目的对2021年采集于我国福建的A组轮状病毒(group A rotavirus,RVA)G3P[8]毒株FJ21351116进行全基因组分子特征分析。方法使用高灵敏度A组轮状病毒全基因组测序方法对FJ21351116进行全基因组测序。用MEGA11.0、Geneious9.0.2和DNASTAR...目的对2021年采集于我国福建的A组轮状病毒(group A rotavirus,RVA)G3P[8]毒株FJ21351116进行全基因组分子特征分析。方法使用高灵敏度A组轮状病毒全基因组测序方法对FJ21351116进行全基因组测序。用MEGA11.0、Geneious9.0.2和DNASTAR软件通过核酸序列分析评估病毒的基因组特征。使用BioEdit v.7.0.9.0和PyMOL v.2.5.2分析VP7和VP4(VP8*)的中和表位。结果我国福建RVA毒株FJ21351116基因型为G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2,系统进化分析显示,FJ21351116株的VP7、VP4、VP3、NSP2-NSP5基因与近几年日本检测到的马样DS-1样G3P[8]基因存在亲缘关系。而VP6、VP1、VP2、NSP1基因与大部分国家G2P[4]的相应基因亲缘关系近,特别是新加坡,表明该毒株是马样G3P[8]毒株与G2P[4]毒株共感染过程中通过基因重配形成的。FJ21351116的VP7/VP4基因与Rotarix和RotaTeq疫苗的进化分析表明,VP7和VP4(VP8*)中和抗原表位与疫苗氨基酸位点均存在多个突变。推测Rotarix和RotaTeq疫苗针对马样DS-1样G3P[8]RVA的保护效果不佳,且与Rotarix的中和抗原表位氨基酸差异高于RotaTeq。结论本研究发现一例中国罕见的DS-1样G3P[8]型RVA毒株,且疫苗株可能对其保护效果差,强调了持续监测RVA毒株及研发高效覆盖面全的RVA疫苗的重要性。展开更多
The main aim of the present paper is to establish an intrinsic investigation of the energy β-conformal change of the most important special Finsler spaces, namely, Ch-recurrent, Cv-recurrent, C0-recurrent, Sv-recurre...The main aim of the present paper is to establish an intrinsic investigation of the energy β-conformal change of the most important special Finsler spaces, namely, Ch-recurrent, Cv-recurrent, C0-recurrent, Sv-recurrent, quasi-C-reducible, semi-C-reducible, C-reducible, P-reducible, C2-like, S3-like, P2-like and h-isotropic, ···, etc. Necessary and sufficient conditions for such special Finsler manifolds to be invariant under an energy β-conformal change are obtained. It should be pointed out that the present work is formulated in a prospective modern coordinate-free form.展开更多
Multisensory enhancement,as a facilitation phenomenon,is responsible for superior behavioral performance when an individual is responding to cross-modal versus modality-specific stimuli.However,the event-related poten...Multisensory enhancement,as a facilitation phenomenon,is responsible for superior behavioral performance when an individual is responding to cross-modal versus modality-specific stimuli.However,the event-related potential（ERP） counterparts of behavioral multisensory enhancement are not well known.We recorded ERPs and behavioral data from 14 healthy volunteers with three types of target stimuli（modality-specific,bimodal,and trimodal） to examine the spatio-temporal electrophysiological characteristics of multisensory enhancement by comparing behavioral data with ERPs.We found a strong correlation between P3 latency and behavioral performance in terms of reaction time（RT）（R = 0.98,P ＆lt;0.001）,suggesting that P3 latency constitutes a temporal measure of behavioral multisensory enhancement.In addition,a fast RT and short P3 latency were found when comparing the modality-specific visual target with the modality-specific auditory and somatosensory targets.Our results indicate that behavioral multisensory enhancement can be identified by the latency and source distribution of the P3 component.These findings may advance our understanding of the neuronal mechanisms of multisensory enhancement.展开更多
文摘目的对2021年采集于我国福建的A组轮状病毒(group A rotavirus,RVA)G3P[8]毒株FJ21351116进行全基因组分子特征分析。方法使用高灵敏度A组轮状病毒全基因组测序方法对FJ21351116进行全基因组测序。用MEGA11.0、Geneious9.0.2和DNASTAR软件通过核酸序列分析评估病毒的基因组特征。使用BioEdit v.7.0.9.0和PyMOL v.2.5.2分析VP7和VP4(VP8*)的中和表位。结果我国福建RVA毒株FJ21351116基因型为G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2,系统进化分析显示,FJ21351116株的VP7、VP4、VP3、NSP2-NSP5基因与近几年日本检测到的马样DS-1样G3P[8]基因存在亲缘关系。而VP6、VP1、VP2、NSP1基因与大部分国家G2P[4]的相应基因亲缘关系近,特别是新加坡,表明该毒株是马样G3P[8]毒株与G2P[4]毒株共感染过程中通过基因重配形成的。FJ21351116的VP7/VP4基因与Rotarix和RotaTeq疫苗的进化分析表明,VP7和VP4(VP8*)中和抗原表位与疫苗氨基酸位点均存在多个突变。推测Rotarix和RotaTeq疫苗针对马样DS-1样G3P[8]RVA的保护效果不佳,且与Rotarix的中和抗原表位氨基酸差异高于RotaTeq。结论本研究发现一例中国罕见的DS-1样G3P[8]型RVA毒株,且疫苗株可能对其保护效果差,强调了持续监测RVA毒株及研发高效覆盖面全的RVA疫苗的重要性。
文摘The main aim of the present paper is to establish an intrinsic investigation of the energy β-conformal change of the most important special Finsler spaces, namely, Ch-recurrent, Cv-recurrent, C0-recurrent, Sv-recurrent, quasi-C-reducible, semi-C-reducible, C-reducible, P-reducible, C2-like, S3-like, P2-like and h-isotropic, ···, etc. Necessary and sufficient conditions for such special Finsler manifolds to be invariant under an energy β-conformal change are obtained. It should be pointed out that the present work is formulated in a prospective modern coordinate-free form.
基金partly supported by the National Natural Science Foundation of China(81271685)Key Project of Science and Technology Fund of Tianjin Municipality,China(10JCZDJC16100)+1 种基金the China Postdoctoral Science Foundation(2012M510754)the Independent Innovative Fund of Tianjin University,Tianjin Municipality,China(1102)
文摘Multisensory enhancement,as a facilitation phenomenon,is responsible for superior behavioral performance when an individual is responding to cross-modal versus modality-specific stimuli.However,the event-related potential（ERP） counterparts of behavioral multisensory enhancement are not well known.We recorded ERPs and behavioral data from 14 healthy volunteers with three types of target stimuli（modality-specific,bimodal,and trimodal） to examine the spatio-temporal electrophysiological characteristics of multisensory enhancement by comparing behavioral data with ERPs.We found a strong correlation between P3 latency and behavioral performance in terms of reaction time（RT）（R = 0.98,P ＆lt;0.001）,suggesting that P3 latency constitutes a temporal measure of behavioral multisensory enhancement.In addition,a fast RT and short P3 latency were found when comparing the modality-specific visual target with the modality-specific auditory and somatosensory targets.Our results indicate that behavioral multisensory enhancement can be identified by the latency and source distribution of the P3 component.These findings may advance our understanding of the neuronal mechanisms of multisensory enhancement.
