Calotropisprocera(Cp)is a traditional medicinal plant that has attracted significant attention for its potential anticancer properties.This review consolidates current research on the Cp bioactive compounds found in C...Calotropisprocera(Cp)is a traditional medicinal plant that has attracted significant attention for its potential anticancer properties.This review consolidates current research on the Cp bioactive compounds found in Cp,including cardenolides,flavonoids,and terpenoids,which exhibit cytotoxic effects against various cancer cells.These compounds function through multiple mechanisms,such as inducing apoptosis,inhibiting cell proliferation,suppressing angiogenesis,and modulating oxidative stress.Preclinical studies demonstrate that Cp extracts effectively reduce tumor size and improve survival rates in animal models.Furthermore,Cp influences key signaling pathways like PI3K/Akt and NF-κB,which contribute to its anticancer potential.Its therapeutic effects extend beyond oncology,encompassing,antinociceptive,anticonvulsant,antimalarial,anthelmintic,antioxidant,antidiabetic,myocardial infarction prevention,schizontocidal,antimicrobial,anti-inflammatory,larvicidal,immunomodulatory,antiulcer,Antifertility,antidiarrheal,estrogenic,and Dermatophytic properties.Despite the promising preclinical data,further investigation is necessary to address challenges such as bioavailability,toxicity,and the standardization of Cp-based treatments.This review highlights the therapeutic promise of Cp as a complementary anticancer agent while emphasizing the need for rigorous clinical trials to confirm its safety and efficacy.展开更多
车地无线技术方案会直接影响地铁P I S的最终运行效果。随着国内城市地铁线路的不断建设以及技术的不断发展进步,对于PIS中车地无线技术方案的选择成为地铁通信系统从业人员关注的重点。本文着重介绍了当前国内地铁PIS中的车地无线技术...车地无线技术方案会直接影响地铁P I S的最终运行效果。随着国内城市地铁线路的不断建设以及技术的不断发展进步,对于PIS中车地无线技术方案的选择成为地铁通信系统从业人员关注的重点。本文着重介绍了当前国内地铁PIS中的车地无线技术方案,并针对PIS当前及未来业务需求、应用现状及技术原理进行分析,提出了适合于PIS业务需求的技术方案。展开更多
基金this manuscript sincerely acknowledge Central South University for their support through the postdoctoral research initiation grant(164990011).
文摘Calotropisprocera(Cp)is a traditional medicinal plant that has attracted significant attention for its potential anticancer properties.This review consolidates current research on the Cp bioactive compounds found in Cp,including cardenolides,flavonoids,and terpenoids,which exhibit cytotoxic effects against various cancer cells.These compounds function through multiple mechanisms,such as inducing apoptosis,inhibiting cell proliferation,suppressing angiogenesis,and modulating oxidative stress.Preclinical studies demonstrate that Cp extracts effectively reduce tumor size and improve survival rates in animal models.Furthermore,Cp influences key signaling pathways like PI3K/Akt and NF-κB,which contribute to its anticancer potential.Its therapeutic effects extend beyond oncology,encompassing,antinociceptive,anticonvulsant,antimalarial,anthelmintic,antioxidant,antidiabetic,myocardial infarction prevention,schizontocidal,antimicrobial,anti-inflammatory,larvicidal,immunomodulatory,antiulcer,Antifertility,antidiarrheal,estrogenic,and Dermatophytic properties.Despite the promising preclinical data,further investigation is necessary to address challenges such as bioavailability,toxicity,and the standardization of Cp-based treatments.This review highlights the therapeutic promise of Cp as a complementary anticancer agent while emphasizing the need for rigorous clinical trials to confirm its safety and efficacy.
文摘车地无线技术方案会直接影响地铁P I S的最终运行效果。随着国内城市地铁线路的不断建设以及技术的不断发展进步,对于PIS中车地无线技术方案的选择成为地铁通信系统从业人员关注的重点。本文着重介绍了当前国内地铁PIS中的车地无线技术方案,并针对PIS当前及未来业务需求、应用现状及技术原理进行分析,提出了适合于PIS业务需求的技术方案。
