期刊文献+
共找到250篇文章
< 1 2 13 >
每页显示 20 50 100
AGGREGATE SPECIAL FUNCTIONS TO APPROXIMATE PERMUTING TRI-HOMOMORPHISMS AND PERMUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS
1
作者 Safoura Rezaei ADERYANI Azam AHADI +1 位作者 Reza SAADATI Hari M.SRIVASTAVA 《Acta Mathematica Scientia》 SCIE CSCD 2024年第1期311-338,共28页
In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better... In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem. 展开更多
关键词 permuting tri-homomorphism in Banach algebra permuting tri-derivation on C*-algebra fixed point theorem Ulam-Hyers-Rassias stability aggregate special functions tri-additiveψ-functional inequality
下载PDF
SOME PERMUTING TRINOMIALS OVER FINITEFIELDS 被引量:1
2
作者 June Bok Lee(Dept. of Math., Yonsei University, Seoul, 120-749,Korea)Young Ho Park (Dept. of Math., Kangwon National University, Chuncheon, 200-701,Korea) 《Acta Mathematica Scientia》 SCIE CSCD 1997年第3期250-254,共5页
Trinomial permutation polynomials of the form xr(ax2s + bxs + c) over Fq have been studied where 3|q-1 and s = (q-1)/3. We derive some necessary and sufficient conditions for these trinomials to be permutation polynom... Trinomial permutation polynomials of the form xr(ax2s + bxs + c) over Fq have been studied where 3|q-1 and s = (q-1)/3. We derive some necessary and sufficient conditions for these trinomials to be permutation polynomials, and construct some examples. Moreover, we discuss the relationship between permutation trinomials of the given type over a tower of finite fields. 展开更多
关键词 MATH SOME permuting TRINOMIALS OVER FINITEFIELDS
下载PDF
OPTIMIZATION OF THE METHOD OF SELECTING THE TOOTH NUMBER SERIES IN A SET OF CHANGE GEARS Part Ⅱ The Rules for Permuting the DBL’s of the First Order and Their Intercalated Sets
3
作者 周启澄 《Journal of China Textile University(English Edition)》 EI CAS 1989年第2期76-86,共11页
The problem in practice of determining the proper combination of Z<sub>i</sub> in a set of changegears may be abstracted to the problem of finding the proper combination and permutation ofthe elements a<... The problem in practice of determining the proper combination of Z<sub>i</sub> in a set of changegears may be abstracted to the problem of finding the proper combination and permutation ofthe elements a<sub>i,i+1</sub> of the set A<sub>1</sub> to give maximum M-d. Some results to find optimal combina-tions of the elements of the set A<sub>1</sub> have been reported in part I. In this part, some rules forpermuting these elements are introduced. By means of these rules, three kinds of intercalated setsof A<sub>1</sub> have been found, namely: (1) Sets with an even left wing, (2) Sets with coincidence of bothwings, and (3) Sets with circulated elements. 展开更多
关键词 PERMUTATION CHANGE gear mechanism difference LOGARITHM OPTIMIZATION combination INTERCALATED SETS
下载PDF
基于EEMD、相关系数、排列熵和小波阈值去噪的新型水下声学信号去噪方法
4
作者 张玉燕 杨志霞 +1 位作者 杜晓莉 罗小元 《哈尔滨工程大学学报(英文版)》 CSCD 2024年第1期222-237,共16页
The complexities of the marine environment and the unique characteristics of underwater channels pose challenges in obtaining reliable signals underwater,necessitating the filtration of underwater acoustic noise.Herei... The complexities of the marine environment and the unique characteristics of underwater channels pose challenges in obtaining reliable signals underwater,necessitating the filtration of underwater acoustic noise.Herein,an underwater acoustic signal denoising method based on ensemble empirical mode decomposition(EEMD),correlation coefficient(CC),permutation entropy(PE),and wavelet threshold denoising(WTD)is proposed.Furthermore,simulation experiments are conducted using simulated and real underwater acoustic data.The experimental results reveal that the proposed denoising method outperforms other previous methods in terms of signal-to-noise ratio,root mean square error,and CC.The proposed method eliminates noise and retains valuable information in the signal. 展开更多
关键词 Ensemble empirical mode decomposition Correlation coefficient Permutation entropy Wavelet threshold denoising Underwater acoustic signal denoising
下载PDF
Weak Fault Feature Extraction of the Rotating Machinery Using Flexible Analytic Wavelet Transform and Nonlinear Quantum Permutation Entropy
5
作者 Lili Bai Wenhui Li +3 位作者 He Ren Feng Li TaoYan Lirong Chen 《Computers, Materials & Continua》 SCIE EI 2024年第6期4513-4531,共19页
Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery,where weak fault characteristic signals hinder accurate fault state representation,we propose a novel feature extrac... Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery,where weak fault characteristic signals hinder accurate fault state representation,we propose a novel feature extraction method that combines the Flexible Analytic Wavelet Transform(FAWT)with Nonlinear Quantum Permutation Entropy.FAWT,leveraging fractional orders and arbitrary scaling and translation factors,exhibits superior translational invariance and adjustable fundamental oscillatory characteristics.This flexibility enables FAWT to provide well-suited wavelet shapes,effectively matching subtle fault components and avoiding performance degradation associated with fixed frequency partitioning and low-oscillation bases in detecting weak faults.In our approach,gearbox vibration signals undergo FAWT to obtain sub-bands.Quantum theory is then introduced into permutation entropy to propose Nonlinear Quantum Permutation Entropy,a feature that more accurately characterizes the operational state of vibration simulation signals.The nonlinear quantum permutation entropy extracted from sub-bands is utilized to characterize the operating state of rotating machinery.A comprehensive analysis of vibration signals from rolling bearings and gearboxes validates the feasibility of the proposed method.Comparative assessments with parameters derived from traditional permutation entropy,sample entropy,wavelet transform(WT),and empirical mode decomposition(EMD)underscore the superior effectiveness of this approach in fault detection and classification for rotating machinery. 展开更多
关键词 Rotating machinery quantum theory nonlinear quantum permutation entropy Flexible Analytic Wavelet Transform(FAWT) feature extraction
下载PDF
Entanglement and Volume Monogamy Features of Permutation Symmetric N-Qubit Pure States with N-Distinct Spinors: GHZ and States
6
作者   Sudha Alevoor Raghavendra Usha Devi +4 位作者 Akshata Shenoy Hejamadi Hosapete Seshadri Karthik Humera Talath Bada Palaiah Govindaraja Attipat Krishnaswamy Rajagopal 《Journal of Quantum Information Science》 CAS 2024年第2期29-51,共23页
We explore the entanglement features of pure symmetric N-qubit states characterized by N-distinct spinors with a particular focus on the Greenberger-Horne-Zeilinger (GHZ) states and , an equal superposition of W and o... We explore the entanglement features of pure symmetric N-qubit states characterized by N-distinct spinors with a particular focus on the Greenberger-Horne-Zeilinger (GHZ) states and , an equal superposition of W and obverse W states. Along with a comparison of pairwise entanglement and monogamy properties, we explore the geometric information contained in them by constructing their canonical steering ellipsoids. We obtain the volume monogamy relations satisfied by states as a function of number of qubits and compare with the maximal monogamy property of GHZ states. 展开更多
关键词 Permutation Symmetric States MONOGAMY Pairwise Entanglement
下载PDF
Differential Spatial Modulation Mapping Algorithms
7
作者 WANG Chanfei CHAI Jianxin XU Yamei 《ZTE Communications》 2024年第3期116-122,共7页
Differential spatial modulation(DSM)is a multiple-input multiple-output(MIMO)transmission scheme.It has attracted extensive research interest due to its ability to transmit additional data without increasing any radio... Differential spatial modulation(DSM)is a multiple-input multiple-output(MIMO)transmission scheme.It has attracted extensive research interest due to its ability to transmit additional data without increasing any radio frequency chain.In this paper,DSM is investigated using two mapping algorithms:Look-Up Table Order(LUTO)and Permutation Method(PM).Then,the bit error rate(BER)performance and complexity of the two mapping algorithms in various antennas and modulation methods are verified by simulation experiments.The results show that PM has a lower BER than the LUTO mapping algorithm,and the latter has lower complexity than the former. 展开更多
关键词 spatial modulation(SM) multiple-input multiple-output(MIMO) Look-Up Table Order(LUTO) Permutation Method(PM) mapping algorithm
下载PDF
日间手术和择期手术的手术相关时长差异性分析 被引量:4
8
作者 罗利 罗永 +2 位作者 杨建超 马洪升 李楠 《统计与信息论坛》 CSSCI 2014年第12期104-107,共4页
对腹腔镜胆囊切除术(以下简称LC)日间手术病人和择期手术病人的手术时长、术后恢复时长、占用手术间时长和术后住院时长分别进行了K-S检验和Permutation检验。结果显示LC日间手术和择期手术病人的手术时长、术后恢复时长、占用手术间时... 对腹腔镜胆囊切除术(以下简称LC)日间手术病人和择期手术病人的手术时长、术后恢复时长、占用手术间时长和术后住院时长分别进行了K-S检验和Permutation检验。结果显示LC日间手术和择期手术病人的手术时长、术后恢复时长、占用手术间时长和术后住院时长均值不相等,分布不相同,样本均来自不同的总体。科研工作者在研究过程中如果涉及到手术时长、术后恢复时长、占用手术间时长和术后住院时长,应考虑是否需要根据是日间手术还是择期手术加以区别对待。 展开更多
关键词 日间手术 择期手术 K-S检验 permutation检验
下载PDF
两个一维总体分布相等性的permutation检验 被引量:4
9
作者 黄群 林洁梅 赵佳因 《辽宁工程技术大学学报(自然科学版)》 CAS 北大核心 2012年第6期929-932,共4页
检验两个一维总体分布的相等性,采用理论证明和数值模拟的方法,在Prastgaard提出的Kolmogorov-Smirnov统计量T1及相应的permutation统计量T 1基础上,提出了基于K-S统计量的新统计量T2及相应的permutation统计量T 2,研究了在一维的情形... 检验两个一维总体分布的相等性,采用理论证明和数值模拟的方法,在Prastgaard提出的Kolmogorov-Smirnov统计量T1及相应的permutation统计量T 1基础上,提出了基于K-S统计量的新统计量T2及相应的permutation统计量T 2,研究了在一维的情形下T2与T 2的分布,并进行了数值模拟.结果表明:新统计量在原假设下有相同的极限分布,数值模拟结果优于原统计量.该方法对检验两总体分布的相等性有一定的参考价值. 展开更多
关键词 permutation方法 K-S统计量 permutation统计量 假设检验 统计推断 经验分布函数 极限分布 数值模拟
下载PDF
新疆喀什-乌恰交汇区潮汐触发地震活动的统计检验 被引量:7
10
作者 李金 蒋海昆 +3 位作者 桂荣 宋金 冀战波 温少妍 《中国地震》 北大核心 2014年第1期64-73,共10页
基于Schuster检验及Permutation检验方法,对喀什-乌恰交汇区地震活动受固体潮触发情况进行日尺度及月尺度检验。其中日尺度分别选取引潮力南北分量、东西分量及潮汐体应力作为潮汐曲线。研究结果显示,该地区地震活动均较多的发生于3种... 基于Schuster检验及Permutation检验方法,对喀什-乌恰交汇区地震活动受固体潮触发情况进行日尺度及月尺度检验。其中日尺度分别选取引潮力南北分量、东西分量及潮汐体应力作为潮汐曲线。研究结果显示,该地区地震活动均较多的发生于3种潮汐的最大值(相位0°)附近,优势发震相位分别为-5.86°、6.60°以及-15.52°,且发生地震的频次随潮汐力的增大而增加;利用3种潮汐曲线(引潮力日尺度南北分量、东西分量以及潮汐体应力)对所有地震进行Schuster检验所得pS值分别为10.52%、2.40%以及2.06%,Permutation检验所得pP值分别为10.90%、2.40%以及2.06%,其中基于引潮力东西分量及潮汐体应力的pS、pP值均低于潮汐触发地震的阈值0.05。月尺度Schuster检验pS值及Permutation检验pP值结果均非常小(接近于0),远低于潮汐触发地震阈值0.05,优势发震相位φ为-1.91°,较为接近月尺度下的固体潮最大值0°(即农历朔、望)。对潮汐触发地震的统计学检验结果即东西向潮汐触发效应大于南北向触发效应的原因进行了初步解释。 展开更多
关键词 喀什-乌恰交汇区 固体潮触发 Schuster检验 Permutation检验
下载PDF
REVERSIBLE LOGIC GATE NETWORK CASCADE BASED ON PERMUTATION GROUP 被引量:1
11
作者 管致锦 秦小麟 戴华 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2008年第3期219-223,共5页
The cascade of reversible logic gate network with n inputs and n outputs forms a group isomorphic to the symmetric group S2^n. Characteristics of a number of gates from the set of all generalized Toffoli gates are stu... The cascade of reversible logic gate network with n inputs and n outputs forms a group isomorphic to the symmetric group S2^n. Characteristics of a number of gates from the set of all generalized Toffoli gates are studied. Any permutation Sn is proved to be generated by a n-cycle 9 and a permutation τ= (ij,ik) together. It shows that any neighboring 2-cycle permutation can be generated by at most two NOT gates without ancilla bit. Based on the above theory, a cascade algorithm for reversible logic gate networks is proposed. A reversible example of logic gate network cascade is given to show the correctness of the algorithm. 展开更多
关键词 logic gates cascade connection permutation group
下载PDF
Bootstrap和Permutation方法在样本率多重比较中的应用 被引量:3
12
作者 钱俊 陈平雁 《中国医院统计》 2008年第1期43-45,共3页
目的介绍Bootstrap和Permutation方法在样本率多重比较中的应用。方法调用SAS中的MULTTEST过程,编写程序实现样本率的两两比较和与控制组比较,并通过实例说明效果。结果运用Bootstrap和Permutation方法能较好解决样本率的多重比较问题... 目的介绍Bootstrap和Permutation方法在样本率多重比较中的应用。方法调用SAS中的MULTTEST过程,编写程序实现样本率的两两比较和与控制组比较,并通过实例说明效果。结果运用Bootstrap和Permutation方法能较好解决样本率的多重比较问题。结论使用Bootstrap和Permutation方法的SAS程序,简单明了,结果准确,使用方便。 展开更多
关键词 BOOTSTRAP PERMUTATION 样本率 多重比较
下载PDF
Matching spatial relation graphs using a constrained partial permutation strategy
13
作者 徐晓刚 孙正兴 刘文印 《Journal of Southeast University(English Edition)》 EI CAS 2003年第3期236-239,共4页
A constrained partial permutation strategy is proposed for matching spatial relation graph (SRG), which is used in our sketch input and recognition system Smart Sketchpad for representing the spatial relationship amon... A constrained partial permutation strategy is proposed for matching spatial relation graph (SRG), which is used in our sketch input and recognition system Smart Sketchpad for representing the spatial relationship among the components of a graphic object. Using two kinds of matching constraints dynamically generated in the matching process, the proposed approach can prune most improper mappings between SRGs during the matching process. According to our theoretical analysis in this paper, the time complexity of our approach is O(n 2) in the best case, and O(n!) in the worst case, which occurs infrequently. The spatial complexity is always O(n) for all cases. Implemented in Smart Sketchpad, our proposed strategy is of good performance. 展开更多
关键词 spatial relation graph graph matching constrained partial permutation graphics recognition
下载PDF
流水车间排列排序专家系统—PFSCH
14
作者 陈荣秋 聂磊 《华中科技大学学报(自然科学版)》 EI CAS CSCD 北大核心 1989年第S1期97-99,共3页
流水车间排列排序问题可以简单表示为:n/m/p/F<sub>max</sub>,其含义为,n个不同的工件(J<sub>1</sub>,J<sub>2</sub>,…,J<sub>n</sub>)要经m台机器(M<sub>1</sub>,M&l... 流水车间排列排序问题可以简单表示为:n/m/p/F<sub>max</sub>,其含义为,n个不同的工件(J<sub>1</sub>,J<sub>2</sub>,…,J<sub>n</sub>)要经m台机器(M<sub>1</sub>,M<sub>2</sub>…,M<sub>m</sub>)加工;加工路线为M<sub>1</sub>—M<sub>2</sub>—…—M<sub>m</sub>,n个工件在每台机器上的加工顺序都一样;p表示排列排序;目标函数是使最长流程时间F<sub>max</sub>(加工周期)最短.n个工件有n!种不同的加工顺序.现已证明,n/m/p/F<sub>max</sub>(m≥3)问题属于NP难题,找不到多项式时间算法.因此,人们提出了若干个启发式算法,其中最著名的是Campbell等人提出的启发式算法(简称为CDS法).Dannenbring曾比较过11种不同的启发式算法的效果,指出“快速接近扩展搜索法(RAES法)”的结果最好.但是,RAES法实质上还是一种列举法,它不从问题本身的结构出发,具有很大的盲目性. 展开更多
关键词 PERMUTATION FLOW-SHOP SCHEDULING PROBLEM HEURISTIC algorithm EXPERT System
下载PDF
On the Julia Sets of Permutable Transcendental Entire Functions
15
作者 朱玲妹 杨德贵 王小灵 《Journal of Southeast University(English Edition)》 EI CAS 2002年第3期270-273,共4页
Let f and g be two permutable transcendental entire functions. In this paper, we first prove that J(fg)=J(f n g m) for any positive integers n and m . Then we prove that the function h(p(z))+az ∈/ B , where h(z) is... Let f and g be two permutable transcendental entire functions. In this paper, we first prove that J(fg)=J(f n g m) for any positive integers n and m . Then we prove that the function h(p(z))+az ∈/ B , where h(z) is any transcendental entire function with h′(z)=0 having infinitely many solutions, p(z) is a polynomial with deg p ≥2 and a(≠0) ∈ C . 展开更多
关键词 singular value Fatou component permutable transcendental entire function
下载PDF
截面数据异方差问题检验技术的比较 被引量:6
16
作者 徐生霞 潘海涛 《统计与决策》 CSSCI 北大核心 2017年第5期16-20,共5页
在忽略异方差的情况下,进行模型的OLS参数估计会导致严重的后果,因此,研究异方差性的检验、选取适当的检验方法是非常重要的理论与实践问题。文章基于蒙特卡罗随机模拟技术,分别在PermutationTest与传统形式下对异方差检验的主要方法有:... 在忽略异方差的情况下,进行模型的OLS参数估计会导致严重的后果,因此,研究异方差性的检验、选取适当的检验方法是非常重要的理论与实践问题。文章基于蒙特卡罗随机模拟技术,分别在PermutationTest与传统形式下对异方差检验的主要方法有:White检验、Park检验、Goldfeld-Quandt检验、Breusch-Pagan/Godfrey检验、Glejser检验,在不同的异方差假定形式下、在不同的样本容量下对这五种检验方法的第一类错误率的控制、检验功效等方面进行充分、完备的研究和讨论,并给出结论供实践工作者参考。 展开更多
关键词 异方差检验技术 蒙特卡罗模拟 R语言 第一类错误率 检验功效 Permutation检验
下载PDF
Single-trial EEG-based emotion recognition using temporally regularized common spatial pattern
17
作者 成敏敏 陆祖宏 王海贤 《Journal of Southeast University(English Edition)》 EI CAS 2015年第1期55-60,共6页
This study addresses the problem of classifying emotional words based on recorded electroencephalogram (EEG) signals by the single-trial EEG classification technique. Emotional two-character Chinese words are used a... This study addresses the problem of classifying emotional words based on recorded electroencephalogram (EEG) signals by the single-trial EEG classification technique. Emotional two-character Chinese words are used as experimental materials. Positive words versus neutral words and negative words versus neutral words are classified, respectively, using the induced EEG signals. The method of temporally regularized common spatial patterns (TRCSP) is chosen to extract features from the EEG trials, and then single-trial EEG classification is achieved by linear discriminant analysis. Classification accuracies are between 55% and 65%. The statistical significance of the classification accuracies is confirmed by permutation tests, which shows the successful identification of emotional words and neutral ones, and also the ability to identify emotional words. In addition, 10 out of 15 subjects obtain significant classification accuracy for negative words versus neutral words while only 4 are significant for positive words versus neutral words, which demonstrate that negative emotions are more easily identified. 展开更多
关键词 emotion recognition temporal regularization common spatial patterns(CSP) two-character Chinese words permutation test
下载PDF
Quantitative Precipitation Forecast Experiment Based on Basic NWP Variables Using Deep Learning 被引量:6
18
作者 Kanghui ZHOU Jisong SUN +1 位作者 Yongguang ZHENG Yutao ZHANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2022年第9期1472-1486,共15页
The quantitative precipitation forecast(QPF)performance by numerical weather prediction(NWP)methods depends fundamentally on the adopted physical parameterization schemes(PS).However,due to the complexity of the physi... The quantitative precipitation forecast(QPF)performance by numerical weather prediction(NWP)methods depends fundamentally on the adopted physical parameterization schemes(PS).However,due to the complexity of the physical mechanisms of precipitation processes,the uncertainties of PSs result in a lower QPF performance than their prediction of the basic meteorological variables such as air temperature,wind,geopotential height,and humidity.This study proposes a deep learning model named QPFNet,which uses basic meteorological variables in the ERA5 dataset by fitting a non-linear mapping relationship between the basic variables and precipitation.Basic variables forecasted by the highest-resolution model(HRES)of the European Centre for Medium-Range Weather Forecasts(ECMWF)were fed into QPFNet to forecast precipitation.Evaluation results show that QPFNet achieved better QPF performance than ECMWF HRES itself.The threat score for 3-h accumulated precipitation with depths of 0.1,3,10,and 20 mm increased by 19.7%,15.2%,43.2%,and 87.1%,respectively,indicating the proposed performance QPFNet improved with increasing levels of precipitation.The sensitivities of these meteorological variables for QPF in different pressure layers were analyzed based on the output of the QPFNet,and its performance limitations are also discussed.Using DL to extract features from basic meteorological variables can provide an important reference for QPF,and avoid some uncertainties of PSs. 展开更多
关键词 deep learning quantitative precipitation forecast permutation importance numerical weather prediction
下载PDF
Microseismic signal denoising by combining variational mode decomposition with permutation entropy 被引量:5
19
作者 Zhang Xing-Li Cao Lian-Yue +2 位作者 Chen Yan Jia Rui-Sheng Lu Xin-Ming 《Applied Geophysics》 SCIE CSCD 2022年第1期65-80,144,145,共18页
Remarkable progress has been achieved on microseismic signal denoising in recent years,which is the basic component for rock-burst detection.However,its denoising effectiveness remains unsatisfactory.To extract the ef... Remarkable progress has been achieved on microseismic signal denoising in recent years,which is the basic component for rock-burst detection.However,its denoising effectiveness remains unsatisfactory.To extract the effective microseismic signal from polluted noisy signals,a novel microseismic signal denoising method that combines the variational mode decomposition(VMD)and permutation entropy(PE),which we denote as VMD–PE,is proposed in this paper.VMD is a recently introduced technique for adaptive signal decomposition,where K is an important decomposing parameter that determines the number of modes.VMD provides a predictable eff ect on the nature of detected modes.In this work,we present a method that addresses the problem of selecting an appropriate K value by constructing a simulation signal whose spectrum is similar to that of a mine microseismic signal and apply this value to the VMD–PE method.In addition,PE is developed to identify the relevant effective microseismic signal modes,which are reconstructed to realize signal filtering.The experimental results show that the VMD–PE method remarkably outperforms the empirical mode decomposition(EMD)–VMD filtering and detrended fl uctuation analysis(DFA)–VMD denoising methods of the simulated and real microseismic signals.We expect that this novel method can inspire and help evaluate new ideas in this field. 展开更多
关键词 DENOISING Microseismic signal Permutation entropy Variational mode decomposition
下载PDF
Phase Ⅱ open-label study of recombinant circularly permuted TRAIL as a single-agent treatment for relapsed or refractory multiple myeloma 被引量:5
20
作者 Yun Leng Lugui Qiu +7 位作者 Jian Hou Yaozhong Zhao Xuejun Zhang Shifang Yang Hao Xi Zhongxia Huang Ling Pan Wenming Chen 《Chinese Journal of Cancer》 SCIE CAS CSCD 2016年第12期699-705,共7页
Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In ... Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In an earlier phase I study, a novel form of recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) that is currently in clinical development for the treatment of hematologic malignancies, i.e., circularly permuted TRAIL(CPT), was well tolerated at a dose of 2.5 mg/kg per day and showed promising preliminary activity in patients with RRMM. This phase II, open-label, multicenter study further investigated the eicacy and safety of 2.5-mg/kg per day CPT as single-agent therapy for patients with RRMM.Methods: Patients with RRMM were treated once daily with CPT(2.5 mg/kg, intravenously) for 14 consecutive days for each 21-day cycle. Clinical response and toxicity were assessed after each treatment cycle.Results: Twenty-seven patients received CPT. Using the European Group for Blood and Marrow Transplantation criteria, we calculated the overall response rate of 33.3% with 1 near-complete response(n CR) and 8 partial responses(PRs). The clinical beneit rate(48.1%) included 1 nCR, 8 PRs, and 4 minimal responses. The most common treatmentrelated adverse events(TRAEs) were fever, aspartate aminotransferase elevation, alanine aminotransferase elevation, leucopenia, rash, neutropenia, and thrombocytopenia. We graded toxicity using the Common Toxicity Criteria for Adverse Events, version 3.0, and determined that 37.0% of patients had at least 1 grade 3–4 TRAE.Conclusions: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted. 展开更多
关键词 Recombinant human circularly permuted TRAIL Phase trial Relapsed or refractory multiple myeloma Efficacy Safety
下载PDF
上一页 1 2 13 下一页 到第
使用帮助 返回顶部