Biodegradable triblock copolymer PLA/PEG/PLA was synthesized by ring-opening bulk polymerization of D,L-lactide in the presence of poly(ethylene glycol) (PEG), in the molecular structure of which, the length of PEG an...Biodegradable triblock copolymer PLA/PEG/PLA was synthesized by ring-opening bulk polymerization of D,L-lactide in the presence of poly(ethylene glycol) (PEG), in the molecular structure of which, the length of PEG and PLA chain segments was made to be quite different. Nanoparticles were prepared by using the copolymer via a double emulsion-evaporation technique. The paticles tended to form the configuration like capsules, i.e., the nanocapsules, because of the great size difference in PEG and PLA segments of the copolymer. Insulin, chosen as a model drug, was encapsulated into nanocapsules. The effect of preparation conditions on the size, insulin encapsulation efficiency, and in vitro drug release behavour of the nanoparticles were investigated. The experimental results show that the nanocapsules had a smooth spherical surface and the mean diameter was in the range from 180 nm to 350 nm, and the entrapment of insulin achieved up to 78.4. The drug-loaded nanocapsules released their content continuously, remarkably different from the corresponding micelles which gave a significant initial burst release followed by a slow release.展开更多
研究的目的是合成具有一定分子量的两亲性磁性PEG5k-PCL4k嵌段共聚物复合微球胶束溶液。首先利用溶剂挥发法制备PEG-PCL嵌段共聚物胶束溶液,然后将Fe3O4纳米颗粒加入到胶束溶液中,制备了两亲性磁性PEG-PCL嵌段共聚物复合颗粒,最后采用XR...研究的目的是合成具有一定分子量的两亲性磁性PEG5k-PCL4k嵌段共聚物复合微球胶束溶液。首先利用溶剂挥发法制备PEG-PCL嵌段共聚物胶束溶液,然后将Fe3O4纳米颗粒加入到胶束溶液中,制备了两亲性磁性PEG-PCL嵌段共聚物复合颗粒,最后采用XRD、FTIR、TEM、1 H NMR及饱和磁化强度对磁性共聚物颗粒的物相、表面结构、微观结构及磁学性能进行了表征。结果表明:所制备的共聚物复合颗粒具有纳米结构、两亲性性能、磁学性能,同时1 H NMR核磁共振能证实了PEG-PCL两嵌段共聚物的组分及聚合单体的比例。展开更多
文摘Biodegradable triblock copolymer PLA/PEG/PLA was synthesized by ring-opening bulk polymerization of D,L-lactide in the presence of poly(ethylene glycol) (PEG), in the molecular structure of which, the length of PEG and PLA chain segments was made to be quite different. Nanoparticles were prepared by using the copolymer via a double emulsion-evaporation technique. The paticles tended to form the configuration like capsules, i.e., the nanocapsules, because of the great size difference in PEG and PLA segments of the copolymer. Insulin, chosen as a model drug, was encapsulated into nanocapsules. The effect of preparation conditions on the size, insulin encapsulation efficiency, and in vitro drug release behavour of the nanoparticles were investigated. The experimental results show that the nanocapsules had a smooth spherical surface and the mean diameter was in the range from 180 nm to 350 nm, and the entrapment of insulin achieved up to 78.4. The drug-loaded nanocapsules released their content continuously, remarkably different from the corresponding micelles which gave a significant initial burst release followed by a slow release.
文摘研究的目的是合成具有一定分子量的两亲性磁性PEG5k-PCL4k嵌段共聚物复合微球胶束溶液。首先利用溶剂挥发法制备PEG-PCL嵌段共聚物胶束溶液,然后将Fe3O4纳米颗粒加入到胶束溶液中,制备了两亲性磁性PEG-PCL嵌段共聚物复合颗粒,最后采用XRD、FTIR、TEM、1 H NMR及饱和磁化强度对磁性共聚物颗粒的物相、表面结构、微观结构及磁学性能进行了表征。结果表明:所制备的共聚物复合颗粒具有纳米结构、两亲性性能、磁学性能,同时1 H NMR核磁共振能证实了PEG-PCL两嵌段共聚物的组分及聚合单体的比例。
