Osteoporosis is one of the common orthopaedic diseases,characterised by increased bone fragility due to reduced bone mass and microstructural degeneration,posing a great threat to patients’quality of life and safety....Osteoporosis is one of the common orthopaedic diseases,characterised by increased bone fragility due to reduced bone mass and microstructural degeneration,posing a great threat to patients’quality of life and safety.In recent years,Chinese medicine(natural)has had a unique advantage in the treatment of osteoporosis and has shown good efficacy.Autophagy is an inherent cellular survival mechanism for the removal and recycling of damaged proteins and organelles and plays an important role in maintaining the stability of the intracellular environment and organ function.Therefore,this article aims to provide a comprehensive review of these Chinese medicines(natural)for the treatment of osteoporosis through autophagy.They have been intensively studied and reported to have effects such as promoting osteogenesis and anti-bone resorption.The Chinese medicines include plants such as Cistanche deserticola,Epimedium,Curculigo orchioides Gaertn,Achyranthes bidentata Blume,Leonurus japonicus Houtt,Ginseng,Chuanxiong Rhizome,Eucommia ulmoides,Morindae Officinalis Radix,Curcuma longa,Polygoni Cuspidati Rhizoma et Radix,Anemarrhena asphodeloides Bunge,Salvia miltiorrhiza Bge and Pueraria Lobata,thus providing evidence for the use of alternative herbal therapies for the effective treatment of osteoporosis.展开更多
Objective: To explorate the influence of replenishing Kidney herbs on dexamethasone (DXM) or retinoic acid (RA) induced osteoporosis in rats.Methods: Model animal of osteoporosis was made by DXM injection or RA throug...Objective: To explorate the influence of replenishing Kidney herbs on dexamethasone (DXM) or retinoic acid (RA) induced osteoporosis in rats.Methods: Model animal of osteoporosis was made by DXM injection or RA through gastrogavage, and some animals received replenishing Kidney herbs during modelling. Changes of serum calcium, phosphate, alkaline phosphatase (ALP), estrogen (E), prostaglandin E2(PGE2), 1, 25-dihydroxyvitamin D3(VD3), uric hydroxyproline (UHP), intestinal calcium absorption, bone ash weight, bone density, bone histopathology as well as the change of intestinal calcium absorption vector-Ca-binding protein D9K (CaBp-D9K) gene and its mRNA expression were examined and compared.Results: DXM or RA could markedly induce bone metabolism disorder, showed as morphologic and histologic changes of bone, in DXM group, decrease of E2, VD3, bone density, bone ash weight, intestinal calcium absorption, increase of PGE2, and in RA group, decrease of serum E2, calcium, phosphate, ALP, UHP, bone density, bone ash weight, and intestinal calcium absorption. These changes could be reduced significantly when rats received replenishing Kidney herbs during modelling, and approached to normal.Conclusion: Osteoporosis induced by long-term application of DXM and low calcium diet feeding is a good animal model for experimental research. Replenishing Kidney herbs could significantly improve bone metabolism disorder induced by DXM or RA展开更多
基金the financial support from the Science and Technology Development Program of Jilin Provincial Science and Technology Department,(No.20210101200JC).
文摘Osteoporosis is one of the common orthopaedic diseases,characterised by increased bone fragility due to reduced bone mass and microstructural degeneration,posing a great threat to patients’quality of life and safety.In recent years,Chinese medicine(natural)has had a unique advantage in the treatment of osteoporosis and has shown good efficacy.Autophagy is an inherent cellular survival mechanism for the removal and recycling of damaged proteins and organelles and plays an important role in maintaining the stability of the intracellular environment and organ function.Therefore,this article aims to provide a comprehensive review of these Chinese medicines(natural)for the treatment of osteoporosis through autophagy.They have been intensively studied and reported to have effects such as promoting osteogenesis and anti-bone resorption.The Chinese medicines include plants such as Cistanche deserticola,Epimedium,Curculigo orchioides Gaertn,Achyranthes bidentata Blume,Leonurus japonicus Houtt,Ginseng,Chuanxiong Rhizome,Eucommia ulmoides,Morindae Officinalis Radix,Curcuma longa,Polygoni Cuspidati Rhizoma et Radix,Anemarrhena asphodeloides Bunge,Salvia miltiorrhiza Bge and Pueraria Lobata,thus providing evidence for the use of alternative herbal therapies for the effective treatment of osteoporosis.
文摘Objective: To explorate the influence of replenishing Kidney herbs on dexamethasone (DXM) or retinoic acid (RA) induced osteoporosis in rats.Methods: Model animal of osteoporosis was made by DXM injection or RA through gastrogavage, and some animals received replenishing Kidney herbs during modelling. Changes of serum calcium, phosphate, alkaline phosphatase (ALP), estrogen (E), prostaglandin E2(PGE2), 1, 25-dihydroxyvitamin D3(VD3), uric hydroxyproline (UHP), intestinal calcium absorption, bone ash weight, bone density, bone histopathology as well as the change of intestinal calcium absorption vector-Ca-binding protein D9K (CaBp-D9K) gene and its mRNA expression were examined and compared.Results: DXM or RA could markedly induce bone metabolism disorder, showed as morphologic and histologic changes of bone, in DXM group, decrease of E2, VD3, bone density, bone ash weight, intestinal calcium absorption, increase of PGE2, and in RA group, decrease of serum E2, calcium, phosphate, ALP, UHP, bone density, bone ash weight, and intestinal calcium absorption. These changes could be reduced significantly when rats received replenishing Kidney herbs during modelling, and approached to normal.Conclusion: Osteoporosis induced by long-term application of DXM and low calcium diet feeding is a good animal model for experimental research. Replenishing Kidney herbs could significantly improve bone metabolism disorder induced by DXM or RA
