Here, dielectric spectroscopy is used in the fre- quency range from 10-2 Hz up to 107 Hz and we found dynamics of the primary α-and intermolecular Johari–Goldstein β-processes are strongly correlated in diglycidyl-...Here, dielectric spectroscopy is used in the fre- quency range from 10-2 Hz up to 107 Hz and we found dynamics of the primary α-and intermolecular Johari–Goldstein β-processes are strongly correlated in diglycidyl-ether of bis-phenol-A and poly phenyl glycidyl-ether (PPGE) over a wide temperature from 193 to 345 K and pressure P range from 0.1 to 600 MPa. In contrast with the widespread opinion of statistical independence of these processes the α-β mutual dependence is quantitatively confirmed in [1] analysing the temperature and pressure behavior of the α-and (JG) β-processes the investigation of the ratio of dielectric strength of two processes close to Tg evidence that the importance of secondary dy namics in relaxing external electric stresses increase in glass formers at high pressures with respect to that of the structural relaxation. We suggest that the thermal agitation, acting above Tg is at the basis of the observed result.展开更多
目的研究达格列净联合西格列汀治疗脆性2型糖尿病患者的临床疗效。方法将2017年7月—2019年7月延安大学附属医院收治的80例脆性2型糖尿病患者作为研究对象,将患者随机分为对照组和观察组,每组各40例。对照组口服磷酸西格列汀片治疗,100 ...目的研究达格列净联合西格列汀治疗脆性2型糖尿病患者的临床疗效。方法将2017年7月—2019年7月延安大学附属医院收治的80例脆性2型糖尿病患者作为研究对象,将患者随机分为对照组和观察组,每组各40例。对照组口服磷酸西格列汀片治疗,100 mg/d。观察组在对照组基础上口服达格列净片,10 mg/d。两组疗程为12周。比较两组治疗前后的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)、日间血糖平均绝对差(MODD)、餐后血糖波动幅度(PPGE)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、肿瘤细胞坏死因子(TNF)-α水平。结果治疗后,两组患者FBG、2 h PG、HbA1c均显著降低(P<0.05),且观察组FBG、2 h PG、HbA1c显著低于对照组(P<0.05)。治疗后,两组患者MODD和PPGE均显著低于治疗前(P<0.05),且观察组MODD和PPGE明显低于对照组(P<0.05)。治疗后,两组患者IL-4、IL-6、TNF-α水平均显著降低(P<0.05),且观察组炎性因子水平显著低于对照组(P<0.05)。结论达格列净联合西格列汀能起到协同作用,有效控制脆性2型糖尿病患者的血糖水平,降低炎性因子水平,减少血糖波动与低血糖的风险。展开更多
文摘Here, dielectric spectroscopy is used in the fre- quency range from 10-2 Hz up to 107 Hz and we found dynamics of the primary α-and intermolecular Johari–Goldstein β-processes are strongly correlated in diglycidyl-ether of bis-phenol-A and poly phenyl glycidyl-ether (PPGE) over a wide temperature from 193 to 345 K and pressure P range from 0.1 to 600 MPa. In contrast with the widespread opinion of statistical independence of these processes the α-β mutual dependence is quantitatively confirmed in [1] analysing the temperature and pressure behavior of the α-and (JG) β-processes the investigation of the ratio of dielectric strength of two processes close to Tg evidence that the importance of secondary dy namics in relaxing external electric stresses increase in glass formers at high pressures with respect to that of the structural relaxation. We suggest that the thermal agitation, acting above Tg is at the basis of the observed result.
文摘目的研究达格列净联合西格列汀治疗脆性2型糖尿病患者的临床疗效。方法将2017年7月—2019年7月延安大学附属医院收治的80例脆性2型糖尿病患者作为研究对象,将患者随机分为对照组和观察组,每组各40例。对照组口服磷酸西格列汀片治疗,100 mg/d。观察组在对照组基础上口服达格列净片,10 mg/d。两组疗程为12周。比较两组治疗前后的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)、日间血糖平均绝对差(MODD)、餐后血糖波动幅度(PPGE)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、肿瘤细胞坏死因子(TNF)-α水平。结果治疗后,两组患者FBG、2 h PG、HbA1c均显著降低(P<0.05),且观察组FBG、2 h PG、HbA1c显著低于对照组(P<0.05)。治疗后,两组患者MODD和PPGE均显著低于治疗前(P<0.05),且观察组MODD和PPGE明显低于对照组(P<0.05)。治疗后,两组患者IL-4、IL-6、TNF-α水平均显著降低(P<0.05),且观察组炎性因子水平显著低于对照组(P<0.05)。结论达格列净联合西格列汀能起到协同作用,有效控制脆性2型糖尿病患者的血糖水平,降低炎性因子水平,减少血糖波动与低血糖的风险。
