Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. Howev-er, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evalua...Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. Howev-er, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apo-lipoprotein E mimetic peptide signiifcantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental ifndings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mito-chondrial apoptotic pathway.展开更多
以Science Citation Index Expanded(SCI-E)数据库为依据,从收录量、作者、著者国家、地区和机构、文献来源、引用次数、发表期刊、覆盖学科等10方面对东华大学1999-2008年间被其收录的论文进行了分析,研究了东华大学科研发展状况及趋势...以Science Citation Index Expanded(SCI-E)数据库为依据,从收录量、作者、著者国家、地区和机构、文献来源、引用次数、发表期刊、覆盖学科等10方面对东华大学1999-2008年间被其收录的论文进行了分析,研究了东华大学科研发展状况及趋势,从而为东华大学增强自身自然科学基础研究提供参考和帮助.展开更多
基金supported by Scientific Research and Development Plan of Hebei Province,No.20276102DKey Project of Scientific Research in Universities of Hebei Province in China,No.ZD2010106
文摘Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. Howev-er, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apo-lipoprotein E mimetic peptide signiifcantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental ifndings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mito-chondrial apoptotic pathway.
文摘以Science Citation Index Expanded(SCI-E)数据库为依据,从收录量、作者、著者国家、地区和机构、文献来源、引用次数、发表期刊、覆盖学科等10方面对东华大学1999-2008年间被其收录的论文进行了分析,研究了东华大学科研发展状况及趋势,从而为东华大学增强自身自然科学基础研究提供参考和帮助.
