Objective To assesse the outcomes of one-stage limb reconstruction after removal of skin cancers defect.Methods This prospective study was conducted from September 2017 to January 2020 and included 15 patients.All pat...Objective To assesse the outcomes of one-stage limb reconstruction after removal of skin cancers defect.Methods This prospective study was conducted from September 2017 to January 2020 and included 15 patients.All patients underwent extensive tumor resection and one-stage Pelnac®reconstruction of large skin defects,and regular postoperative follow-up was scheduled.At the 6-month follow-up,tumor recurrence and scar quality was assessed using the Vancouver Scar Scale(VSS).None of the patients exhibited infection,wound necrosis,hematoma,seroma,or recurrence.Results All the skin grafts were well accepted by the patients.Nine patients reported normal or near-normal sensory function,while six reported slight sensory loss.No cases of significant functional loss were observed.We enrolled 10 men and 5 women with a mean age of 63.9 years(range:46-78 years).The mean follow-up duration was 20.6 months(range:12-36 months).The skin tumors were located on the feet(n=4),forearms(n=3),and legs(n=8).The malignant tumors included malignant melanomas(13.3%),basal cell carcinomas(33.3%),and squamous cell carcinomas(53.3%).The mean operative time was 40.7 min.Two patients underwent radiotherapy.The average length of hospital stay was 2.6 days.The mean skin defect area was 33.2 cm^(2)(range:16.6-51.6 cm^(2)).The patient satisfaction score(regarding the aesthetic appearance of the grafted area)was 79.7/100,and the VSS score was 3.8.Conclusion Pelnac®dermal templates facilitate efficient and reliable reconstruction of skin defects after skin cancer resection.展开更多
Background:Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss.However,for patients with extensive burns,split-thickness skin grafting is limited by donor skin availabil...Background:Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss.However,for patients with extensive burns,split-thickness skin grafting is limited by donor skin availability.Grafting split-thickness skin minced into micrografts increases the expansion ratio but may reduce wound repair quality.Dermal substitutes such as Pelnac can enhance the healing of full-thickness skin wounds,but their application currently requires two surgeries.The present study investigated whether it is possible to repair full-thickness skin defects and improve wound healing quality in a single surgery using Pelnac as an overlay of minced split-thickness skin grafts in a rat model.Methods:A full-thickness skin defect model was established using male Sprague-Dawley rats of 10 weeks old.The animals were randomly divided into control and experimental groups in which Vaseline gauze and Pelnac,respectively,were overlaid on minced split-thickness skin grafts to repair the defects.Wound healing rate and quality were compared between the two groups.For better illustration of the quality of wound healing,some results were compared with those obtained for normal skin of rats.Results:We found that using Pelnac as an overlay for minced split-thickness skin grafts accelerated wound closure and stimulated cell proliferation and tissue angiogenesis.In addition,this approach enhanced collagen synthesis and increased the formation of basement membrane and dermis as well as the expression of growth factors related to wound healing while reducing scar formation.Conclusions:Using minced split-thickness skin grafts overlaid with Pelnac enables the reconstruction of fullthickness skin defects in a single step and can increase the healing rate while improving the quality of wound healing.展开更多
文摘Objective To assesse the outcomes of one-stage limb reconstruction after removal of skin cancers defect.Methods This prospective study was conducted from September 2017 to January 2020 and included 15 patients.All patients underwent extensive tumor resection and one-stage Pelnac®reconstruction of large skin defects,and regular postoperative follow-up was scheduled.At the 6-month follow-up,tumor recurrence and scar quality was assessed using the Vancouver Scar Scale(VSS).None of the patients exhibited infection,wound necrosis,hematoma,seroma,or recurrence.Results All the skin grafts were well accepted by the patients.Nine patients reported normal or near-normal sensory function,while six reported slight sensory loss.No cases of significant functional loss were observed.We enrolled 10 men and 5 women with a mean age of 63.9 years(range:46-78 years).The mean follow-up duration was 20.6 months(range:12-36 months).The skin tumors were located on the feet(n=4),forearms(n=3),and legs(n=8).The malignant tumors included malignant melanomas(13.3%),basal cell carcinomas(33.3%),and squamous cell carcinomas(53.3%).The mean operative time was 40.7 min.Two patients underwent radiotherapy.The average length of hospital stay was 2.6 days.The mean skin defect area was 33.2 cm^(2)(range:16.6-51.6 cm^(2)).The patient satisfaction score(regarding the aesthetic appearance of the grafted area)was 79.7/100,and the VSS score was 3.8.Conclusion Pelnac®dermal templates facilitate efficient and reliable reconstruction of skin defects after skin cancer resection.
文摘Background:Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss.However,for patients with extensive burns,split-thickness skin grafting is limited by donor skin availability.Grafting split-thickness skin minced into micrografts increases the expansion ratio but may reduce wound repair quality.Dermal substitutes such as Pelnac can enhance the healing of full-thickness skin wounds,but their application currently requires two surgeries.The present study investigated whether it is possible to repair full-thickness skin defects and improve wound healing quality in a single surgery using Pelnac as an overlay of minced split-thickness skin grafts in a rat model.Methods:A full-thickness skin defect model was established using male Sprague-Dawley rats of 10 weeks old.The animals were randomly divided into control and experimental groups in which Vaseline gauze and Pelnac,respectively,were overlaid on minced split-thickness skin grafts to repair the defects.Wound healing rate and quality were compared between the two groups.For better illustration of the quality of wound healing,some results were compared with those obtained for normal skin of rats.Results:We found that using Pelnac as an overlay for minced split-thickness skin grafts accelerated wound closure and stimulated cell proliferation and tissue angiogenesis.In addition,this approach enhanced collagen synthesis and increased the formation of basement membrane and dermis as well as the expression of growth factors related to wound healing while reducing scar formation.Conclusions:Using minced split-thickness skin grafts overlaid with Pelnac enables the reconstruction of fullthickness skin defects in a single step and can increase the healing rate while improving the quality of wound healing.
