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Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine
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作者 Leyan Xuan Yingying Hou +8 位作者 Lu Liang Jialin Wu Kai Fan Liming Lian Jianhua Qiu Yingling Miao Hossein Ravanbakhsh Mingen Xu Guosheng Tang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第10期576-617,共42页
Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells or drug carriers,that are promising for tissue engineering and regenerative medicine.Microgels ... Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells or drug carriers,that are promising for tissue engineering and regenerative medicine.Microgels can also be aggregated into microporous scaffolds,promoting cell infiltration and proliferation for tissue repair.This review gives an overview of recent developments in the fabrication techniques and applications of microgels.A series of conventional and novel strategies including emulsification,microfluidic,lithography,electrospray,centrifugation,gas-shearing,three-dimensional bioprinting,etc.are discussed in depth.The characteristics and applications of microgels and microgel-based scaffolds for cell culture and delivery are elaborated with an emphasis on the advantages of these carriers in cell therapy.Additionally,we expound on the ongoing and foreseeable applications and current limitations of microgels and their aggregate in the field of biomedical engineering.Through stimulating innovative ideas,the present review paves new avenues for expanding the application of microgels in cell delivery techniques. 展开更多
关键词 microgels Cell delivery Scaffolds 3D bioprinting Single-cell microgels
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Preparation of Manganese Oxide Hollow Spheres Using pH-responsive Microgels as Templates
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作者 张伟 张志成 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2009年第3期327-332,340,共7页
Manganese oxide hollow spheres were prepared by a novel and facile approach using pH- responsive microgels as templates. The final products were thoroughly characterized with X-ray powder diffraction, thermogravimetri... Manganese oxide hollow spheres were prepared by a novel and facile approach using pH- responsive microgels as templates. The final products were thoroughly characterized with X-ray powder diffraction, thermogravimetric analysis, scanning electron microscopy, Fourier transform infrared, and transmission electron microscopy. The results reveal that the shell thickness of manganese oxide hollow spheres increased with the dosage of KMnO4, which implies that a controllable and feasible strategy for manganese oxide hollow spheres prepa- ration has been established. Further studies on the microgels template showed some of them had an irreversible swelling/deswelling transition due to the uneven cross-link extent. Based on the results, a probable formation mechanism for the hollow spheres was proposed. 展开更多
关键词 pH-responsive microgel Templates based strategy Manganese oxide hollowsphere
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Application of Monodisperse Thermo-Responsive Composite Microgels with Core-Shell Structure Based on Au@Ag Bimetallic Nanorod as Core in Surface Enhanced Raman Spectroscopy Substrate 被引量:1
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作者 董旭 陈思远 査刘生 《Journal of Donghua University(English Edition)》 EI CAS 2016年第1期112-116,共5页
The monodisperse Au@Ag bimetallic nanorod is encapsulated by crosslinked poly( N-isopropylacrylamide)( PNIPAM) to produce thermo-responsive composite microgel with well-defined core-shell structure( Au@ Ag NR@ PNIPAM ... The monodisperse Au@Ag bimetallic nanorod is encapsulated by crosslinked poly( N-isopropylacrylamide)( PNIPAM) to produce thermo-responsive composite microgel with well-defined core-shell structure( Au@ Ag NR@ PNIPAM microgel)by seed-precipitation polymerization method using butenoic acid modified Au @ Ag NRs as seeds. When the temperature of the aqueous medium increases from 20℃ to 50℃,the localized surface plasmon resonance( LSPR) band of the entrapped Au @ Ag NR is pronouncedly red-shifted because of the decreased spatial distances between them as a result of shrinkage of the microgels,leading to their plasmonic coupling. The temperature tunable plasmonic coupling is demonstrated by temperature dependence of the surface enhanced Raman spectroscopy( SERS) signal of 1-naphthol in aqueous solution. Different from static plasmonic coupling modes from nanostructured assembly or array system of noble metals,the proposed plasmonic coupling can be dynamically controlled by environmental temperature. Therefore, the thermo responsive hybrid microgels have potential applications in mobile LSPR or SERS microsensors for living tissues or cells. 展开更多
关键词 smart composite microgels core-shell structure Au@Ag bimetallic nanorods thermo-responsiveness surface enhanced Raman spectroscopy(SERS)
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Structured Microgels through Microfluidic Assembly and Their Biomedical Applications 被引量:1
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作者 Rong-Cong Luo Chia-Hung Chen 《Soft》 2012年第1期1-23,共23页
Droplet based microfluidic is an effective, versatile and scalable approach which can be used to produce structured microgels with desirable features. The high degree of control endowed with microfluidics enables the ... Droplet based microfluidic is an effective, versatile and scalable approach which can be used to produce structured microgels with desirable features. The high degree of control endowed with microfluidics enables the formation of various functional microgels such as multicompartment encapsulations, Janus shaped particles and non spherical microgels. These microgels have aroused great interest in biological engineering aspect, since they outperform their counterparts produced from other techniques and have been applied in drug delivery, 3 Dimensional cell culture, micro tissues, single cell assay, tissue engineering and bioimaging. In this review, we will summarize the fabrication processes, technology comparisons and the usages in biomedical applications. 展开更多
关键词 DROPLET Microfluidic microgels CELL ENCAPSULATION TISSUE Engineering
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Surface Properties of the Microgels Based on N-isopropylacrylamide and Tert-butyl Acrylate by Using N,N′-methylene-bis(acrylamide) and Clay as Cross-linker 被引量:1
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作者 张青松 路平 +2 位作者 查刘生 马敬红 梁伯润 《Journal of Donghua University(English Edition)》 EI CAS 2006年第5期36-40,共5页
Adopting N, N'-methylene-bis (aculamide) (MBA) and inorganic clay (hectorite) as chemical and physical crosslinking agent, respectively, a series temperature sensitive microgels, based on N-isopropylacrylamide ... Adopting N, N'-methylene-bis (aculamide) (MBA) and inorganic clay (hectorite) as chemical and physical crosslinking agent, respectively, a series temperature sensitive microgels, based on N-isopropylacrylamide (NIPAM) as a main monomer and tert-butyl acrylate (tBA) as a comonomer were synthesized by surfactant-free emulsion polymerization (SFEP). The microgel particle size and morphology was investigated by means of Atomic Force Microscope (AFM). The surface tension of latex particles was measured by OCA 40 Micro Video based contact angle measuring device. The results showed that the particle size of the microgels with clay as cross-linker was smaller than that using MBA as chemical cross-linker, but exterior morphology of physical microgels is not as clean and neat as chemical microgels. In general, surface tension decreases with increasing hydrophobic tBA content. These smart microgels varied with tetnperature have the potential applications in the field of drug delivery and intelligent gel fiber. 展开更多
关键词 N-ISOPROPYLACRYLAMIDE microgel tert-butyl acrylate surface tension Atomic Force Microscope.
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PARAMETERS AFFECTING PARTICLE SIZE OF POLYBUTYL-ACRYLATE MICROGELS
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作者 王霞 余云照 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1989年第4期354-359,共6页
The factors affecting particle size of reactive microgels formed during the self-emulsifying copolymerization of unsaturated polyester (UP)with butyl acrylate (BA)have been studied. The parameters discussed are: the p... The factors affecting particle size of reactive microgels formed during the self-emulsifying copolymerization of unsaturated polyester (UP)with butyl acrylate (BA)have been studied. The parameters discussed are: the proportion of the UP in the monomer mixture, the molecular weight and the carboxyl value of the UP, the phase ratio, the electrolyte concentration and the polar solvent additive. The seeding emulsion polymerization is discussed as well.It turned out that the particle size of the reactive microgels can be controlled in a definite range by changing the experimental conditions. However the particle size distribution becomes broader as the average diameter increases. It is suggested that the agglomeration of primary particles plays an important role during the growth of microgel particle. 展开更多
关键词 Emulsion polymerization microgel Unsaturated polyester.
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Application of reactive acrylate microgels in water-base coatings
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作者 撒圣淑 张宝华 +2 位作者 杨青 王夏琴 毛志平 《Journal of Shanghai University(English Edition)》 CAS 2009年第1期67-71,共5页
Reactive acrylate microgels with different reactive groups such as carboxyl, hydroxide groups had excellent properties such as quick-dry, low viscosity, high adhesion and hardness, which made them extensively used in ... Reactive acrylate microgels with different reactive groups such as carboxyl, hydroxide groups had excellent properties such as quick-dry, low viscosity, high adhesion and hardness, which made them extensively used in preparing paints or in coating-modification. Reactive acrylate microgels were prepared by emulsion co-polymerization with zwitterions surfactant, anionic surfactant and nonionic surfactant as co-emulsifier. The water-base baking paints made from reactive acrylate microgels and melamine-formaldehyde resin had excellent combination properties. The aluminium powder can be well-dispersed in the paints. The influences of monomer components on the properties of the water-base baking paints were discussed in this paper. And the baking paints were also compared with the marketing solvent acrylate baking paints. It was found that the water-base acrylate amino baking paints had better combination properties than the organic solvent acrylate baking paints, which means that the water-base baking paints had a bright marketing future. 展开更多
关键词 ACRYLATE reactive microgels water-base baking paints elamine-formaldehyde resin
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STABILITY OF POLY(N,N'-METHYLENEBISACRYLAMIDE-co-4-VINYLPYRIDINE)MICROGEL DISPERSION AND ADJUSTMENT OF THE HYDROPHOBICITY IN THE MICROGELS
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作者 Qing-de Chen Xing-hai Shen and Hong-cheng Gao Department of Applied Chemistry,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2005年第6期635-642,共8页
In the UV-Vis spectra of pure light-scattering systems, there is an exponential relationship between absorbance and wavelength (A = Kλ^-n). Here, the exponent n is named as flocculation-coagulation parameter. In th... In the UV-Vis spectra of pure light-scattering systems, there is an exponential relationship between absorbance and wavelength (A = Kλ^-n). Here, the exponent n is named as flocculation-coagulation parameter. In the present paper, the effects of different additives on the stability of poly(N,N'-methylenebisacrylamide-co-4-vinylpyridine) (poly(Bis-co-4-VP)) microgel dispersion were studied in detail via this parameter. The results showed that the stability of the dispersion mainly comes from the ionization of pyridine groups, making the microgel positively charged on its surface. This was confirmed by the measurement of Zeta potential and the result of conductometric titration. The result of fluorescence analysis indicated that the hydrophobicity in the microgels is enhanced with the increase in total 4-VP unit content. 展开更多
关键词 microgel dispersion(s) 4-VINYLPYRIDINE Flocculation-coagulation parameter Zeta potential
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Preparation and Properties of Hydroxyethyl Methacrylate Chemically Modified Temperature-Sensitive Microgels
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作者 马晓梅 席靖宇 +1 位作者 赵喜安 唐小真 《Journal of Shanghai Jiaotong university(Science)》 EI 2004年第4期85-90,共6页
A novel series of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (p(NIPAM-co-HEMA)) microgels were prepared through precipitation polymerization. Nuclear magnetic resonance (NMR), transmission electron micro... A novel series of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (p(NIPAM-co-HEMA)) microgels were prepared through precipitation polymerization. Nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV) and dynamic light scattering (DLS) were employed to characterize the microgels. The experimental results indicate that the prepared microgels with narrow distribution remain good temperature sensitivity after incorporation of functional-OH groups. In marked contrast to the general rule, incorporation of hydrophilic HEMA makes the volume-phase-transition temperature shift to the lower temperature due to the strong intermolecular H-bonding between amide and -OH groups, -OH and -OH groups. 展开更多
关键词 microgels N-ISOPROPYLACRYLAMIDE temperature-sensitivity volume-phase transition
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Phototactic Poly(N-isopropyl acrylamide)Microgels with Photoresponsive Property
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作者 Xiao-ran Wu Xiang Xue +1 位作者 Jing-hang Wang He-wen Liu 《Chinese Journal of Chemical Physics》 SCIE EI CAS CSCD 2022年第5期823-834,I0012,I0013,共14页
Smart functional microgels hold great potential in a variety of applications,especially in drug transportation.However,current drug carriers based on physiological internal stimuli cannot efficiently orientate to desi... Smart functional microgels hold great potential in a variety of applications,especially in drug transportation.However,current drug carriers based on physiological internal stimuli cannot efficiently orientate to designated locations.Therefore,it is necessary to introduce the self-propelled particles to the drug release of the microgels.In order to study self-propulsion of microgels induced by light,it is also a challenge to prepare micronsized microgels so that they can be observed directly under optical microscopes.In this work,phototactic microgels with photoresponsive properties are prepared.The microgel particles can be observed by confocal laser scanning microscopy.The photoresponsive properties of microgels are fully investigated by various instruments.Light can also regulate the state of the microgel solution,making it switch between turbidity and clarity.The phototaxis of particles irradiated by UV light was studied,which may be used for microgels enrichment and drug transportation and release. 展开更多
关键词 PHOTOTAXIS PHOTORESPONSIVE Poly(N-isopropyl acrylamide) microgel
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The shape, size and thermal behavior of PNIPAM microgels with high cross-linker amount
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作者 ZHANG Qing-song ZHA Liu-sheng +1 位作者 MA Jing-hong LIANG Bo-run 《材料科学与工程(中英文版)》 2007年第1期13-18,共6页
关键词 PNIPAM 化学交联剂 热行为 微凝胶 形状 异丙基丙烯酰胺 透射电子显微镜 剂量
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Conformance control by a microgel in a multi-layered heterogeneous reservoir during CO_(2) enhanced oil recovery process 被引量:2
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作者 Zheyu Liu Jian Zhang +6 位作者 Xianjie Li Chunming Xu Xin Chen Bo Zhang Guang Zhao Han Zhang Yiqiang Li 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2022年第3期324-334,共11页
Injecting CO_(2)into the underground for oil displacement and shortage is an important technique for carbon capture,utilization and storage(CCUS).One of the main problems during the CO_(2)injection is the channeling p... Injecting CO_(2)into the underground for oil displacement and shortage is an important technique for carbon capture,utilization and storage(CCUS).One of the main problems during the CO_(2)injection is the channeling plugging.Finding an effective method for the gas channeling plugging is a critical issue in the CO_(2)EOR process.In this work,an acid-resistance microgel named dispersed particle gel(DPG)was characterized and its stability was tested in the CO_(2)environment.The microgel size selection strategies for the homogeneous and heterogeneous reservoirs were respectively investigated using the single core flooding and three parallel core flooding experiments.Moreover,the comparison of microgel alternate CO_(2)(MAC)injection and water alternate CO_(2)(WAC)injection in the dual core flooding experiments were presented for the investigation of the role of microgel on the conformance control in CO_(2)flooding process.The results have shown that the microgel featured with ANH and CAN groups can keep its morphology after aging 7 days in the CO_(2)environment.Where,the small microgel with unobstructed migration and large microgel with good plugging efficiency for the high permeability zone were respectively featured with the higher recovery factor in homogeneous and heterogeneous conditions,which indicate they are preferred used for the oil displacement and conformance control.Compared to WAC injection,MAC injection had a higher incremental recovery factor of 12.4%.It suggests the acid-resistance microgel would be a good candidate for the conformance control during CO_(2)flooding process. 展开更多
关键词 Carbon dioxide microgels Enhanced oil recovery Conformance control Porous media
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Sacrificial microgel‑laden bioink‑enabled 3D bioprinting of mesoscale pore networks 被引量:8
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作者 Lei Shao Qing Gao +5 位作者 Chaoqi Xie Jianzhong Fu Meixiang Xiang Zhenjie Liu Liulin Xiang Yong He 《Bio-Design and Manufacturing》 CSCD 2020年第1期30-39,共10页
Three-dimensional(3D)bioprinting is a powerful approach that enables the fabrication of 3D tissue constructs that retain complex biological functions.However,the dense hydrogel networks that form after the gelation of... Three-dimensional(3D)bioprinting is a powerful approach that enables the fabrication of 3D tissue constructs that retain complex biological functions.However,the dense hydrogel networks that form after the gelation of bioinks often restrict the migration and proliferation of encapsulated cells.Herein,a sacrificial microgel-laden bioink strategy was designed for directly bioprinting constructs with mesoscale pore networks(MPNs)for enhancing nutrient delivery and cell growth.The sacrificial microgel-laden bioink,which contains cell/gelatin methacryloyl(GelMA)mixture and gelled gelatin microgel,is first thermo-crosslinked to fabricate temporary predesigned cell-laden constructs by extrusion bioprinting onto a cold platform.Then,the construct is permanently stabilized through photo-crosslinking of GelMA.The MPNs inside the printed constructs are formed after subsequent dissolution of the gelatin microgel.These MPNs allowed for effective oxygen/nutrient diffusion,facilitating the generation of bioactive tissues.Specifically,osteoblast and human umbilical vein endothelial cells encapsulated in the bioprinted large-scale constructs(≥1 cm)with MPNs showed enhanced bioactivity during culture.The 3D bioprinting strategy based on the sacrificial microgel-laden bioink provided a facile method to facilitate formation of complex tissue constructs with MPNs and set a foundation for future optimization of MPN-based tissue constructs with applications in diverse areas of tissue engineering. 展开更多
关键词 Sacrificial microgel Gelatin methacryloyl(GelMA) 3D bioprinting Mesoscale pore networks(MPNs) Tissue engineering
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Non-isothermal crystallization kinetics of reactive microgel/nylon 6 blends 被引量:1
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作者 何敏 宗思琪 +2 位作者 周亚欢 郭怀兵 樊庆春 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2015年第8期1403-1407,共5页
The non-isothermal crystallization kinetics of reactive microgel/nylon 6 blends was investigated by differential scanning calorimetry(DSC). The Mo equation was employed to analyze the non-isothermal crystallization da... The non-isothermal crystallization kinetics of reactive microgel/nylon 6 blends was investigated by differential scanning calorimetry(DSC). The Mo equation was employed to analyze the non-isothermal crystallization data. The crystallization activation energies were also evaluated by the Kissinger method. The results show that the crystallization onset temperature(T onset) and crystallization peak temperature(T p) decrease with the increase of the content of reactive microgel, while ΔT(T onset–T p), the crystallization half-time(t1/2) and the crystallization enthalpy(ΔH c) increase. The required cooling rates of blends are higher than that of neat nylon6 in order to achieve the same relative crystallinity in a unit of time. The crystallization activation energies of the reactive microgel/nylon 6 blends are greater than those of the neat nylon 6. When the content of reactive microgel is 30%, the relative crystallinity(X t) reaches the maximum. 展开更多
关键词 Reactive microgel Nylon 6 Non-isothermal crystallization kinetics Crystallization activation energy
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CURE OF A MICROGEL-EPOXY RESIN TWO-PHASE POLYMER WITH ETHYLENE DIAMINE
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作者 宋爱腾 黄伟 余云照 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1992年第3期276-280,共5页
The curing of a microgel-epoxy resin two phase polymer prepared by in situ copolymerization of unsaturated polyester with acrylic monomer was studied. The unsaturated unit reacted with N—H during the cure of the resi... The curing of a microgel-epoxy resin two phase polymer prepared by in situ copolymerization of unsaturated polyester with acrylic monomer was studied. The unsaturated unit reacted with N—H during the cure of the resin with ethylene diamine. The Michael type reaction was ten times more rapid than the addition of N—H to epoxide.This was accounted for the lower apparent activation energy of the curing of the two phase resin. 展开更多
关键词 Epoxy resin CURING microgel Michael reaction
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PREPARATION OF MICROGEL-EPOXY RESIN TWO-PHASE POLYMERS BY IN SITU POLYMERIZATION~*
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作者 余云照 吴湘洪 宋爱腾 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1991年第4期333-338,共6页
Microgel-epoxy resin two-phase polymers were prepared by in situ copolymerization of ethylenic monomers with unsaturated polyesters. The choice of monomers and the effect of monomer concentration on microgel particle ... Microgel-epoxy resin two-phase polymers were prepared by in situ copolymerization of ethylenic monomers with unsaturated polyesters. The choice of monomers and the effect of monomer concentration on microgel particle size were discussed. Agglomeration of particles played a significant role in the early stage of polymerization. The microgel dispersion in epoxy resin was stable after the finish of polymerization. Upon curing the particles remained well dispersed. 展开更多
关键词 Epoxy resin microgel two-phase polymer
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The effect of fat on properties and filling characteristics of myofibrillar protein emulsion microgels
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作者 Jiashi Chen Keqing Lin +4 位作者 Liping Zhang Zhigang Zhang Song Miao Baodong Zheng Longtao Zhang 《Food Bioscience》 SCIE 2022年第6期2009-2014,共6页
Emulsion microgels are micron-sized particles formed by one or more emulsion droplets surrounded by soft solids.It is inferred that their special structure affords interesting filling properties in protein gels.Differ... Emulsion microgels are micron-sized particles formed by one or more emulsion droplets surrounded by soft solids.It is inferred that their special structure affords interesting filling properties in protein gels.Different fat types affect the properties of emulsion microgels leading to different filling effects.The influence of fat types(soybean oil,lard,and coconut oil)on the myofibrillar protein emulsion microgels was studied by particle size,microstructure,and rheology.The filling properties were investigated in a protein gel model.The results show that coconut oil emulsion microgels had the smallest particle size,the thickest gel shell and the highest storage modulus.The apparent viscosity of all treatments showed shear thinning behavior and that of coconut oil treatment was significantly higher.With the increase in fat contents,the thixotropic ring area of coconut oil and lard treatment increased,while that of soybean oil treatment decreased.The filling properties in the protein gel model were analyzed by rheology,texture,microstructure and cooking loss measurement.Adding emulsion microgels to pure gels could increase the storage modulus of gels,and the storage modulus of gels filled with coconut oil emulsion microgels was the highest,indicating that emulsion microgels were active fillers.When the amount of addition was more than 10%,the texture properties of the filled gels improved,which was attributed to the enhanced density of the microstructure.In addition,the cooking loss was also reduced,and the gels filled with coconut oil emulsion microgels had the best performance. 展开更多
关键词 Myofibrillar protein Fat Emulsion microgels Rheology Filling effect
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Highly Sensitive Poly-N-isopropylacrylamide Microgel-based Electrochemical Biosensor for the Detection of SARS-COV-2 Spike Protein
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作者 CHEN Hao HOU Zhi Yuan +5 位作者 CHEN Die LI Ting WANG Yi Ming DE LIMA Marcelo Andrade YANG Ying GUO Zhen Zhong 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2023年第3期269-278,共10页
Objective Late 2019 witnessed the outbreak and widespread transmission of coronavirus disease 2019(COVID-19),a new,highly contagious disease caused by novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).... Objective Late 2019 witnessed the outbreak and widespread transmission of coronavirus disease 2019(COVID-19),a new,highly contagious disease caused by novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Consequently,considerable attention has been paid to the development of new diagnostic tools for the early detection of SARS-CoV-2.Methods In this study,a new poly-N-isopropylacrylamide microgel-based electrochemical sensor was explored to detect the SARS-CoV-2 spike protein(S protein)in human saliva.The microgel was composed of a copolymer of N-isopropylacrylamide and acrylic acid,and gold nanoparticles were encapsulated within the microgel through facile and economical fabrication.The electrochemical performance of the sensor was evaluated through differential pulse voltammetry.Results Under optimal experimental conditions,the linear range of the sensor was 10-13-10-9 mg/m L,whereas the detection limit was 9.55 fg/mL.Furthermore,the S protein was instilled in artificial saliva as the infected human saliva model,and the sensing platform showed satisfactory detection capability.Conclusion The sensing platform exhibited excellent specificity and sensitivity in detecting spike protein,indicating its potential application for the time-saving and inexpensive detection of SARS-CoV-2. 展开更多
关键词 microgel SARS-CoV-2 Spike protein DETECTION
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POLY(N-ISOPROPYL ACRYLAMIDE) MICROGEL DOPED WITH LUMINESCENT PBS QUANTUM DOTS
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作者 ZHAO Xusheng GAN Jianqun +2 位作者 CHUCHI Sam LIU Guanghua CHEN Aimin 《Chinese Journal of Reactive Polymers》 2007年第1期55-60,共6页
Thiol-stabilized PbS quantum dots (QDs) with dimensions 3-5 nm capped with a mixture of 1-thioglycerol/dithioglycerol (TGL/DTG) were coUoidally prepared at room temperature. Room temperature photoluminescence quan... Thiol-stabilized PbS quantum dots (QDs) with dimensions 3-5 nm capped with a mixture of 1-thioglycerol/dithioglycerol (TGL/DTG) were coUoidally prepared at room temperature. Room temperature photoluminescence quantum efficiency of freshly prepared PbS QDs (7%-11%) remained higher than 5% upon aging for three weeks when the nanocrystals (NCs) were stored in an ice-bath in the dark, and higher than 5%for at least five weeks when extra DTG ligands were introduced into the nanocrystal solution followed by stirring every two weeks. Poly(N-isopropyl acrylamide) (PNIPAM) microgels were produced via precipitation polymerization with dimensions of ca. 230 nm and polydispersity of 3-5%. Incorporation of PbS QDs into PNIPAM microgels indicated that PbS can be incorporated into the interior of microgel particles and not at the microgel interface. The combination of reasonable room temperature quantum efficiency and strong, efficient luminescence covering the 1.3-1.55 μm telecommunication window makes these nanoparticles promising materials in optical devices and telecommunications. 展开更多
关键词 Poly(N-isopropyl acrylamide) microgel PbS quantum dots PHOTOLUMINESCENCE Photoluminescence quantum efficiency Incorporation/infiltration.
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油藏开发非均相智能调驱评价及模拟预测方法
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作者 曹琳 张新龙 +3 位作者 刘伟 尹彦君 盛广龙 赵辉 《长江大学学报(自然科学版)》 2024年第5期82-93,共12页
储层原生非均质性及次生非均质性导致开发后期形成优势渗流通道,剩余油分布复杂且启动困难。智能微凝胶深部调驱能够通过吸附膨胀实现高渗通道封堵,同时能够差异性降低油水相渗透率实现流度高效调整。基于连接元数值模拟方法,考虑“堵... 储层原生非均质性及次生非均质性导致开发后期形成优势渗流通道,剩余油分布复杂且启动困难。智能微凝胶深部调驱能够通过吸附膨胀实现高渗通道封堵,同时能够差异性降低油水相渗透率实现流度高效调整。基于连接元数值模拟方法,考虑“堵大不堵小”的封堵机理及“堵水不堵油”的驱油机理,建立了智能微凝胶调驱数值模拟方法,实现了油水动态快速计算与预测。通过引入洛伦兹系数等建立了非均相调驱效果评价方法,能够定量评价调驱前后的储层改造效果。概念算例及实际算例应用效果表明,提出的非均相智能调驱评价及模拟预测方法能够定量评价改善开发效果的程度,实现非均相智能微凝胶驱油快速、准确预测,对于现场调驱方案制定具有应用价值。 展开更多
关键词 非均相 智能微凝胶 连接元方法 调驱模拟
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