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Catheter-Assisted Interlaminar Approach for Cervical Epidural Steroid Injection in Patient with Cervical Stenosis Caused by Ossification of Posterior Longitudinal Ligament: A Case Report
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作者 Yong-Hui Liu You-Wen Wu 《Case Reports in Clinical Medicine》 2024年第8期304-308,共5页
We present the case of a 64-year-old man with cervical ossification of the posterior longitudinal ligament (OPLL) experiencing chronic neck pain and radiculopathy for 6 months. A catheter-assisted interlaminar Cervica... We present the case of a 64-year-old man with cervical ossification of the posterior longitudinal ligament (OPLL) experiencing chronic neck pain and radiculopathy for 6 months. A catheter-assisted interlaminar Cervical Epidural Steroid Injection (CESI) was performed under fluoroscopic guidance, targeting the affected C2-C6 levels. Significant improvement was observed after this procedure, with decreased pain scores (visual analogue scale (VAS) 8 to 2) and improved mobility. This technique not only enhances the effectiveness of CESI but also reduces the likelihood of complications such as stroke or epidural hematoma and thus provides an alternative treatment option for patients with multiple stenotic levels who are unsuitable for surgery or are unresponsive to conservative therapy such as medication or physical therapy. 展开更多
关键词 Catheter-Assisted Interlaminar Cervical Epidural Steroid Injection Ossification of posterior longitudinal ligament Cervical Stenosis
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Regression of intervertebral disc calcification combined with ossification of the posterior longitudinal ligament:A case report
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作者 Xu-Dong Wang Xian-Jun Su +1 位作者 Yao-Kun Chen Wen-Gang Wang 《World Journal of Clinical Cases》 SCIE 2021年第24期7285-7291,共7页
BACKGROUND Intervertebral disc calcification(IDC)combined with ossification of the posterior longitudinal ligament(OPLL)in cervical discs is rarely reported.This case study presents a rare case of IDC combined with OP... BACKGROUND Intervertebral disc calcification(IDC)combined with ossification of the posterior longitudinal ligament(OPLL)in cervical discs is rarely reported.This case study presents a rare case of IDC combined with OPLL in the C2-C3 segment.CASE SUMMARY Here,we present a case of a 6-year-old Asian boy with severe neck pain and stiffness.Physical examination showed no neurological or other abnormalities.Digital radiography and computed tomography(CT)revealed a calcified intervertebral disc and OPLL at the C2-C3 vertebrae.The spinal canal compromise at C2-C3 was approximately 50%on magnetic resonance imaging.The final diagnosis was IDC combined with OPLL.We applied a neck brace for the patient to protect the neck.The patient's neck pain and stiffness recovered significantly within approximately 3 wk.At the 3 mo follow-up,the follow-up CT showed resolution of the ossified intervertebral disc herniation,and a small amount of calcification and slight OPLL remained at the involved segment.CONCLUSION IDC combined with OPLL is a relatively rare condition in children.However,the majority of patients could have a favorable outcome,and the ossified mass in the canal would be spontaneously resolved with conservative therapy. 展开更多
关键词 Intervertebral disc calcification Ossification of the posterior longitudinal ligament DIAGNOSIS TREATMENT Case report
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Enlarged laminectomy for ossification of posterior longitudinal ligament in cervical spine
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作者 赵晓涛 《外科研究与新技术》 2011年第2期83-84,共2页
Objective To introduce surgical strategy of enlarged laminectomy (with partial facet joint dissection to expose nerve root) ,and to discuss its benefit for cervicalossification of posterior longitudinal ligament (OPLL)
关键词 OPLL Enlarged laminectomy for ossification of posterior longitudinal ligament in cervical spine JOA
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The clinical features and treatment strategies of thoracic ossification of posterior longitudinal ligament
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作者 孙景城 《外科研究与新技术》 2011年第2期101-101,共1页
Objective To study the clinical features and surgical strategies of thoracic spinal stenosis caused by ossification of posterior longitudinal ligament(OPLL).Methods From January 2004 to March 2009,21 cases of tho-raci... Objective To study the clinical features and surgical strategies of thoracic spinal stenosis caused by ossification of posterior longitudinal ligament(OPLL).Methods From January 2004 to March 2009,21 cases of tho-racic spinal stenosis 展开更多
关键词 OPLL The clinical features and treatment strategies of thoracic ossification of posterior longitudinal ligament JOA
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"Cave-in"technique: 360° circumferential decompression for thoracic spinal stenosis with ossification of posterior longitudinal ligament
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作者 刘晓光 《外科研究与新技术》 2011年第2期99-100,共2页
Objective To investigate the surgical techniqueand efficiency of the "Cave-in" 360° circumferential decompression for thoracic spinal stenosis(TSS)with ossification of posterior longitudinal ligament(OP... Objective To investigate the surgical techniqueand efficiency of the "Cave-in" 360° circumferential decompression for thoracic spinal stenosis(TSS)with ossification of posterior longitudinal ligament(OPLL).Methods From October 2005 to 展开更多
关键词 OPLL Cave-in"technique circumferential decompression for thoracic spinal stenosis with ossification of posterior longitudinal ligament
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DAPK2 promotes autophagy to accelerate the progression of ossification of the posterior longitudinal ligament through the mTORC1 complex
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作者 LEI SHI JIANSHI YIN +2 位作者 YU CHEN JIANGANG SHI JINHAO MIAO 《BIOCELL》 SCIE 2024年第9期1389-1400,共12页
Background:Ossification of the posterior longitudinal ligament(OPLL)is a prevalent condition in orthopedics.While death-associated protein kinase 2(DAPK2)is known to play roles in cellular apoptosis and autophagy,its ... Background:Ossification of the posterior longitudinal ligament(OPLL)is a prevalent condition in orthopedics.While death-associated protein kinase 2(DAPK2)is known to play roles in cellular apoptosis and autophagy,its specific contributions to the advancement of OPLL are not well understood.Methods:Ligament fibroblasts were harvested from patients diagnosed with OPLL.Techniques such as real-time reverse transcriptasepolymerase chain reaction(RT-qPCR)and Western blot analysis were employed to assess DAPK2 levels in both ligament tissues and cultured fibroblasts.The extent of osteogenic differentiation in these cells was evaluated using an alizarin red S(ARS)staining.Additionally,the expression of ossification markers and autophagy markers was quantified.The autophagic activity was further analyzed through LC3 immunofluorescence and transmission electron microscopy(TEM).An in vivo heterotopic bone formation assay was conducted in mice to assess the role of DAPK2 in ossification.Results:Elevated DAPK2 expression was confirmed in both OPLL patient tissues and derived fibroblasts,in contrast to non-OPLL controls.Silencing of DAPK2 significantly curtailed osteogenic differentiation and autophagy in these fibroblasts,evidenced by decreased levels of LC3,and Beclin1,and reduced autophagosome formation.Additionally,DAPK2 was found to inhibit the mechanistic target of the rapamycin complex 1(mTORC1)complex’s activity.In vivo studies demonstrated that DAPK2 facilitates ossification,and this effect could be counteracted by the mTORC1 inhibitor rapamycin.Conclusion:DAPK2 enhances autophagy and osteogenic processes in OPLL through modulation of the mTORC1 pathway. 展开更多
关键词 Ossification of the posterior longitudinal ligament DAPK2 Autophagy mTORC1
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Association between two polymorphisms of the bone morphogenetic protein-2 gene with genetic susceptibility to ossification of the posterior longitudinal ligament of the cervical spine and its severity 被引量:25
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作者 WANG Hao YANG Zhao-hui +3 位作者 LIU Dong-mei WANG Ling MENG Xiang-long TIAN Bao-peng 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第18期1806-1810,共5页
Background Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic background. Previous studies have shown that bone morphogenetic protein-2 (BMP2) and BMP2 mRNA are expressed in ossifying ... Background Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic background. Previous studies have shown that bone morphogenetic protein-2 (BMP2) and BMP2 mRNA are expressed in ossifying matrix and chondrocytes adjacent to cartilaginous areas of OPLL tissues and mesenchymal cells with fibroblastic features in the immediate vicinity of the cartilaginous areas. It is suggested that BMP2 plays different roles in the different stages of development of OPLL. However, it remains unknown which factors induce ligament cells to produce BMP2. Methods OPLL patients (n=-192) and non-OPLL controls (n=304) were studied. Radiographs of the cervical spine were analyzed for extent of OPLL. We investigated whether single nucleotide polymorphisms of exons 3(-726) T/C and 3(-583) NG in the BMP2 gene are statistically associated with genetic susceptibility to OPLL in Chinese Han subjects. Results There was no statistical difference between the occurrence of exons 3(-726) T/C and 3(-583) NG and the occurrence of OPLL in the cervical spine. However, there was a significant association between occurrence of exon 3(-726) T/C polymorphism and occurrence of OPLL in males of cases and controls in the cervical spine. In addition, no significant association was found between the exons 3(-726) T/C and 3(-583) A/G with number of ossified cervical vertebrae in OPLL patients. Conclusions Exon 3(-583) A/G polymorphism in BMP2 gene is not associated with the occurrence and the extent of OPLL in the cervical spine. Chinese Han male patients with TC and CC genotypes in exon 3(-726) T/C have genetic susceptibility to OPLL but not to more extensive OPLL in the cervical spine. 展开更多
关键词 ossification of the posterior longitudinal ligament bone morphogenetic protein-2 single nucleotide polymorphisms case control study
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Linkage of three polymorphisms on chromosome 20p12 to ossification of the posterior longitudinal ligament of spine and its severity in Han Chinese patients 被引量:13
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作者 YAN Liang ZHAO Wei-guang +3 位作者 LI Jin-jun YANG Hui WANG Hao LIN Xin 《Chinese Medical Journal》 SCIE CAS CSCD 2010年第17期2341-2346,共6页
Background Ossification of the posterior longitudinal ligament (OPLL) is characterized by the replacement of ligamentous tissue with new ectopic bone formation, and has a strong genetic background. Because of the ab... Background Ossification of the posterior longitudinal ligament (OPLL) is characterized by the replacement of ligamentous tissue with new ectopic bone formation, and has a strong genetic background. Because of the abnormal bone metabolic features and the strong genetic component, osteoporosis is a related disorder with OPLL. Three polymorphisms on chromosome 20p12 were identified associated with the risk of osteoporosis and osteoporotic fracture.The rs996544 (C/T) "TT" and rs965291 (G/A) "AA" genotypes conferred higher risks for vertebral and hip fractures. The osteoporosis haplotype is defined by two polymorphisms, rs1116867 (A) and D35548 (T). However, it remains unknown whether these three polymorphisms predispose to an increased frequency and severity of OPLL in Han Chinese patients.Methods A total of 420 OPLL patients and 506 age- and sex-matched controls were studied. Three single nucleotide polymorphisms (SNPs), rs996544 (C/T), rs965291 (G/A) and rs1116867 (A/G), were analyzed by direct sequencing.Associations between these SNPs with the occurrence and extent of OPLL were statistically evaluated.Results There was no significant association between the rs996544 (C/T) polymorphism and the prevalence of OPLL.The rs1116867 (A/G) polymorphism "AG" genotype was associated with the occurrence of OPLL. The rs1116867 (A/G) polymorphism "G" allele was associated with the occurrence of OPLL, but not with the extent of OPLL. The rs965291 (G/A) polymorphism in female patients was statistically different between cases and controls (P 〈0.05). The rs965291 (G/A) polymorphism "A" allele was associated with the occurrence of OPLL in female patients. For the rs965291 (G/A)polymorphism, patients with the "A" allele (genotype, "AG" or "AA") showed a significantly greater number of ossified cervical vertebrae than those without the "A" allele (genotype, "GG", P 〈0.05), particularly in female patients.Conclusions The rs1116867 (A/G) and rs965291 (G/A) polymorphisms on chromosome 20p12 are associated with the occurrence and the extent of OPLL, at least in Han Chinese subjects. Our data should advance our understanding of the molecular etiology of OPLL and may guide approaches to prevent the onset of OPLL. 展开更多
关键词 ossification of the posterior longitudinal ligament single nucleotide polymorphisms susceptibility polymerase chain reaction
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Classification and management of the tandem ossification of the posterior longitudinal ligament and flaval ligament 被引量:8
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作者 GUO Jiong-jiong YANG Hui-lin +2 位作者 Kenneth M.C. Cheung TANG Tian-si Keith D.K. Luk 《Chinese Medical Journal》 SCIE CAS CSCD 2009年第2期219-224,共6页
Objective To provide appropriate guidelines for treatment of tandem ossification of the posterior longitudinal ligament (OPLL) and flaval ligament (OFL). Data sources Published articles about OPLL and OFL were sel... Objective To provide appropriate guidelines for treatment of tandem ossification of the posterior longitudinal ligament (OPLL) and flaval ligament (OFL). Data sources Published articles about OPLL and OFL were selected using Medline and Embase electronic databases. Study selection An English literature search from January 1980 to December 2006 was conducted. Because many reported cases were incorporated in OFL studies, the key words for search were OFL or OFL and OPLL. The first step revealed 93 studies of which 13 reports of tandem OPLL and OFL (tandem ossification) were selected. Results All studies were case series or case report and advocated that the primary therapy for tandem ossification should be operative. The clinical outcomes of surgery were evaluated in most reports, predominantly using the JOA scores. Gender is the only factor which has prognostic value. A higher proportion of women was found in the failure group A two- stage classification of tandem ossification was developed to relate diagnosis to outcome. Conclusions All patients with suspected ossification of the spinal ligaments should undergo routine MRI screening of the whole spine. The correlation of the classification with surgical treatments needs further studies to validate its usefulness. Chin Med J 2009; 122(2):219-224 展开更多
关键词 OSSIFICATION posterior longitudinal ligament flaval ligament ligamentum flavum tandem
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A single nucleotide polymorphism in the human bone morphogenetic protein-2 gene (109T〉G) affects the Smad signaling pathway and the predisposition to ossification of the posterior longitudinal ligament of the spine 被引量:8
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作者 YAN Liang CHANG Zhen +3 位作者 LIU Yang LI Yi-bing HE Bao-rong HAO Ding-jun 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第6期1112-1118,共7页
Background Although various systemic and local factors such as abnormal carbohydrate or calcium metabolism, aging, and hormonal disturbances have been suggested as causes of ossification of the posterior longitudinal ... Background Although various systemic and local factors such as abnormal carbohydrate or calcium metabolism, aging, and hormonal disturbances have been suggested as causes of ossification of the posterior longitudinal ligament (OPLL), the etiology of OPLL is not fully understood. The purpose of this study was to investigate whether bone morphogenetic protein (BMP)-2 is a candidate gene to modify the susceptibility of OPLL and the mechanism of signal transduction in ossification. Methods A total of 420 OPLL patients and 506 age- and sex-matched controls were studied. The complete coding sequence of the human BMP-2 gene was analyzed using polymerase chain reaction (PCR) and direct sequencing. All single nucleotide polymorphisms (SNPs) were detected and genotyped. BMP-2 expression vectors containing positive polymorphisms were constructed and transfected into the C3H10T1/2 cells. The expression of BMP-2 and the Smad signal pathway in positive cell clones were detected by Western blotting. The alkaline phosphatase (ALP) activity was determined using quantitative detection kits. Results The frequencies for the 109T〉G and 570A〉T polymorphisms were different between the case and control groups. The "TG" genotype in 109T〉G polymorphism is associated with the occurrence of OPLL, the frequency of the "G" allele is significantly higher in patients with OPLL than in control subjects (P 〈0.001). The "AT" genotype in 570A〉T polymorphism is associated with the occurrence of OPLL, the frequency of the "T" allele is significantly higher in patients with OPLL than in control subjects (P=0.005). Western blotting analysis revealed that the expression of P-Smadl/5/8 protein transfected by wild-type or mutant expression vectors were significantly higher than control groups (P 〈0.05), but there was no statistical difference in each experimental group (P 〉0.05). The expression of Smad4 protein transfected by wild-type or mutant expression vectors was significantly higher than control groups (P 〈0.05). The expression of Smad4 protein transfected by pcDNA3.1-BMP2 (109G) and pcDNA3.1-BMP2 (109G, 570T) was significantly higher than the other experimental groups (P 〈0.05). The increase in ALP activity has been detected in pcDNA3.1-BMP2 (109G) and pcDNA3.1-BMP2 (109G, 570T) transfected cells up to 4 weeks after stable transfection. Activity of ALP was (30.56±0.46) nmol.min^-1.mg^-1 protein and (29.62±0.68) nmol.min^-1.mg^-1 protein, respectively. This was statistically different compared with the other experimental groups (P 〈0.05). Conclusions BMP-2 is the predisposing gene of OPLL. The "TG" genotype in the 109T〉G and the "AT" genotype in the 570A〉T polymorphisms are associated with the occurrence of OPLL. The 109T〉G polymorphism in exon-2 of the BMP-2 gene is positively associated with the level of Smad4 protein expression and the activity of ALP. The Smad mediated sicjnaling pathway plays an important role durincl the Datholoqical process of OPLL induced by SNPs of BMP-2 aene. 展开更多
关键词 ossification of the posterior longitudinal ligament single nucleotide polymorphisms bone morphogenetic protein-2 signal transduction
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Clinical results and intramedullary signal changes of posterior decompression with transforaminal interbody fusion for thoracic myelopathy caused by combined ossification of the posterior longitudinal ligament and ligamentum flavum 被引量:11
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作者 Wang Lin-feng Liu Fa-jing +3 位作者 Zhang Ying-ze Shen Yong Ding Wen-yuan Xu Jia-xin 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第20期3822-3827,共6页
Background Surgical treatment of thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) is technically demanding, and the results t... Background Surgical treatment of thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) is technically demanding, and the results tend to be unfavorable. Various operative approaches and treatment strategies have been attempted, and posterior decompression with transforaminal thoracic interbody fusion (PTTIF) may be the optimal method with which the anterior-posterior compression was removed in one step. It is comparatively less traumatic with fewer serious complications. 展开更多
关键词 transforaminal thoracic interbody fusion thoracic myelopathy ossification of posterior longitudinal ligament ossification of ligamentum flavum intramedullary signal change
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T allele at site 6007 of bone morphogenetic protein-4 gene increases genetic susceptibility to ossification of the posterior longitudinal ligament in male Chinese Han population 被引量:6
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作者 MENG Xiang-long WANG Hao +3 位作者 YANG Hui HAI Yong TIAN Bao-peng LIN Xin 《Chinese Medical Journal》 SCIE CAS CSCD 2010年第18期2537-2542,共6页
Background Several candidate genes of ossification of the posterior longitudinal ligament (OPLL) susceptibility have been identified, but their polymorphisms account for only a small percent of the total variance. B... Background Several candidate genes of ossification of the posterior longitudinal ligament (OPLL) susceptibility have been identified, but their polymorphisms account for only a small percent of the total variance. Bone morphogenetic protein-4 (BMP4) is a potent ectopic ossification inducing factor. BMP4 protein and mRNA are present in cells from OPLL patients, but not non-OPLL controls. A single nucleotide polymorphism of 6007C〉T(rs17563) of BMP4 has been reported to affect bone density in postmenopausal women. Thus, BMP4 may function in OPLL development. Appropriately, the relationship between BMP4 polymorphisms and OPLL was investigated. Methods A case-control association study investigated the genetic etiology in 179 OPLL patients and 298 non-OPLL controls. Extent of OPLL was analyzed by radiologic examinations. Whether single nucleotide polymorphism (SNP) of -5826G〉A(rs1957860) 5' of the transcription start site and 6007C〉T(rs17563) in exon 4 of the BMP4 gene were statistically associated with genetic susceptibility to OPLL in Chinese Han subjects was assessed. Results A significant statistical difference in genotype of 6007C〉T polymorphism between male OPLL patients and male controls was evident, and the frequency of "TT" genotype in male OPLL patients was significantly higher than in male controls (P=0.039). The frequency of the "T" allele was also significantly higher in male OPLL subjects than in male controls (P=0.014, OR=1.57). A significant difference was also observed between the 6007C〉T polymorphism and the number of ossified cervical vertebrae in OPLL patients, while no statistical difference was apparent between the -5826G〉A polymorphism and OPLL occurrence. Conclusions The T allele in the 6007C〉T polymorphism may be a risk factor for male Han Chinese with ossification of the posterior longitudinal ligament in the cervical spine. Chinese Han male patients with CT and TT 6007C〉T genotypes have a genetic susceptibility to OPLL and more extensive OPLL in the cervical spine. 展开更多
关键词 ossification of the posterior longitudinal ligament bone morphogenetic protein-4 single nucleotide polymorphisms case control study
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Circumferential decompression via the posterior approach for the surgical treatment of multilevel thoracic ossification of the posterior longitudinal ligaments: a single institution comparative study 被引量:4
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作者 Liu Xiao Zhu Bin Liu Xiaoguang Liu Zhongjun Dang Gengting 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第19期3371-3377,共7页
Background The treatment strategies for multilevel thoracic ossification of the posterior longitudinal ligaments (T-OPLL) were rarely reported. The aim of this study was to investigate the clinical outcomes and comp... Background The treatment strategies for multilevel thoracic ossification of the posterior longitudinal ligaments (T-OPLL) were rarely reported. The aim of this study was to investigate the clinical outcomes and complications of circumferential decompression for multilevel T-OPLL and compare two different methods in the management of the OPLL (resection or floating). Methods Data of sequentially treated patients who received surgical treatment for thoracic spinal stenosis caused by multilevel T-OPLL from January 2005 to February 2012 were retrospectively reviewed. Based on the surgical approaches applied, the patients were divided into two groups. Group A consisted the patients who received posterior decompression and group B consisted the patients who received circumferential decompression via the posterior approach. Group B was further divided into two subgroups: subgroup 1 (the resection group) where the OPLL was completely resected and subgroup 2 (the floating group) where the OPLL was floated. Results A total of 49 patients were included in the study. Fourteen patients with single posterior decompression were included in group A and 35 patients who received circumferential decompression were included in group B. In group B, 29 patients had complete resection of the ossified posterior longitudinal ligaments, while the other six underwent a flotation procedure. The follow-up data were available in 39 patients. Mean JOA scores improved from 5.4 ± 1.8 to 7.5 ± 2.8 in group A and from 3.7 ± 1.8 to 7.9 ± 2.4 in group B. The main complications included cerebrospinal fluid (CSF) leakage and postoperative neurelogic deterioration (ND). Twenty-three of the 25 cases with postoperative CSF leakage achieved a complete recovery at the last follow-up and 12 of the 15 cases with ND achieved some neurological improvement at the last follow-up. Conclusions Circumferential decompression via the posterior approach is an effective surgical method for thoracic spinal stenosis caused by multilevel OPLL of the thoracic spine. Patients who receive complete resection of the ossified posterior longitudinal ligaments may have better recovery rate than the "floating" group. 展开更多
关键词 ossification of the posterior longitudinal ligament MULTILEVEL thoracic spinal stenosis intraoperative ultrasonography
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Quantitative analysis of cyclooxygenase 2 in the posterior longitudinal ligament of cervical spondylotic myelopathy 被引量:1
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作者 SONG Hong-xing Michael Scarpatetti +5 位作者 Wolfgang Kreil SHEN Hui-liang Koppany Bodo Birgit Ebner Heribert Schrottner Michael Mokry 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第16期2480-2484,共5页
Background Cervical spondylotic myelopathy (CSM), in part, results from degeneration of the posterior longitudinal ligament (PLL), which mechanically compresses the spinal cord. Much research was done on the ossif... Background Cervical spondylotic myelopathy (CSM), in part, results from degeneration of the posterior longitudinal ligament (PLL), which mechanically compresses the spinal cord. Much research was done on the ossification of PLL, but not concerning the non-ossifying degeneration of cervical PLL. The degeneration of cervical PLL may be related to inflammation. The aim of this study was to elucidate the pathological features of the PLL and the role of cyclooxygenase 2 (COX-2) in the degeneration of the PLL in CSM. Methods A total of 23 PLL specimens were collected during surgery from patients with CSM for the histological and immunohistochemical (type II collagen and Ki-67) study. For the control group 14 cervical PLL autopsy specimens were investigated in the same manner, mRNA expression of COX-2 was quantitatively measured by real-time reverse transcription-polymerase chain reaction (RT-PCR) from 18 PLL specimens of patients with CSM and 18 PLL specimens of autopsy cases. Immunohistochemistry was used to evaluate the cellular location of COX-2 in PLL. Results A distinct amount of fibrotic area, chondrometaplastic tissue and calcification were found in the PLL of the patient group, compared with the control group. Type II collagen was apparent around chondrometaplastic cells. Ki-67 positive reaction was less than 5%. A COX-2 positive reaction was found in 9 of the patient specimens (39.1%) in which the COX-2 was released from vascular endothelial cells in the PLL. However, such reactions were not found in the control group. Real-time PCR showed that the mRNA expression level of COX-2 in the patient group was significantly higher than that in the control group (P〈0.01). Conclusions Chondrometaplastic tissue producing type II collagen was identified as the most predominant pathological feature in the degenerative PLL. The higher expression of COX-2 might be related to degeneration of the PLL in CSM. 展开更多
关键词 posterior longitudinal ligament cyclooxygenase 2 IMMUNOHISTOCHEMISTRY polymerase chain reaction
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Removal versus preservation of the posterior longitudinal ligament in Bryan cervical disc arthroplasty 被引量:1
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作者 Yang Da-long Ding Wen-yuan +3 位作者 Zhang Ying-ze Zhang Wei Xu Jia-xin Shen Yong 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第20期3812-3816,共5页
Background Bryan cervical disc arthroplasty can be used to restore and maintain the mobility and function of the involved cervical spinal segments. The efficiency of posterior longitudinal ligament (PLL) resection i... Background Bryan cervical disc arthroplasty can be used to restore and maintain the mobility and function of the involved cervical spinal segments. The efficiency of posterior longitudinal ligament (PLL) resection in anterior cervical decompression and fusion has been demonstrated. However, no clinical reports have compared PLL removal with preservation in Bryan cervical disc arthroplasty. This study aimed to assess the role of removal of PLL in Bryan cervical disc arthroplasty at an 18-month follow-up. 展开更多
关键词 posterior longitudinal ligament Bryan cervical disc arthroplasty functional spinal unit
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A Case of Acute Cauda Equina Syndrome for Combined Lumbar Ossification of the Posterior Longitudinal and Yellow Ligament 被引量:2
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作者 Kazumasa Nakamura Yuichirou Yokoyama +5 位作者 Akihito Wada Yasuhiro Inoue Keiji Hasegawa Shintaro Tsuge Hiroshi Takahashi Yasuaki Iida 《Open Journal of Orthopedics》 2014年第6期145-149,共5页
Acute cauda equina syndrome is known as a symptom of lumbar disc herniation, but to date, there have been no reports of cases caused by lumbar vertebral ligament ossification. We encountered a 61-year-old female patie... Acute cauda equina syndrome is known as a symptom of lumbar disc herniation, but to date, there have been no reports of cases caused by lumbar vertebral ligament ossification. We encountered a 61-year-old female patient with acute cauda equina syndrome associated with lumbar vertebral OPLL and OLF. The symptoms were improved by emergency laminectomy. One year after the surgery, the disturbances of gait and urination have been resolved. 展开更多
关键词 LUMBAR SPINE OSSIFICATION of the YELLOW ligament OSSIFICATION of the posterior longitudinal ligament Cauda Equina Syndrome
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自噬相关基因Beclin1和LC3在颈椎后纵韧带骨化组织中的表达及其与成骨因子的相关性分析 被引量:1
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作者 连笑宇 邵佳 +4 位作者 高坤 余正红 菅炎鹏 王一公 高延征 《中国脊柱脊髓杂志》 CAS CSCD 北大核心 2024年第1期70-76,共7页
目的:探讨自噬相关基因Beclin1和LC3在颈椎后纵韧带骨化组织中的表达水平及其与成骨因子的相关性。方法:收集2020年10月~2021年5月经手术切除的颈椎后纵韧带骨化(ossification of posterior longitudinal ligament,OPLL)患者的18例后纵... 目的:探讨自噬相关基因Beclin1和LC3在颈椎后纵韧带骨化组织中的表达水平及其与成骨因子的相关性。方法:收集2020年10月~2021年5月经手术切除的颈椎后纵韧带骨化(ossification of posterior longitudinal ligament,OPLL)患者的18例后纵韧带组织标本(OPLL组)和15例非骨化的颈椎后纵韧带组织标本(非OPLL组)。苏木精-伊红(hematoxylin-eosin,HE)染色观察颈椎后纵韧带组织形态学改变;Von Kossa染色观察颈椎后纵韧带钙盐沉积情况;通过免疫组织化学染色及实时定量聚合酶链反应(RT-qPCR)技术分别测定两组标本中Beclin1、微管相关蛋白轻链(microtubule associated protein light chain 3,LC3)和Runt-相关转录因子-2(runt-related transcription factor 2,RUNX2),骨形态发生蛋白-2(bone morphogenetic protein-2,BMP-2)及Osterix的mRNA及蛋白的表达水平;采用Pearson相关性分析行Beclin1、LC3与RUNX2、BMP2及Osterix的关系研究。结果:与非OPLL组相比,OPLL组细胞形态较大且形状不规则,细胞核较明显;Von Kossa染色可见非OPLL组无明显钙盐沉积,而OPLL组可见棕黑色钙盐并聚积成片状或团状;Beclin1、LC3、RUNX2、BMP2及Osterix的蛋白及mRNA在OPLL组中的表达水平显著高于非OPLL组(P<0.05);Beclin1 mRNA表达水平与BMP2、RUNX2和Osterix具有显著相关性(P<0.05,r>0.5),而LC3与成骨因子不具备相关性。结论:自噬相关基因Beclin1和LC3在颈椎OPLL组织中显著高表达,Beclin1与后纵韧带成骨密切相关。 展开更多
关键词 后纵韧带 颈椎 自噬 成骨因子 相关性
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颈椎前路椎体骨化物可控前移融合对后纵韧带骨化物和内植物影响的有限元分析
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作者 李良奎 黄永灿 +1 位作者 王鹏 于滨生 《中国组织工程研究》 CAS 北大核心 2025年第9期1761-1767,共7页
背景:颈椎前路椎体骨化物可控前移融合对颈椎力学的影响尚未明确,既往研究主要集中在颈椎前路椎体骨化物可控前移融合的手术技巧、中长期疗效和术后并发症等。目的:运用有限元方法分析颈椎前路椎体骨化物可控前移融合对颈椎后纵韧带骨... 背景:颈椎前路椎体骨化物可控前移融合对颈椎力学的影响尚未明确,既往研究主要集中在颈椎前路椎体骨化物可控前移融合的手术技巧、中长期疗效和术后并发症等。目的:运用有限元方法分析颈椎前路椎体骨化物可控前移融合对颈椎后纵韧带骨化物和内植物生物力学的影响。方法:选择一名健康男性志愿者进行全颈椎薄层CT扫描,应用有限元分析软件构建正常全颈椎模型,与既往文献进行对比验证其有效性;随后在模型上构建累及C4、C5和C6节段的连续型颈椎后纵韧带骨化物的术前模型;以术前模型为基础,创建颈椎前路椎体骨化物可控前移融合手术三维有限元模型,约束2个模型C7椎体下表面,于C1椎体上表面施加50 N的轴向力和1.0 N·m的力矩,在屈伸、侧弯、旋转6个工况下,分析颈椎前路椎体骨化物可控前移融合对骨化物和内植物应力的影响。结果与结论:①从术前模型得出骨化物应力主要集中在C4/5节段,在前屈、后伸、左侧弯、右侧弯、左旋转、右旋转6个工况下骨化物最大应力分别为10.1,148.6,68.9,74.8,83.8和85.1 MPa;②颈椎前路椎体骨化物可控前移融合术后,骨化物应力集中分布区域未见明显改变,但该手术会改变骨化物应力大小,除在前屈位颈椎前路椎体骨化物可控前移融合模型骨化物应力较术前模型增大(+44.7%)外,在其他5个工况下,骨化物应力较术前模型明显降低,其中后伸位下降最明显(-74.1%),在左侧弯、右侧弯、左旋转、右旋转下骨化物应力分别下降62.2%,63.3%,66.4%,67.9%;③钛板、螺钉应力主要集中在头尾两端,后伸应力最大(149.5 MPa),前屈应力最小(43.3 MPa);4个椎间融合器应力主要集中在C3/4、C6/7融合器,应力主要分布在融合器的上下表面周围,后伸应力最大(30.8 MPa),前屈应力最小(11.5 MPa);内植物(钛板、螺钉和椎间融合器)应力主要集中于头尾两端,应力较大易导致头尾两端钛板、螺钉断裂和内植物下沉;④提示颈椎前路椎体骨化物可控前移融合能明显降低骨化物应力,可能有助于防止过度增生从而压迫神经,在术后需密切关注头尾两端螺钉松动、断裂或钛板移位、断裂等情况。 展开更多
关键词 颈椎后纵韧带骨化症 颈椎前路椎体骨化物可控前移融合术 有限元分析 韧带骨化物 内植物 生物力学
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弹簧韧带损伤的研究进展
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作者 赵文博(综述) 余彬 +1 位作者 梁益建 王洋(审校) 《现代医药卫生》 2024年第15期2657-2661,共5页
弹簧韧带损伤在临床上往往容易被忽略,原因在于其发病机制较为隐匿,临床症状体征不典型。若弹簧韧带损伤得不到及时正确处理,可能导致扁平足畸形等,严重时甚至引起足部长期慢性疼痛。该文从弹簧韧带损伤的解剖和临床特征、治疗方式及术... 弹簧韧带损伤在临床上往往容易被忽略,原因在于其发病机制较为隐匿,临床症状体征不典型。若弹簧韧带损伤得不到及时正确处理,可能导致扁平足畸形等,严重时甚至引起足部长期慢性疼痛。该文从弹簧韧带损伤的解剖和临床特征、治疗方式及术后康复等方面进行了综述。加强对弹簧韧带损伤的相关研究,降低其漏诊及误诊率,正确治疗弹簧韧带损伤及术后正规康复训练,是目前足踝外科领域研究的热点和难点。选择最佳的方式来修复损伤的弹簧韧带,以及后期制定个性化康复方案将是未来研究的重要方向。 展开更多
关键词 弹簧韧带 胫后肌腱 内侧纵弓 综述
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微RNA在颈椎后纵韧带骨化症中的作用和机制研究进展 被引量:1
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作者 吴昊 王珑清 +3 位作者 陈清 赵琦 石明亮 杨立利 《脊柱外科杂志》 2024年第2期123-128,共6页
颈椎后纵韧带骨化症(OPLL)是附着于椎体后缘的后纵韧带在多因素作用下发生异常增厚和骨化的现象,是常见的颈椎退行性疾病之一,可导致严重的感觉和运动功能障碍^([1])。目前,OPLL的发生机制尚不清楚,其早期诊断和治疗方式仍然有限。有文... 颈椎后纵韧带骨化症(OPLL)是附着于椎体后缘的后纵韧带在多因素作用下发生异常增厚和骨化的现象,是常见的颈椎退行性疾病之一,可导致严重的感觉和运动功能障碍^([1])。目前,OPLL的发生机制尚不清楚,其早期诊断和治疗方式仍然有限。有文献^([1])报道,遗传与环境因素共同参与了OPLL的发生。 展开更多
关键词 微RNA 颈椎 骨化 后纵韧带骨化 文献综述
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