The twelfth year of the Kaiyuan Reign during the Tang Dynasty （725 A. D.）Each iron ox is about 3.3 m long and 2.5 m high, weighs about 30 t, and is mounted on a square ron base which is 2.3 m wide and 0.5 m thick. B...The twelfth year of the Kaiyuan Reign during the Tang Dynasty （725 A. D.）Each iron ox is about 3.3 m long and 2.5 m high, weighs about 30 t, and is mounted on a square ron base which is 2.3 m wide and 0.5 m thick. Behind the rear legs of each iron ox, there is a large horizontal iron bar which is about 2.33 m long, 0.4 m in diameter, and was used to support the iron chain bridge across over the roaring Yellow River. Under the square iron base, there are 6 slant iron columns buried in the ground, each of which is about 3 m long and 0.4 m in diameter. The iron base and columns weigh about 40 t. The total weight of each whole iron ox sculpture is approximately 70 t展开更多
The PARK2 gene is a common disease gene in Han Chinese patients with Parkinson＇s disease.The detection of mutations in the PARK2 gene remains low.To investigate the role PARK2 gene mutations play in the pathogenesis ...The PARK2 gene is a common disease gene in Han Chinese patients with Parkinson＇s disease.The detection of mutations in the PARK2 gene remains low.To investigate the role PARK2 gene mutations play in the pathogenesis of Parkinson＇s disease,30 Han Chinese patients with early-onset Parkinson＇s disease and 38 normal controls were studied to determine the sequence changes of 1,4,6 and 7 exon sections.In the 30 patients with Parkinson＇s disease,a heterozygous intron mutation（nt 119,G→G/A）in exon 1 was detected in one case;a homozygous intron mutation（nt 526500,T→C）between intron 3 and exon 4 in fourteen cases was found;a heterozygous intron mutation（nt 526607,G→G/A）between intron 3 and exon 4 was observed in eight cases;an exon 6missense mutation（nt 754317,C→C/T;codon 193,CGG→CGG/TGG;aa 193,Arg→Arg/Trp）in three cases was seen;and an exon 7 missense mutation（nt 941943,C→A/C;codon 272,CTC→CTC/ATC;aa 272,Leu→Leu/lle）was found in one case.These changes were not found in the normal population.The results indicated that the PARK2 exons 6 and 7 mutations are possibly pathogenic mutations,along with the intron 3-exert 4 and exon 1 mutations.PARK2 gene mutations are possible factors leading to the onset of Parkinson＇s disease.展开更多
文摘The twelfth year of the Kaiyuan Reign during the Tang Dynasty （725 A. D.）Each iron ox is about 3.3 m long and 2.5 m high, weighs about 30 t, and is mounted on a square ron base which is 2.3 m wide and 0.5 m thick. Behind the rear legs of each iron ox, there is a large horizontal iron bar which is about 2.33 m long, 0.4 m in diameter, and was used to support the iron chain bridge across over the roaring Yellow River. Under the square iron base, there are 6 slant iron columns buried in the ground, each of which is about 3 m long and 0.4 m in diameter. The iron base and columns weigh about 40 t. The total weight of each whole iron ox sculpture is approximately 70 t
文摘The PARK2 gene is a common disease gene in Han Chinese patients with Parkinson＇s disease.The detection of mutations in the PARK2 gene remains low.To investigate the role PARK2 gene mutations play in the pathogenesis of Parkinson＇s disease,30 Han Chinese patients with early-onset Parkinson＇s disease and 38 normal controls were studied to determine the sequence changes of 1,4,6 and 7 exon sections.In the 30 patients with Parkinson＇s disease,a heterozygous intron mutation（nt 119,G→G/A）in exon 1 was detected in one case;a homozygous intron mutation（nt 526500,T→C）between intron 3 and exon 4 in fourteen cases was found;a heterozygous intron mutation（nt 526607,G→G/A）between intron 3 and exon 4 was observed in eight cases;an exon 6missense mutation（nt 754317,C→C/T;codon 193,CGG→CGG/TGG;aa 193,Arg→Arg/Trp）in three cases was seen;and an exon 7 missense mutation（nt 941943,C→A/C;codon 272,CTC→CTC/ATC;aa 272,Leu→Leu/lle）was found in one case.These changes were not found in the normal population.The results indicated that the PARK2 exons 6 and 7 mutations are possibly pathogenic mutations,along with the intron 3-exert 4 and exon 1 mutations.PARK2 gene mutations are possible factors leading to the onset of Parkinson＇s disease.
