2-硝基-5-苄氧基甲苯的合成

2-硝基-5-苄氧基甲苯是有机中间体,可以进一步采用Reissert法合成吲哚类化合物。以间甲酚为原料,采用一步硝化法,先0℃以下亚硝化,再程序升温至45℃氧化得到4-硝基间甲酚粗品。产品精制后收率为76.5%,高于两步硝化法的收率52%。探索了苄基三乙基氯化铵、四丁基溴化铵、OP-10、聚乙二醇200和聚乙二醇600等几种相转移催化剂对该步反应收率的影响。聚乙二醇600的相转移催化作用明显,精制后产品收率在89%以上。4-硝基间甲酚与氯化苄在乙醇钠作催化剂的条件下制备2-硝基-5-苄氧基甲苯,收率为86.9%。合成2-硝基-5-苄氧基甲苯的总收率达77%以上。通过熔点、红外和气质联用对产品进行了表征。

Zinc-mediated reactions on salicylaldehyde for Botrytis cinerea control

Botrytis cinerea is a necrotrophic fungusth at a ffects various plant species.Chemical control is an ecessity and as much as possible,eco-friendly conditions and bioresources to obtain these chemicals should be used.In this context,a series of products w as obtained from salicylaldehyde using zinc as a powerful reagent and tested for antifungal activity against Botrytis cinerea.