In this work, we describe the one-pot synthesis of PEGylated mesoporous silica nanoparticles （MSNs） with uniform shape, tunable sizes, and narrow size distributions. The size of these nanoparticles can be controlled...In this work, we describe the one-pot synthesis of PEGylated mesoporous silica nanoparticles （MSNs） with uniform shape, tunable sizes, and narrow size distributions. The size of these nanoparticles can be controlled from 49 nm to 98 nm by simply varying the concentration oftriethanolamine during the base- catalyzed sol-gel reaction. Particles were characterized by transmission electron microscopy, dynamic light scattering, Fourier transform infrared spectrometry, thermogravimetric analysis, and nitrogen adsorption-desorption measurements. These PEGylated MSNs exhibited excellent long-term stability in biological media, which ensures their potential applications in drug delivery.展开更多
基金supported by the Self-determined Research Program of Jiangnan University(Nos.JUSRP11214 and JUSRP 51319B to JY)
文摘In this work, we describe the one-pot synthesis of PEGylated mesoporous silica nanoparticles （MSNs） with uniform shape, tunable sizes, and narrow size distributions. The size of these nanoparticles can be controlled from 49 nm to 98 nm by simply varying the concentration oftriethanolamine during the base- catalyzed sol-gel reaction. Particles were characterized by transmission electron microscopy, dynamic light scattering, Fourier transform infrared spectrometry, thermogravimetric analysis, and nitrogen adsorption-desorption measurements. These PEGylated MSNs exhibited excellent long-term stability in biological media, which ensures their potential applications in drug delivery.
