This paper presents the results of studying the frequency dependence of permittivity and dielectric loss of fishbone (Fb) Kutum and polyethylene composites filled with nanoparticles fishbone Kutum and the influence of...This paper presents the results of studying the frequency dependence of permittivity and dielectric loss of fishbone (Fb) Kutum and polyethylene composites filled with nanoparticles fishbone Kutum and the influence of aluminum(Al) nanoparticles with dimensions 80-nm on the dielectric properties of polymer composites. Studies were carried out at the frequency range of 0 - 1 MHz. It was found that the variation of the volume of filler content of fishbone and aluminum nanoparticles might be prepared composite materials with the required dielectric parameters.展开更多
Nonalcoholic steatohepatitis(NASH)is a spectrum of chronic liver disease characterized by hepatic lipid metabolism disorder.Recent reports emphasized the contribution of triglyceride and diglyceride accumulation to NA...Nonalcoholic steatohepatitis(NASH)is a spectrum of chronic liver disease characterized by hepatic lipid metabolism disorder.Recent reports emphasized the contribution of triglyceride and diglyceride accumulation to NASH,while the other lipids associated with the NASH pathogenesis remained unexplored.The specific purpose of our study was to explore a novel pathogenesis and treatment strategy of NASH via profiling the metabolic characteristics of lipids.Herein,multi-omics techniques based on LC—Q-TOF/MS,LC—MS/MS and MS imaging were developed and used to screen the action targets related to NASH progress and treatment.A methionine and choline deficient(MCD)diet-induced mouse model of NASH was then constructed,and Schisandra lignans extract(SLE)was applied to alleviate hepatic damage by regulating the lipid metabolism-related enzymes CES2A and CYP4A14.Hepatic lipidomics indicated that MCD-diet led to aberrant accumulation of phosphatidylethanolamines(PEs),and SLE could significantly reduce the accumulation of intrahepatic PEs.Notably,exogenous PE(18:0/18:1)was proved to significantly aggravate the mitochondrial damage and hepatocyte apoptosis.Supplementing PE(18:0/18:1)also deteriorated the NASH progress by up regulating intrahepatic proinflammatory and fibrotic factors,while PE synthase inhibitor exerted a prominent hepatoprotective role.The current work provides new insights into the relationship between PE metabolism and the pathogenesis of NASH.展开更多
文摘This paper presents the results of studying the frequency dependence of permittivity and dielectric loss of fishbone (Fb) Kutum and polyethylene composites filled with nanoparticles fishbone Kutum and the influence of aluminum(Al) nanoparticles with dimensions 80-nm on the dielectric properties of polymer composites. Studies were carried out at the frequency range of 0 - 1 MHz. It was found that the variation of the volume of filler content of fishbone and aluminum nanoparticles might be prepared composite materials with the required dielectric parameters.
基金supported by the National Natural Science Foundation of China(Grant Number:82274194)Jiangsu Natural Science Funds(Grant Number:BK20211224,China)the Project of State Key Laboratory of Natural Medicines(Grant Number:SKLNMZZ202001,China)。
文摘Nonalcoholic steatohepatitis(NASH)is a spectrum of chronic liver disease characterized by hepatic lipid metabolism disorder.Recent reports emphasized the contribution of triglyceride and diglyceride accumulation to NASH,while the other lipids associated with the NASH pathogenesis remained unexplored.The specific purpose of our study was to explore a novel pathogenesis and treatment strategy of NASH via profiling the metabolic characteristics of lipids.Herein,multi-omics techniques based on LC—Q-TOF/MS,LC—MS/MS and MS imaging were developed and used to screen the action targets related to NASH progress and treatment.A methionine and choline deficient(MCD)diet-induced mouse model of NASH was then constructed,and Schisandra lignans extract(SLE)was applied to alleviate hepatic damage by regulating the lipid metabolism-related enzymes CES2A and CYP4A14.Hepatic lipidomics indicated that MCD-diet led to aberrant accumulation of phosphatidylethanolamines(PEs),and SLE could significantly reduce the accumulation of intrahepatic PEs.Notably,exogenous PE(18:0/18:1)was proved to significantly aggravate the mitochondrial damage and hepatocyte apoptosis.Supplementing PE(18:0/18:1)also deteriorated the NASH progress by up regulating intrahepatic proinflammatory and fibrotic factors,while PE synthase inhibitor exerted a prominent hepatoprotective role.The current work provides new insights into the relationship between PE metabolism and the pathogenesis of NASH.
