Protective Effects of Oyster Extract Against Hepatic Tissue Injury in Alcoholic Liver Diseases

Oyster extract is an effective bioactivity component. It has abundant nutritional value and antiviral, antitumor and im- mune defense fimctions. The role of oyster extract in treating liver injury has been paid more attention. We use Wistar rats to make alcoholic liver disease model through injecting alcohol into rats＇ stomachs. These rats were randomly divided into five groups： model group, control group, low-dose, middle-dose and high-dose experimental group with a dose of 0.12gkg-1, 0.40gkg-1, and 1.20gkg-1 alcoholic. After nine weeks, serum biomarkers （ALT, AST, TG and TCHO）, malondialdehyde （MDA）, glutathione （GSH）, C3a, CSa, IL-17, TNF-a, anti-MAA-HAS IgC~ CD3＋, CD4＋, CDS＋, NK cell activation and zinc content were assessed. The results showed that the serum biomarkers（ALT, AST, TG and TCHO）, MDA content, anti-MAA-HSA IgG, serum C3a, CSa IL-17 and TNF-a levels of oyster extract treatment groups were significantly decreased in comparison with model group. On the contrary, GSH showed ad- verse trend. Serum CD3＋, CD4＋ and NK cell activation were significantly increased in middle-dose group and high-dose group compared with model group, and there was decrease of CD8＋ activity in high-dose group. Plasma Zn level was decreased in model group compared with that in control group. Meanwhile, Mean plasma Zn levels increased dramatically following the dose increase of a given oyster extract.

Oyster Extract Capsule

Oyster extract capsules produced by the Shenzhen Neptunus Pharmaceutical Co. Ltd. is a natural marine tonicprepared from extracting the essence of fresh oysters using a special biological technique. It contains taurine, all essential amino acids, glycogen, vitamins, protein metabolism and trace elements. Oyster extract which is effective in suppressing