Techniques for mining information from distributed data sources accessible over the Internet are a growing area of research.The mobile Agent paradigm opens a new door for distributed data mining and knowledge discover...Techniques for mining information from distributed data sources accessible over the Internet are a growing area of research.The mobile Agent paradigm opens a new door for distributed data mining and knowledge discovery applications.In this paper we present the design of a mobile agent system which couples service discovery,using a logical language based application programming interface,and database access.Combining mobility with database access provides a means to create more efficient data mining applications.The processing of data is moved to network wide data locations instead of the traditional approach of bringing huge amount of data to the processing location.Our proposal aims at implementing system tools that will enable intelligent mobile Agents to roam the Internet searching for distributed data services.Agents access the data,discover patterns,extract useful information from facts recorded in the databases,then communicate local results back to the user.The user then generates a global data model through the aggregation of results provided by all Agents.This overcomes barriers posed by network congestion,poor security,and unreliability.展开更多
目的：探讨葛根芩连汤整方剂量变化治疗溃疡性结肠炎的量效关系，获得基于药效学的经方“剂量阈”。方法：采用2，4，6-三硝基苯磺酸（TNBS）／乙醇法诱导溃疡性结肠炎实验大鼠模型，正常组除外，分为：正常组、溃疡性结肠炎模型组、柳...目的：探讨葛根芩连汤整方剂量变化治疗溃疡性结肠炎的量效关系，获得基于药效学的经方“剂量阈”。方法：采用2，4，6-三硝基苯磺酸（TNBS）／乙醇法诱导溃疡性结肠炎实验大鼠模型，正常组除外，分为：正常组、溃疡性结肠炎模型组、柳氮磺吡啶肠溶片组，葛根芩连汤整方剂量变化的9个剂量组（分别为生药1．65，4．95，8．25，11．55，14．85，18．15，21．45。24．75，28．05g·kg-1），给药1次／d，共5d。观察大鼠的一般情况，计算大鼠疾病活动指数（DAI）指数，比色法检测匀浆上清液髓质过氧化酶（MPO）、丙二醛（MDA）、超氧化物岐化酶（SOD）活性；经GraphPadPrism6软件拟合量效曲线，评价葛根芩连汤治疗溃疡性结肠炎模型大鼠的量一效关系，计算相关剂量参数。结果：综合实验数据分析，以MPO活性为指标，经Graph Pad Prism6Demo拟合后，拟合方程与模型相似度高，量效曲线呈反向“s”型，且有意义，算出的剂量阈参数如下：[D]20-[D]80为15．39～17．11g.kg-1，中位剂量：[D]50 16．25g·kg-1，阈剂量：[D]20 15．39g·kg-1。结论：葛根芩连汤治疗治疗溃疡性结肠炎模型大鼠的量一效曲线呈现反向“s”型，提示其中剂量为有效治疗范围，即大致在15．39～17．11g·kg-1。展开更多
文摘Techniques for mining information from distributed data sources accessible over the Internet are a growing area of research.The mobile Agent paradigm opens a new door for distributed data mining and knowledge discovery applications.In this paper we present the design of a mobile agent system which couples service discovery,using a logical language based application programming interface,and database access.Combining mobility with database access provides a means to create more efficient data mining applications.The processing of data is moved to network wide data locations instead of the traditional approach of bringing huge amount of data to the processing location.Our proposal aims at implementing system tools that will enable intelligent mobile Agents to roam the Internet searching for distributed data services.Agents access the data,discover patterns,extract useful information from facts recorded in the databases,then communicate local results back to the user.The user then generates a global data model through the aggregation of results provided by all Agents.This overcomes barriers posed by network congestion,poor security,and unreliability.
文摘目的：探讨葛根芩连汤整方剂量变化治疗溃疡性结肠炎的量效关系，获得基于药效学的经方“剂量阈”。方法：采用2，4，6-三硝基苯磺酸（TNBS）／乙醇法诱导溃疡性结肠炎实验大鼠模型，正常组除外，分为：正常组、溃疡性结肠炎模型组、柳氮磺吡啶肠溶片组，葛根芩连汤整方剂量变化的9个剂量组（分别为生药1．65，4．95，8．25，11．55，14．85，18．15，21．45。24．75，28．05g·kg-1），给药1次／d，共5d。观察大鼠的一般情况，计算大鼠疾病活动指数（DAI）指数，比色法检测匀浆上清液髓质过氧化酶（MPO）、丙二醛（MDA）、超氧化物岐化酶（SOD）活性；经GraphPadPrism6软件拟合量效曲线，评价葛根芩连汤治疗溃疡性结肠炎模型大鼠的量一效关系，计算相关剂量参数。结果：综合实验数据分析，以MPO活性为指标，经Graph Pad Prism6Demo拟合后，拟合方程与模型相似度高，量效曲线呈反向“s”型，且有意义，算出的剂量阈参数如下：[D]20-[D]80为15．39～17．11g.kg-1，中位剂量：[D]50 16．25g·kg-1，阈剂量：[D]20 15．39g·kg-1。结论：葛根芩连汤治疗治疗溃疡性结肠炎模型大鼠的量一效曲线呈现反向“s”型，提示其中剂量为有效治疗范围，即大致在15．39～17．11g·kg-1。
