The present paper is basically written as a non-apologetic strong defence of the thesis that computation is part and parcel of a physical theory and by no means a mere numerical evaluation of the prediction of a theor...The present paper is basically written as a non-apologetic strong defence of the thesis that computation is part and parcel of a physical theory and by no means a mere numerical evaluation of the prediction of a theory which comes towards the end. Various general considerations as well as specific examples are given to illustrate and support our arguments. These examples range from the practical aspect to almost esoteric considerations but at the end, everything converges towards a unity of theory and computation presented in the form of modern fractal logic and transfinite quantum field theory in a Cantorian spacetime. It is true that all our examples are taken from physics but our discussion is applicable in equal measure to a much wider aspect of life.展开更多
Some of the important features of the bands occur in the present study. The band called amide A is available in all the diseased and healthy controls and the frequency of the band ranges from 3380 cm﹣1 to 3480.74 cm...Some of the important features of the bands occur in the present study. The band called amide A is available in all the diseased and healthy controls and the frequency of the band ranges from 3380 cm﹣1 to 3480.74 cm﹣1. The band due to C-H band and called hydrocarbon band was found only in paralytic and Alzheimer diseased along with normal healthy controls. Carbide band (C=C) is found only in Duchenne muscular dystrophy, paralytic and Alzheimer’s disease patients. Amide I was intact in all disorders with normal persons. Peroxide band (O-O) was found in all the cases of study. Amide IV band was found in paralytic, muscular dystrophy, Alzheimer’s diseases and normal controls. The amide V band was found in Alzheimer’s diseases only. The appearance or disappearance of the bands is a good sign to understand the mechanisms at the molecular level. FTIR spectroscopy may help in the diagnosis of the disease at the early stage of the onset. This spectroscopy can be used nicely for the study of hair, vaginal fluid, nails, urine, mucus, semen, synovial fluid, blood, hemoproteins, skin, and tears for human beings. We can also use it to understand the effect of adulteration on food and paint technology. FTIR is an indicator to explore the changes occurring at molecular level.展开更多
Purpose: To find the effect of lumbrokinase (LK) on P-selectin and E-selectin in ischemic rats. Methods: Male healthy Spragur-Dawley rats weighing 180-220 g (n=90) were divided into 4 groups: (1) normal control group ...Purpose: To find the effect of lumbrokinase (LK) on P-selectin and E-selectin in ischemic rats. Methods: Male healthy Spragur-Dawley rats weighing 180-220 g (n=90) were divided into 4 groups: (1) normal control group (n=5), (2) sham-operated group (n=35), (3) ischemic group (n=35), (4) LK group (n=15). LK 10mg/kg (2000UK activity of LK) was given by intraperitoneal injection in the LK group 30 minutes before experiment. Same volume of normal saline was given in the sham-operated group and ischemic group. The ischemic model was made by modified Haruo Nagasawa's method. Immunohistochemistry was used to observe the P-selectin and E-selectin positive cells in the ischemic region. Results: P-selectin and E-selectin positive cells in ischemic regions were observed in the ischemic group, and the peak of expression was at 6 hours and 12 hours, respectively. The similar changes were not observed in normal control group. There were only a few positive cells in the sham-operated group. In LK group, the P-selectin and E-selectin positive cells were significantly less than those in the ischemic group (P<0.05 at 3 hours after the onset, P<0.01 at 6 hours and P<0.01 at 12 hours, respectively). Conclusions: LK might significantly decrease the immunoreactions of P-selectin and E-selectin in ischemic lesion.展开更多
In-stream nutrient release and retention control the timing and quantity of export at the watershed outlet by mobilization and transport of phosphorus (P) sources from land to the channel, and remobilization of transi...In-stream nutrient release and retention control the timing and quantity of export at the watershed outlet by mobilization and transport of phosphorus (P) sources from land to the channel, and remobilization of transient stores of P from stream beds. We investigated the significance of stream processes in regulating P loading to the Cannonsville watershed, NY, USA. A mass balance of estimated P inputs to the stream with observed P export at the watershed outlet was used to quantify P delivery and explore the behavior of P. Stream channel transport of both dissolved and particulate P is found to be non-conservative, with dissolved P being retained during low flows and particulate P released during high flows. The results suggest that differences in the magnitude and relative importance of in-stream biogeochemical processes under different flow regimes regulate P delivery in ways that may influence ecological impacts to downstream river reaches and reservoirs.展开更多
A diagnostic analysis of two explosive cyclogeneses and one general cyclone over the North- west Pacific Ocean in 1979 is presented by potential vorticity and E-P flux. The analysis results demon- strate that main dyn...A diagnostic analysis of two explosive cyclogeneses and one general cyclone over the North- west Pacific Ocean in 1979 is presented by potential vorticity and E-P flux. The analysis results demon- strate that main dynamic mechanism of explosive cyclogenesis development is upper-layer forcing action and large condensation latent heatproduced by lower-layer aqueous vapour transportation.展开更多
Coordinated numerical ensemble experiments with six different state-of-the-art atmosphere models were used to evaluate and quantify the impact of global SST(from reanalysis data)on the early winter Arctic warming duri...Coordinated numerical ensemble experiments with six different state-of-the-art atmosphere models were used to evaluate and quantify the impact of global SST(from reanalysis data)on the early winter Arctic warming during 1982-2014.Two sets of experiments were designed:in the first set(EXP1),OISSTv2 daily sea-ice concentration and SST variations were used as the lower boundary forcing,while in the second set(EXP2)the SST data were replaced by the daily SST climatology.In the results,the multi-model ensemble mean of EXP1 showed a nearsurface(~850 hPa)warming trend of 0.4℃/10 yr,which was 80%of the warming trend in the reanalysis.The simulated warming trend was robust across the six models,with a magnitude of 0.36-0.50℃/10 yr.The global SST could explain most of the simulated warming trend in EXP1 in the mid and low troposphere over the Arctic,and accounted for 58%of the simulated near-surface warming.The results also suggest that the uppertropospheric warming(~200 hPa)over the Arctic in the reanalysis is likely not a forced signal;rather,it is caused by natural climate variability.The source regions that can potentially impact the early winter Arctic warming are explored and the limitations of the study are discussed.展开更多
Background: Recently, it has become apparent that reactive oxygen species (ROS) play a critical role in the initiation of atherosclerosis. In this study, the effect of radical scavenger edaravone to the leukocyte roll...Background: Recently, it has become apparent that reactive oxygen species (ROS) play a critical role in the initiation of atherosclerosis. In this study, the effect of radical scavenger edaravone to the leukocyte rolling and to the expression of adhesion molecules on microvascular endothelium was investigated. Methods: DSS induced rat colitis model was used as an inflammation model. Edaravone (10.5 mg/kg, Mitsubishi Tanabe Pharma Corporation, Japan) was used to examine the action of ROS. Images of leukocyte rolling in mesenteric microvessels were investigated in a fluorescence bio-imaging model. Each cross section from the target blood vessel (aotic root, aorta, superior mesenteric artery) were examined by immune-peroxidase staining with anti-P-selectin, E-selectin, ICAM-1 antibody using the streptavidin/biotinylated horseradish peroxidase method. Results: 1) Leukocyte rolling in mesenteric microvessels was significantly increased in colitis. The number of rolling leukocyte was significantly decreased in edaravone group than placebo group (501.3 ± 39.2 vs 252.2 ± 37.2 count/100 μm/10 min). 2) The expression of P-selectin in endothelial cell was significantly increased in colitis. However, this expression was decreased in edaravone group. 3) The expression of E-selectin was not induced to intact aortic root and aorta. In the superior mesenteric artery, the expression was induced by inflammation, and it was attenuated by edaravone. 4) There was little expression of ICAM-1 in both intact aortic root and aortas. While, in the superior mesenteric artery, the expression was confirmed only in placebo group in colitis, and it was attenuated in edaravone group. Conclusions: It was suggested that administration of edaravone led to improving a haemostasis of microcirculation based on down-regulation of adhesion molecules. These results support the evidence that ROS plays a critical role in micro- vascular dysfunction.展开更多
To obtain the wound dressings which can accelerate healing effectively,vitamin E D-α-Tocopherol polyethylene glycol succinate(vitamin E TPGS),one of the common derivatives of the unstable vitamins E,was successfully ...To obtain the wound dressings which can accelerate healing effectively,vitamin E D-α-Tocopherol polyethylene glycol succinate(vitamin E TPGS),one of the common derivatives of the unstable vitamins E,was successfully incorporated into P(LLA-CL)nanofibers by electrospinning.Electron microscopy showed that the smooth cylindrical fibers were obtained,albeit with a small amount of beading visible for the vitamins-loaded fibers.The diameters of the P(LLA-CL)fibers decreased with the addition of vitamins.The incorporation of the vitamin E TPGS in the electrospun fibers was confirmed by Fourier transform infrared spectroscopy(FTIR).Moreover,X-ray diffraction(XRD)indicated that vitamin E TPGS existed in the amorphous physical form after electrospinning.Fibers containing vitamin E TPGS showed a sustained release profile over more than 100 h in vitro.Antibacterial tests demonstrated that fibers loaded with vitamin E TPGS were effective in inhibiting the growth of E.coli and S.aureus.MTT assay showed that the fibers could promote the proliferation of L929 fibroblasts.These results above demonstrate the potential of P(LLA-CL)/vitamins E TPGS(P/E)as advanced wound dressing materials.展开更多
In the present work, the structure and impact properties of copolymers of polypropylenewith low ethylene contents have been investigated. Based on the results of ^(13)C--NMR, FTIR,WAXD, DSC, PLM and SEM, the relations...In the present work, the structure and impact properties of copolymers of polypropylenewith low ethylene contents have been investigated. Based on the results of ^(13)C--NMR, FTIR,WAXD, DSC, PLM and SEM, the relationship between impact properties and morphology of thecopolymers has been discussed. The high impact properties of copolymer ICP2 may attribute tothe relatively higher ethylene content and homogeneous ethylene unit distribution. The size andits distribution of spherulite in the copolymers and cycloid cavities dispersed in polypropylenecontinue phase may also be two important factors which affect the impact properties of these materials.展开更多
Objective To investigate the effects of thoracic epidural analgesia on postoperat ive hypertension in patients with PD A.Methods48cases of PDA were randomly divided into NTEA group(n =22)and TEAgroup(n =26).General an...Objective To investigate the effects of thoracic epidural analgesia on postoperat ive hypertension in patients with PD A.Methods48cases of PDA were randomly divided into NTEA group(n =22)and TEAgroup(n =26).General anesthesia was used for NTE Agroup,and intramuscular injection of peth idine 1mg /kg was used when postopera tive pain occurs;general anesthesia combined with thoracic epidural anesthesia were used for TEAgroup,a nd thoracic epidural analgesia was u sed for postoperative analgesia.BP,HR,RR,SpO 2 ,EKG were monitored during and after operatio n,angiotenic was used when the BP ele vated more than 20%compared with before operation.Results Analgesia effect on TEA group was better than that of NTEA group(P <0.05),also postoperative BP was signific antly higher than that of before operation in NTEA group(P <0.01),and 18cases need nitroglycerin or s odium nitroprusside therapy;there was no significantly in-crease of BP in TEA group,only 2cases need nitroglycerin therapy.Conclusion TEA had an excellent effect of postop erative pain-relief and blocked sympathetic nerve in patien ts with PDA,so it could reduce postoperative hypertension effectively.展开更多
文摘The present paper is basically written as a non-apologetic strong defence of the thesis that computation is part and parcel of a physical theory and by no means a mere numerical evaluation of the prediction of a theory which comes towards the end. Various general considerations as well as specific examples are given to illustrate and support our arguments. These examples range from the practical aspect to almost esoteric considerations but at the end, everything converges towards a unity of theory and computation presented in the form of modern fractal logic and transfinite quantum field theory in a Cantorian spacetime. It is true that all our examples are taken from physics but our discussion is applicable in equal measure to a much wider aspect of life.
文摘Some of the important features of the bands occur in the present study. The band called amide A is available in all the diseased and healthy controls and the frequency of the band ranges from 3380 cm﹣1 to 3480.74 cm﹣1. The band due to C-H band and called hydrocarbon band was found only in paralytic and Alzheimer diseased along with normal healthy controls. Carbide band (C=C) is found only in Duchenne muscular dystrophy, paralytic and Alzheimer’s disease patients. Amide I was intact in all disorders with normal persons. Peroxide band (O-O) was found in all the cases of study. Amide IV band was found in paralytic, muscular dystrophy, Alzheimer’s diseases and normal controls. The amide V band was found in Alzheimer’s diseases only. The appearance or disappearance of the bands is a good sign to understand the mechanisms at the molecular level. FTIR spectroscopy may help in the diagnosis of the disease at the early stage of the onset. This spectroscopy can be used nicely for the study of hair, vaginal fluid, nails, urine, mucus, semen, synovial fluid, blood, hemoproteins, skin, and tears for human beings. We can also use it to understand the effect of adulteration on food and paint technology. FTIR is an indicator to explore the changes occurring at molecular level.
文摘Purpose: To find the effect of lumbrokinase (LK) on P-selectin and E-selectin in ischemic rats. Methods: Male healthy Spragur-Dawley rats weighing 180-220 g (n=90) were divided into 4 groups: (1) normal control group (n=5), (2) sham-operated group (n=35), (3) ischemic group (n=35), (4) LK group (n=15). LK 10mg/kg (2000UK activity of LK) was given by intraperitoneal injection in the LK group 30 minutes before experiment. Same volume of normal saline was given in the sham-operated group and ischemic group. The ischemic model was made by modified Haruo Nagasawa's method. Immunohistochemistry was used to observe the P-selectin and E-selectin positive cells in the ischemic region. Results: P-selectin and E-selectin positive cells in ischemic regions were observed in the ischemic group, and the peak of expression was at 6 hours and 12 hours, respectively. The similar changes were not observed in normal control group. There were only a few positive cells in the sham-operated group. In LK group, the P-selectin and E-selectin positive cells were significantly less than those in the ischemic group (P<0.05 at 3 hours after the onset, P<0.01 at 6 hours and P<0.01 at 12 hours, respectively). Conclusions: LK might significantly decrease the immunoreactions of P-selectin and E-selectin in ischemic lesion.
文摘In-stream nutrient release and retention control the timing and quantity of export at the watershed outlet by mobilization and transport of phosphorus (P) sources from land to the channel, and remobilization of transient stores of P from stream beds. We investigated the significance of stream processes in regulating P loading to the Cannonsville watershed, NY, USA. A mass balance of estimated P inputs to the stream with observed P export at the watershed outlet was used to quantify P delivery and explore the behavior of P. Stream channel transport of both dissolved and particulate P is found to be non-conservative, with dissolved P being retained during low flows and particulate P released during high flows. The results suggest that differences in the magnitude and relative importance of in-stream biogeochemical processes under different flow regimes regulate P delivery in ways that may influence ecological impacts to downstream river reaches and reservoirs.
文摘A diagnostic analysis of two explosive cyclogeneses and one general cyclone over the North- west Pacific Ocean in 1979 is presented by potential vorticity and E-P flux. The analysis results demon- strate that main dynamic mechanism of explosive cyclogenesis development is upper-layer forcing action and large condensation latent heatproduced by lower-layer aqueous vapour transportation.
基金supported by the National Key R&D Program of China[grant number 2017YFE0111800]the National Natural Science Foundation of China[grant numbers 41790472 and 41661144005]partly supported by the EU H2020 Blue-Action project[grant number 727852]。
文摘Coordinated numerical ensemble experiments with six different state-of-the-art atmosphere models were used to evaluate and quantify the impact of global SST(from reanalysis data)on the early winter Arctic warming during 1982-2014.Two sets of experiments were designed:in the first set(EXP1),OISSTv2 daily sea-ice concentration and SST variations were used as the lower boundary forcing,while in the second set(EXP2)the SST data were replaced by the daily SST climatology.In the results,the multi-model ensemble mean of EXP1 showed a nearsurface(~850 hPa)warming trend of 0.4℃/10 yr,which was 80%of the warming trend in the reanalysis.The simulated warming trend was robust across the six models,with a magnitude of 0.36-0.50℃/10 yr.The global SST could explain most of the simulated warming trend in EXP1 in the mid and low troposphere over the Arctic,and accounted for 58%of the simulated near-surface warming.The results also suggest that the uppertropospheric warming(~200 hPa)over the Arctic in the reanalysis is likely not a forced signal;rather,it is caused by natural climate variability.The source regions that can potentially impact the early winter Arctic warming are explored and the limitations of the study are discussed.
文摘Background: Recently, it has become apparent that reactive oxygen species (ROS) play a critical role in the initiation of atherosclerosis. In this study, the effect of radical scavenger edaravone to the leukocyte rolling and to the expression of adhesion molecules on microvascular endothelium was investigated. Methods: DSS induced rat colitis model was used as an inflammation model. Edaravone (10.5 mg/kg, Mitsubishi Tanabe Pharma Corporation, Japan) was used to examine the action of ROS. Images of leukocyte rolling in mesenteric microvessels were investigated in a fluorescence bio-imaging model. Each cross section from the target blood vessel (aotic root, aorta, superior mesenteric artery) were examined by immune-peroxidase staining with anti-P-selectin, E-selectin, ICAM-1 antibody using the streptavidin/biotinylated horseradish peroxidase method. Results: 1) Leukocyte rolling in mesenteric microvessels was significantly increased in colitis. The number of rolling leukocyte was significantly decreased in edaravone group than placebo group (501.3 ± 39.2 vs 252.2 ± 37.2 count/100 μm/10 min). 2) The expression of P-selectin in endothelial cell was significantly increased in colitis. However, this expression was decreased in edaravone group. 3) The expression of E-selectin was not induced to intact aortic root and aorta. In the superior mesenteric artery, the expression was induced by inflammation, and it was attenuated by edaravone. 4) There was little expression of ICAM-1 in both intact aortic root and aortas. While, in the superior mesenteric artery, the expression was confirmed only in placebo group in colitis, and it was attenuated in edaravone group. Conclusions: It was suggested that administration of edaravone led to improving a haemostasis of microcirculation based on down-regulation of adhesion molecules. These results support the evidence that ROS plays a critical role in micro- vascular dysfunction.
基金Science and Technology Commission of Shanghai Municipality,China(No.16410723700)“111 Project”Biomedical Textile Materials Science and Technology,China(No.B07024)UK-China Joint Laboratory for Therapeutic Textiles Based at Donghua University
文摘To obtain the wound dressings which can accelerate healing effectively,vitamin E D-α-Tocopherol polyethylene glycol succinate(vitamin E TPGS),one of the common derivatives of the unstable vitamins E,was successfully incorporated into P(LLA-CL)nanofibers by electrospinning.Electron microscopy showed that the smooth cylindrical fibers were obtained,albeit with a small amount of beading visible for the vitamins-loaded fibers.The diameters of the P(LLA-CL)fibers decreased with the addition of vitamins.The incorporation of the vitamin E TPGS in the electrospun fibers was confirmed by Fourier transform infrared spectroscopy(FTIR).Moreover,X-ray diffraction(XRD)indicated that vitamin E TPGS existed in the amorphous physical form after electrospinning.Fibers containing vitamin E TPGS showed a sustained release profile over more than 100 h in vitro.Antibacterial tests demonstrated that fibers loaded with vitamin E TPGS were effective in inhibiting the growth of E.coli and S.aureus.MTT assay showed that the fibers could promote the proliferation of L929 fibroblasts.These results above demonstrate the potential of P(LLA-CL)/vitamins E TPGS(P/E)as advanced wound dressing materials.
基金Supported by the National Natural Science Foundation of China
文摘In the present work, the structure and impact properties of copolymers of polypropylenewith low ethylene contents have been investigated. Based on the results of ^(13)C--NMR, FTIR,WAXD, DSC, PLM and SEM, the relationship between impact properties and morphology of thecopolymers has been discussed. The high impact properties of copolymer ICP2 may attribute tothe relatively higher ethylene content and homogeneous ethylene unit distribution. The size andits distribution of spherulite in the copolymers and cycloid cavities dispersed in polypropylenecontinue phase may also be two important factors which affect the impact properties of these materials.
文摘Objective To investigate the effects of thoracic epidural analgesia on postoperat ive hypertension in patients with PD A.Methods48cases of PDA were randomly divided into NTEA group(n =22)and TEAgroup(n =26).General anesthesia was used for NTE Agroup,and intramuscular injection of peth idine 1mg /kg was used when postopera tive pain occurs;general anesthesia combined with thoracic epidural anesthesia were used for TEAgroup,a nd thoracic epidural analgesia was u sed for postoperative analgesia.BP,HR,RR,SpO 2 ,EKG were monitored during and after operatio n,angiotenic was used when the BP ele vated more than 20%compared with before operation.Results Analgesia effect on TEA group was better than that of NTEA group(P <0.05),also postoperative BP was signific antly higher than that of before operation in NTEA group(P <0.01),and 18cases need nitroglycerin or s odium nitroprusside therapy;there was no significantly in-crease of BP in TEA group,only 2cases need nitroglycerin therapy.Conclusion TEA had an excellent effect of postop erative pain-relief and blocked sympathetic nerve in patien ts with PDA,so it could reduce postoperative hypertension effectively.
