Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer cells.One of the most exciting advances withi...Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer cells.One of the most exciting advances within this field is the targeting of neoantigens,which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal cells.Although neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment,early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint inhibitors.Progress made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of neoantigens.Consequently,personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents recurrences.This review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines,and also discusses challenges and future perspectives for this innovative approach,particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors.展开更多
By using the multi-taper method(MTM)of singular value decomposition(SVD),this study investigates the interdecadal evolution(10-to 30-year cycle)of precipitation over eastern China from 1951 to 2015 and its relationshi...By using the multi-taper method(MTM)of singular value decomposition(SVD),this study investigates the interdecadal evolution(10-to 30-year cycle)of precipitation over eastern China from 1951 to 2015 and its relationship with the North Pacific sea surface temperature(SST).Two significant interdecadal signals,one with an 11-year cycle and the other with a 23-year cycle,are identified in both the precipitation and SST fields.Results show that the North Pacific SST forcing modulates the precipitation distribution over China through the effects of the Pacific Decadal Oscillation(PDO)-related anomalous Aleutian low on the western Pacific subtropical high(WPSH)and Mongolia high(MH).During the development stage of the PDO cold phase associated with the 11-year cycle,a weakened WPSH and MH increased the precipitation over the Yangtze River Basin,whereas an intensified WPSH and MH caused the enhanced rain band to move northward to North China during the decay stage.During the development stage of the PDO cold phase associated with the 23-year cycle,a weakened WPSH and MH increased the precipitation over North China,whereas an intensified WPSH and the weakened MH increased the precipitation over South China during the decay stage.The 11-year and 23-year variabilities contribute differently to the precipitation variations in the different regions of China,as seen in the 1998flooding case.The 11-year cycle mainly accounts for precipitation increases over the Yangtze River Basin,while the 23-year cycle is responsible for the precipitation increase over Northeast China.These results have important implications for understanding how the PDO modulates the precipitation distribution over China,helping to improve interdecadal climate prediction.展开更多
位于美国特拉华州纽瓦克的Covation Bio PDO公司宣布将田纳西州Loudon工厂的生物基1,3-丙二醇(PDO)产能扩大33 kt/a。目前,该工厂的产能为77 kt/a,上一次扩建是在2019年。PDO于2006年首次商业化,有多种用途。它是Sorona■的原料,Sorona...位于美国特拉华州纽瓦克的Covation Bio PDO公司宣布将田纳西州Loudon工厂的生物基1,3-丙二醇(PDO)产能扩大33 kt/a。目前,该工厂的产能为77 kt/a,上一次扩建是在2019年。PDO于2006年首次商业化,有多种用途。它是Sorona■的原料,Sorona■是一种用于地毯和织物的部分生物基聚对苯二甲酸三甲酯纤维。PDO还应用于鞋类、服装、个人护理、家庭护理、制药、食品和香料。展开更多
The subtropical North and South Pacific Meridional Modes(NPMM and SPMM)are well known precursors of El Niño-Southern Oscillation(ENSO).However,relationship between them is not constant.In the early 1980,the relat...The subtropical North and South Pacific Meridional Modes(NPMM and SPMM)are well known precursors of El Niño-Southern Oscillation(ENSO).However,relationship between them is not constant.In the early 1980,the relationship experienced an interdecadal transition.Changes in this connection can be attributed mainly to the phase change of the Pacific decadal oscillation(PDO).During the positive phase of PDO,a shallower thermocline in the central Pacific is responsible for the stronger trade wind charging(TWC)mechanism,which leads to a stronger equatorial subsurface temperature evolution.This dynamic process strengthens the connection between NPMM and ENSO.Associated with the negative phase of PDO,a shallower thermocline over southeastern Pacific allows an enhanced wind-evaporation-SST(WES)feedback,strengthening the connection between SPMM and ENSO.Using 35 Coupled Model Intercomparison Project Phase 6(CMIP6)models,we examined the NPMM/SPMM performance and its connection with ENSO in the historical runs.The great majority of CMIP6 models can reproduce the pattern of NPMM and SPMM well,but they reveal discrepant ENSO and NPMM/SPMM relationship.The intermodal uncertainty for the connection of NPMM-ENSO is due to different TWC mechanism.A stronger TWC mechanism will enhance NPMM forcing.For SPMM,few models can simulate a good relationship with ENSO.The intermodel spread in the relationship of SPMM and ENSO owing to SST bias in the southeastern Pacific,as WES feedback is stronger when the southeastern Pacific is warmer.展开更多
Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limi...Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limited heterogeneity and the divorce from clinical practice of models lead to extremely low success rate of novel anticancer drugs during clinical trials (less than 10%). In recent years, because of the high heterogeneity and human derived tumor matrix, patient-derived tumor models have been gradually applied to the preclinical evaluation of various antitumor drugs, which shows certain advantages in predicting the clinical efficacy of antitumor drugs. Optimize the drug combination through patient-derived tumor models to achieve individualized medicine has gradually become an indispensable strategy in clinical cancer therapy. The current review summarized the development of patient-derived tumor models, characterized the application, advantages and challenges of them in preclinical antitumor drug evaluation and clinical precise medicine, which will provide a scientific basis and novel insights for further basic research, drug development and clinical application.展开更多
本文利用HadISST的月平均海温数据以及ORAS3再分析数据,研究了PDO(Pacific Decadal Oscillation)不同位相对ENSO(El Niño and South Oscillation)非对称的年代际调整。对PDO不同位相的海表温度异常(SSTA,sea surface temperature a...本文利用HadISST的月平均海温数据以及ORAS3再分析数据,研究了PDO(Pacific Decadal Oscillation)不同位相对ENSO(El Niño and South Oscillation)非对称的年代际调整。对PDO不同位相的海表温度异常(SSTA,sea surface temperature anomaly)的偏度分析发现,PDO正位相期间东太平洋的ENSO非对称明显强于PDO负位相期间。同时,通过对次表层(50~150m)海洋热量收支计算发现,东太平洋次表层非线性动力加热项(NDH,nonlinear dynamical heating)在PDO不同位相下也有明显的变化,PDO正位相期间东太平洋的次表层NDH明显强于PDO负位相期间,NDH的差异主要是由其纬向分量NDHx的差异引起的。东太平洋更强的次表层NDHx使PDO正位相期间El Niño事件和La Niña事件次表层温度异常(SubTA,subsurface temperature anomaly)的差距更大,从而引起SSTA的非对称,导致PDO正位相期间东太平洋的ENSO非对称比PDO负位相期间强。展开更多
基金supported by grants from the National Clinical Research Center Cancer Fundthe Haihe Laboratory of Synthetic Biology(22HHSWSS00004)。
文摘Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer cells.One of the most exciting advances within this field is the targeting of neoantigens,which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal cells.Although neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment,early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint inhibitors.Progress made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of neoantigens.Consequently,personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents recurrences.This review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines,and also discusses challenges and future perspectives for this innovative approach,particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors.
基金supported by the National Natural Science Foundation of China(Grant No.42030410)Laoshan Laboratory(No.LSKJ202202403-2)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB40000000)the Startup Foundation for Introducing Talent of NUIST。
文摘By using the multi-taper method(MTM)of singular value decomposition(SVD),this study investigates the interdecadal evolution(10-to 30-year cycle)of precipitation over eastern China from 1951 to 2015 and its relationship with the North Pacific sea surface temperature(SST).Two significant interdecadal signals,one with an 11-year cycle and the other with a 23-year cycle,are identified in both the precipitation and SST fields.Results show that the North Pacific SST forcing modulates the precipitation distribution over China through the effects of the Pacific Decadal Oscillation(PDO)-related anomalous Aleutian low on the western Pacific subtropical high(WPSH)and Mongolia high(MH).During the development stage of the PDO cold phase associated with the 11-year cycle,a weakened WPSH and MH increased the precipitation over the Yangtze River Basin,whereas an intensified WPSH and MH caused the enhanced rain band to move northward to North China during the decay stage.During the development stage of the PDO cold phase associated with the 23-year cycle,a weakened WPSH and MH increased the precipitation over North China,whereas an intensified WPSH and the weakened MH increased the precipitation over South China during the decay stage.The 11-year and 23-year variabilities contribute differently to the precipitation variations in the different regions of China,as seen in the 1998flooding case.The 11-year cycle mainly accounts for precipitation increases over the Yangtze River Basin,while the 23-year cycle is responsible for the precipitation increase over Northeast China.These results have important implications for understanding how the PDO modulates the precipitation distribution over China,helping to improve interdecadal climate prediction.
文摘位于美国特拉华州纽瓦克的Covation Bio PDO公司宣布将田纳西州Loudon工厂的生物基1,3-丙二醇(PDO)产能扩大33 kt/a。目前,该工厂的产能为77 kt/a,上一次扩建是在2019年。PDO于2006年首次商业化,有多种用途。它是Sorona■的原料,Sorona■是一种用于地毯和织物的部分生物基聚对苯二甲酸三甲酯纤维。PDO还应用于鞋类、服装、个人护理、家庭护理、制药、食品和香料。
基金Supported by the National Natural Science Foundation of China(NSFC)(No.41976027)。
文摘The subtropical North and South Pacific Meridional Modes(NPMM and SPMM)are well known precursors of El Niño-Southern Oscillation(ENSO).However,relationship between them is not constant.In the early 1980,the relationship experienced an interdecadal transition.Changes in this connection can be attributed mainly to the phase change of the Pacific decadal oscillation(PDO).During the positive phase of PDO,a shallower thermocline in the central Pacific is responsible for the stronger trade wind charging(TWC)mechanism,which leads to a stronger equatorial subsurface temperature evolution.This dynamic process strengthens the connection between NPMM and ENSO.Associated with the negative phase of PDO,a shallower thermocline over southeastern Pacific allows an enhanced wind-evaporation-SST(WES)feedback,strengthening the connection between SPMM and ENSO.Using 35 Coupled Model Intercomparison Project Phase 6(CMIP6)models,we examined the NPMM/SPMM performance and its connection with ENSO in the historical runs.The great majority of CMIP6 models can reproduce the pattern of NPMM and SPMM well,but they reveal discrepant ENSO and NPMM/SPMM relationship.The intermodal uncertainty for the connection of NPMM-ENSO is due to different TWC mechanism.A stronger TWC mechanism will enhance NPMM forcing.For SPMM,few models can simulate a good relationship with ENSO.The intermodel spread in the relationship of SPMM and ENSO owing to SST bias in the southeastern Pacific,as WES feedback is stronger when the southeastern Pacific is warmer.
基金the Scientific Research Project Funding of Jianghan University(2023zd053)The Scientific Research Project Funding of Jianghan University(2021jczx-002).
文摘Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limited heterogeneity and the divorce from clinical practice of models lead to extremely low success rate of novel anticancer drugs during clinical trials (less than 10%). In recent years, because of the high heterogeneity and human derived tumor matrix, patient-derived tumor models have been gradually applied to the preclinical evaluation of various antitumor drugs, which shows certain advantages in predicting the clinical efficacy of antitumor drugs. Optimize the drug combination through patient-derived tumor models to achieve individualized medicine has gradually become an indispensable strategy in clinical cancer therapy. The current review summarized the development of patient-derived tumor models, characterized the application, advantages and challenges of them in preclinical antitumor drug evaluation and clinical precise medicine, which will provide a scientific basis and novel insights for further basic research, drug development and clinical application.
文摘本文利用HadISST的月平均海温数据以及ORAS3再分析数据,研究了PDO(Pacific Decadal Oscillation)不同位相对ENSO(El Niño and South Oscillation)非对称的年代际调整。对PDO不同位相的海表温度异常(SSTA,sea surface temperature anomaly)的偏度分析发现,PDO正位相期间东太平洋的ENSO非对称明显强于PDO负位相期间。同时,通过对次表层(50~150m)海洋热量收支计算发现,东太平洋次表层非线性动力加热项(NDH,nonlinear dynamical heating)在PDO不同位相下也有明显的变化,PDO正位相期间东太平洋的次表层NDH明显强于PDO负位相期间,NDH的差异主要是由其纬向分量NDHx的差异引起的。东太平洋更强的次表层NDHx使PDO正位相期间El Niño事件和La Niña事件次表层温度异常(SubTA,subsurface temperature anomaly)的差距更大,从而引起SSTA的非对称,导致PDO正位相期间东太平洋的ENSO非对称比PDO负位相期间强。
