In automotive industries,panel acoustic contribution analysis(PACA)is used to investigate the contributions of the body panels to the acoustic pressure at a certain point of interest.Currently,PACA is implementedmostl...In automotive industries,panel acoustic contribution analysis(PACA)is used to investigate the contributions of the body panels to the acoustic pressure at a certain point of interest.Currently,PACA is implementedmostly by either experiment-based methods or traditional numerical methods.However,these schemes are effort-consuming and inefficient in solving engineering problems,thereby restraining the further development of PACA in automotive acoustics.In this work,we propose a PACA scheme using discontinuous isogeometric boundary element method(IGABEM)to build an easily implementable and efficient method to identify the relative acoustic contributions of each automotive body panel.Discontinuous IGABEMis more accurate and converges faster than continuous BEM and IGABEM in the interior sound pressure evaluation of automotive compartments.In this work,a contribution ratio is defined to estimate the relative acoustic contribution of the structure panels;it can be calculated by reusing the coefficient matrix that has already been generated in the sound pressure evaluation process.The utilization of the parallel technique enables the proposed method to be more efficient than conventional methods;it is validated in two numerical examples,including a car passenger compartment subjected to realistic boundary conditions.A sound pressure response experiment based on a steel box is conducted to verify the accuracy of the interior sound pressure calculation using discontinuous IGABEM.This work is expected to promote the practical process of IGABEM for application in automotive acoustic problems.展开更多
In the past three years, RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats （CRISPR） adaptive immune system has been used to facilitate efficient genome editing in ...In the past three years, RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats （CRISPR） adaptive immune system has been used to facilitate efficient genome editing in many model and non-model animals. However, its application in nonhuman primates is still at the early stage, though in view of the similarities in anatomy, physiology, behavior and genetics, closely related nonhuman primates serve as optimal models for human biology and disease studies. In this review, we summarize the current proceedings of gene editing using CRISPR/Cas9 in nonhuman primates.展开更多
基金funded by the National Natural Science Foundation of China (Grant No.52175111)。
文摘In automotive industries,panel acoustic contribution analysis(PACA)is used to investigate the contributions of the body panels to the acoustic pressure at a certain point of interest.Currently,PACA is implementedmostly by either experiment-based methods or traditional numerical methods.However,these schemes are effort-consuming and inefficient in solving engineering problems,thereby restraining the further development of PACA in automotive acoustics.In this work,we propose a PACA scheme using discontinuous isogeometric boundary element method(IGABEM)to build an easily implementable and efficient method to identify the relative acoustic contributions of each automotive body panel.Discontinuous IGABEMis more accurate and converges faster than continuous BEM and IGABEM in the interior sound pressure evaluation of automotive compartments.In this work,a contribution ratio is defined to estimate the relative acoustic contribution of the structure panels;it can be calculated by reusing the coefficient matrix that has already been generated in the sound pressure evaluation process.The utilization of the parallel technique enables the proposed method to be more efficient than conventional methods;it is validated in two numerical examples,including a car passenger compartment subjected to realistic boundary conditions.A sound pressure response experiment based on a steel box is conducted to verify the accuracy of the interior sound pressure calculation using discontinuous IGABEM.This work is expected to promote the practical process of IGABEM for application in automotive acoustic problems.
基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13010000)the National Natural Science Foundation of China(31130051)
文摘In the past three years, RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats （CRISPR） adaptive immune system has been used to facilitate efficient genome editing in many model and non-model animals. However, its application in nonhuman primates is still at the early stage, though in view of the similarities in anatomy, physiology, behavior and genetics, closely related nonhuman primates serve as optimal models for human biology and disease studies. In this review, we summarize the current proceedings of gene editing using CRISPR/Cas9 in nonhuman primates.
