Osteoporosis and associated fractures are the most common chronic metabolic bone disease and represent a major global health problem.With the aging of the population,osteoporosis has been a severe threat to the health...Osteoporosis and associated fractures are the most common chronic metabolic bone disease and represent a major global health problem.With the aging of the population,osteoporosis has been a severe threat to the health of the middle-aged and elderly,especially middle-aged and older women,the prevalence rate of osteoporosis in women is three times higher than that in men.By 2020,the number of patients with osteoporosis increased to 286.6 million.The number of hip fractures reached to 1.6382 million.The number of patients with osteoporosis will rise to 533.3 million in 2050.1 The theme for World Menopause Day 2021 was"Bone Health",which was decided by the Board of the International Menopause Society(IMS).展开更多
Objective: Falls are one of the most common direct causes of fractures which are major causes of morbidity and mortality in osteoporosis patient. There are many factors related to falls, by interfering of fall prevent...Objective: Falls are one of the most common direct causes of fractures which are major causes of morbidity and mortality in osteoporosis patient. There are many factors related to falls, by interfering of fall prevention education on the patients with osteoporosis, our study is to investigate whether fall prevention education can reduce the falling rate on the osteoporosis patients treated with zoledronic acid. Methods: A total of 178 eligible female patients who first visited our osteoporosis department during January 2016 to June 2017 were invited to participate in this study, and all participants were randomly divided into an observation group (92 cases) and an intervention group (86 cases). All patients were administrated zoledronic acid once and received a questionnaire survey about factors related to falls at the beginning and a year later. The patients in the observation group only received regular orders of adopting a healthy lifestyle while those in the intervention group received fall prevention assessment and education, and a telephone follow-up and reinforced fall prevention education a month after discharge. A year later, relevant data regarding the falls of each patient of both groups during the year and the data of the questionnaire survey were collected for intergroup comparison. Results: The difference of the improvement of fall risk factors between the two groups is statistically significant (P Conclusion: For an osteoporosis patient treated with zoledronic acid, fall prevention education is an effective method to reduce the risk of falling, which would result in a lower risk of fractures and a better prognosis.展开更多
Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone form...Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global omentin-1 knockout（omentin-1^-/-） mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities. Using an inflammatory cell model induced by tumor necrosis factor-α（TNF-α）, we determined that recombinant omentin-1 reduces the production of proinflammatory factors in the TNF-α-activated macrophages, and suppresses their anti-osteoblastic and pro-osteoclastic abilities. In the magnesium silicate-induced inflammatory osteoporosis mouse model, the systemic administration of adenoviral-delivered omentin-1 significantly protects from osteoporotic bone loss and inflammation. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of inflammatory bone diseases by downregulating the proinflammatory cytokines.展开更多
Objective: To evaluate the efficacy of Genni-anchun (GNC) in preventing primary osteoporosis. Methods: Fifty female SD rats of 10 - 12 months old were randomly divided into five groups. Except those in the sham operat...Objective: To evaluate the efficacy of Genni-anchun (GNC) in preventing primary osteoporosis. Methods: Fifty female SD rats of 10 - 12 months old were randomly divided into five groups. Except those in the sham operation group, animals were ovariectomized bilaterally. The gastric perfusion was started immediately after operation, with normal saline to the sham operation group and model group; GNC to high dose (2 ml) and low dos (1 ml) GNC groups and Nilestriol to the NE group, every day for 3 months. Animals were sacrificed at the end of experiment, their vertebra and展开更多
Objective: The purpose of this study was to examine the relationships between osteoporosis knowledge, beliefs and calcium intake among college students. This study also examined perceived susceptibility, severity, ben...Objective: The purpose of this study was to examine the relationships between osteoporosis knowledge, beliefs and calcium intake among college students. This study also examined perceived susceptibility, severity, benefits, barriers and self-efficacy related to osteoporosis prevention. Participants: Seven hundred and ninety two (n = 792) men and women ages 17 - 31 of all ethnicities at a mid-western regional university in the US participated in the study. Methods: The Osteoporosis Knowledge Test, Osteoporosis Health Belief Scale, and Osteoporosis Preventing Behaviors Survey were utilized. Each of these tools were previously validated and found reliable. Correlation and multiple regression analyses were completed. Results: Participants did not perceive themselves as susceptible to osteoporosis and perceived minimal barriers to calcium intake. Their knowledge was minimal concerning alternate sources of calcium. Conclusions: Prevention programs should aim to increase osteoporosis knowledge of risk factors and osteoprotective behaviors and to decrease high-risk behaviors during college years when behavior changes can have the strongest impact on bone health.展开更多
目的了解骨质疏松性椎体压缩骨折二级预防失败患者骨代谢指标及骨密度的特点。方法选择2015年1月至2020年1月在我院骨科因骨质疏松性椎体压缩骨折行2次或2次以上手术治疗的患者为观察组研究对象,共65例,同时选择同时期行手术治疗的非多...目的了解骨质疏松性椎体压缩骨折二级预防失败患者骨代谢指标及骨密度的特点。方法选择2015年1月至2020年1月在我院骨科因骨质疏松性椎体压缩骨折行2次或2次以上手术治疗的患者为观察组研究对象,共65例,同时选择同时期行手术治疗的非多次脊柱压缩骨折患者219例作为配对资料对照组,回顾性分析这284例患者临床资料,记录其术前骨代谢标志物水平及骨密度(bone mineral density,BMD)结果并进行两组患者间比较。结果观察组患者骨代谢标志物中人血清和血浆中的总I型前胶原氨基端肽(tP1NP)、N⁃MID骨钙素(OCN)以及血清25⁃羟维生素D(25⁃hydroxy vitamin D,25OHD)水平与对照组相比差异无统计学意义(P>0.05),骨代谢标志物I型胶原羧基端肽β特殊序列(β⁃CTX)水平明显高于对照组(P<0.05)。两组患者髋部BMD值、股骨颈BMD值差异无统计学意义(P>0.05),观察组腰椎BMD值明显低于对照组(P<0.05)。结论骨质疏松性椎体压缩骨折二级预防失败患者具有更为活跃的骨吸收状态及更低的腰椎骨密度。展开更多
目的:检索、评价及总结老年肌少-骨质疏松症病人预防骨折的最佳证据。方法:按照“6S”资源金字塔模型,由上至下检索BMJ Best Practice、UpToDate、美国国立指南库(Clinical Practice Guidelines,CPG)、美国骨科医师学会(American Academ...目的:检索、评价及总结老年肌少-骨质疏松症病人预防骨折的最佳证据。方法:按照“6S”资源金字塔模型,由上至下检索BMJ Best Practice、UpToDate、美国国立指南库(Clinical Practice Guidelines,CPG)、美国骨科医师学会(American Academy of Orthopaedic Surgeons,AAOS)、苏格兰校际指南网络(Scottish Intercollegiate Guidelines Network,SIGN)、PubMed、加拿大安大略省注册护士协会(Registered Nurses′Association of Ontario,RNAO)、医脉通、中国知网、维普数据库等有关老年肌少-骨质疏松症病人骨折预防管理的临床指南、专家共识、系统评价、随机对照试验。检索时限为建库至2023年10月1日。采用AGREEⅡ工具对临床指南进行质量评价,采用澳大利亚Joanna Briggs Institutel(JBI)标准评价专家共识方法学质量,采用JBI标准评价系统评价的方法学质量。结果:最终纳入11篇文献,从危险因素、筛查工具、用药护理、运动指导、营养管理和生活指导6个方面得出26条证据。结论:汇总了26条最佳证据,为预防与管理老年肌少-骨质疏松症病人发生骨折提供了循证依据。展开更多
基金supported by China Health Promotion Foundation(CHPF-2018-OP-11)Beijing Municipal Administration of Hospitals' Ascent Plan of China(DFL20181401).
文摘Osteoporosis and associated fractures are the most common chronic metabolic bone disease and represent a major global health problem.With the aging of the population,osteoporosis has been a severe threat to the health of the middle-aged and elderly,especially middle-aged and older women,the prevalence rate of osteoporosis in women is three times higher than that in men.By 2020,the number of patients with osteoporosis increased to 286.6 million.The number of hip fractures reached to 1.6382 million.The number of patients with osteoporosis will rise to 533.3 million in 2050.1 The theme for World Menopause Day 2021 was"Bone Health",which was decided by the Board of the International Menopause Society(IMS).
文摘Objective: Falls are one of the most common direct causes of fractures which are major causes of morbidity and mortality in osteoporosis patient. There are many factors related to falls, by interfering of fall prevention education on the patients with osteoporosis, our study is to investigate whether fall prevention education can reduce the falling rate on the osteoporosis patients treated with zoledronic acid. Methods: A total of 178 eligible female patients who first visited our osteoporosis department during January 2016 to June 2017 were invited to participate in this study, and all participants were randomly divided into an observation group (92 cases) and an intervention group (86 cases). All patients were administrated zoledronic acid once and received a questionnaire survey about factors related to falls at the beginning and a year later. The patients in the observation group only received regular orders of adopting a healthy lifestyle while those in the intervention group received fall prevention assessment and education, and a telephone follow-up and reinforced fall prevention education a month after discharge. A year later, relevant data regarding the falls of each patient of both groups during the year and the data of the questionnaire survey were collected for intergroup comparison. Results: The difference of the improvement of fall risk factors between the two groups is statistically significant (P Conclusion: For an osteoporosis patient treated with zoledronic acid, fall prevention education is an effective method to reduce the risk of falling, which would result in a lower risk of fractures and a better prognosis.
基金supported by the Excellent Young Scientist Foundation of the National Natural Science Foundation of China(Grant No.81522012)the National Natural Science Foundation of China(Grant No.81670807,81600699,81702237,81701383,81400858)+8 种基金the Thousand Youth Talents Plan of China(Grant No.D1119003)the Hunan Youth Talent Project(Grant No.2016RS3021)the Innovation Driven Project of Central South University(2016CX028)the Youth Foundation of Xiangya Hospital in Central South University(Grant No.2016Q10)the Fundamental Research Funds for the Central Universities of Central South University(Grant No.2017zzts032,2017zzts014)the Hunan Province Natural Science Foundation of China(Grant No.2017JJ3501)the China Postdoctoral Science Foundation(Grant No.2017M612596)the Natural Science Foundation for Distinguished Yong Scholars of Guangdong Province(2016A030306051)the National Basic Research Program of China(973 Program,Grant no.2014CB942903)
文摘Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global omentin-1 knockout（omentin-1^-/-） mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities. Using an inflammatory cell model induced by tumor necrosis factor-α（TNF-α）, we determined that recombinant omentin-1 reduces the production of proinflammatory factors in the TNF-α-activated macrophages, and suppresses their anti-osteoblastic and pro-osteoclastic abilities. In the magnesium silicate-induced inflammatory osteoporosis mouse model, the systemic administration of adenoviral-delivered omentin-1 significantly protects from osteoporotic bone loss and inflammation. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of inflammatory bone diseases by downregulating the proinflammatory cytokines.
文摘Objective: To evaluate the efficacy of Genni-anchun (GNC) in preventing primary osteoporosis. Methods: Fifty female SD rats of 10 - 12 months old were randomly divided into five groups. Except those in the sham operation group, animals were ovariectomized bilaterally. The gastric perfusion was started immediately after operation, with normal saline to the sham operation group and model group; GNC to high dose (2 ml) and low dos (1 ml) GNC groups and Nilestriol to the NE group, every day for 3 months. Animals were sacrificed at the end of experiment, their vertebra and
文摘Objective: The purpose of this study was to examine the relationships between osteoporosis knowledge, beliefs and calcium intake among college students. This study also examined perceived susceptibility, severity, benefits, barriers and self-efficacy related to osteoporosis prevention. Participants: Seven hundred and ninety two (n = 792) men and women ages 17 - 31 of all ethnicities at a mid-western regional university in the US participated in the study. Methods: The Osteoporosis Knowledge Test, Osteoporosis Health Belief Scale, and Osteoporosis Preventing Behaviors Survey were utilized. Each of these tools were previously validated and found reliable. Correlation and multiple regression analyses were completed. Results: Participants did not perceive themselves as susceptible to osteoporosis and perceived minimal barriers to calcium intake. Their knowledge was minimal concerning alternate sources of calcium. Conclusions: Prevention programs should aim to increase osteoporosis knowledge of risk factors and osteoprotective behaviors and to decrease high-risk behaviors during college years when behavior changes can have the strongest impact on bone health.
文摘目的了解骨质疏松性椎体压缩骨折二级预防失败患者骨代谢指标及骨密度的特点。方法选择2015年1月至2020年1月在我院骨科因骨质疏松性椎体压缩骨折行2次或2次以上手术治疗的患者为观察组研究对象,共65例,同时选择同时期行手术治疗的非多次脊柱压缩骨折患者219例作为配对资料对照组,回顾性分析这284例患者临床资料,记录其术前骨代谢标志物水平及骨密度(bone mineral density,BMD)结果并进行两组患者间比较。结果观察组患者骨代谢标志物中人血清和血浆中的总I型前胶原氨基端肽(tP1NP)、N⁃MID骨钙素(OCN)以及血清25⁃羟维生素D(25⁃hydroxy vitamin D,25OHD)水平与对照组相比差异无统计学意义(P>0.05),骨代谢标志物I型胶原羧基端肽β特殊序列(β⁃CTX)水平明显高于对照组(P<0.05)。两组患者髋部BMD值、股骨颈BMD值差异无统计学意义(P>0.05),观察组腰椎BMD值明显低于对照组(P<0.05)。结论骨质疏松性椎体压缩骨折二级预防失败患者具有更为活跃的骨吸收状态及更低的腰椎骨密度。
文摘目的:检索、评价及总结老年肌少-骨质疏松症病人预防骨折的最佳证据。方法:按照“6S”资源金字塔模型,由上至下检索BMJ Best Practice、UpToDate、美国国立指南库(Clinical Practice Guidelines,CPG)、美国骨科医师学会(American Academy of Orthopaedic Surgeons,AAOS)、苏格兰校际指南网络(Scottish Intercollegiate Guidelines Network,SIGN)、PubMed、加拿大安大略省注册护士协会(Registered Nurses′Association of Ontario,RNAO)、医脉通、中国知网、维普数据库等有关老年肌少-骨质疏松症病人骨折预防管理的临床指南、专家共识、系统评价、随机对照试验。检索时限为建库至2023年10月1日。采用AGREEⅡ工具对临床指南进行质量评价,采用澳大利亚Joanna Briggs Institutel(JBI)标准评价专家共识方法学质量,采用JBI标准评价系统评价的方法学质量。结果:最终纳入11篇文献,从危险因素、筛查工具、用药护理、运动指导、营养管理和生活指导6个方面得出26条证据。结论:汇总了26条最佳证据,为预防与管理老年肌少-骨质疏松症病人发生骨折提供了循证依据。
