Insulin-Like Growth Factor-1 and Osteocalcin Are Correlated with Markers of Osteoporosis in Postmenopausal Women with Type-2 Diabetes

Objective: The study was conducted to evaluate the relation between insulin-like growth factor-1 and osteocalcin and markers of bone modulation (osteoprotegerin;OPG, receptor activator nuclear kappa B;RANK and RANK ligand;RANKL) in postmenopausal Type 2 diabetic women with and without osteoporosis. Methods: The study was conducted on 90 female divided into three groups (30 each). Group I included healthy postmenopausal women as a control, Group II included diabetic postmenopausal women without osteoporosis Group III included diabetic postmenopausal women with osteoporosis. Fasting blood samples were obtained for the determination of blood glucose, HbA1c, total and ionized calcium, OPG, RANK and RANKL. Also the levels of IGF-1 and osteocalcin were assessed. Results: In postmenopausal Type 2 diabetic women, the osteoporosis resulted in derangement in OPG/sRANKL system. The serum level of OPG was elevated while sRANKL declines in osteoporotic postmenopausal Type 2 diabetic women. IGF-1 level decreased in diabetic postmenopausal women but those women with osteoporosis showed a great decline by about 60%. IGF-1 level in osteoporotic diabetic postmenopausal women was correlated with BMD and most bone turnover markers (OPG, sRANKL, OPG/sRANKL). Osteocalcin declined significantly only in those women with osteoporosis not without osteoporosis. Conclusions: The circulating levels of OPG and sRANKL were not useful markers for bone status in postmenopausal women while the circulating levels of IGF-1 and osteocalcin might give useful information about bone status in postmenopausal diabetic women.

肥胖型男性2型糖尿病患者性激素和骨钙素水平的变化及其与IR的相关性

目的:探讨肥胖型男性2型糖尿病(T2D M)患者性激素、血清骨钙素(OC)水平的变化情况及其与胰岛素抵抗(I R)的相关性。方法:以我院收治的肥胖型男性T2D M患者100例为T2D M组,另选45例年龄相仿、同期来我院体检的健康男性作为对照组。记录所有受试者的一般临床资料,检测性激素水平,包括促卵泡激素(F S H)、黄体生成素(L H)、雌二醇(E2)、睾酮(T);检测OC、空腹血糖(FBG)、餐后2小时血糖(2hPBG)、空腹胰岛素(F I N S)水平,并计算胰岛素抵抗指数(HOMA-IR);采用P e a r s on相关性分析分析性激素、OC水平与HOMAIR的相关性。结果:T2D M组患者的F B G、2h P B G、F I N S、H b A1c、H O M A-I R、E2水平均显著高于对照组(P<0.05);O C水平、T水平显著低于对照组(P<0.05)。肥胖型男性T2D M患者血清E2水平与H O M A-I R成正相关关系(r=0.172,P<0.05),血清T水平、OC水平与H OMA-IR成负相关关系(r=-0.166、r=-0.216,P<0.05)。结论:肥胖型男性T2D M患者OC水平、E2水平、T水平与I R有关,改善肥胖型男性T2D M患者OC及性激素水平对于改善IR情况、缓解病情可能具有积极意义。