P.S测井技术的工程应用

P.S测井技术是地震勘探方法之一 ,也是一种简便、快速、准确的原位测试技术。通过P.S测井可测定岩土体的弹性波速 (Vp、Vs) ,为工程设计提供所需的动弹性力学参数、划分建筑物场地类别、评价地震效应、进行场地地震反应分析和地震破坏潜势分析等。文中简述了P.S测井技术的工作原理、现场实测技术以及数据处理和资料分析过程。最后结合两个实例说明了 P.

SphK1/S1P/S1PR2信号通路促进肌生成:运动改善骨骼肌健康的新视角

背景:近年来,运动改善骨骼肌的健康已成为学者们关注的一个重要研究内容,适宜的运动对骨骼肌具有积极的作用,其中在运动激活鞘氨醇激酶1(sphingosine kinase1,SphK1)/鞘氨醇-1-磷酸(sphingosine-1-phosphate,S1P)/鞘氨醇-1-磷酸受体2(sphingosine-1-phosphate receptor2,S1PR2)信号通路如何改善骨骼肌的健康,正受到科研人员的重视。目的:研究运动经SphK1/S1P/S1PR2信号通路如何改善骨骼肌的健康,探索治疗相关肌肉疾病的新方法,以改善人的骨骼肌健康。方法:检索Web of Science、PubMed、中国知网、万方和维普数据库从建库至今与文章主题相关的文献,以“signaling pathway,SphK1,S1P,S1PR2,skeletal muscle,satellite cell,myogenesis,exercise”为英文检索词,以“信号通路,SphK1,S1P,S1PR2,骨骼肌,卫星细胞,肌生成,运动”为中文检索词,最终纳入69篇文献进行分析。结果与结论:①SphK1/S1P/S1PR2信号通路是一个复杂的调控网络,通过SphK1催化产生的S1P,与S1PR2等受体的相互作用,触发下游信号转导过程,进而调控细胞、组织、器官和系统的多种生物学功能。②SphK1/S1P/S1PR2信号通路能调控卫星细胞增殖和成肌细胞分化,改善肌生成。③文章通过文献资料调研法分析了SphK1/S1P/S1PR2信号通路的生理基础以及运动对其影响的可能性。急性有氧运动可提高骨骼肌中SphK1的表达,人体和动物研究中已证实急性和长期运动均可提高骨骼肌中S1P水平,另外研究表明长期抗阻运动可提高S1PR2在骨骼肌中的表达,部分实验结果表明急性和长期运动对肌肉或者血液中S1P水平无显著影响,出现不同结果的原因可能是选择的研究对象、方式、强度及频率不同,而具体机制尚不明确。④研究认为,运动能够促进SphK1/S1P/S1PR2信号通路在骨骼肌中的表达,调控下游相关信号通路,并且针对这一信号通路的研究可能为骨骼肌疾病的治疗提供新的策略和方法,从而改善骨骼肌健康。⑤未来应深化对SphK1/S1P/S1PR2信号通路与骨骼肌健康关联的研究,进一步揭示其与卫星细胞、成肌细胞的调控关系及与上下游通路的相互作用,挖掘其临床应用价值,制定康复方案时考虑该通路变化,探索不同运动对该通路的影响机制,并将其作为潜在治疗靶点,结合人体肌肉模型提升研究深度和准确性。

改良阴式L.P.S子宫切除术的护理配合

目的:总结阴式L.P.S子宫切除术的护理配合特点,探讨安全有效的手术方法。方法:对186例阴式L.P.S子宫切除术患者的护理配合情况进行回顾分析。结果:手术均顺利完成且恢复良好。结论:充分的术前准备,良好的手术配合是保证手术成功的关键。

EXISTENCE AND UNIQUENESS OF SOLUTIONS FOR NONLINEAR FRACTIONAL DIFFERENTIAL EQUATIONS WITH NON-SEPARATED TYPE INTEGRAL BOUNDARY CONDITIONS

In this paper, we study a boundary value problem of nonlinear fractional dif- ferential equations of order q （1 〈 q 〈 2） with non-separated integral boundary conditions. Some new existence and uniqueness results are obtained by using some standard fixed point theorems and Leray-Schauder degree theory. Some illustrative examples are also presented. We extend previous results even in the integer case q = 2.

Inversion of two-dimensional tidal open boundary conditions of M_2 constituent in the Bohai and Yellow Seas

Two-dimensional tidal open boundary conditions of the M2 constituent in the Bohai and Yellow Seas(BYS) have been estimated by assimilating T/P altimeter data.During inversion,independent point(IP) strategy was used,in which several IPs on the open boundary is assumed,values at these IPs can be optimized with an adjoint method,and those at other grid points are determined by linearly interpolating the values at IPs.The reasonability and feasibility of the model are tested by ideal twin experiments.In the practical experiment(PE) after assimilation,the cost function may reach 1% or less of its initial value.Mean absolute errors in amplitude and phase can be less than 5 cm and 5°,respectively,and the obtained co-chart can show the character of the M2 constituent in the BYS.The results of the PE indicate that using only two IPs on the open boundary can yield better simulated results.

On a Discrete Fractional Boundary Value Problem with Nonlocal Fractional Boundary Conditions

In this paper, we investigate the nonlinear fractional difference equation with nonlocal fractional boundary conditions. We derive the Green's function for this problem and show that it satisfies certain properties. Some existence results are obtained by means of nonlinear alternative of Leray-Schauder type theorem and Krasnosel-skii's fixed point theorem.

Sufficient Optimality Conditions for Multiobjective Programming Involving (V, ρ)h,ψ-type Ⅰ Functions

New classes of functions namely (V, ρ)_(h,φ)-type I, quasi (V, ρ)_(h,φ)-type I and pseudo (V, ρ)_(h,φ)-type I functions are defined for multiobjective programming problem by using BenTal's generalized algebraic operation. The examples of (V, ρ)_(h,φ)-type I functions are given. The sufficient optimality conditions are obtained for multi-objective programming problem involving above new generalized convexity.

Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer's disease and related neurodegenerative conditions

Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.

LANDESMAN-LAZER TYPE (p,q)-EQUATIONS WITH NEUMANN CONDITION

We consider a Neumann problem driven by the(p,g)-Laplacian under the Landesman-Lazer type condition.Using the classical saddle point theorem and other classical results of the calculus of variations,we show that the problem has at least one nontrivial weak solution.

Spline Fictitious Boundary Element Alternating Method for Edge Crack Problems with Mixed Boundary Conditions

The alternating method based on the fundamental solutions of the infinite domain containing a crack,namely Muskhelishvili’s solutions,divides the complex structure with a crack into a simple model without crack which can be solved by traditional numerical methods and an infinite domain with a crack which can be solved by Muskhelishvili’s solutions.However,this alternating method cannot be directly applied to the edge crack problems since partial crack surface of Muskhelishvili’s solutions is located outside the computational domain.In this paper,an improved alternating method,the spline fictitious boundary element alternating method(SFBEAM),based on infinite domain with the combination of spline fictitious boundary element method(SFBEM)and Muskhelishvili’s solutions is proposed to solve the edge crack problems.Since the SFBEM and Muskhelishvili’s solutions are obtained in the framework of infinite domain,no special treatment is needed for solving the problem of edge cracks.Different mixed boundary conditions edge crack problems with varies of computational parameters are given to certify the high precision,efficiency and applicability of the proposed method compared with other alternating methods and extend finite element method.

The Quantum Condition That Should Have Been Assumed by Bohr When Deriving the Energy Levels of a Hydrogen Atom

Bohr assumed a quantum condition when deriving the energy levels of a hydrogen atom. This famous quantum condition was not derived logically, but it beautifully explained the energy levels of the hydrogen atom. Therefore, Bohr’s quantum condition was accepted by physicists. However, the energy levels predicted by the eventually completed quantum mechanics do not match perfectly with the predictions of Bohr. For this reason, it cannot be said that Bohr’s quantum condition is a perfectly correct assumption. Since the mass of an electron which moves inside a hydrogen atom varies, Bohr’s quantum condition must be revised. However, the newly derived relativistic quantum condition is too complex to be assumed at the beginning. The velocity of an electron in a hydrogen atom is known as the Bohr velocity. This velocity can be derived from the formula for energy levels derived by Bohr. The velocity v of an electron including the principal quantum number n is given by αc/n. This paper elucidates the fact that this formula is built into Bohr’s quantum condition. It is also concluded in this paper that it is precisely this velocity formula that is the quantum condition that should have been assumed in the first place by Bohr. From Bohr’s quantum condition, it is impossible to derive the relativistic energy levels of a hydrogen atom, but they can be derived from the new quantum condition. This paper proposes raising the status of the previously-known Bohr velocity formula.

Bioleaching behavior and surface property of pyrites in different metallogenic conditions

The bioleaching behaviors and surface properties of pyrites in two metallogenic conditions by Sulfobacillus thermosulfidooxidans were investigated by adsorption tests, zeta-potential measurements and bioleaching experiments. It is found that there were significant differences in the microorganism adsorption capacity, electrokinetic properties and bioleaching behaviors for the two pyrites. The S. thermosulfidooxidans adsorption capacity on high temperature hydrothermal(hy_high_temp) pyrite is larger than that on sendimentary coal(sed_coal) pyrite. It may be that more extracellular polymeric substances(EPS) is produced when it is difficult for microorganism to make use of hy_high_temp pyrite as source of energy, and get leaching bacteria attached to pyrite by means of EPS. The zeta-potential measurements indicated that zeta-potential value of hy_high_temp pyrite was higher than that of sed_coal pyrite in pH range of 2–10. After interacting with cells, the IEP(Iso-Electric Point) of hy_high_temp pyrite shifted obviously to that of bacterial. In contrast, the IEP of sed_coal pyrite remained unchanged nearly. The bioleaching results showed that hy_high_temp pyrite did not dissolve and the leaching extent was only 0.82%, while that of sed_coal pyrite was 34.59%. Attempts were taken to illustrate the remarkable difference between bioleaching results of two pyrites from a semiconductor energy band theory perspective.

Intranasal Administration of Conditioned Medium from Cultured Mesenchymal Stem Cells Improves Cognitive Impairment in Olfactory Bulbectomized Mice

Alzheimer’s disease (AD) is the common cause of dementia which shows the neuro-pathologies like an accumulation of amyloid-β (Aβ) and degeneration of cholinergic neuron. Olfactory bulbectomized (OBX) mice show some of AD features, so they have been used to research as AD model. Mesenchymal stem cells (MSCs) can differentiate into many kinds of cells, including neuronal cells. In this study, we intranasally administrated the conditioned medium derived from cultured umbilical cord (UC) MSCs. The intranasal administration of the MSCs medium restored the cognitive impairment observed in OBX mice. In addition, the decreased number of choline acetyltransferase-positive cells in the medial septum was restored by the conditioned medium administration. In conclusion, MSCs-derived conditioned medium may have protective effects of cholinergic neurons in the medial septum, thereby rescuing the cognitive impairment of OBX.

Electrical Power Losses in a Photovoltaic Solar Cell Operating under Partial Shading Conditions

The aim of this paper is to determine the power losses recorded by a PV generator operating under partial shading conditions. These losses are evaluated through two distinct methods. The first method is based on mathematical modeling, while the second is based on Simulink’s physical model. The losses recorded are considerable and increase as a function of the increase in the percentage of shading up to a limit value where they become constant in the case where an ideal by-pass diode is connected in parallel with the modules. This limit value is non-existent in the case where the bypass diode is not ideal, which in fact corresponds to the real model. However, it emerges that the power losses are minimized in a PV system comprising bypass diodes, in particular in the case where the partial shading is considerable.

Construction of Wave-free Potentials and Multipoles in a Two-layer Fluid Having Free-surface Boundary Condition with Higher-order Derivatives

There is a large class of problems in the field of fluid structure interaction where higher-order boundary conditions arise for a second-order partial differential equation. Various methods are being used to tackle these kind of mixed boundary-value problems associated with the Laplace’s equation （or Helmholtz equation） arising in the study of waves propagating through solids or fluids. One of the widely used methods in wave structure interaction is the multipole expansion method. This expansion involves a general combination of a regular wave, a wave source, a wave dipole and a regular wave-free part. The wave-free part can be further expanded in terms of wave-free multipoles which are termed as wave-free potentials. These are singular solutions of Laplace’s equation or two-dimensional Helmholz equation. Construction of these wave-free potentials and multipoles are presented here in a systematic manner for a number of situations such as two-dimensional non-oblique and oblique waves, three dimensional waves in two-layer fluid with free surface condition with higher order partial derivative are considered. In particular, these are obtained taking into account of the effect of the presence of surface tension at the free surface and also in the presence of an ice-cover modelled as a thin elastic plate. Also for limiting case, it can be shown that the multipoles and wave-free potential functions go over to the single layer multipoles and wave-free potential.

Global and Blow-up Solutions to a p-Laplace Equation with Nonlocal Source and Nonlocal Boundary Condition

This paper deals with an evolution p-Laplace equation with nonlocal source subject to weighted nonlocal Dirichlet boundary conditions. We give sufficient conditions for the existence of global and non-global solutions.

DATA MODELING METHOD BASED ON PARTIAL LEAST SQUARE REGRESSION AND APPLICATIO N IN CORRELATION ANALYSIS OF THE STATOR BARS CONDITION PARAMETERS

Objective To investigate v arious data message of the stator bars condition parameters under the condition that only a few samples are available, especially about correlation information between the nondestructive parameters and residual breakdown voltage of the stat or bars. Methods Artificial stator bars is designed to simulat e the generator bars. The partial didcharge( PD) and dielectric loss experiments are performed in order to obtain the nondestructive parameters, and the residua l breakdown voltage acquired by AC damage experiment. In order to eliminate the dimension effect on measurement data, raw data is preprocessed by centered-compr ess. Based on the idea of extracting principal components, a partial least squar e (PLS) method is applied to screen and synthesize correlation information betwe en the nondestructive parameters and residual breakdown voltage easily. Moreover , various data message about condition parameters are also discussed. Re sults Graphical analysis function of PLS is easily to understand vario us data message of the stator bars condition parameters. The analysis Results ar e consistent with result of aging testing. Conclusion The meth od can select and extract PLS components of condition parameters from sample dat a, and the problems of less samples and multicollinearity are solved effectively in regression analysis.

Stabilization of Discrete-time 2-D T-S Fuzzy Systems Based on New Relaxed Conditions

This paper is concerned with the problem of stabilization of the Roesser type discrete-time nonlinear 2-D system that plays an important role in many practical applications. First, a discrete-time 2-D T-S fuzzy model is proposed to represent the underlying nonlinear 2-D system. Second, new quadratic stabilization conditions are proposed by applying relaxed quadratic stabilization technique for 2-D case. Third, for sake of further reducing conservatism, new non-quadratic stabilization conditions are also proposed by applying a new parameter-dependent Lyapunov function, matrix transformation technique, and relaxed technique for the underlying discrete-time 2-D T-S fuzzy system. Finally, a numerical example is provided to illustrate the effectiveness of the proposed results.

Extinction of Weak Solutions for Nonlinear Parabolic Equations with Nonstandard Growth Conditions

This paper deals with the extinction of weak solutions of the initial and boundary value problem for ut = div（（｜u｜σ ＋ d0）｜ u｜^p（x）-2 u）. When the exponent belongs to different intervals, the solution has different singularity （vanishing in finite time）.

Investigation of Numerical Conditions of Moving Particle Semi‑implicit for Two‑Dimensional Wedge Slamming

The sensitivity of moving particle semi-implicit(MPS)simulations to numerical parameters is investigated in this study.Although the verifcation and validation(V&V)are important to ensure accurate numerical results,the MPS has poor perfor-mance in convergences with a time step size.Therefore,users of the MPS need to tune numerical parameters to ft results into benchmarks.However,such tuning parameters are not always valid for other simulations.We propose a practical numerical condition for the MPS simulation of a two-dimensional wedge slamming problem(i.e.,an MPS-slamming condition).The MPS-slamming condition is represented by an MPS-slamming number,which provides the optimum time step size once the MPS-slamming number,slamming velocity,deadrise angle of the wedge,and particle size are decided.The simulation study shows that the MPS results can be characterized by the proposed MPS-slamming condition,and the use of the same MPS-slamming number provides a similar fow.