To the Editor:Neonatal diabetes mellitus(NDM)is defined as diabetes diagnosed within 6 months after birth and occurs in approximately one in every 90,000 to 160,000 live births,with an 80%yield due to a known genetic ...To the Editor:Neonatal diabetes mellitus(NDM)is defined as diabetes diagnosed within 6 months after birth and occurs in approximately one in every 90,000 to 160,000 live births,with an 80%yield due to a known genetic diagnosis.NDM can be classified as transient(TNDM),permanent(PNDM),or syndromic,in which TNDM accounts for approximately 45%of all cases of NDM.Overexpression of genes on chromosome 6q24 is the most common cause of TNDM(OMIM_601410),which accounts for approximately 70%of all cases and occurs by one of three mechanisms:(1)paternal uniparental disomy(41%),(2)duplication of paternal alleles(33%),or(3)hypomethylation of the maternal allele(26%)[1].展开更多
文摘To the Editor:Neonatal diabetes mellitus(NDM)is defined as diabetes diagnosed within 6 months after birth and occurs in approximately one in every 90,000 to 160,000 live births,with an 80%yield due to a known genetic diagnosis.NDM can be classified as transient(TNDM),permanent(PNDM),or syndromic,in which TNDM accounts for approximately 45%of all cases of NDM.Overexpression of genes on chromosome 6q24 is the most common cause of TNDM(OMIM_601410),which accounts for approximately 70%of all cases and occurs by one of three mechanisms:(1)paternal uniparental disomy(41%),(2)duplication of paternal alleles(33%),or(3)hypomethylation of the maternal allele(26%)[1].
