目的探讨细胞S相激酶相关蛋白(S-phasekinase associated protein 2,Skp2)、p27蛋白与喉鳞状细胞癌(简称喉癌)各临床因素及预后的相关性。方法采用免疫组化SP法检测79例喉癌患者肿瘤组织的Skp2、p27表达。结果喉癌中Skp2高表达率(53.16%...目的探讨细胞S相激酶相关蛋白(S-phasekinase associated protein 2,Skp2)、p27蛋白与喉鳞状细胞癌(简称喉癌)各临床因素及预后的相关性。方法采用免疫组化SP法检测79例喉癌患者肿瘤组织的Skp2、p27表达。结果喉癌中Skp2高表达率(53.16%)显著高于正常喉组织(0%,P<0.05);喉癌Skp2蛋白低表达组的5年生存率(72.18%)显著高于高表达组(44.17%,P<0.01)。p27蛋白在喉癌和癌旁喉组织中的高表达率分别为30.38%和90%,差异具有显著性(P<0.05);喉癌p27蛋白高表达组的5年生存率(72.98%)显著高于低表达组(51.13%,P<0.01)。将Skp2和p27结合分析,Skp2高表达并p27低表达组的5年生存率最低,与另一组相比具有显著性差异(P=0.001)。结论Skp2蛋白通过降解靶蛋白p27可能在喉癌发生、发展中发挥重要作用。展开更多
Sodium ion capacitors(SICs) have been considered as a kind of promising devices to achieve both high power and energy density. However, it is still a challenge to achieve high energy output at elevated power delivery ...Sodium ion capacitors(SICs) have been considered as a kind of promising devices to achieve both high power and energy density. However, it is still a challenge to achieve high energy output at elevated power delivery due to the poor rate capability of battery-type electrode materials and the kinetic mismatch with capacitor-type electrode materials. In this work, to fabricate SICs, P2-Na_(0.67)Co_(0.5)Mn_(0.5)O_2(P2-NCM)was chosen as the battery-type cathode material, and a typical metal-organic framework(MOF) material,zeolitic imidazolate framework-8(ZIF-8) derived carbon(ZDC) was utilized as the capacitor-type anode material. Due to the kinetic match and high-rate performance of both electrodes, the ZDC//P2-NCM SICs exhibited an energy output of 18.8 Wh kg^(-1) at a high power delivery of 12.75 kW kg^(-1).展开更多
Charging P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)to 4.5 V for higher capacity is enticing.However,it leads to severe capacity fading,ascribing to the lattice oxygen evolution and the P2-O2 phase transformation.Here,the Mg Fe_...Charging P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)to 4.5 V for higher capacity is enticing.However,it leads to severe capacity fading,ascribing to the lattice oxygen evolution and the P2-O2 phase transformation.Here,the Mg Fe_(2)O_(4) coating and Mg,Fe co-doping were constructed simultaneously by Mg,Fe surface treatment to suppress lattice oxygen evolution and P2-O2 phase transformation of P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)at deep charging.Through ex-situ X-ray diffraction(XRD)tests,we found that the Mg,Fe bulk co-doping could reduce the repulsion between transition metals and Na+/vacancies ordering,thus inhibiting the P2-O2 phase transition and significantly reducing the irreversible volume change of the material.Meanwhile,the internal electric field formed by the dielectric polarization of Mg Fe_(2)O_(4) effectively inhibits the outward migration of oxidized O^(a-)(a<2),thereby suppressing the lattice oxygen evolution at deep charging,confirmed by in situ Raman and ex situ XPS techniques.P2-Na NM@MF-3 shows enhanced high-voltage cycling performance with capacity retentions of 84.8% and 81.3%at 0.1 and 1 C after cycles.This work sheds light on regulating the surface chemistry for Na-layered oxide materials to enhance the high-voltage performance of Na-ion batteries.展开更多
Sodium-ion intercalation oxides generally possess high compositional diversity according to their different stacking sequences.The sodium diffusion pathway in layered P-type materials used in sodium-ion batteries is o...Sodium-ion intercalation oxides generally possess high compositional diversity according to their different stacking sequences.The sodium diffusion pathway in layered P-type materials used in sodium-ion batteries is open,which can increase their rate capability by directly transmitting Na+between adjacent triangular prismatic channels,rather than passing through an intermediate tetrahedral site in O-type structure.However,how the structure chemistry of the P-type oxides determines their electrochemical properties has not been fully understood yet.Herein,by comparing the crystalline structures,electrochemical behaviors,ion/electron transport dynamics of a couple of P-type intercalation cathodes,P2-Na_(2/3)Ni1/3Mn_(2/3)O_(2)and P3-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)with the same compositions,we demonstrate experimentally and computationally that the P2 phase delivers better cycling stability and rate capability than the P3 counterpart due to the predominant contribution of the faster intrinsic Na diffusion kinetics in the P2 bulk.We also point out that it is the electronic conductivity that captures the key electrochemistry of layered P3-type materials and makes them possible to enhance the sodium storage performance.The results reveal that the correlation between stacking structure and functional properties in two typical layered P-type cathodes,providing new guidelines for preparing and designing alkali-metal layered oxide materials with improved battery performance.展开更多
文摘目的探讨细胞S相激酶相关蛋白(S-phasekinase associated protein 2,Skp2)、p27蛋白与喉鳞状细胞癌(简称喉癌)各临床因素及预后的相关性。方法采用免疫组化SP法检测79例喉癌患者肿瘤组织的Skp2、p27表达。结果喉癌中Skp2高表达率(53.16%)显著高于正常喉组织(0%,P<0.05);喉癌Skp2蛋白低表达组的5年生存率(72.18%)显著高于高表达组(44.17%,P<0.01)。p27蛋白在喉癌和癌旁喉组织中的高表达率分别为30.38%和90%,差异具有显著性(P<0.05);喉癌p27蛋白高表达组的5年生存率(72.98%)显著高于低表达组(51.13%,P<0.01)。将Skp2和p27结合分析,Skp2高表达并p27低表达组的5年生存率最低,与另一组相比具有显著性差异(P=0.001)。结论Skp2蛋白通过降解靶蛋白p27可能在喉癌发生、发展中发挥重要作用。
基金supported by Tianjin Municipal Science and Technology Commission (16PTSYJC00010 and 17JCZDJC37100)the National Natural Science Foundation of China (21773126)
文摘Sodium ion capacitors(SICs) have been considered as a kind of promising devices to achieve both high power and energy density. However, it is still a challenge to achieve high energy output at elevated power delivery due to the poor rate capability of battery-type electrode materials and the kinetic mismatch with capacitor-type electrode materials. In this work, to fabricate SICs, P2-Na_(0.67)Co_(0.5)Mn_(0.5)O_2(P2-NCM)was chosen as the battery-type cathode material, and a typical metal-organic framework(MOF) material,zeolitic imidazolate framework-8(ZIF-8) derived carbon(ZDC) was utilized as the capacitor-type anode material. Due to the kinetic match and high-rate performance of both electrodes, the ZDC//P2-NCM SICs exhibited an energy output of 18.8 Wh kg^(-1) at a high power delivery of 12.75 kW kg^(-1).
基金supported by the Special Project for the Central Government to Guide Local Technological Development (GUIKE ZY20198008)the Guangxi Technology Base and talent Subject (GUIKE AD20238012,AD20297086)+5 种基金the Natural Science Foundation of Guangxi Province (2021GXNSFDA075012)the National Natural Science Foundation of China (51902108,52104298,22169004)the National Natural Science Foundation of China (U20A20249)the Regional Innovation and Development Joint Fundthe Guangxi Innovation Driven Development Subject (GUIKE AA19182020,19254004)the Special Fund for Guangxi Distinguished Expert。
文摘Charging P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)to 4.5 V for higher capacity is enticing.However,it leads to severe capacity fading,ascribing to the lattice oxygen evolution and the P2-O2 phase transformation.Here,the Mg Fe_(2)O_(4) coating and Mg,Fe co-doping were constructed simultaneously by Mg,Fe surface treatment to suppress lattice oxygen evolution and P2-O2 phase transformation of P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)at deep charging.Through ex-situ X-ray diffraction(XRD)tests,we found that the Mg,Fe bulk co-doping could reduce the repulsion between transition metals and Na+/vacancies ordering,thus inhibiting the P2-O2 phase transition and significantly reducing the irreversible volume change of the material.Meanwhile,the internal electric field formed by the dielectric polarization of Mg Fe_(2)O_(4) effectively inhibits the outward migration of oxidized O^(a-)(a<2),thereby suppressing the lattice oxygen evolution at deep charging,confirmed by in situ Raman and ex situ XPS techniques.P2-Na NM@MF-3 shows enhanced high-voltage cycling performance with capacity retentions of 84.8% and 81.3%at 0.1 and 1 C after cycles.This work sheds light on regulating the surface chemistry for Na-layered oxide materials to enhance the high-voltage performance of Na-ion batteries.
基金supported by the National Natural Science Foundation of China (U1607128,52102302 and 21521005)Natural Science Foundation of Beijing (2222020)+1 种基金the Young Talent Support Plan and Siyuan Scholar of Xi’an Jiaotong University (DQ6J011 and DQ1J009)State Key Laboratory of Electrical Insulation and Power Equipment (EIPE23313)
文摘Sodium-ion intercalation oxides generally possess high compositional diversity according to their different stacking sequences.The sodium diffusion pathway in layered P-type materials used in sodium-ion batteries is open,which can increase their rate capability by directly transmitting Na+between adjacent triangular prismatic channels,rather than passing through an intermediate tetrahedral site in O-type structure.However,how the structure chemistry of the P-type oxides determines their electrochemical properties has not been fully understood yet.Herein,by comparing the crystalline structures,electrochemical behaviors,ion/electron transport dynamics of a couple of P-type intercalation cathodes,P2-Na_(2/3)Ni1/3Mn_(2/3)O_(2)and P3-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)with the same compositions,we demonstrate experimentally and computationally that the P2 phase delivers better cycling stability and rate capability than the P3 counterpart due to the predominant contribution of the faster intrinsic Na diffusion kinetics in the P2 bulk.We also point out that it is the electronic conductivity that captures the key electrochemistry of layered P3-type materials and makes them possible to enhance the sodium storage performance.The results reveal that the correlation between stacking structure and functional properties in two typical layered P-type cathodes,providing new guidelines for preparing and designing alkali-metal layered oxide materials with improved battery performance.
