Various low molecular weight chitosans were prepared by oxidative degradation with H2O2, and characterized by IR,13C-NMR and gel permeation chromatography. Their carboxylic contents increased with decrease in molecula...Various low molecular weight chitosans were prepared by oxidative degradation with H2O2, and characterized by IR,13C-NMR and gel permeation chromatography. Their carboxylic contents increased with decrease in molecular weight (M w ). The antitumor test of the samples against sarcoma 180 tumors suggested that the water-soluble chitosan with higherM w have higher inhibitory ratioin vivo. The introduction of carboxylic group is advantage to water-solubility of chitosan, but more acidic groups might decrease the function of amino groups of chitosan against sarcoma 180 tumor.展开更多
基金SupportedbytheNationalNaturalScienceFoundationofChina (No .2 99770 14 )
文摘Various low molecular weight chitosans were prepared by oxidative degradation with H2O2, and characterized by IR,13C-NMR and gel permeation chromatography. Their carboxylic contents increased with decrease in molecular weight (M w ). The antitumor test of the samples against sarcoma 180 tumors suggested that the water-soluble chitosan with higherM w have higher inhibitory ratioin vivo. The introduction of carboxylic group is advantage to water-solubility of chitosan, but more acidic groups might decrease the function of amino groups of chitosan against sarcoma 180 tumor.
