Four a-galactosyl phytosphingosine 2,6’-diamide analogs were prepared from 2,6’-diamino a-galactosylphytosphingosine and the aromatic-bearing carboxylic acids. After purification with High Performance Liquid Chromat...Four a-galactosyl phytosphingosine 2,6’-diamide analogs were prepared from 2,6’-diamino a-galactosylphytosphingosine and the aromatic-bearing carboxylic acids. After purification with High Performance Liquid Chromatography, a flowcytometry for the four compounds for stimulation of human Va24+/Vb11+ NKT cell populations was carried out. Additional keto groups on the acyl chains of the 2,6’-diamide compound was associated with the enhanced stimulating effect.展开更多
An efficient and practical route to synthesize （2S,3S,4R）-2-azido-3,4-O-isopropyllidene-1,3,4-octadecanetriol from D-galactose in 18% overall yield was described, which required ten steps of reactions and only four ...An efficient and practical route to synthesize （2S,3S,4R）-2-azido-3,4-O-isopropyllidene-1,3,4-octadecanetriol from D-galactose in 18% overall yield was described, which required ten steps of reactions and only four times column chromatography purification.展开更多
文摘Four a-galactosyl phytosphingosine 2,6’-diamide analogs were prepared from 2,6’-diamino a-galactosylphytosphingosine and the aromatic-bearing carboxylic acids. After purification with High Performance Liquid Chromatography, a flowcytometry for the four compounds for stimulation of human Va24+/Vb11+ NKT cell populations was carried out. Additional keto groups on the acyl chains of the 2,6’-diamide compound was associated with the enhanced stimulating effect.
文摘An efficient and practical route to synthesize （2S,3S,4R）-2-azido-3,4-O-isopropyllidene-1,3,4-octadecanetriol from D-galactose in 18% overall yield was described, which required ten steps of reactions and only four times column chromatography purification.
