Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has b...Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last decades.However,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic strategies.Increasing evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s disease.These receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s disease.This review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.展开更多
After a century of relative stability in the electricity sector,the widespread adoption of distributed energy resources,along with recent advancements in computing and communication technologies,has fundamentally alte...After a century of relative stability in the electricity sector,the widespread adoption of distributed energy resources,along with recent advancements in computing and communication technologies,has fundamentally altered how energy is consumed,traded,and utilized.This change signifies a crucial shift as the power system evolves from its traditional hierarchical organization to a more decentralized approach.At the heart of this transformation are innovative energy distribution models,like peer-to-peer(P2P)sharing,which enable communities to collaboratively manage their energy resources.The effectiveness of P2P sharing not only improves the economic prospects for prosumers,who generate and consume energy,but also enhances energy resilience and sustainability.This allows communities to better leverage local resources while fostering a sense of collective responsibility and collaboration in energy management.However,there is still no extensive implementation of such sharing models in today’s electricitymarkets.Research on distributed energy P2P trading is still in the exploratory stage,and it is particularly important to comprehensively understand and analyze the existing distributed energy P2P trading market.This paper contributes with an overview of the P2P markets that starts with the network framework,market structure,technical approach for trading mechanism,and blockchain technology,moving to the outlook in this field.展开更多
随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境...随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境效益的社会福利函数,研究分布式电能产消者通过合作联盟形式实现社会福利最大化的途径。设计一种依据产消者对联盟社会福利贡献值分配合作剩余的机制,激励产消者合作的积极性以维持联盟的稳定。算例分析表明:相较于P2G(peer-to-grid)交易和非合作P2P交易,产消者以合作联盟方式参与电力P2P交易的社会福利分别提升了62.62%、33.79%。因此,以市场化的方式组建合作联盟参与电力P2P交易并合理分配利益,可挖掘分布式清洁能源就地消纳的潜力,促进能源消费的绿色低碳转型。展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos.6043302060773111(国家自然科学基金)+1 种基金the Program for New Century Excellent Talents in University of China under Grant No.NCET-05-0683(新世纪优秀人才支持计划)the Program for Changjiang Scholars and Innovative Research Team in University of China under Grant No.IRT0661(长江学者和创新团队发展计划)
文摘Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last decades.However,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic strategies.Increasing evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s disease.These receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s disease.This review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.
基金funded by the National Natural Science Foundation of China(52167013)the Key Program of Natural Science Foundation of Gansu Province(24JRRA225)Natural Science Foundation of Gansu Province(23JRRA891).
文摘After a century of relative stability in the electricity sector,the widespread adoption of distributed energy resources,along with recent advancements in computing and communication technologies,has fundamentally altered how energy is consumed,traded,and utilized.This change signifies a crucial shift as the power system evolves from its traditional hierarchical organization to a more decentralized approach.At the heart of this transformation are innovative energy distribution models,like peer-to-peer(P2P)sharing,which enable communities to collaboratively manage their energy resources.The effectiveness of P2P sharing not only improves the economic prospects for prosumers,who generate and consume energy,but also enhances energy resilience and sustainability.This allows communities to better leverage local resources while fostering a sense of collective responsibility and collaboration in energy management.However,there is still no extensive implementation of such sharing models in today’s electricitymarkets.Research on distributed energy P2P trading is still in the exploratory stage,and it is particularly important to comprehensively understand and analyze the existing distributed energy P2P trading market.This paper contributes with an overview of the P2P markets that starts with the network framework,market structure,technical approach for trading mechanism,and blockchain technology,moving to the outlook in this field.
文摘随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境效益的社会福利函数,研究分布式电能产消者通过合作联盟形式实现社会福利最大化的途径。设计一种依据产消者对联盟社会福利贡献值分配合作剩余的机制,激励产消者合作的积极性以维持联盟的稳定。算例分析表明:相较于P2G(peer-to-grid)交易和非合作P2P交易,产消者以合作联盟方式参与电力P2P交易的社会福利分别提升了62.62%、33.79%。因此,以市场化的方式组建合作联盟参与电力P2P交易并合理分配利益,可挖掘分布式清洁能源就地消纳的潜力,促进能源消费的绿色低碳转型。
