Solid phase exchange radioiodination method was used to label the compound.Pharmacokinetics was studied in rats and the data were dealt with by computer. The results indicate that the compound would be a potential myo...Solid phase exchange radioiodination method was used to label the compound.Pharmacokinetics was studied in rats and the data were dealt with by computer. The results indicate that the compound would be a potential myocardial imaging agent.展开更多
β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L ...β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.展开更多
目的探讨心得宁口服液对大鼠慢性心衰模型血清中血管紧张素Ⅱ(Ang-Ⅱ)、B型脑钠肽(BNP)、心肌肌钙蛋白Ⅰ(cTnⅠ)、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-a(8)、磷酸腺苷(ATP)和白介素-6(IL-6)水平的影响。方法采用每周腹腔注射盐酸多柔比...目的探讨心得宁口服液对大鼠慢性心衰模型血清中血管紧张素Ⅱ(Ang-Ⅱ)、B型脑钠肽(BNP)、心肌肌钙蛋白Ⅰ(cTnⅠ)、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-a(8)、磷酸腺苷(ATP)和白介素-6(IL-6)水平的影响。方法采用每周腹腔注射盐酸多柔比星(2 mL·kg^(-1)腹腔注射,每周1次,共6周,累积总量24 mg·kg-1)建立大鼠慢性心衰模型,观察20,10,5 m L·kg^(-1)心得宁口服液对慢性心衰模型大鼠血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-a、ATP和IL-6水平的影响。结果大鼠慢性心衰模型造模成功。与模型组相比,20,10,5 m L·kg^(-1)心得宁口服液能显著降低血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-α水平(P<0.01);显著升高ATP水平(P<0.01),20,10 mL·kg^(-1)心得宁口服液能显著降低血清IL-6水平(P<0.01),5 m L·kg^(-1)心得宁口服液能明显降低血清IL-6水平(P<0.05)。结论心得宁口服液可明显改善大鼠慢性心衰模型的作用。展开更多
文摘Solid phase exchange radioiodination method was used to label the compound.Pharmacokinetics was studied in rats and the data were dealt with by computer. The results indicate that the compound would be a potential myocardial imaging agent.
文摘β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.
文摘目的探讨心得宁口服液对大鼠慢性心衰模型血清中血管紧张素Ⅱ(Ang-Ⅱ)、B型脑钠肽(BNP)、心肌肌钙蛋白Ⅰ(cTnⅠ)、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-a(8)、磷酸腺苷(ATP)和白介素-6(IL-6)水平的影响。方法采用每周腹腔注射盐酸多柔比星(2 mL·kg^(-1)腹腔注射,每周1次,共6周,累积总量24 mg·kg-1)建立大鼠慢性心衰模型,观察20,10,5 m L·kg^(-1)心得宁口服液对慢性心衰模型大鼠血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-a、ATP和IL-6水平的影响。结果大鼠慢性心衰模型造模成功。与模型组相比,20,10,5 m L·kg^(-1)心得宁口服液能显著降低血清Ang-Ⅱ、BNP、cTnⅠ、CRP、TNF-α水平(P<0.01);显著升高ATP水平(P<0.01),20,10 mL·kg^(-1)心得宁口服液能显著降低血清IL-6水平(P<0.01),5 m L·kg^(-1)心得宁口服液能明显降低血清IL-6水平(P<0.05)。结论心得宁口服液可明显改善大鼠慢性心衰模型的作用。
