畸力
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EFFECT OF PULSED ELECTROMAGNETIC FIELD AND BIOMECHANICAL FORCE ON ORTHODONTIC TOOTH MOVEMENT
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作者 陈青蓉 楼昭华 +2 位作者 蔡中 刘侃 彭适生 《Medical Bulletin of Shanghai Jiaotong University》 CAS 1991年第2期81-85,共5页
The purpose of this experiment is to investigate the effect of pulsed electromagnetic field (PEMF) and biomechanical force on orthodontic tooth movement by means of measurement of gross tooth movement anatomic data, l... The purpose of this experiment is to investigate the effect of pulsed electromagnetic field (PEMF) and biomechanical force on orthodontic tooth movement by means of measurement of gross tooth movement anatomic data, light microscopic evaluation and transmission electromicroscopic evaluation. The results indicate that PEMF combined with biomechanical force could accelerate the rate and amount of orthodontic tooth movement, enhance bone deposition in tension side and resorption in compression side. The results also suggest that PEMF could accelerate orthodontic tooth movement as a result of increase in quantity of active cells, PEMF couldn’t change the ultrastructure of cells. 展开更多
关键词 putsed ELECTROMAGNETIC field orthodontic tooth movement
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Factors Associated with Orthodontic Tooth Movement in Periodontally Compromised Patients
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作者 Devinder Preet Singh 《Open Journal of Stomatology》 2015年第11期268-279,共12页
There is no consistent relationship between malocclusion and periodontal disease but certain characteristics of malocclusion can promote a pathologic environment conducive to periodontal disease. One of the dramatic m... There is no consistent relationship between malocclusion and periodontal disease but certain characteristics of malocclusion can promote a pathologic environment conducive to periodontal disease. One of the dramatic means available to improve the local environmental factors is through orthodontic tooth movement. The pretreatment periodontal conditions can include excessive tooth mobility, advanced crestal bone loss, infrabony defects, tipped molars, furcation involvement, and hard and soft tissue dehiscences. Movement of teeth in the presence of periodontal inflammation can result in an increased loss of attachment and irreversible crestal loss. Although absolute reduction in bone and attachment levels does not contraindicate orthodontic correction, it does increase the difficulty of delivering controlled orthodontic mechanics that would potentially minimize further bone loss. The present review article discusses the various factors that are associated with orthodontic tooth movement in periodontally compromised patients namely: 1) tooth movement into infrabony pockets;2) tooth movement into compromised bone areas;3) tooth movement through cortical bone;4) extrusion (eruption);5) intrusion;6) tipping. 展开更多
关键词 MALOCCLUSION orthodontic tooth movement PERIODONTAL DISEASE
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Cell biology in orthodontic tooth movement:The known and the unknown
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作者 RENYi-jin 《上海口腔医学》 CAS CSCD 2005年第2期182-189,共8页
This review is aimed at providing, at the cellular level, a concise and complete overview of the important knowledge on the mechanism of orthodontic tooth movement to orthodontists and postgraduates who are involved o... This review is aimed at providing, at the cellular level, a concise and complete overview of the important knowledge on the mechanism of orthodontic tooth movement to orthodontists and postgraduates who are involved or interested in basic research. The construction of this article was oriented to the following key questions: Where an osteoclast starts to its first resorption site? When the cascade of a resorption cycle starts? What are the factors involved in bone remodeling and how they orchestrate? What happens before and after the formation of a resorption pit? Major findings in these aspects were summarized and discussed. In addition, related biological phenomenon such as orthodontically induced root resorption was intensively reviewed. By means of an updated and systematic review, the author intended to introduce more biological evidence to orthodontic intervention and to encourage evidence-based treatment in daily orthodontic practice. 展开更多
关键词 细胞生物学 牙疾病 牙科医生 治疗 破骨细胞
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Dynamic Analysis of the Expression of HSP70 during Experimental Tooth Movement in Rats
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作者 毛靖 齐娟 +1 位作者 李平 谢晖 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2006年第6期706-708,共3页
In this study, the expression of HSP70 during experimental tooth movement was dynamically observed and the relationship between HSP70 and orthodontic periodontal tissue remodeling were observed. The orthodontic applia... In this study, the expression of HSP70 during experimental tooth movement was dynamically observed and the relationship between HSP70 and orthodontic periodontal tissue remodeling were observed. The orthodontic appliance was placed between the right maxillary first molar and maxillary central incisors of adult SD rats to establish a rat molar movement model. Immunohistochemistry was performed 1, 3, 5, 7 and 14 day(s) after orthodontic force application to observe the expression and localization of inducible HSP70. The expression of HSP70 was strongly positive in the early stage of the tooth movement, became gradually less positive, and was weakly positive in the restoration stage. There was difference in staining pattern between different parts of PDL during the same period. These results suggest that the expression of HSP70 and difference in staining pattern among different parts of PDL during orthodontic tooth movement in rats may be implicated in stress response and remodeling of periodontal tissue. 展开更多
关键词 orthodontic tooth movement IMMUNOHISTOCHEMISTRY heat shock protein 70
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Low-intensity pulsed ultrasound reduces alveolar bone resorption during orthodontic treatment via Lamin A/C-Yes-associated protein axis in stem cells 被引量:1
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作者 Tong Wu Fu Zheng +7 位作者 Hong-Yi Tang Hua-Zhi Li Xin-Yu Cui Shuai Ding Duo Liu Cui-Ying Li Jiu-Hui Jiang Rui-Li Yang 《World Journal of Stem Cells》 SCIE 2024年第3期267-286,共20页
BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or to... BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or tooth root resorption.Low-intensity pulsed ultrasound(LIPUS),a noninvasive physical therapy,has been shown to promote bone fracture healing.It is also reported that LIPUS could reduce the duration of orthodontic treatment;however,how LIPUS regulates the bone metabolism during the orthodontic treatment process is still unclear.AIM To investigate the effects of LIPUS on bone remodeling in an orthodontic tooth movement(OTM)model and explore the underlying mechanisms.METHODS A rat model of OTM was established,and alveolar bone remodeling and tooth movement rate were evaluated via micro-computed tomography and staining of tissue sections.In vitro,human bone marrow mesenchymal stem cells(hBMSCs)were isolated to detect their osteogenic differentiation potential under compression and LIPUS stimulation by quantitative reverse transcription-polymerase chain reaction,Western blot,alkaline phosphatase(ALP)staining,and Alizarin red staining.The expression of Yes-associated protein(YAP1),the actin cytoskeleton,and the Lamin A/C nucleoskeleton were detected with or without YAP1 small interfering RNA(siRNA)application via immunofluorescence.RESULTS The force treatment inhibited the osteogenic differentiation potential of hBMSCs;moreover,the expression of osteogenesis markers,such as type 1 collagen(COL1),runt-related transcription factor 2,ALP,and osteocalcin(OCN),decreased.LIPUS could rescue the osteogenic differentiation of hBMSCs with increased expression of osteogenic marker inhibited by force.Mechanically,the expression of LaminA/C,F-actin,and YAP1 was downregulated after force treatment,which could be rescued by LIPUS.Moreover,the osteogenic differentiation of hBMSCs increased by LIPUS could be attenuated by YAP siRNA treatment.Consistently,LIPUS increased alveolar bone density and decreased vertical bone absorption in vivo.The decreased expression of COL1,OCN,and YAP1 on the compression side of the alveolar bone was partially rescued by LIPUS.CONCLUSION LIPUS can accelerate tooth movement and reduce alveolar bone resorption by modulating the cytoskeleton-Lamin A/C-YAP axis,which may be a promising strategy to reduce the orthodontic treatment process. 展开更多
关键词 Low-intensity pulsed ultrasound Bone resorption OSTEOGENESIS Cytoskeleton-Lamin A/C-Yes-associated protein axis Bone marrow mesenchymal stem cells orthodontic tooth movement
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3D打印个性化正畸装置对单根牙垂直移动的三维有限元分析
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作者 曹怡琳 王心彧 +5 位作者 庄妍 王亚茹 姜至秀 刘丹瑜 门九旭 丁元圣 《中国组织工程研究》 CAS 北大核心 2025年第16期3360-3368,共9页
背景:基于牙齿垂直移动原理,通过数字化设计结合3D打印制作个性化正畸装置,可使个性化正畸装置与单个切牙形成支抗系统。借助微种植体绝对支抗作用可对单根牙在三维方向上进行精准控制。目的:基于生物力学原理设计了牙位11、12、21、22... 背景:基于牙齿垂直移动原理,通过数字化设计结合3D打印制作个性化正畸装置,可使个性化正畸装置与单个切牙形成支抗系统。借助微种植体绝对支抗作用可对单根牙在三维方向上进行精准控制。目的:基于生物力学原理设计了牙位11、12、21、22压低移动与伸长移动的个性化正畸装置,通过三维有限元法分析个性化正畸装置的安全性与其对牙齿的移动作用。方法:应用Mimics、Geomagic Wrap、SolidWorks和Ansys Workbench软件分别建立了上颌前牙区(牙位11、12、21、22)牙槽骨-牙周膜-上颌切牙-个性化悬臂微种植体-连接板-个性化托槽的三维有限元模型,每个牙位分别设置个性化压低移动与伸长移动正畸装置,加载300 g拉力或推力,分析个性化正畸装置各部件应力水平,计算牙齿位移与牙周膜应力分布情况。结果与结论:①个性化压低移动正畸装置受到的最大等效应力为162.90 MPa,个性化伸长移动正畸装置受到的最大等效应力239.57 MPa,二者的最大等效应力均位于个性化托槽加力附件的垂直部分,个性化正畸装置各部件所受等效应力均在屈服强度内,均具有良好的安全性;②在个性化正畸装置作用下,牙齿初始位移呈现整体压低或伸长移动的趋势,垂直方向上的位移远远超过在水平方向和矢状方向上的位移;牙周膜根尖或颈部位置出现等效应力峰值,在根尖区牙周膜出现等效应力集中区域;③结果显示,个性化正畸装置可以使牙位11、12、21、22近似达到压低移动或伸长移动的目的,初步证实了个性化垂直移动正畸装置的有效性。 展开更多
关键词 3D打印个性化正畸装置 单根牙 压低移动 伸长移动 三维有限元分析 支抗 生物力学
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Effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats 被引量:10
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作者 Jian-Hao Yang Zheng-Chen Li +5 位作者 Wei-Dong Kong Wu Zhang Ying-Ping Jia Yue-Lan Zhang Lin-Bo Liu Xue-Ping Han 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第10期757-761,共5页
Objective:To investigate effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats.Methods:Eighty SD rats were randomly divided into 4 groups,blank control group... Objective:To investigate effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats.Methods:Eighty SD rats were randomly divided into 4 groups,blank control group(group A)with 5 rats,treatment normal group(group B)with 25 rats,inflammation control group(group(group C)with 25 rats,inflammation treatment group(group D)with 25 rats.Immunohistochemistry and histomorphometric analysis was performed to measure the expression of IL-6,IL-8 and the firet molar to the recent movement in the distance.Results:The expression of IL-8 reached a maximum on day 5 and declined thereafter in group B;the expression of IL-6 reached a maximum on day 5 in group B.The expression of IL-6 and IL-8 was gradually weakened with time in group C.The expression of IL-6 and IL-8 were high,and reached a maximum on day 5 and declined thereafter in group D.AD of positive cells in group D were higher than group B at each time point(P<0.05).The time which 0.49 N orthodontic force was loaded was longer,orthodontic tooth movement distance was greater.Movement distance in group D were longer than group B(P<0.05).Conclusions:Orthodontic force as well as inflammatory stimulus can evoke the expression of IL-6 and IL-8.Under the combined effects of inflammation and orthodontic force,the expression of IL-6,IL-8will increase. 展开更多
关键词 orthodontic tooth movement INFLAMMATORY PERIODONTAL tissue INTERLEUKIN-6 INTERLEUKIN-8
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Applications of stem cells in orthodontics and dentofacial orthopedics:Current trends and future perspectives 被引量:6
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作者 Shiva Safari Arezoo Mahdian Saeed Reza Motamedian 《World Journal of Stem Cells》 SCIE CAS 2018年第6期66-77,共12页
A simple overview of daily orthodontic practice involves use of brackets, wires and elastomeric modules. However, investigating the underlying effect of orthodontic forces shows various molecular and cellular changes.... A simple overview of daily orthodontic practice involves use of brackets, wires and elastomeric modules. However, investigating the underlying effect of orthodontic forces shows various molecular and cellular changes. Also, orthodontics is in close relation with dentofacial orthopedics which involves bone regeneration. In this review current and future applications of stem cells(SCs) in orthodontics and dentofacial orthopedics have been discussed. For craniofacial anomalies, SCs have been applied to regenerate hard tissue(such as treatment of alveolar cleft) and soft tissue(such as treatment of hemifacial macrosomia). Several attempts have been done to reconstruct impaired temporomandibular joint. Also, SCs with or without bone scaffolds and growth factors have been used to regenerate bone following distraction osteogenesis of mandibular bone or maxillary expansion. Current evidence shows that SCs also have potential to be used to regenerate infrabony alveolar defects and move the teeth into regenerated areas. Future application of SCs in orthodontics could involve accelerating tooth movement, regenerating resorbed roots and expanding tooth movement limitations. However, evidence supporting these roles is weak and further studies are required to evaluate the possibility of these ideas. 展开更多
关键词 Alveolar bone grafting Dentofacial DEFORMITIES Distraction osteogenesis Guided tissue regeneration orthodonticS orthodontic tooth movement ORTHOGNATHIC surgery Periodontitis Root RESORPTION Stem cells
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Periodontally accelerated osteogenic orthodontics with platelet-rich fibrin in an adult patient with periodontal disease:A case report and review of literature 被引量:9
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作者 Min Xu Xiao-Yu Sun Jian-Guang Xu 《World Journal of Clinical Cases》 SCIE 2021年第6期1367-1378,共12页
BACKGROUND In the clinical scenario,adult patients with periodontal diseases and dental malformation,characterized by dental crowding in lower anterior teeth with the thin biotype,often require orthodontic treatment.T... BACKGROUND In the clinical scenario,adult patients with periodontal diseases and dental malformation,characterized by dental crowding in lower anterior teeth with the thin biotype,often require orthodontic treatment.This case report aimed to evaluate the clinical and radiographic outcomes of periodontally accelerated osteogenic orthodontics(PAOO)combined with autologous platelet-rich fibrin(PRF)in an adult patient with class I malocclusion along with dental crowding,a thin periodontal biotype,and buccal plate deficiency.CASE SUMMARY A 32-year-old female complaining of dental crowding and gingival bleeding was referred to the orthodontic clinic.The patient underwent periodontal risk assessment prior to orthodontic treatment.She was diagnosed with a high risk of gingival recession due to dental crowding,root prominence,loss of buccal plates,and a thin gingival tissue biotype.The treatment regimen included PAOO combined with autologous PRF for alveolar augmentation and interproximal enamel reduction for moderate dental crowding.Clinically,PAOO-assisted orthodontic tooth movement in this case showed enhanced periodontium remodeling.Radiographic outcomes also showed statistically significant improvements(P<0.01)in the mandibular buccal alveolar bone.CONCLUSION This case report suggests the combination of autologous PRF with PAOO to enhance bone augmentation and long-term tissue support in adult orthodontic patients with periodontal disease. 展开更多
关键词 Periodontally accelerated osteogenic orthodontics orthodontic tooth movement Platelet-rich fibrin Bone augmentation Periodontal biotype Case report
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Biological Changes on the Compressing Side of Orthodontic Teeth Stimulating by Soft laser 被引量:3
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作者 ZHANGDong-liang OUYANGJie +1 位作者 WERNERGoetz ANDREASJaeger 《口腔医学研究》 CAS CSCD 2003年第3期204-208,共5页
目的 :研究在弱激光作用下接受正畸力作用的牙齿的压力侧出现的生物学变化 ,为临床应用弱激光加速牙齿移动提供理论依据。方法 :实验动物分 2组 ,每组 2 0只。A组动物接受正畸力 ,B组动物除接受正畸力之外 ,还接受弱激光照射。采用免疫... 目的 :研究在弱激光作用下接受正畸力作用的牙齿的压力侧出现的生物学变化 ,为临床应用弱激光加速牙齿移动提供理论依据。方法 :实验动物分 2组 ,每组 2 0只。A组动物接受正畸力 ,B组动物除接受正畸力之外 ,还接受弱激光照射。采用免疫组化检测层连蛋白的组间表达变化 ,采用原位杂交检测RANKL(receptoractivatorofNF -kBligand)mRNA的组间表达变化。结果 :免疫组化结果表明 ,新生血管活跃的高峰期出现在接受正畸力的第7d。与A组相比 ,接受弱激光照射的B组呈现层连蛋白的高表达。同样 ,与A组相比 ,原位杂交检测发现在接受弱激光照射的B组中 ,正畸牙压力侧呈现RANKLmRNA的高表达。结论 :弱激光照射后能够促进正畸牙压力侧血管新生 (呈现层连蛋白高表达 ) ,从而促进破骨细胞的分化激活。此外弱激光还能够促进破骨细胞活化因子RANKL的表达 ,增强正畸牙压力侧的破骨细胞的活性 。 展开更多
关键词 口腔正畸学 层连蛋白 正畸力 RANKL 弱激光照射
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The Expression of MMP-3 and TIMP-1 During Orthodontic Periodontium Remodeling in Rats 被引量:3
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作者 FENGXue Duanying-zhong +1 位作者 LIYong-ming LINZhu 《口腔医学研究》 CAS CSCD 2003年第2期118-121,共4页
目的 :观察大鼠正畸牙周组织改建过程中基质金属蛋白酶 - 3(MMP - 3)和金属蛋白酶组织抑制因子 - 1(TIMP - 1)表达的变化 ,探讨MMP - 3及TIMP - 1与正畸牙齿移动的关系。方法 :在SD成年大鼠上颌右侧第一磨牙与上颌切牙之间安置正畸装置 ... 目的 :观察大鼠正畸牙周组织改建过程中基质金属蛋白酶 - 3(MMP - 3)和金属蛋白酶组织抑制因子 - 1(TIMP - 1)表达的变化 ,探讨MMP - 3及TIMP - 1与正畸牙齿移动的关系。方法 :在SD成年大鼠上颌右侧第一磨牙与上颌切牙之间安置正畸装置 ,建立大鼠磨牙移动实验模型。于牙齿移动 1、3、5、7、14d后取材分别进行免疫组化染色、图像分析。结果 :牙齿移动 1d后 ,牙周组织细胞MMP - 3表达增强 ,5d后MMP - 3表达达到高峰 ,此时破骨细胞胞浆亦呈强阳性表达。以后MMP - 3表达有所下降 ,但仍高于对照组。而TIMP - 1于牙齿移动 3d后表达开始增强 ,7d后显著表达。结论 :MMP - 3及TIMP - 1参与了正畸牙周组织改建过程 ,MMP - 3在破骨细胞性骨吸收中起着重要作用。 展开更多
关键词 正畸牙移动 基质金属蛋白酶-3 金属蛋白酶组织抑制因子-1 破骨细胞性骨吸收 动物实验
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正畸过程中牙齿三维方向变化的模型测量方法研究进展 被引量:1
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作者 李冉(综述) 侯彦 +1 位作者 刘娜 张扬(审校) 《中国美容医学》 CAS 2024年第3期189-193,共5页
牙齿三维方向上移动效率的评价是评估正畸疗效的重要内容之一。随着科学技术的发展,矫治器及矫正技术不断进步,用于研究正畸矫治牙齿三维方向移动效率的方法和工具也在不断更新。本文以牙齿移动测量方式发展为主线,介绍了由手工石膏模... 牙齿三维方向上移动效率的评价是评估正畸疗效的重要内容之一。随着科学技术的发展,矫治器及矫正技术不断进步,用于研究正畸矫治牙齿三维方向移动效率的方法和工具也在不断更新。本文以牙齿移动测量方式发展为主线,介绍了由手工石膏模型测量转向利用计算机软件对数字化模型的测量过程和依据,并对三维数字化模型数据获取方式、储存文件格式及可选择的分析处理软件进行了说明,以及回顾了前人对三维数字化模型进行三维重叠的部分研究,总结了目前对光学扫描及X线扫描得到的两种三维模型数据常用的配准方法和配准区域的选择。 展开更多
关键词 正畸学 三维测量 三维重叠 牙模型 牙移动
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两种隐形正畸序列磨牙远移的有限元比较 被引量:1
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作者 李慧 张栋梁 《医用生物力学》 CAS CSCD 北大核心 2024年第2期326-331,共6页
目的比较两种远中移动序列的无托槽隐形矫治在磨牙远移方面的执行效果。方法建立包含牙体、牙周膜、牙槽骨及隐形矫治器的下颌右侧7颗牙齿有限元模型,分别选用两种推磨牙远中移动对牙齿进行模拟第二磨牙远移0.5 mm的过程,采用牙槽骨重... 目的比较两种远中移动序列的无托槽隐形矫治在磨牙远移方面的执行效果。方法建立包含牙体、牙周膜、牙槽骨及隐形矫治器的下颌右侧7颗牙齿有限元模型,分别选用两种推磨牙远中移动对牙齿进行模拟第二磨牙远移0.5 mm的过程,采用牙槽骨重建技术模拟长期牙齿移动效果。结果V型、ZC远中移动序列第二磨牙最大远中位移分别为0.27、0.34 mm,ZC远中移动执行效率增大13.34%;牙齿内倾分别矫正0.18、0.44 mm,舌侧内倾角度分别矫正1.15°、2.69°,ZC舌侧内倾矫正率提高15.01%;远端倾斜分别增大1.83°、0.84°,ZC远端倾斜角度减小54.10%。结论ZC远中移动序列方法在无托槽隐形矫治中能够更有效地实现磨牙远中移动,减少磨牙远中倾斜和矫正磨牙舌侧内倾,为无托槽隐形矫治创造前牙间隙提供有利条件。 展开更多
关键词 无托槽隐形矫治 牙齿移动序列 下颌磨牙远移 有限元分析
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微创骨皮质切开术与经典改良骨皮质切开术对成人正畸牙移动的临床效果对比 被引量:1
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作者 杨雅娴 李玉如 彭德志 《河南医学研究》 CAS 2024年第8期1400-1403,共4页
目的比较微创骨皮质切开术与经典改良骨皮质切开术对成人正畸牙移动的临床效果。方法选取2020年1月至2022年12月在郑州大学第一附属医院就诊的120例错颌畸形成人患者,依据手术方式进行分组,即接受经典改良骨皮质切开术治疗的患者60例纳... 目的比较微创骨皮质切开术与经典改良骨皮质切开术对成人正畸牙移动的临床效果。方法选取2020年1月至2022年12月在郑州大学第一附属医院就诊的120例错颌畸形成人患者,依据手术方式进行分组,即接受经典改良骨皮质切开术治疗的患者60例纳入改良组,接受微创骨皮质切开术治疗的患者60例纳入微创组。统计两组牙排齐时间、间隙关闭时间、牙齿位置移动变化量、软组织变化量、硬组织变化量。结果微创组牙排齐时间、间隙关闭时间短于改良组(P<0.05);术后1、2、3个月微创组牙位置变化量均大于改良组(P<0.05);两组软组织变化量差异无统计学意义(P>0.05);改良组硬组织上颌骨前后突距离、上颌骨鼻距离、A点至颧弓的垂直距离、上颌骨硬组织高度变化量均大于微创组(P<0.05),两组硬组织A点至第二上臼齿的垂直距离、上颌骨第二上臼齿的硬组织高度变化量差异均无统计学意义(P>0.05)。结论微创骨皮质切开术与经典改良骨皮质切开术加速成人正畸牙移动效果相仿,牙排齐时间、间隙关闭时间方面微创骨皮质切开术更具优势,但经典改良骨皮质切开术在上颌骨和下颌骨调整方面更具优势。 展开更多
关键词 正畸牙移动 成人 微创 骨皮质切开术
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特立帕肽对骨质疏松大鼠正畸牙移动中牙根吸收影响的mirco-CT研究
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作者 宿晨曦 张程 +1 位作者 何姝姝 邹淑娟 《口腔医学研究》 CAS CSCD 北大核心 2024年第2期136-141,共6页
目的:使用mirco-CT探究特立帕肽对骨质疏松大鼠正畸牙移动过程中牙根吸收的影响。方法:将72只8周龄的雌性Wistar大鼠均分为去势组、特立帕肽组和对照组,对去势组及特立帕肽组行去卵巢手术并对对照组行假手术处理。12周后,对大鼠左上第... 目的:使用mirco-CT探究特立帕肽对骨质疏松大鼠正畸牙移动过程中牙根吸收的影响。方法:将72只8周龄的雌性Wistar大鼠均分为去势组、特立帕肽组和对照组,对去势组及特立帕肽组行去卵巢手术并对对照组行假手术处理。12周后,对大鼠左上第一磨牙施加50 g牙移动力;每日给予特立帕肽组大鼠特立帕肽溶液皮下注射,去势组及对照组给予等量的PBS溶液。牙移动第0、7、14、21天处死大鼠、取材并行micro-CT扫描分析。结果:各组从7 d起可开始观察到牙根吸收陷窝,且陷窝体积随时间延长逐渐增大。去势组大鼠的牙根吸收与对照组相比较为严重,特立帕肽治疗可以显著降低骨质疏松大鼠牙移动21 d时的牙根吸收。结论:骨质疏松状态可加重大鼠牙移动过程中的牙根吸收,间歇性应用特立帕肽可以减少骨质疏松大鼠正畸牙移动中的牙根吸收。 展开更多
关键词 骨质疏松 正畸牙移动 特立帕肽 牙根吸收
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大麻素2型受体在加速正畸牙移动中的作用
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作者 范登莹 翟浩嫣 +6 位作者 刘慧娟 赵圆 李东娜 乔星 康文静 朱德超 刘春艳 《安徽医科大学学报》 CAS 北大核心 2024年第2期212-218,共7页
目的 探讨大麻素2型受体(CB2)在正畸过程中对小鼠正畸牙移动(OTM)速率和压力侧牙周组织改建的作用。方法 筛选CB2^(-/-)和同窝WT型各30只雄性小鼠,6周龄时建立牙齿移动模型,建模时间分别为0、3、7、14、21 d(n=6)后取材,经体视显微镜测... 目的 探讨大麻素2型受体(CB2)在正畸过程中对小鼠正畸牙移动(OTM)速率和压力侧牙周组织改建的作用。方法 筛选CB2^(-/-)和同窝WT型各30只雄性小鼠,6周龄时建立牙齿移动模型,建模时间分别为0、3、7、14、21 d(n=6)后取材,经体视显微镜测量牙移动距离;HE染色观察根压力区牙周组织变化;TRAP染色统计根压力区破骨细胞数量;免疫组织化学染色观察根压力区基质金属蛋白酶-9(MMP-9)阳性单核细胞和多核细胞的数量变化。结果 正畸牙移动距离测量结果显示,在21 d内,随着时间延长,牙齿移动距离逐渐增加,且3、7、14、21 d时CB2^(-/-)组牙齿移动距离均较WT小鼠增加;HE染色显示OTM第14天时CB2^(-/-)小鼠压力区牙周膜间隙宽度大于WT小鼠(P<0.000 1);TRAP染色显示14 d时,在第一磨牙远中根压力区硬骨板处,CB2^(-/-)小鼠的破骨细胞数量大于WT小鼠(P<0.001);MMP-9免疫组织化学染色显示OTM 14 d时,在压力区牙周膜区域,CB2^(-/-)小鼠的MMP-9(+)单核细胞和MMP-9(+)多核细胞数量均大于WT小鼠(P<0.05)。结论 CB2可加速正畸力作用下牙齿移动速率。CB2缺失加速正畸牙移动是通过加速牙移动过程中压力侧骨吸收实现的。 展开更多
关键词 大麻素2型受体 正畸牙移动 压力区 骨改建 破骨细胞
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