Objective: To assess the presence of normal or abnormal pattern electroretinogram (PERG) and visual evoked potential (VEP)-responses in patients with ocular hypertension or open-angle glaucoma (OAG). Design: Retrospec...Objective: To assess the presence of normal or abnormal pattern electroretinogram (PERG) and visual evoked potential (VEP)-responses in patients with ocular hypertension or open-angle glaucoma (OAG). Design: Retrospective,cross-sectional,case-control study. Participants: Eighty normal control subjects (mean age,51.77± 6.04 years; 80 eyes),68 ocular hypertension patients (mean age,51.58± 7.12; 68 eyes; intraocular pressure IOP < 18 mmHg under pharmacological treatment; Humphrey field analysis HFA 24/2 mean deviation MD >-2 decibels dB),and 84 OAG patients (mean age,52.77± 5.28; 84 eyes; IOP < 18 mmHg under pharmacological treatment; HFA24/2mean deviation between-2 and-23 dB)were enrolled. Methods: Simultaneous recording of PERGs and VEPs using high-contrast (80% ) 15 checkerboard stimuli reversed at the rate of 2 reversals per second. Main Outcome Measures: Pattern electroretinogram P50 and VEP P100 implicit times were considered delayed when exceeding the limit of mean values of controls plus 2 standard deviations (SDs). Pattern electroretinogram P50 to N95 and VEP N75 to P100 amplitudes were considered reduced when exceeding the limit of mean values of controls minus 2 SDs. Results: Pattern electroretinogram: P50 implicit times were delayed in 58 of 68 (85.30% ) ocular hypertension eyes and 83 of 84 (98.80% )OAG eyes; P50 toN95 amplitudes were reduced in 47 (69.12% ) ocular hypertension eyes and 84 (100% ) OAG eyes. Visual evoked potential: P100 implicit times were delayed in 58 (85.30% ) ocular hypertension eyes and 84 (100% ) OAG eyes; reduced N75 to P100 amplitudes were observed in 39 (57.35% ) ocular hypertension eyes and 73 (86.90% ) OAG eyes. Ocular hypertension eyes showed no significant correlations (Pearson test,P>0.01) between electrophysiological parameters and age,IOP before or under medical treatment,HFA,and corneal thickness values. Significant correlations (P<0.01) were observed in OAG eyes between electrophysiological results and HFA values. Pattern electroretinogram and VEP responses were normal in all control eyes. Conclusions: Combined PERG/VEP recordings identified a large percentage of ocular hypertension eyes with impairment of the innermost retinal layers,not withstanding normal optic disc morphology and normal HFA. In OAG eyes,PERG P50 to N95 amplitude and VEP P100 implicit time showed the highest sensitivity/specificity for the detection of a visual dysfunction. The presence of abnormal PERG and/or VEP responses did not allow a clearcut separation between ocular hypertension and OAG eyes.展开更多
目的探讨血栓通注射液联合鼠神经生长因子治疗非动脉炎性前部缺血性视神经病变(AION)的疗效观察。方法选取2013年6月—2015年6月沈阳市第四人民医院眼科收治的非动脉炎性AION患者88例,按治疗方案的差别将患者分为对照组和治疗组,每组各4...目的探讨血栓通注射液联合鼠神经生长因子治疗非动脉炎性前部缺血性视神经病变(AION)的疗效观察。方法选取2013年6月—2015年6月沈阳市第四人民医院眼科收治的非动脉炎性AION患者88例,按治疗方案的差别将患者分为对照组和治疗组,每组各44例。对照组肌肉注射注射用鼠神经生长因子,18μg/次加入到0.9%生理盐水或灭菌注射用水2 m L中溶解,1次/d。治疗组在对照组治疗基础上静脉滴注血栓通注射液,5 m L加入到0.9%生理盐水250 m L,1次/d。两组患者均连续治疗4周。观察两组的临床疗效,同时比较两组视野缺损(MD)、P100波潜伏期、视盘各象限视神经纤维层厚度(ATRNFL)、视力提高行数。结果治疗后,对照组和治疗组的总有效率分别为77.27%、93.18%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者MD、P100潜伏期较治疗前显著减小,同组治疗前后差异具有统计学意义(P<0.05);且治疗组的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组ATRNFL均较治疗前减小,但治疗后治疗组ATRNFL较对照组高,两组比较差异具有统计学意义(P<0.05);并且治疗后对照组ATRNFL较正常值低。治疗组的视力提高行数高于对照组,两组比较差异具有统计学意义(P<0.05)。结论血栓通注射液联合鼠神经生长因子治疗非动脉炎性AION具有较好的临床疗效,可明显改善视力,有效提高视野,具有一定的临床推广应用价值。展开更多
目的探讨明目地黄丸联合复方樟柳碱治疗视神经萎缩的临床疗效。方法选择2014年6月—2015年6月西安市中医医院眼科收治的视神经萎缩患者88例,按照治疗方案不同分为对照组和治疗组,每组各44例。对照组颞浅动脉旁皮下注射复方樟柳碱注射液,...目的探讨明目地黄丸联合复方樟柳碱治疗视神经萎缩的临床疗效。方法选择2014年6月—2015年6月西安市中医医院眼科收治的视神经萎缩患者88例,按照治疗方案不同分为对照组和治疗组,每组各44例。对照组颞浅动脉旁皮下注射复方樟柳碱注射液,2 m L/次,1次/d。治疗组在对照组治疗方法上口服明目地黄丸,1丸/次,2次/d。两周为1个疗程,两组患者均连续治疗3个疗程,每个疗程间隔5 d。观察两组患者的临床疗效,同时比较两组视野缺损、P100波潜伏期、视力提高行数的变化。结果治疗后,对照组和治疗组总有效率分别为75.00%、90.91%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者视野缺损、P100波潜伏期均显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组视力提高行数优于对照组,两组比较差异具有统计学意义(P<0.05)。对照组和治疗组不良反应发生率分别为2.27%、4.55%,两组比较差异无统计学意义。结论明目地黄丸联合复方樟柳碱治疗视神经萎缩的临床疗效显著,可促进患者视力恢复,减小视野缺损,具有一定的临床推广应用价值。展开更多
文摘Objective: To assess the presence of normal or abnormal pattern electroretinogram (PERG) and visual evoked potential (VEP)-responses in patients with ocular hypertension or open-angle glaucoma (OAG). Design: Retrospective,cross-sectional,case-control study. Participants: Eighty normal control subjects (mean age,51.77± 6.04 years; 80 eyes),68 ocular hypertension patients (mean age,51.58± 7.12; 68 eyes; intraocular pressure IOP < 18 mmHg under pharmacological treatment; Humphrey field analysis HFA 24/2 mean deviation MD >-2 decibels dB),and 84 OAG patients (mean age,52.77± 5.28; 84 eyes; IOP < 18 mmHg under pharmacological treatment; HFA24/2mean deviation between-2 and-23 dB)were enrolled. Methods: Simultaneous recording of PERGs and VEPs using high-contrast (80% ) 15 checkerboard stimuli reversed at the rate of 2 reversals per second. Main Outcome Measures: Pattern electroretinogram P50 and VEP P100 implicit times were considered delayed when exceeding the limit of mean values of controls plus 2 standard deviations (SDs). Pattern electroretinogram P50 to N95 and VEP N75 to P100 amplitudes were considered reduced when exceeding the limit of mean values of controls minus 2 SDs. Results: Pattern electroretinogram: P50 implicit times were delayed in 58 of 68 (85.30% ) ocular hypertension eyes and 83 of 84 (98.80% )OAG eyes; P50 toN95 amplitudes were reduced in 47 (69.12% ) ocular hypertension eyes and 84 (100% ) OAG eyes. Visual evoked potential: P100 implicit times were delayed in 58 (85.30% ) ocular hypertension eyes and 84 (100% ) OAG eyes; reduced N75 to P100 amplitudes were observed in 39 (57.35% ) ocular hypertension eyes and 73 (86.90% ) OAG eyes. Ocular hypertension eyes showed no significant correlations (Pearson test,P>0.01) between electrophysiological parameters and age,IOP before or under medical treatment,HFA,and corneal thickness values. Significant correlations (P<0.01) were observed in OAG eyes between electrophysiological results and HFA values. Pattern electroretinogram and VEP responses were normal in all control eyes. Conclusions: Combined PERG/VEP recordings identified a large percentage of ocular hypertension eyes with impairment of the innermost retinal layers,not withstanding normal optic disc morphology and normal HFA. In OAG eyes,PERG P50 to N95 amplitude and VEP P100 implicit time showed the highest sensitivity/specificity for the detection of a visual dysfunction. The presence of abnormal PERG and/or VEP responses did not allow a clearcut separation between ocular hypertension and OAG eyes.
文摘目的探讨血栓通注射液联合鼠神经生长因子治疗非动脉炎性前部缺血性视神经病变(AION)的疗效观察。方法选取2013年6月—2015年6月沈阳市第四人民医院眼科收治的非动脉炎性AION患者88例,按治疗方案的差别将患者分为对照组和治疗组,每组各44例。对照组肌肉注射注射用鼠神经生长因子,18μg/次加入到0.9%生理盐水或灭菌注射用水2 m L中溶解,1次/d。治疗组在对照组治疗基础上静脉滴注血栓通注射液,5 m L加入到0.9%生理盐水250 m L,1次/d。两组患者均连续治疗4周。观察两组的临床疗效,同时比较两组视野缺损(MD)、P100波潜伏期、视盘各象限视神经纤维层厚度(ATRNFL)、视力提高行数。结果治疗后,对照组和治疗组的总有效率分别为77.27%、93.18%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者MD、P100潜伏期较治疗前显著减小,同组治疗前后差异具有统计学意义(P<0.05);且治疗组的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组ATRNFL均较治疗前减小,但治疗后治疗组ATRNFL较对照组高,两组比较差异具有统计学意义(P<0.05);并且治疗后对照组ATRNFL较正常值低。治疗组的视力提高行数高于对照组,两组比较差异具有统计学意义(P<0.05)。结论血栓通注射液联合鼠神经生长因子治疗非动脉炎性AION具有较好的临床疗效,可明显改善视力,有效提高视野,具有一定的临床推广应用价值。
文摘目的探讨明目地黄丸联合复方樟柳碱治疗视神经萎缩的临床疗效。方法选择2014年6月—2015年6月西安市中医医院眼科收治的视神经萎缩患者88例,按照治疗方案不同分为对照组和治疗组,每组各44例。对照组颞浅动脉旁皮下注射复方樟柳碱注射液,2 m L/次,1次/d。治疗组在对照组治疗方法上口服明目地黄丸,1丸/次,2次/d。两周为1个疗程,两组患者均连续治疗3个疗程,每个疗程间隔5 d。观察两组患者的临床疗效,同时比较两组视野缺损、P100波潜伏期、视力提高行数的变化。结果治疗后,对照组和治疗组总有效率分别为75.00%、90.91%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者视野缺损、P100波潜伏期均显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组视力提高行数优于对照组,两组比较差异具有统计学意义(P<0.05)。对照组和治疗组不良反应发生率分别为2.27%、4.55%,两组比较差异无统计学意义。结论明目地黄丸联合复方樟柳碱治疗视神经萎缩的临床疗效显著,可促进患者视力恢复,减小视野缺损,具有一定的临床推广应用价值。
